Abstract: The present invention relates to a method for degrading a polysaccharide in the field of food, medicine or chemical industry. In particular, a molecular chain of the polysaccharide is broken by ozone into polysaccharides with smaller molecular weights, oligoses and/or oligosaccharides. The polysaccharides include linear or branched glycans extracted from plants, traditional Chinese medicinal materials, animals, fungi, or microorganisms and sulfated polysaccharides or esterified polysaccharides formed by sulfation or esterification thereof. As an oxidizing agent in the reaction, the ozone can be used alone or can be used under the catalysis of a base, a metal ion, hydrogen peroxide, UV light, or activated carbon to accelerate the reaction.

Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of diabetes.

Abstract: A block data archiving method carried out by a blockchain node is described. The method includes determining to-be-archived block data when detecting that a resource of a block stored in the first blockchain node meets a block data archiving condition. The method further includes sending an archiving request to one or more other blockchain nodes; negotiating a consensus with the blockchain node in the same group based on received consensus response information fed back by the blockchain node in the same group one or more other blockchain nodes; and sending the to-be-archived block data to a third-party storage server for archiving in accordance with determining that a consensus is reached and a consensus result that the first blockchain node is a consensus blockchain node is obtained. The consensus result is used to determine the first blockchain node or any blockchain node in the same group is a consensus blockchain node.

Abstract: Provided herein are T cell receptor (TCR) fusion proteins (TFPs), T cells engineered to express one or more MUC16 or IL 13R?2 or MSLN TFPs, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: A computer system is provided. The computer system includes a memory and at least one processor coupled to the memory and configured to detect open eyes in an image received from a camera of the computer; recognize properties of the open eyes including orientation, designation as a left or right eye, and relative position of the eyes; group the detected open eyes into pairs of eyes based on the recognized properties; measure pupillary distance (e.g. represented in image pixels) of each of the pairs of eyes; identify the pair of eyes associated with the largest pupillary distance as the eyes closest to the camera; calculate a relative distance from the camera to the closest pair of eyes, the relative distance calculated as a ratio of the camera focal length to the largest pupillary distance; and reduce brightness of the computer screen if the relative distance is less than a threshold ratio.

Abstract: Methods and systems for using machine learning to provide application recommendations are described herein. A computing device may capture a first edge frame of a first application displayed at the computing device. The computing device may apply machine learning to the first edge frame of the first application to identify a context tag. The computing device may identify applications subsequently accessed in a sequential manner after accessing the first application in a context corresponding to the identified context tag, where each of the applications corresponds to a context level score. The computing device may identify a second application, which may have a higher context level score than remaining applications. Along with the first application, the computing device may display a selectable interface element corresponding to the second application, and selection of the selectable interface element may cause display of an application list that includes the second application.

Abstract: Typically, when a user switches sessions between devices, the user authenticates the sessions by providing user account information, password, and/or pin code input or other credentials. However, when the user is frequently switching sessions between devices, authenticating sessions may result in the user reducing or even stopping switching across mobile devices. Systems and methods according to this disclosure provide automatic session roaming across mobile devices using proximity authentication. Upon detecting an indication to initiate session roaming, the source device automatically roams the session on the source device to a target device based on a proximity of the source device to the target device. The session is handed off from the source device to the target device as an authenticated user session.

Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of inflammation.

Abstract: The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.

Abstract: The present invention relates to an alginic oligosaccharic diacid composition comprising a mannuronic diacid of Formula (IV) or a pharmaceutically acceptable salt thereof, wherein n is an integer selected from 1 to 9, m is selected from 0, 1 or 2, m? is selected from 0 or 1, and wherein the total weight of alginic oligosaccharic diacid wherein n=1-5 accounts for more than 60% of the total weight of the composition; the total weight of guluronic acids accounts for less than 50% of the total weight of the composition.

Abstract: The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.

Abstract: The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: A piston pressure device includes a gas concentration-regulating piston pressure device and a high temperature autoclave. In the gas concentration-regulating piston pressure device, the proportion and concentration of corrosive gases can be accurately adjusted, intermediate gases can be stored and filled into the high temperature autoclave according to experimental needs, and an actual corrosion process in oilfield is accurately simulated. Meanwhile, the corrosive gases can be supplemented in real time during the experiment, and dynamic gas distribution in a high-temperature high-pressure corrosion experiment process is realized.

Abstract: Provided herein are T cell receptor (TCR) fusion proteins (TFPs) having specificity for more than one tumor cell associated antigen, T cells engineered to express one or more TFP, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: Methods and systems for determining information of applications are described herein. A computing device may receive, from one or more client devices, data indicating application usage events. The computing device may determine, based on the data, popular applications that a target user regularly uses. The computing device may determine, based on the data, recommended applications that users similar to the target user regularly use. The computing device may determine, based on the popular applications and/or the recommended applications, a collection of applications for the target user. The collection of applications may be displayed on a user interface of a client device associated with the target user for expedited access of interested applications.

Abstract: Techniques are disclosed for providing messaging participant identity leak prevention. An example methodology implementing the techniques includes, receiving, by a computing device, a message from a sender to a recipient via a software application running on the computing device, the software application having a non-confidential messaging view and a confidential messaging view. The method also includes determining a message type of the message, the message type is one of a non-confidential message or a confidential message, and displaying the message in the confidential messaging view of the software application in response to a determination that the message type indicates a confidential message, the confidential messaging view being distinct from the non-confidential messaging view, wherein messaging participant identity information is obfuscated in the display of the message in the confidential messaging view.

Abstract: Provided are a class of fused-cyclic pyrazolone formamide compounds and a preparation method therefor, a pharmaceutical composition and the use thereof. Specifically, provided is a compound having the structure as shown in formula (I) (with each group defined in the description). The compound can be used as an AXL inhibitor in the preparation of a pharmaceutical composition for treating tumors.

Abstract: A catalyst for producing light aromatics with heavy aromatics, a method for preparing the catalyst, and a use thereof are disclosed. The catalyst comprises a carrier, component (1), and component (2), wherein component (1) comprises one metal element or more metal elements selected from a group consisting of Pt, Pd, Ir, and Rh, and component (2) comprises one metal element or more metal elements selected from a group consisting of IA group, IIA group, IIIA group, IVA group, IB group, IIB group, IIIB group, IVB group, VB group, VIB group, VIIB group, La group, and VIII group other than Pt, Pd, Ir, and Rh. The catalyst can be used for producing light aromatics with heavy aromatics, whereby heavy aromatics hydrogenation selectivity and light aromatics yield can be improved.

Abstract: A computing system may determine that first data was copied from a first application to a buffer of a first computing environment, and that the first data was received by a second application in a second computing environment. The computing system may identify second data copied from the first application to the buffer and, in response to the second data being copied from the first application to the buffer and based at least in part on the second application having received the first data, may cause the second data to be transferred from the buffer to the second computing environment. The computing system may further evaluate the second data to determine whether it includes potentially private information, and may cause the second data to be transferred to the second computing environment based at least in part on the second data being free of potentially private information.

Abstract: Typically, when a user switches sessions between devices, the user authenticates the sessions by providing user account information, password, and/or pin code input or other credentials. However, when the user is frequently switching sessions between devices, authenticating sessions may result in the user reducing or even stopping switching across mobile devices. Systems and methods according to this disclosure provide automatic session roaming across mobile devices using proximity authentication. Upon detecting an indication to initiate session roaming, the source device automatically roams the session on the source device to a target device based on a proximity of the source device to the target device. The session is handed off from the source device to the target device as an authenticated user session.