Abstract: Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction, resulting in unacceptable signal to noise ratio (SNR). To overcome this limitation, a novel OCT angiography technique based on the decorrelation of OCT signal amplitude due to flow was created. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion noise. Inter-B-scan decorrelation can be determined using the narrower spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range.

Abstract: A beverage container that includes a main body portion having an open top, a closed bottom and an interior that defines a first volume, and a removable cover that includes a bottom and a generally cylindrical side wall extending upwardly from the bottom. The bottom and the generally cylindrical side wall cooperate to define a cover cavity, the removable cover is removably engaged with the main body portion, and the bottom includes a plug opening defined therethrough. A breathable plug is received in the plug opening. The plug allows a liquid disposed within the first volume to breathe with respect to an exterior of the beverage container.

Abstract: Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection artifacts from the outer retina and for combining brightness, orientation, and position information in a context-aware saliency model to quantify CNV area in OCT angiograms.

Abstract: Pharmaceutical formulations for treating bacterial or fungal infections comprising iclaprim or its enantiomers and a sulfonamide antibiotic, and treatment and manufacturing methods, kits and dosage forms thereof, are provided.

Abstract: A light-emitting diode (LED) filament with a heat-dissipating structure includes multiple LED chips, multiple conductive carriers and a package layer. Each conductive carrier takes the form of a metal sheet and the multiple conductive carriers are spaced apart from each other. Each LED chip is commonly carried by and is electrically connected to two of the multiple conductive carriers adjacent to the LED chip. The package layer covers the multiple LED chips and the multiple conductive carriers with two lateral edge portions of each conductive carrier exposed from the package layer. The LED filament is mounted inside a light bulb. Because the multiple conductive carriers are partially exposed from the package layer, heat generated by the multiple LED chips can be dissipated to an ambient environment without affecting lighting efficiency and light output as a result of accumulated heat.

Abstract: A light-emitting diode (LED) light source includes a plurality of electricity-conducting holding elements, and each electricity-conducting holding element is made of a thin metal sheet. The bendable LED light source increases installation of sufficient number of LED dies by lengthening the length of the LED light source. The LED light source is bent to form a spring-like helical structure and then is placed inside a lamp cover. The helical LED light source is fastened on a T-shaped element by a plurality of fastening elements and the T-shaped element is fixed on an insulated holder. Accordingly, a bulb-type LED lamp is implemented.

Abstract: Methods and systems for determining a percentage composition of aqueous cells in an anterior chamber of an eye of a subject based on cell reflectance distributions calculated from OCT image data are disclosed. In one example approach, determining a percentage composition of detected aqueous cells may comprise calculating a percentage of the detected aqueous cells which are polymorphonuclear and calculating a percentage of detected aqueous cells which are mononuclear.

Abstract: A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.

Abstract: Described herein is an optical coherence tomograph (OCT) angiography technique based on the decorrelation of OCT signal amplitude to provide flow information. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion nose. Inter-B-scan decorrelation can be determined using the individual spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range. Such images provide significant improvement of signal-to-noise ratio (SNR) for both flow detection and connectivity of microvascular networks compared to other techniques. Further, creation of isotropic resolution cells can be useful for quantifying flow having equal sensitivity to axial and transverse flow.

Abstract: Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection artifacts from the outer retina and for combining brightness, orientation, and position information in a context-aware saliency model to quantify CNV area in OCT angiograms.

Abstract: A needle-bearing hub for a pen needle is provided with a distal patient-facing side having an enlarged surface for contact with the subject's skin. The enlarged surface is provided with a radius of curvature that increases the likelihood that the needle reaches full injection depth when an injection is performed at an inclined angle with respect to the surface of the skin and with to the desired depth less discomfort to the patient.

Abstract: Disclosed are methods and systems for measuring areas of nonperfusion in the retina using OCT imaging. The disclosed methods and systems allow for the automated segmentation and quantification of avascular areas of the retina utilizing information obtained from both structural OCT and OCT angiography (OCTA) data. The disclosed methods include filtering approaches which enhance vessel structure while suppressing noise, dynamic thresholding approaches to mitigate the detrimental effects of within-scan variability and low scan quality, and distance transform-based approaches to improve detection of ischemic regions. When combined with methods such as projection-resolved OCTA, the sensitivity to detect nonperfusion within different plexuses of the inner retina is demonstrated. In the clinical setting of diabetic retinopathy, the disclosed methods and systems show high sensitivity and specificity to detect the mild non-proliferative form of the disease with high reproducibility.

Abstract: Disclosed are systems and methods for characterizing corneal shape abnormalities. These methods may be used to differentiate corneas having subclinical keratoconus from other conditions which cause distortion of corneal shape, including warpage of the cornea due to contact lens wear. Also disclosed is classification scheme to aid diagnosis of corneal conditions and thereby guide clinical decision making regarding patient treatment. This classification scheme is based on computed properties of corneal shape, is amenable to automation, and may be implemented in an integrated system or provided in the form of software encoded on a computer-readable medium.

Abstract: User-friendly attachment mechanisms for pen needles provide improved handling and ease of use, including locking installation and removal features and sensory feedback when a needle-bearing hub is seated on a pen.

Abstract: A mould lifting device is suitable for use in lifting and rotating a middle mould. At each of two lateral surfaces of the middle mould is provided a pivot portion. The mould lifting device includes: a platform, two longitudinal guide assemblies, two transmissions, a power assembly, two lifting members, two push members, two pivot arms, and two covers. When the pivot arms lift and rotate the middle mould, the lifted portion of the covers will not be pushed by the lifting portions of the lifting members anymore, and the covers will naturally pivot downward by gravity to make the cover portions cover the openings of the restricting grooves, which prevents the disengagement of the pivot portions of the middle mould from the restricting grooves, and thus improving the stability and security of the middle mould during the course of lifting and rotation.

Abstract: The present invention discloses a method for controlling a fan in a tiny computer. The method controls the fan for a CPU according a DTS temperature of the CPU. If the CPU (or DTS) operates at a relatively low temperature less than or equal to a set temperature, the fan for the CPU stops running rather than always runs so as to reduce power consumption and noise caused by the running fan to provide a better user experience. It may increase useful time of the fan for the CPU, and reduce costs of customer service and maintenance.

Abstract: Methods and systems for improving quantification of OCT angiography data are disclosed. The disclosure specifically relates to methods for compensating for the effect of tissue reflectance to improve the accuracy and repeatability of OCT angiography measurements. These improvements are effected by deriving and then utilizing a dynamic thresholding approach to process decorrelation data to properly classify flow versus non-flow data in OCT angiograms. The disclosed methods overcome quantification errors associated with within-scan variations in reflectance as well as repeatability problems associated with differences in scan quality over successive imaging sessions.

Abstract: Therapeutic methods, kits, dosing regimens and uses of a medicament comprising iclaprim are provided, for example, for the treatment of bacterial infection. The administration of iclaprim in a fixed amount can achieve a Cmax(ss) below about 800 ng/mL, a T>MIC of between about 30% to about 95% and a ratio of AUC/MIC of about 20 to about 85, and the bacterial infection can be treated. The fixed amount can be about 70 mg to about 100 mg. The bacterial infection treated may be caused, or related to, drug-resistant bacteria including S. pneumoniae, H. influenzae, S. aureus, K. pneumoniae and M. catarrhalis. The bacterial infection may manifest as a skin and skin structure infection, pneumonia, asthma, emphysema and/or other adverse pulmonary conditions.