Abstract: The present disclosure relates to a Pyrimido[5,4-b]indolizine or pyrimido[5,4-b]pyrrolizine compound, preparation method thereof and use thereof. The compounds of the present invention have good inhibitory activities against BTK at the molecular and cellular levels. Importantly, the compounds of the present invention have low activity against Ramos cells of normal human B lymphoma cells, and have high activity against BTK-sensitive human diffuse large B lymphoma TMD8 cells, indicating that these type of compounds with novel structural are highly selective, off-target phenomenon and corresponding side effects are low. Thus it is a selective inhibitor of BTK with development potential.

Abstract: The present application provides use of an algal proteoglycan extract and a composition comprising the same in treating or preventing tumor, pain, inflammation or diseases mediated by inflammatory factors.

Abstract: The invention describes an aryl-2,2?-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2?-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.

Abstract: A soil measurement system is provided, comprising a soil surveying device, a radio receiver, a plurality of subterranean antennas, and a processor. The soil surveying device comprises a wireless radio transmitter configured to emit a wireless signal at a predetermined bandwidth in a predetermined spectrum. The plurality of subterranean antennas are in an array electronically connected to the radio receiver and configured to be mounted in a subterranean environment at different depths in the subterranean environment. Each of the plurality of subterranean antennas is configured to receive the wireless signal at a respective point in time. The processor is configured to determine a relative time of flight of the received wireless signal between the plurality of antennas at the respective point in time, and estimate a soil permittivity based on the determined relative time of flight. The measurement system may be applied to materials other than soil, in some examples.

Abstract: Provided are compositions and methods for treating cancer comprising the use of a immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy. The immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy shows synergistic effects in cancer treatment.

Abstract: Disclosed herein are embodiments of systems, methods, and products comprising a data power server for secure storage and retrieval of trade data. The server receives a request from a user to review or confirm one or more trade documents via a webserver. The server communicates with a connector grid server to retrieve the user's accessible documents. The connector grid server determines the electronic file IDs that are accessible to the user based on the accessibility policy. The server instructs a digital library server to download the electronic files containing the requested trade data. The digital library server retrieves and downloads the electronic files based on the file IDs. The webserver renders a GUI displaying the electronic files on an electronic client device operated by the user. Upon receiving the confirmation response from the user, the server instructs the digital library server to update the trade status.

Abstract: The invention relates to a compound of formula (I): wherein variables are as defined in the specification. The compound is an inhibitor of an ERK kinase, e.g. ERK1 and/or ERK2 kinase. The invention also relates to the use of the compound and a method for preparing the compound, and a pharmaceutical composition containing the compound.

Abstract: A method for generating an augmented reality module by an apparatus is described. Processing circuitry of the apparatus obtains preset third party software development interface information, the third party software development interface information being uniformly encapsulated with an AR core engine and an AR rendering engine, and a system parameter and pose information that are associated with the AR core engine being passed into the AR rendering engine. The processing circuitry generates, according to the third party software development interface information and a document configured corresponding to the third party software development interface information, an AR module of a mobile client, the correspondingly configured document comprising interface use information of the AR core engine and the AR rendering engine.

Abstract: Use of an algal proteoglycan extract and a composition comprising the same in the manufacture of a medicament for treating or preventing tumor, pain, inflammation or diseases mediated by inflammatory factors.

Abstract: A consensus process recovery method and a related node, where the method includes determining, by a plurality of nodes, a target instance from one or more secondary instances, where a throughput of the target instance is higher than a throughput of a primary instance, and obtaining, by a first node and all second nodes, a consensus to replace the primary instance with the target instance as a new primary instance, where the second nodes are backup nodes running the target instance, and the first node is a primary node running the target instance.

Abstract: Methods and systems for performing real time digital content concealment are described herein. A computing device may, in response to detecting a user within view of an image capture device of a client device, perform a first type of text recognition on a first region of digital content and a second type of text recognition on a second region of the digital content, where the first type of text recognition is determined based on a first type of content items contained in the first region and the second type of text recognition is determined based on a second type of content items contained in the second region. Based at least in part on rules corresponding to the user, the computing device may determine content items within the digital content to be concealed, and may modify the digital content to conceal the content items.

Abstract: A rotary fatigue tester with complex loads includes a pump, a first motor, a second motor, a circulatory loop, an experimental kettle body, and a holding device. The experimental kettle body is a cylindrical tank, the circulatory loop is located on the experimental kettle body, a pump is located within the circulatory loop and is connected with a corrosive gas pipeline; the holding device is located within the experimental kettle body for fixing a test piece, a force-bearing pole is located at one side of the experimental kettle body for applying a shear force to the test piece, the holding device and the force-bearing pole are connected with the first motor and the second motor respectively. The rotary fatigue tester is able to simultaneously apply the axial alternating load and tangential alternating load to the test piece, for simulating the force of the test piece under complex loads.

Abstract: A photovoltaic module comprises a back substrate having a plurality of conductive interconnects on top thereof. A conductive interconnect includes a first contact region and a second contact region. The photovoltaic module further comprises a plurality of photovoltaic cells comprising front electrodes disposed on a front surface of a photovoltaic layer on top of back electrodes on top of a support substrate. A plurality of back vias extending through the support substrate of a first cell form an electrical contact between the back electrodes and the second contact region, and a plurality of front vias extending through the support substrate, the back electrodes and the photovoltaic layer of a second cell form an electrical contact between the front electrodes and the first contact region, and is insulated from an electrical contact with the back electrodes and a P side of the photovoltaic layer.

Abstract: Provided in the present invention are a compound having the effects of preventing and treating diseases related to IDH mutation, and a preparation method and use thereof.

Abstract: Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.

Abstract: Disclosed are a 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, a preparation method therefor and an application thereof. Specifically, disclosed are three crystalline forms, i.e., crystalline forms A, B, and C, of 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride (formula I), preparation methods for the three crystalline forms, and use of the three crystalline forms in preparation of drugs.

Abstract: Provided in the present invention are a substituted amino six-membered nitric heterocyclic ring compound and a preparation and use thereof. In particular, provided in the present invention is a compound as shown by general formula (I) below, wherein the definition of each group is as described in the description. The compound of the present invention has an excellent tyrosine kinase inhibitory activity, and can thus be used to prepare a series of medicines for treating diseases related to tyrosine kinase inhibitory activity.

Abstract: Methods and systems for performing real time digital content concealment are described herein. A computing device may, in response to detecting a user within view of an image capture device of a client device, perform a first type of text recognition on a first region of digital content and a second type of text recognition on a second region of the digital content, where the first type of text recognition is determined based on a first type of content items contained in the first region and the second type of text recognition is determined based on a second type of content items contained in the second region. Based at least in part on rules corresponding to the user, the computing device may determine content items within the digital content to be concealed, and may modify the digital content to conceal the content items.

Abstract: The present disclosure relates to 7-substituted pyrrolo[2,1-f][1,2,4]triazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof. These compounds show good PI3K inhibitory activity, can effectively inhibit the activity of PI3K kinase, and has significant enhancement and improvement of pharmacokinetic properties, such as bioavailability, due to the introduction of the 7-position group; furthermore, the compounds of the present disclosure exhibit an unpredictable high selectivity and strong inhibitory activity on PI3K?, and thus these compounds can be used for treating diseases related to PI3K pathway, especially for anti-cancer or for the treatment of tumors, leukemias and autoimmune diseases. After further optimizing and screening, the compounds are expected to be developed into a new type of anti-tumor drugs.

Abstract: Methods and systems for performing real time digital content concealment are described herein. A computing device may, in response to detecting a user within view of an image capture device of a client device, perform a first type of text recognition on a first region of digital content and a second type of text recognition on a second region of the digital content, where the first type of text recognition is determined based on a first type of content items contained in the first region and the second type of text recognition is determined based on a second type of content items contained in the second region. Based at least in part on rules corresponding to the user, the computing device may determine content items within the digital content to be concealed, and may modify the digital content to conceal the content items.