Abstract: The invention features methods of treating melanoma by modulating an activity of GDF6 in melanoma cells. In one aspect, the methods involve downregulating an activity of GDF6, for example, by using an anti-GDF6 binding molecule, such as an inactivating antibody. Another aspect features treating a subject by first screening for the presence of GDF6 and then treating the subject with an inhibitor of a GDF6 activity. Screening assays for identification of modulators of an activity of GDF6 are also featured.

Abstract: Techniques for providing an image download protection may be provided. In particular, an original image may be protected from being downloaded by providing a substitute image in its place, identified by a plurality of layers that are configured to look substantially similar to the original image. However, when a user device attempts to quickly store the image (e.g., by right-clicking on the image and selecting “save”), the user device can be hindered from downloading the substantially similar looking image because only one layer may be stored on the user device. In some examples, the layer of the image looks substantially distinct from the original image, but the layer in combination with a plurality of other layers can look substantially similar to the original image.

Abstract: A retention system is for an electrical switching apparatus. The electrical switching apparatus includes a frame having a number of slots, a cover coupled to the frame, an electrical component enclosed by the frame and the cover, separable contacts enclosed by the frame and the cover, and an operating mechanism to open and close the separable contacts. The retention system includes: at least one bundle of wires having a plurality of individual wires extending through a corresponding one of the number of slots to be electrically connected to the electrical component; and at least one restriction mechanism each comprising an insulative sleeve surrounding a corresponding one of the at least one bundle of wires, and a blocking member connected to the insulative sleeve. The blocking member engages the frame to prevent undesired movement of the individual wires with respect to the corresponding one of the number of slots.

Abstract: A competitive table game includes a rapidly spinning game wheel, an annular collection area, a base, and a plurality of rollable playing pieces. The game wheel is rotatably connected onto the base while the annular collection area is concentrically positioned around the game wheel. During each game, the players roll the plurality of rollable playing pieces on a smooth top surface of the game wheel as the plurality of rollable playing pieces is tangentially positioned on the smooth top surface and released attempting to match the linear velocity at the respective position on the game wheel. Then the plurality of rollable playing pieces moves across the smooth top surface and drops into the annular collection area, where the winner of each game is determined according to the game rules of each different game and the positioning of the plurality of rollable playing pieces. Other embodiments are described and shown.

Abstract: A spray tip (22) comprises a tip body (100), a tip piece (102), and a pre-orifice piece (104). The tip body has a fluid channel (114) along a channel axis (Ac). The tip piece is disposed within the fluid channel, and has a stepped, narrowing passage (124) that terminates in an outlet orifice (24). The pre-orifice piece has an inlet passage (112), and is disposed within the fluid channel, abutting and immediately upstream of the tip piece. The pre-orifice piece and the tip piece together define a turbulating chamber (106) therebetween.

Abstract: Improved capabilities are described for identifying a first classification scheme associated with product attributes of a first grouping of products, identifying a second classification scheme associated with product attributes of a second grouping of products, and receiving a record of data relating to an item, the classification of which is uncertain. It may also involve receiving a dictionary of attributes associated with products and assigning the item to at least one of the classification schemes based on probabilistic matching among the attributes in the classification schemes, the attributes in the dictionary of attributes and the known attributes of the item.

Abstract: Systems and methods are presented that may involve receiving a causal fact dataset including facts relating to items perceived to cause actions, wherein the causal fact dataset includes a data attribute that is associated with a causal fact datum. It may also involve pre-aggregating a plurality of the combinations of a plurality of causal fact data and associated data attributes in a causal bitmap. It may also involve selecting a subset of the pre-aggregated combinations based on suitability of a combination for the analytic purpose. It may also involve storing the subset of pre-aggregated combinations to facilitate querying of the subset.

Abstract: A needle guide device for releasable mounting on an imaging transducer or on an adaptor bracket on an imaging transducer is disclosed. The needle guide device includes a universal lockable mounting member which is configured for slidable releasable engagement with a coupling member on a specially constructed imaging transducer or on a conventional imaging transducer onto which a specially constructed adaptor is mounted. The needle guide device makes use of a slidable mounting member to cooperate with the coupling member. The needle guide device is adjustable to establish various selectable angular trajectories for a needle and has a low profile form factor to result in the creation of a minimal blind zone when mounted on the transducer and even if establishing a large angle for shallow needle penetration.

Abstract: In embodiments of the present invention improved capabilities are described for identifying a first classification scheme associated with product attributes of a first grouping of products, identifying a second classification scheme associated with product attributes of a second grouping of products, and receiving a record of data relating to an item, the classification of which is uncertain. It may also involve receiving a dictionary of attributes associated with products and assigning the item to at least one of the classification schemes based on probabilistic matching among the attributes in the classification schemes, the attributes in the dictionary of attributes and the known attributes of the item.

Abstract: A system improve amplifier efficiency of operation relative to that of an amplifier with fixed biasing and fixed matching conditions receives a power level and an indicator of amplifier operation. The indicator is at least one of channel, channel bandwidth, out-of band spectral requirements, spectral mask requirements, error vector magnitude, modulation rate, and modulation type. A controller generates a control signal based at least in part on the power level and the indicator to control at least one of the bias current and the matching conditions of matching circuits. The matching conditions and bias current for channels at an edge of a channel band are different from the bias current and matching conditions for channels nearer a center of the channel band.

Abstract: A certificate grant list is provided. The certificate grant list may be stored in a memory, at the network device. The certificate grant list may store information associated with a client-device certificate, where the client-device certificate permits the client-device access to a secure service.

Abstract: An interface assembly is for a trip unit of an electrical switching apparatus including a housing, separable contacts, and an operating mechanism for opening and closing the separable contacts. The trip unit cooperates with the operating mechanism and includes an enclosure, a controller, and a cover member having a plurality of indicia. The interface assembly includes at least one adjustment knob assembly having a post member and a ring member, which includes a cutout. The post member has first and second opposing ends. The ring member is disposed on the second end. The adjustment knob assembly pivots among a plurality of positions to adjust the controller. Each position corresponds to a predetermined setting of the trip unit. The ring member substantially overlays all but one of the indicia, which is exposed by the cutout to indicate the adjustment knob assembly position and corresponding trip unit setting.

Abstract: A system and method improve amplifier efficiency of operation relative to that of a matching circuit with fixed matching conditions. A power level representing a level of transmission power from an amplifier circuit and an indicator of amplifier circuit operation are provided. The indicator is at least one of channel, channel bandwidth, out-of band spectral requirements, spectral mask requirements, error vector magnitude, modulation rate, and modulation type. The matching conditions for a matching circuit of an amplifying transistor are adjusted based at least in part on the power level and the indication where the matching conditions are different for channels at an edge of a channel band than for channels nearer a center of the channel band.

Abstract: A non-transitory computer-readable medium for managing power consumption in a network of network devices is disclosed. The computer-readable medium stores instructions, that when executed by one or more processors, cause the one or more processors to perform certain operations. The operations include monitoring network data traffic, establishing a network power management policy based on the monitored data traffic, and enforcing the network power policy. The enforcing is carried out by centrally managing a powered state of a portion of the network based on power consumption criteria.

Abstract: A network-based application can establish a secure network connection to a switch. A unique identifier (UID) is generated for the network-based application, and a secure authentication request is generated from the network-based application. The UID for the network-based application is embedded in the secure authentication request. The secure authentication request is communicated to the switch. A response to the secure authentication request is received from the switch. One or more operations are performed that utilize the UID to establish a secure communication channel between the network-based application and the switch.

Abstract: A golf putting aid is provided. The golf putting aid includes a body, a first arm, and a second arm. The body has a substantially flat top and bottom surface and includes a front side, a rear side, a first side, and a second side. The rear side includes a straight edge. The first arm protrudes from the front side at the first side of the body, and the second arm protrudes from the front side at the second side of the body. The first arm 16 and the second arm form a slot in between sized to receive a golf ball within.

Abstract: Circuit breakers include an arc chamber and an arc chute comprising a plurality of arc plates in the arc chamber. The circuit breakers also include a line conductor assembly with at least one arc runner attached to a line conductor in the arc chamber. The arc runner can extend below but adjacent to a bottom arc plate to thereby guide a respective arc into the arc chute.

Abstract: An arc runner assembly for use in a circuit interrupter provides a pair of arc runners that are situated at opposite sides of a stationary contact of the circuit interrupter. If used in a DC application, the arc runner assembly is configured to communicate a positive DC arc along one of the arc runners in a first direction away from the stationary contact and is further configured to communicate a negative DC arc along the other arc runner in another direction away from the stationary contact. The arc runner assembly additionally includes a support that is electrically engaged with a conductor of the circuit interrupter on a surface opposite that on which the stationary contact is disposed. The improved arc runner assembly advantageously facilitates extinction of electrical arc and extinguishes both positive and negative DC arcs in a DC application.

Abstract: A high-pressure bi-directional sealing system having outer support rings (30, 32), annular, axial seals (100, 300) between the outer support rings (30, 32), inner support rings (150, 160) located between the annular, axial seals (100, 300) and a redundant seal (200) that is located between the inner support rings (150, 160). The outer support rings (30, 32), seals (100, 300), inner support rings (150, 160) and redundant seal (200) are located within a space between an outer tube (12) and an inner tube (14) that is telescopically disposed within the outer tube (12). Seals (100) and (300) are oriented in opposite directions. Specifically, the opening of seal (100) is facing in a first direction and the opening of seal (300) is facing in a second direction that is opposite the first direction. This configuration enables the high-pressure bi-directional sealing system to handle pressure in both directions.

Abstract: A competitive table game includes a rapidly spinning game wheel, an annular collection area, a base, and a plurality of rollable playing pieces. The game wheel is rotatably connected onto the base while the annular collection area is concentrically positioned around the game wheel. During each game, the players roll the plurality of rollable playing pieces on a smooth top surface of the game wheel as the plurality of rollable playing pieces is tangentially positioned on the smooth top surface and released attempting to match the linear velocity at the respective position on the game wheel. Then the plurality of rollable playing pieces moves across the smooth top surface and drops into the annular collection area, where the winner of each game is determined according to the game rules of each different game and the positioning of the plurality of rollable playing pieces. Other embodiments are described and shown.