Abstract: A drug delivery system is disclosed which may be a throwaway or reusable device for delivery at least one drug to a patient. Also described is a method for administering a drug using said device and a packaged drug for use with said device. The drug delivery device (10) comprises a housing (12), a means (14) for generating a force capable of pushing a drug (16) from a packaging (18) into a human or animal body, a means (20) for transmitting said force to push the drug (16) from the packaging (18) into the human and animal body, and a means (38, 42b) for triggering the device. Where the device is a single use drug delivery (10) a packaged drug (100) forms an integral part of the device.

Abstract: The present invention provides for assisting a user in efficiently interacting with a mobile device by providing a persistent graphical user interface, e.g., a sidebar tile. This persistent user interface allows direct exposure to the mobile device without requiring the user to launch or open an application for interacting with the mobile device. Further this persistent user interface may include state or status information for attributes or features of a mobile device, e.g., battery power, ringer volume, signal strength, etc., which may be represented as objects or bar parts. These objects that show status may be automatically updated for providing a useful visual representation showing the current state of the features. Further, the persistent user interface may include objects representing the functionality of the mobile device, e.g., configuration, ringer volume, making a call, etc., which provides for easy accessibility at a single entry point for interacting with the mobile device.

Abstract: A separable, flexible connection arrangement is provided for connection of two conductors. In one arrangement, the separable, flexible connection arrangement is utilized to provide an externally removable bushing for connecting an electrical component located within a sealed enclosure.

Abstract: The present invention provides for a distributed computing system that is capable of determining when data needs to be synced between two computer devices because data has changed on at least a remote device. More particularly, the present invention provides for a sync adapter that uses sync data to detect that a property on a device is new and needs to synchronize with corresponding data on another machine. The sync data is specific to the two devices in that the sync data mirrors data that was last synchronized between these two computing devices. Other example embodiments use the sync data to detect and mark data as low fidelity data for identifying any date and time information associated with the low fidelity data as potentially unreliable.

Abstract: The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Abstract: The invention herein pertains to improved methods and apparatus for electrically coupling components within a digital data system without the use of ribbon cables and other wires. The disclosed coupling device comprises a body member and at least one finger member. The body member physically and electrically couples with components mounted on a circuit board by mating with component pins extending on a solder side of the circuit board. The finger member is conjoined with the body member, and is a flexible, twistable, thin member containing electrically conductive vias coupled which couple the mounted components with an electrical connected located at the distal end of the finger member. The electrical connector at the distal end of the finger member can be a solder pad, a further member body, or other electrically coupling connector device. The finger member is designed to impact cooling air flow less than the disturbances created by conventional component coupling methods and apparatus, e.g.

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

Abstract: Proteins are identified that exhibit an altered expression in mammalian cardiac tissue in response to A3 agonist infusion. These proteins are termed A3 receptor-mediated cardioprotective proteins (A3Ps) and protein isoforms (A3PIs) and are useful as pharmaceuticals and as targets in screening methods for identifying an agent capable of modulating the expression of one or more A3P and/or A3PI.

Abstract: Fusion proteins have been discovered that contain a calpastatin peptide and a signal sequence capable of delivering the fusion protein into a cell. These proteinS can be used to inhibit calpain and may, more specifically, be used to inhibit platelet aggregation or degranulation; to inhibit or reverse erythrocyte sickling; to inhibit a human immunodeficiency virus (HIV); or to inhibit unwanted cellular proliferation or migration.

Abstract: The invention relates to a novel drug delivery technology. More particularly the invention relates to a method of delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient: to a throwaway or reusable device for delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient in a manner as set out by the method; to a pioneer projectile form use in said method; to formulations for use in said method and to an injectate comprising a pioneer projectile and formulation. It also relates to a disposable component containing either a pioneer projectile or an injectate.

Abstract: System and method for measurement, DAQ, and control operations. A measurement module includes measurement circuitry for performing signal conditioning and/or signal conversion, and interface circuitry which provides an interface for the measurement circuitry. A carrier unit couples to the interface circuitry of the module. A computer system couples to the carrier unit and stores one or more hardware configuration programs. The interface circuitry communicates an interface protocol describing the interface, e.g., to the carrier unit or the computer system. The computer system provides a hardware configuration program in response to the communicated interface protocol, and programs one or more programmable hardware elements on the carrier unit with the hardware configuration program. After being configured, the programmable hardware elements interface with the measurement module in accordance with the communicated interface protocol.

Abstract: Methods for treating cancer are described herein. The methods include administering to an HIV-negative patient an m-calpain inhibitor such as ritonavir. Ritonavir or other m-calpain inhibitors can also be co-administered with other therapeutic agents such as a Cox-2 inhibitor, a taxane, or a proteasome inhibitor. Methods for determining whether a patient will respond to a particular method of treatment are also described herein.

Abstract: Seismic horizons are transferred between two three-dimensional seismic data volumes which cover the same area. The seismic data volumes are time-aligned to generate a time-shift volume. A seismic horizon is selected and the time-shift volume is applied to the seismic horizon, generating a time-shifted seismic horizon.

Abstract: A riser card, such as a peripheral component interconnect (PCI) card, attaches to a circuit board such as a mother board in a transverse orientation and has a first connector and a second connector attached to opposing sides of the card for receiving expansion cards. In one embodiment, the first connector is offset from the second connector with respect to an axis in the plane of the riser card. In another embodiment, the first and second connectors each have a first and last pin, and the first pin of the first card is opposite the first pin of the second connector. The riser card may mount one expansion board right side up, and the second board upside down. The first and second connectors can be female connectors which are each matable with a male connector on the corresponding expansion board, or can be card edge connectors. The expansion boards, when mated with the connectors, are substantially parallel to, but offset from the circuit board.