Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.

Abstract: Positive allosteric modulators of melanocortin receptors, especially allosteric potentiators of the receptors MC3R and MC4R are described herein. Also provided are pharmaceutical compositions containing the positive allosteric modulators and methods of treating obesity or an obesity-related disorder such as type 2 diabetes, comprising administering an effective amount of the positive allosteric modulator.

Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.

Abstract: Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described, wherein the compounds have formula I: In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein.

Abstract: A plurality of network addresses from a distributed client is obtained, at least a first portion of the obtained network addresses including resolved network address responses to distributed client requests for resolved network addresses corresponding to one or more network location indicators associated with a first web service. Test content is obtained, based on one or more of the network addresses included in the first portion. It is determined whether the obtained test content includes unauthorized content.

Abstract: A computer implemented method for fusing images taken by a plurality of cameras is disclosed, comprising the steps of: receiving a plurality of images of the same scene taken by the plurality of cameras; generating Laplacian pyramid images for each source image of the plurality of images; applying contrast normalization to the Laplacian pyramids images; performing pixel-level fusion on the Laplacian pyramid images based on a local salience measure that reduces aliasing artifacts to produce one salience-selected Laplacian pyramid image for each pyramid level; and combining the salience-selected Laplacian pyramid images into a fused image. Applying contrast normalization further comprises, for each Laplacian image at a given level: obtaining an energy image from the Laplacian image; determining a gain factor that is based on at least the energy image and a target contrast; and multiplying the Laplacian image by a gain factor to produce a normalized Laplacian image.

Abstract: A system and method automatically generates an object-oriented, textual program from a graphical model, and verifies the performance of the textual program as compared to the graphical model. The graphical model may have a plurality of interconnected blocks, and each block may have a plurality of parameters. One or more of the blocks are mapped to a system object, and the block's parameters are mapped to properties of the system object. An object-oriented, executable textual string is generated automatically for the block. The generated string includes at least one command to: instantiate a system object having functionality that matches the block; set one or more properties of the system object based on the block's parameters; and run the instantiated object.

Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: Embodiments of the present invention provide a method and an apparatus for configuring a transmission mode, where the method includes: obtaining channel matrix information, where the channel matrix information is any one of the following: a precoding matrix indicator which most matches a current uplink channel matrix of a terminal, a current downlink precoding matrix indicator of the terminal, an uplink channel matrix of the terminal and the precoding matrix indicator which most matches the current uplink channel matrix of the terminal, and the uplink channel matrix of the terminal and the current downlink precoding matrix indicator of the terminal; determining performance of data transmission performed by adopting a closed-loop mode and an open-loop mode according to the channel matrix information, and selecting the data transmission mode according to the determined performance of data transmission, where the data transmission mode includes the open-loop mode, the closed-loop mode.

Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma.

Abstract: The invention discloses a method and device for processing the FOTA upgrade. The method comprises: a transmitting terminal configures resources and transmits an upgrade package for version upgrade to a receiving terminal; the receiving terminal is upgraded by the received upgrade package and transmits identification information which is used for indicating the upgrade result of the receiving terminal to the transmitting terminal over the resources corresponding to the upgrade package; and the transmitting terminal determines the upgrade result of the receiving terminal according to the identification information. The invention improves the reliability and stability of the system.

Abstract: Game theory models may be used for producing a strategy and schedule for patrolling an area like a rail transportation system. In some instances, the model may account for events that cause a patrol unit to deviate from a patrol schedule and route. For example, a patrol schedule may be generated for one or more patrol units using a Bayesian Stackelberg game theory model based on a map of the public transportation system, a schedule of the transports, a list of the one or more patrolling units, a probability distribution for the occurrence of the passenger not paying to ride the transports, a list of the one or more possible events that would delay the patrol units, and a probability distribution for the occurrence of the one or more possible events that would delay the patrolling units represented by a Markov-decision process.

Abstract: A buffer to buffer credit recovery mechanism is disclosed in which the ports involved in the credit recovery operation are synchronized while credit recovery is being enabled and during a credit recovery operation when credit recovery parameters are being reset. Buffer to buffer credit recovery involves exchanging primitive control signals and parameters during the login sequence to enable credit recovery. Once credit is lost; there may be a need for resetting a link to reset the credit recovery counters and BB credits. Both of these processes require synchronization between the ports involved in the credit recovery mechanism. This synchronization is achieved by enabling credit recovery during the Link Reset protocol negotiation and ensuring that no frames or R_RDYs are exchanged during the procedure.

Abstract: A method and apparatus for optimizing image quality based on scene content comprising a sensor for generating a sequence of frames where each frame in the sequence of frames comprises content representing a scene and a digital processor, coupled to the sensor, for performing scene content analysis and for establishing a window defining a number of input frames from the sensor and processed output frames, and for aligning and combining the number of frames in the window to form an output frame, wherein sensor parameters and frame combination parameters are adjusted based on scene content.

Abstract: A Layer 2 network switch is partitionable into a plurality of switch fabrics. The single-chassis switch is partitionable into a plurality of logical switches, each associated with one of the virtual fabrics. The logical switches behave as complete and self-contained switches. A logical switch fabric can span multiple single-chassis switch chassis. Logical switches are connected by inter-switch links that can be either dedicated single-chassis links or logical links. An extended inter-switch link can be used to transport traffic for one or more logical inter-switch links. Physical ports of the chassis are assigned to logical switches and are managed by the logical switch. Legacy switches that are not partitionable into logical switches can serve as transit switches between two logical switches.

Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.

Abstract: The present invention discloses a progress adjustment method and an electronic device, the progress adjustment method is applied to an electronic device including a display unit on which data contents corresponding to first data are output in a chronological order, the method comprising displaying a progress bar corresponding to the first data on the display unit, and unit progress of the progress bar being a first unit progress; when obtaining a first input operation, controlling switching of the data contents of the first data with the first unit progress according to the first input operation; obtaining a second sliding operation; and generating a first sub progress bar based on a current progress unit that includes a progress identifier on the progress bar according to the second sliding operation; unit progress of the first sub progress bar being a second unit progress.

Abstract: The present disclosure discloses an information processing method and an electronic apparatus, for solving a technical problem that when a user inputs a voice instruction different from the fixed voice instruction due to incapability of remembering the fixed voice instruction, the electronic devices cannot respond or will mistakenly respond. The method including determining a current application corresponding to a current application interface on the display unit as a first application, the current application interface being a first application interface to which the first application corresponds; obtaining M input objects on the first application interface, M being an integer equal to or larger than one; processing the M input objects to obtain M pieces of prompt information of M character phrases corresponding to the M input objects, the M pieces of prompt information being capable of being displayed on the display unit.

Abstract: Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase. Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase. Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.