Abstract: A computer-implemented method for space frame design involves constructing a load stress map in a geometrical boundary representation of a design space, defining attachment points and load application points in the design space, creating a starting network of interconnecting lines between each two of the attachment points and load application points in the design space, assigning load application factors to each line of the starting network of interconnecting lines based on values of the load stress map, generating potential space frame designs by culling different subsets of lines of the starting network of interconnecting lines for each potential space frame design according to variable culling parameters, evaluating the potential space frame designs with respect to optimization parameters, combining the culling parameters for the potential space frame designs the performance score of which is above a predefined performance threshold, and iterating the steps of generating potential space frame designs and e

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: An urban design pipeline automatically generates design options for an urban design project based on a financial model. The urban design pipeline includes a geometry engine that generates candidate designs to meet various design criteria and design objectives associated with the urban design project. The urban design pipeline also includes an evaluation engine that evaluates the candidate designs based on the financial model. The financial model quantifies the financial performance of any given candidate design. The urban design pipeline operates iteratively to improve the candidate designs until one or more convergence criteria are met, thereby generating a set of design options with acceptable financial performance.

Abstract: A system for delivery of liquid to and removal of liquid from a sample is provided. The system includes a primary device that contains the sample and at least one valve configured to allow liquid to be delivered to and removed from the sample; at least one reservoir that is configured to receive a volume of liquid; a secondary device including at least one port configured to receive the at least one reservoir and configured to be coupled to the primary device; and a tertiary device configured to receive the secondary device and comprising mechanical modules that deliver the volume of liquid from the at least one reservoir to the sample and remove the volume of liquid from the sample. Positioning the primary device in the secondary device causes the volume of liquid in the at least one reservoir to be delivered to the sample contained within the primary device.

Abstract: A design space analyzer generates a parametric model associated with a design problem. The design space analyzer then discretizes various parameters associated with the model and generates a plurality of sample designs using different combinations of discretized parameters. The design space analyzer also computes one or more metrics for each sample design. In this fashion, the design space analyzer generates a coarse approximation of the design space associated with the design problem. The design space analyzer then evaluates portions of that approximation, at both global and local scales, to identify portions of the design space that meet certain feasibility criteria. Finally, the design space analyzer modifies the design space to facilitate more efficient exploration during optimization.

Abstract: Synthetic minimal cells (SMC) are provided for delivering a therapeutic or diagnostic agent to a subject or to a site within a subject in need of treatment or diagnosis. SMCs may be targeted to the site or sense the site and initiate production and release of the therapeutic or diagnostic agent. SMCs comprise a sensor, at least one genetic circuit and outputting means to deliver the therapeutic agent.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: One embodiment of the present invention sets forth a technique for evaluating productive congestion within an architectural space design. The technique includes generating a space analysis graph for the architectural space design. The technique further includes determining a traversal value for at least a first node of a plurality of nodes included in the space analysis graph, determining a centroid of the plurality of nodes, determining a path within the space analysis graph from at least the first node to the centroid, and determining a productive congestion metric based on at least the path from the first node to the centroid and the traversal value of the first node.

Abstract: Various embodiments include methods and apparatus structured to install an optical fiber cable into a well at a well site. In a from-bottom-to-top embodiment, an anchor deployed at a selected location in a hole of the well can be used and the optical fiber cable can be pulled up to a surface of the well from the selected location. In a from-top-to-bottom embodiment, an optical fiber cable can be moved down from the surface until an end of the optical fiber cable is locked at a selected location by a catcher disposed at the selected location. With the optical fiber cable in the well, a portion of the optical fiber cable can be coupled to surface instrumentation. Additional apparatus, systems, and methods can be implemented in a variety of applications.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria and design objectives associated with the urban design project and then generates numerous candidate designs that meet the design criteria and optimize the design objectives to varying degrees. The evaluation engine evaluates each candidate design to generate a set of metrics. The geometry engine modifies the candidate designs based on corresponding metrics to generate candidate designs that better meet the design criteria and more effectively achieve the design objectives.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: A method for delivering a therapeutic agent to a tumor through a target vessel includes delivering the therapeutic agent through a lumen of a catheter which has been coated or otherwise structured to reduce the wall shear stress during delivery of the immunotherapy and by generating turbulent flow during the delivery of the therapeutic agent.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria and design objectives associated with the urban design project and then generates numerous candidate designs that meet the design criteria and optimize the design objectives to varying degrees. The evaluation engine evaluates each candidate design to generate a set of metrics. The geometry engine modifies the candidate designs based on corresponding metrics to generate candidate designs that better meet the design criteria and more effectively achieve the design objectives.

Abstract: Churn-aware training of a classifier which reduces the difference between predictions of two different models, such as a prior generation of a classification model and a subsequent generation. A second dataset of labelled data is scored on a prior generation of a classification model, wherein the prior generation was trained on a first dataset of labelled data. A subsequent generation of a classification model is trained with the second dataset of labelled data, wherein in training of the subsequent generation, weighting of at least some of the labelled data in the second dataset, such as labelled data threat yielded an incorrect classification, is adjusted based on the score of such labelled data in the prior generation.

Abstract: The invention relates to a computer-implemented system and method for automatic collection, analysis and reporting of data relating to a cybersecurity threat. The method may comprise the steps of: presenting an interface through which an executable can be configured and automatically generated; transmitting the executable to a client to enable the client to execute the executable on client systems to automatically collect forensic data; receiving from the client an encrypted data package that includes the forensic data; using a forensic toolset to automatically analyze the forensic data; presenting an option to select one or more of at least two types of output reports designed for different types of readers; inputting the analysis files into an automatic report generator to automatically generate the types of output reports selected by the client; and sending the output reports selected by the client to the client.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: A computer-implemented method for space frame design involves constructing a load stress map in a geometrical boundary representation of a design space, defining attachment points and load application points in the design space, creating a starting network of interconnecting lines between each two of the attachment points and load application points in the design space, assigning load application factors to each line of the starting network of interconnecting lines based on values of the load stress map, generating potential space frame designs by culling different subsets of lines of the starting network of interconnecting lines for each potential space frame design according to variable culling parameters, evaluating the potential space frame designs with respect to optimization parameters, combining the culling parameters for the potential space frame designs the performance score of which is above a predefined performance threshold, and iterating the steps of generating potential space frame designs and e

Abstract: Interactive visualization systems and methods are disclosed herein. The system includes a data source, user input device, processor, and display. The data source obtains a data set comprising B cell receptor and/or T cell receptor data associated with a plurality of cells. The user input device receives a user-selected first parameter under which to analyze the data set. The processor performs the method by identifying a plurality of clonotype groups in the data set using the first parameter, identifying subclonotypes within the clonotype groups (wherein each identified subclonotype comprises cells having identical V(D)J transcripts), and processing the data to define a visualization model that can display a compressed view of the clonotype groups and of the plurality of subclonotypes. The display renders a visualization of said data set according to said visualization model.

Abstract: Various aspects of the present disclosure may be directed toward apparatuses, systems, and methods that include a medical device including an elongate body having a proximal portion, a distal portion, and three mutually perpendicular planes. The medical device may include a first steering line and a second steering line and a first stiffening material and a second stiffening material. The first stiffening material and the second stiffening material may be configured to maintain planarity of deflection of at least the distal portion of the elongate body.