Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.

Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.

Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Abstract: A user device enters a power save mode in which only the physical layer of its wireless communication system and minimal logic circuitry remains on. In a first implementation the minimal logic circuitry is in the MAC or the digital portion of the radio on a communication card, and the logic monitors the 802.11 traffic indication map (TIM) to determine whether traffic for the user device exists. If it does, the user is alerted or the device is powered on. In an optimum mode the minimal logic circuitry listens for a special sequence unique to the device, and if it detects the sequence leaves the power save mode.

Abstract: Disclosed is a method for changing channels in a digital television transport stream, which comprises accessing the digital television transport stream, itself comprising a plurality of multiplexed channels, by using a first tuner, displaying a first program channel from the digital television transport stream, detecting and storing in a buffer memory recent video data from a second channel while displaying the first channel by using a second tuner, immediately recalling and presenting a complete video frame from the stored video data of the second channel for display when the second channel is selected by the user, and displaying real-time video from the second channel when decodable real-time video data is available from the transport stream.

Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.

Abstract: A grain cleaner is taught including features for facilitating maintenance and repair of the cleaner over previous grain cleaners. In particular, the grain cleaner has an indent cylinder assembly which includes a removable cylinder. The cylinder is removed by unwrapping it from around a frame. The grain cleaner also includes at least some augers with drop away troughs. The grain cleaner also includes grain cleaning assemblies such as, for example, indent cylinders and rotary screen drums and/or grain cleaning assemblies drive systems which are mounted on framework members capable of pivoting outwardly from the machine allowing access to machinery and components positioned centrally within the grain cleaner.

Abstract: A grain cleaner has an indent cylinder assembly which includes a removable cylinder. The cylinder is removed by unwrapping it from around a frame. The grain cleaner also includes at least some augers with drop away troughs. The grain cleaner also includes grain cleaning assemblies such as, for example, indent cylinders and rotary screen drums and/or grain cleaning assemblies drive systems which are mounted on framework members capable of pivoting outwardly from the machine allowing access to machinery and components positioned centrally within the grain cleaner.

Abstract: This invention is a data processing apparatus which operates on instruction controlling plural processor actions. Each instruction includes a data unit section and a data transfer section. These instruction sections are independent and may include differing options. In the preferred embodiment, each instruction is 64 bits. The data unit section includes a data operation field that indicates the type of arithmetic logic unit operation and six operand fields. The six operand fields include four source data register fields and two destination register fields. The data unit (110) includes a multiplication unit (220) and an arithmetic logic unit (230). The data unit (110) may include a barrel rotator (235) for one input of the arithmetic logic unit (230). The rotated data may be stored in the first destination register instead of the multiply result. The address unit (120) operations according to the data transfer operation field. This could be a load, a store or a register to register move.

Abstract: A system for utilizing metadata created either at a central location for shared use by connected users, or at each individual user's location, to enhance user's enjoyment of available broadcast programming content. A variety of mechanisms are employed for automatically and manually identifying and designating programming segments, associating descriptive metadata which the identified segments, distributing the metadata for use at client locations, and using the supplied metadata to selectively record and playback desired programming.

Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.

Abstract: A data processing apparatus including a multiplier unit forming a product from L bits of each two data buses of N bits each N is greater than L. The multiplier forms a N bit output having a first portion which is the L most significant bits of the of product and a second portion which is M other bits not including the L least significant bits of the product, where N is the sum of M and L. In the preferred embodiment the M other bits are derived from other bits of the two input data busses, such as the M other bits of the first input data bus. An arithmetic logic unit performs parallel operations (addition, subtraction, Boolean functions) controlled by the same instructions. This arithmetic logic unit is divisible into a selected number of sections for performing identical operations on independent sections of its inputs. The multiplier unit may form dual products from separate parts of the input data.

Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.

Abstract: Disclosed are apparatus and methods for conversion of hydrocarbon feed streams into liquid products. One embodiment of an apparatus includes a pressure vessel that contains a synthesis gas production device, a synthesis gas conditioning device and a synthesis gas conversion device wherein the synthesis gas production device and the synthesis gas conditioning device are nested within the synthesis gas conversion device. One embodiment of a method includes providing a hydrocarbon feed stream and producing a synthesis gas stream from the hydrocarbon feed stream in a synthesis gas production device. Subsequently, the synthesis gas stream is conditioned by removing heat from the synthesis gas stream through a first hollow body into a reactant feed stream that is then fed into the synthesis gas production device. Finally, the synthesis gas stream is converted to form a liquid product stream.

Abstract: Compounds which bind to toxins associated with enteric bacterial infection, compositions including the compounds, methods for the neutralization of toxins in a patient, and methods for the diagnosis of bacterial and viral infections are disclosed. Toxins which can be bound by the compounds include pentameric toxins, for example SLTs, such as those from salmonella, camylobacter and other bacteria, verotoxins from E. coli, cholera toxin, clostridium difficile toxins A and B, bacterial pili from enteropathogenic E. coli (EPEC) and enterotoxigenic E. coli (ETEC) and viral lectins such as viral hemagglutinins. The compounds include a core molecule bound to a plurality of linker arms, which in turn are bound to a plurality of bridging moieties, which in turn are bound to at least one, and preferably, two or more ligands which bind to the toxin. The presence of a plurality of bridged dimers of the ligands is responsible for the increased binding affinity of the compounds relative to the ligands themselves.

Abstract: A data processing apparatus including a multiplier unit forming a product from L bits of each two data buses of N bits each N is greater than L. The multiplier forms a N bit output having a first portion which is the L most significant bits of the of product and a second portion which is M other bits not including the L least significant bits of the product, where N is the sum of M and L. In the preferred embodiment the M other bits are derived from other bits of the two input data busses, such as the M other bits of the first input data bus. An arithmetic logic unit performs parallel operations (addition, subtraction, Boolean functions) controlled by the same instructions. This arithmetic logic unit is divisible into a selected number of sections for performing identical operations on independent sections of its inputs. The multiplier unit may form dual products from separate parts of the input data.

Abstract: A method for forming a sum of the absolute value of the difference between each pair of numbers of respective first and second sets of numbers. The method includes forming the difference between a first number of the first set and a second number of the second set. Next this difference is either added to or subtracted from a running sum based upon the sign of this difference. This is repeated until all number pairs are either added to or subtracted from the running sum of absolute values of the differences. The initial subtraction is used to set a status bit in a flag register (211) based upon a less than zero output or the carry-out. The status bit controls whether the difference is added to or subtracted from the running sum. The conditional addition to or subtraction from the running sum may generate a carry-out representing the most significant bit of the running sum. This carry-out is stored and later added to the running sum to recover the most significant overflow bits.

Abstract: The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.

Abstract: A data processing apparatus includes a three input arithmetic logic unit (230) that generates a combination of the three inputs that is selected by a function signal. Data registers (200) store the three data inputs and the arithmetic logic unit output. The second input signal comes from a controllable barrel rotator (235). The rotate amount is a default rotate amount stored in a special data register, a predetermined set of bits of data recalled from a data register or zero. A one's constant source (236) is connected to the barrel rotator (235) to supply a multibit digital signal of "1". This permits generating a second input signal of the form 2.sup.N, with N being the rotate amount. The output of the barrel rotator (235) may be stored independently of the arithmetic logic unit (230) result. In the preferred embodiment of this invention, the three input arithmetic logic unit (230) is embodied in a data processor circuits as a part of a multiprocessor integrated circuit (100) used in image processing.

Abstract: A data processing apparatus includes a three input arithmetic logic unit (230) that generates a combination of the three inputs that is selected by a function signal. Data registers (200) store the three data inputs and the arithmetic logic unit output. The second input signal comes from a controllable shifter (235). The shift amount is a default shift amount stored in a special data register, a predetermined set of bits of data recalled from a data register or zero. A one's constant source (236) is connected to the shifter (235) to supply a multibit digital signal of "1". This permits generating a second input signal of the form 2.sup.N, with N being the shift amount. The output of the shifter (235) may be stored independently of the arithmetic logic unit (230) result. The third input signal comes from a multiplexer (233) that selects between an instruction specified immediate field, data recalled from a data register or a mask input from a mask generator (239).