Abstract: The present disclosure relates to 7-substituted pyrrolo[2,1-f][1,2,4]triazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof. These compounds show good PI3K inhibitory activity, can effectively inhibit the activity of PI3K kinase, and has significant enhancement and improvement of pharmacokinetic properties, such as bioavailability, due to the introduction of the 7-position group; furthermore, the compounds of the present disclosure exhibit an unpredictable high selectivity and strong inhibitory activity on PI3K?, and thus these compounds can be used for treating diseases related to PI3K pathway, especially for anti-cancer or for the treatment of tumors, leukemias and autoimmune diseases. After further optimizing and screening, the compounds are expected to be developed into a new type of anti-tumor drugs.

Abstract: A consensus process recovery method and a related node, where the method includes determining, by a plurality of nodes, a target instance from one or more secondary instances, where a throughput of the target instance is higher than a throughput of a primary instance, and obtaining, by a first node and all second nodes, a consensus to replace the primary instance with the target instance as a new primary instance, where the second nodes are backup nodes running the target instance, and the first node is a primary node running the target instance.

Abstract: An antibody may be capable of specifically binding CD137 or an antigen binding fragment thereof, wherein the light chain variable region and the heavy chain variable region have one or more mutations. The antibody or antigen binding fragment thereof may be used in preparing a drug. The antibody or an antigen binding fragment thereof may specifically bind CD137, and may include a light chain variable region VL and a heavy chain variable region VH, wherein compared to a sequence as shown in SEQ ID NO: 103, the VL comprises one or more VL amino acid mutations, and the VL amino acid mutation occurs at one or more positions: V3, A10, K44, D71, and/or V77.

Abstract: Disclosed is an SOMCL-9112 solid dispersion. The SOMCL-9112 solid dispersion is characterized by being prepared from the following raw materials in percentage by weight: 5 percent to 60 percent of SOMCL-9112, 5 percent to 90 percent of pharmaceutically acceptable matrix polymer, 0 percent to 20 percent of surfactant, 0 percent to 20 percent of flow aid and 0 percent to 20 percent of plasticizer. Also disclosed are a preparation method of the SOMCL-9112 solid dispersion, a solid medicinal preparation containing the solid dispersion and application of the solid dispersion for preparing a medicine for treating cancer.

Abstract: Described embodiments provide systems and methods for balancing user sessions using load pattern forecasting are provided here. A device can determine a pattern of load distribution for a session prior to establishment of the session on a server of a computing environment. The pattern can be indicative of load on a server to run the session for a range of time. The device can determine an amount of usage of the plurality of servers on a per server basis. The usage can be indicative of sessions to be run on individual servers for the range of time. The device can select one of the plurality of servers on which to run the session based on a comparison of the pattern of load distribution for the session and the determined amounts of usage of the plurality servers. The device can assign the session to the selected server of the computing environment to balance resource usage across the computing environment.

Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.

Abstract: Disclosed are a 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, a preparation method therefor and an application thereof. Specifically, disclosed are three crystalline forms, i.e., crystalline forms A, B, and C, of 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride (formula I), preparation methods for the three crystalline forms, and use of the three crystalline forms in preparation of drugs.

Abstract: A microwave sensor device is for detecting activity and for sending and/or receiving a communications signal to/from a second microwave sensor device. A microwave transceiver is used for transmitting a microwave transmit signal and for receiving a microwave receive signal. For motion detection, the microwave receive signal is a reflected version of the microwave transmit signal and the signals are processed to identify first signal characteristics. For communication, the microwave transmit signal is a communications signal for detection at another sensor device. The transmit and microwave receive signals are processed to identify second characteristics. This sensor device detects motion and also transmits and/or receives a communications signal using the same transceiver. In particular, the communications signal is designed to be detected by a remote sensor device in the same way as for motion detection.

Abstract: Wax esters (WE) and triacylglycerols (TAG) can be accumulated in large amounts in plant cells. The present invention relates to insect pheromone precursors which are produced as components of WE or TAG in plants. Further the invention concerns means and methods for the production of plant cells producing WE and/or TAG containing insect pheromone precursors in form of either a fatty acid or a fatty alcohol. Said method uses plants where wax esters are modified by desaturase, fatty acyl reductase and wax ester synthase or the triacylglycerol is modified by a desaturase. Finally the insect pheromone precursors can be extracted and used in the manufacturing of insect pheromones from WE and TAG.

Abstract: A system and method that automatically terminates an application. A method includes monitoring activity data points for an application launched by a client device within a workspace environment. The activity data points may include user interactions with a physical interface component and background interactions occurring with the application. State data for each file associated with the application is monitored and, if a determination is made that the application is inactive based on the activity data points, the method determines if a file associated with the application includes unsaved content based on state data. If it is determined that no files for the application include unsaved content, the method forecasts whether the application will be inactive for a future period based on the activity data. The application is terminated if it is determined that no files for the application include unsaved content and the application is forecast to be inactive.

Abstract: The present invention relates to a method for degrading a polysaccharide in the field of food, medicine or chemical industry. In particular, a molecular chain of the polysaccharide is broken by ozone into polysaccharides with smaller molecular weights, oligoses and/or oligosaccharides. The polysaccharides include linear or branched glycans extracted from plants, traditional Chinese medicinal materials, animals, fungi, or microorganisms and sulfated polysaccharides or esterified polysaccharides formed by sulfation or esterification thereof. As an oxidizing agent in the reaction, the ozone can be used alone or can be used under the catalysis of a base, a metal ion, hydrogen peroxide, UV light, or activated carbon to accelerate the reaction.

Abstract: A computer system may include a server configured to provide access to a plurality of shared applications, and a client computing device. The client computing device may have a display associated therewith and cooperate with the server to run shared applications from among the plurality of shared applications, determine at least one group of the shared applications running on the client computing device having a relationship therebetween based upon a sequence in which the shared applications are activated, and display the shared applications from the at least one group on the display.

Abstract: A block data archiving method carried out by a blockchain node is described. The method includes determining to-be-archived block data when detecting that a resource of a block stored in the first blockchain node meets a block data archiving condition. The method further includes sending an archiving request to one or more other blockchain nodes; negotiating a consensus with the blockchain node in the same group based on received consensus response information fed back by the blockchain node in the same group one or more other blockchain nodes; and sending the to-be-archived block data to a third-party storage server for archiving in accordance with determining that a consensus is reached and a consensus result that the first blockchain node is a consensus blockchain node is obtained. The consensus result is used to determine the first blockchain node or any blockchain node in the same group is a consensus blockchain node.

Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of diabetes.

Abstract: Provided herein are T cell receptor (TCR) fusion proteins (TFPs), T cells engineered to express one or more MUC16 or IL 13R?2 or MSLN TFPs, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: A computer system is provided. The computer system includes a memory and at least one processor coupled to the memory and configured to detect open eyes in an image received from a camera of the computer; recognize properties of the open eyes including orientation, designation as a left or right eye, and relative position of the eyes; group the detected open eyes into pairs of eyes based on the recognized properties; measure pupillary distance (e.g. represented in image pixels) of each of the pairs of eyes; identify the pair of eyes associated with the largest pupillary distance as the eyes closest to the camera; calculate a relative distance from the camera to the closest pair of eyes, the relative distance calculated as a ratio of the camera focal length to the largest pupillary distance; and reduce brightness of the computer screen if the relative distance is less than a threshold ratio.

Abstract: Methods and systems for using machine learning to provide application recommendations are described herein. A computing device may capture a first edge frame of a first application displayed at the computing device. The computing device may apply machine learning to the first edge frame of the first application to identify a context tag. The computing device may identify applications subsequently accessed in a sequential manner after accessing the first application in a context corresponding to the identified context tag, where each of the applications corresponds to a context level score. The computing device may identify a second application, which may have a higher context level score than remaining applications. Along with the first application, the computing device may display a selectable interface element corresponding to the second application, and selection of the selectable interface element may cause display of an application list that includes the second application.

Abstract: Typically, when a user switches sessions between devices, the user authenticates the sessions by providing user account information, password, and/or pin code input or other credentials. However, when the user is frequently switching sessions between devices, authenticating sessions may result in the user reducing or even stopping switching across mobile devices. Systems and methods according to this disclosure provide automatic session roaming across mobile devices using proximity authentication. Upon detecting an indication to initiate session roaming, the source device automatically roams the session on the source device to a target device based on a proximity of the source device to the target device. The session is handed off from the source device to the target device as an authenticated user session.

Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of inflammation.

Abstract: The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.