Abstract: A hydraulic buffer device includes a first chamber, a second chamber, and a buffering space disposed under the first and second chambers, an air bladder disposed in the buffering space, an oil chamber disposed above the first and second chambers and divided by a piston into upper and lower chamber portions, and an annular passage disposed around the oil chamber. When the piston is moved downwardly within the oil chamber, the hydraulic oil flows from the lower chamber portion into the buffering space via the first chamber to contract the air bladder so that, upon expansion of the air bladder, air pressure in the air bladder pushes the hydraulic oil to flow from the buffering space into the upper chamber portion via the second chamber and the annular passage.

Abstract: A foot plate device is connected to a prosthetic lower leg of an artificial foot, and includes a flexible foot plate. The foot plate has a front plate section, an inclined intermediate plate section extending rearwardly and upwardly from a rear end of the front plate section, and a rear plate section extending rearwardly from a rear end of the intermediate plate section and generally parallel to the front plate section. The front plate section has at least one open-ended slot formed vertically therethrough and extending across the front plate section along a longitudinal direction of the foot plate, so as to divide the front plate section into two force-receiving plate portions. The rear plate section is connected with the prosthetic lower leg.

Abstract: A method of forming a semiconductor device is provided that includes forming a first metal semiconductor alloy on a semiconductor containing surface, forming a dielectric layer over the first metal semiconductor alloy, forming an opening in the dielectric layer to provide an exposed surface the first metal semiconductor alloy, and forming a second metal semiconductor alloy on the exposed surface of the first metal semiconductor alloy. In another embodiment, the method includes forming a gate structure on a channel region of a semiconductor substrate, forming a dielectric layer over at least a source region and a drain region, forming an opening in the dielectric layer to provide an exposed surface the semiconductor substrate, forming a first metal semiconductor alloy on the exposed surface of the semiconductor substrate, and forming a second metal semiconductor alloy on the first metal semiconductor alloy.

Abstract: In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: A method of forming a semiconductor device is provided that includes forming a gate structure on a channel portion of a semiconductor substrate, forming an interlevel dielectric layer over the gate structure, and forming a opening through the interlevel dielectric layer to an exposed surface of the semiconductor substrate containing at least one of the source region and the drain region. A metal semiconductor alloy contact is formed on the exposed surface of the semiconductor substrate. At least one dielectric sidewall spacer is formed on sidewalls of the opening. An interconnect is formed within the opening in direct contact with the metal semiconductor alloy contact.

Abstract: A method, a device, and a system for managing permission information are provided. The method includes: receiving a permission modification instruction, where the permission modification instruction is used to instruct modification of permission information of a file; modifying the permission information according to the permission modification instruction of the file; and sending an Identifier (ID) of the file and the modified permission information to a server. The device includes: a modification module, a processing module, and a first sending module. The system includes: a client and a server. The server and the file jointly store the permission information, thereby effectively improving the flexibility of file encryption, reducing the burden of the server, and improving the performance of the server.

Abstract: An electrical structure is provided that includes a dielectric layer present on a semiconductor substrate and a via opening present through the dielectric layer. An interconnect is present within the via opening. A metal semiconductor alloy contact is present in the semiconductor substrate. The metal semiconductor alloy contact has a perimeter defined by a convex curvature relative to a centerline of the via opening. The endpoints for the convex curvature that defines the metal semiconductor alloy contact are aligned to an interface between a sidewall of the via opening, a sidewall of the interconnect and an upper surface of the semiconductor substrate.

Abstract: In a replacement gate scheme, a continuous material layer is deposited on a bottom surface and a sidewall surface in a gate cavity. A vertical portion of the continuous material layer is removed to form a gate component of which a vertical portion does not extend to a top of the gate cavity. The gate component can be employed as a gate dielectric or a work function metal portion to form a gate structure that enhances performance of a replacement gate field effect transistor.

Abstract: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides.

Abstract: Antimicrobial or preservative compositions with high user comfort and/or low ocular irritation. The compositions comprise a polyquaternary ammonium compound and an amidoamine having an alcohol group and exhibit synergistic antimicrobial activity. The compositions may be used as stand-alone antimicrobials/preservatives or may be incorporated into other ocular compositions such as those for ocular lens care or the treatment of ocular conditions.

Abstract: The invention discloses binding agents to the E746-A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.

Abstract: Disclosed herein are stable oil-in-water emulsion ophthalmic topical liquid compositions having an average particle size less than 1 ?m including at least one plant-derived oil other than castor oil wherein the oil comprises only aliphatic side chains free of polar pendent groups. The oil-in-water emulsion ophthalmic topical liquid compositions also include a hydrophilic surfactant having an HLB value between approximately 10 and 14, a vegetable oil-derived hydrophobic non-co-block surfactant having unsaturated side chains that contain less than four oxygen atoms having an HLB value between approximately 4 and 6 and is a liquid at room temperature. The oil-in-water emulsion ophthalmic topical liquid compositions disclosed herein can further include an amount of cyclosporine A or polyphenol in an amount effective to relieve dry eye symptoms.

Abstract: The present embodiments relate to a novel method of making quaternary ammonium polymers comprising the steps of: a) mixing 1,4-bis-dimethylamino-2-butene, triethanolamine, water and an acid; and b) introducing a 1,4-dihalo-2-butene to the mixture so as to initiate a reaction resulting in the quaternary ammonium polymer.

Abstract: An energy detection method is provided. The method obtains an initial time point of an input signal with reference to a digital signal corresponding to the input signal. An ith sample value is obtained by sampling the digital signal. The (i?M?N+1)th to the (i?N)th sample values and the (i?N+1)th to the ith sample value are buffered. The weighting coefficient is set to with initial value. A first parameter is obtained according to the weighting coefficient and the (i?M?N+1)th to the (i?N)th sample values, and a second parameter is obtained according to the (i?N+1)th to the ith sample values. A comparison between the first parameter and the second parameter is made, and the sampling time point of the (i?N+1)th sample value is determined as the signal initial time point when the second parameter is greater than the first parameter.

Abstract: A multi-carrier receiver, multi-carrier transmitter and a multi-carrier transceiver system are provided. The multi-carrier receiver includes a first processing unit, a router and a second processing unit. The first processing unit has M first processing paths, applies intensity processing on at least a RF signal for outputting sub-carrier signals. The router has M input terminals and N output terminals, where the M input terminals are respectively coupled to the M first processing paths and receive the sub-carrier signals. The router outputs the sub-carrier signals to the N output terminals and the received signal at each output terminal of the router includes the sub-carrier signal at each input terminal. The second processing unit has N second processing paths respectively coupled to the N output terminals for demodulating the sub-carrier signals and applies an analog-to-digital conversion on the demodulated signals for generating digital signals, where M and N are greater than 0.

Abstract: A multi-carrier receiver, multi-carrier transmitter and a multi-carrier transceiver system are provided. The multi-carrier receiver includes at least a first processing unit, a routed switch and a second processing unit. The first processing unit has M first processing paths, performs intensity processing to at least one RF signal for outputting sub-carrier signals. The routed switch has M input terminals and N output terminals, where the M input terminals are respectively coupled to the M first processing paths and receive the sub-carrier signals. The routed switch connects each input terminal to at least one output terminal or none of the output terminals according to a control signal. The second processing unit has N second processing paths respectively coupled to the N output terminals for demodulating the sub-carrier signals and performing an analog-to-digital conversion to the demodulated signals for generating digital signals, where M and N are greater than 0.

Abstract: A ophthalmic composition, comprising: an aqueous liquid medium, and an effective amount of polyquaternium-1 made by a process of: a) mixing 1,4-bis-dimethylamino-2-butene, triethanolamine and an acid; b) introducing a 1,4-dichloro-2-butene to the mixture, and c) isolating polyquaternium-1 having a molecular weight as determined by a proton NMR method of about 10,000 or more, at a yield of at least about 50%.

Abstract: The present invention provides a method of forming asymmetric field-effect-transistors.

Abstract: Semiconductor devices and methods for fabricating the same are provided. An exemplary embodiment of a semiconductor device comprises a substrate with a plurality of isolation structures formed therein, defining first and second areas over the substrate. A transistor is formed on a portion of the substrate in the first and second areas, respectively, wherein the transistor in the second area is formed with merely a pocket doping region in the substrate adjacent to a drain region thereof. A first dielectric layer is formed over the substrate, covering the transistor formed in the first and second areas. A plurality of first contact plugs is formed through the first dielectric layer, electrically connecting a source region and a drain region of the transistor in the second area, respectively. A second dielectric layer is formed over the first dielectric layer with a capacitor formed therein, wherein the capacitor electrically connects one of the first contact plugs.

Abstract: A multipurpose solution for contact lens care, comprising: an aqueous liquid medium; a quaternary ammonium polymer having an average molecular weight as determined by the proton NMR method of at least 28 k, and methods for making the same.