Abstract: Disclosed is a novel system and method to develop computational models of membrane conductances through training a multi-layer perceptron to predict a channel's responses (conductances) to different conditions (voltage histories). Initially, at each time step of the dAPC protocol the current generated across the TCL1 cell membrane is determined by the history of voltages calculated in the model compartment. These data collected from dAPC are then used to train a perceptron, whose inputs are select time points in this history, and whose output predicts the channel conductances measured by the dAPC apparatus. The trained perceptron then becomes a model of the channel, comprising a specific set of historical voltage data points from compartment models provided as inputs to a specific combination of hidden units to produce an output that predicts channel conductance given a particular voltage history.

Abstract: Disclosed is a novel system and method to develop computational models of membrane conductances through training a multi-layer perceptron to predict a channel's responses (conductances) to different conditions (voltage histories). Initially, at each time step of the dAPC protocol the current generated across the TCL1 cell membrane is determined by the history of voltages calculated in the model compartment. These data collected from dAPC are then used to train a perceptron, whose inputs are select time points in this history, and whose output predicts the channel conductances measured by the dAPC apparatus. The trained perceptron then becomes a model of the channel, comprising a specific set of historical voltage data points from compartment models provided as inputs to a specific combination of hidden units to produce an output that predicts channel conductance given a particular voltage history.

Abstract: An information processing system, computer readable storage medium, and method for regulating input data streams of a stream computing environment. A processor of the information processing system captures one or more data streams history of inputs and outputs of a working stream computing environment (SCE). The processor off-line simulates at least one candidate training model of the SCE processing input data streams and output data streams according to the one or more data streams history. The processor varies modulation of the input data streams into the candidate training model during the off-line simulation, analyzes effects of the varying modulation of input data streams on the off-line simulation of the SCE, determines, based on the analyzing, effectiveness of each of the at least one candidate training model of the SCE to regulate input data streams without affecting, within acceptable tolerance limits, the SCE processing of the output data streams.

Abstract: An information processing system and a computer readable storage medium, for regulating input data streams of a stream computing environment. A processor of the information processing system captures one or more data streams history of inputs and outputs of a working stream computing environment (SCE). The processor off-line simulates at least one candidate training model of the SCE processing input data streams and output data streams according to the one or more data streams history. The processor varies modulation of the input data streams into the candidate training model during the off-line simulation, analyzes effects of the varying modulation of input data streams on the off-line simulation of the SCE, determines, based on the analyzing, effectiveness of each of the at least one candidate training model of the SCE to regulate input data streams without affecting, within acceptable tolerance limits, the SCE processing of the output data streams.

Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

Abstract: A single use rigid package containing pharmaceutical compositions which protects tablets, capsules, soft shell pills against hard transporting conditions and undesired rupture. The package comprises at least four sections made from a single sheet foldable into a folded configuration. At least two sections are carrier sections pivotally connected to each other and each comprising cavities for housing pharmaceutical compositions. Two sections are end sections not comprising cavities, the end sections being foldable to adjacent and at least partly covering the carrier sections when the sheet is folded so as to protect the carrier sections. The package allows for personal transportation, e.g. in a pocket, and it is easy and convenient to open for people of all levels of ability and dexterity. Its design allows for transport as standard mail withstanding temperature fluctuation, vibrations and shocks, mechanical pressure and variation in atmospheric pressure which may occur during transport.

Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

Abstract: A gas detection system comprising a gas sensor having a detection surface for detecting an analyte gas, the accuracy of detection being degraded by the presence of an unwanted gas at the sensor, and a thermal scrubber layer directly adjacent said detection surface of the gas sensor defining a diffusion path for the analyte and unwanted gases to traverse through to the detection surface, the diffusion path having a sufficient length and the thermal scrubber being heated by the heater to a sufficient temperature capable of at least partially thermally decomposing the unwanted gas prior to contacting the detection surface to thereby improve the accuracy of the sensor. The system further comprises a heater that is preferably arranged to heat both the detection surface and the thermal scrubber. The invention is particularly useful for improving the performance of an NO2 gas sensor in the presence of ozone (O3).

Abstract: Systems, methods and computer program products that facilitate the sale of perishable inventory such as tickets to a limited capacity event are provided. Through the targeting of fans who are interested in access to the perishable inventory and are within a geographic location that permits them to go to an event location within a limited amount of time, there can be increased attendance at the events. Optionally, a fan's passion level can be considered when determining whether to make an offer.

Abstract: A disposable rigid package containing pharmaceutical compositions which protects tablets, capsules, soft shell pills against hard transporting conditions and undesired rupture. The package allows for personal transportation, e.g. in a pocket, and it is easy and convenient to open for people of all level of ability and dexterity. Its design allows for transport as standard mail withstanding temperature fluctuation, vibrations and shocks, mechanical pressure and variation in atmospheric pressure which may occur during transport.

Abstract: A disposable rigid package containing pharmaceutical compositions which protects tablets, capsules, soft shell pills against hard transporting conditions and undesired rupture. The package allows for personal transportation, e.g. in a pocket, and it is easy and convenient to open for people of all level of ability and dexterity. Its design allows for transport as standard mail withstanding temperature fluctuation, vibrations and shocks, mechanical pressure and variation in atmospheric pressure which may occur during transport.

Abstract: The invention relates to a system for opening a medical blister package which is easy and convenient to open for people of all level of ability and dexterity. Its design allows for selective access to the blisters by following a predetermined opening sequence, therefore minimizing involuntary wrong up taking of medicine due to patient errors as wrong sequential opening is not achievable by involuntary mistakes.

Abstract: Fused aromatic compounds of Formula I are PPAR gamma agonists or partial agonists and are useful for weekly dosing in the treatment or control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Abstract: A gas detection system comprising a gas sensor having a detection surface for detecting an analyte gas, the accuracy of detection being degraded by the presence of an unwanted gas at the sensor, and a thermal scrubber layer directly adjacent said detection surface of the gas sensor defining a diffusion path for the analyte and unwanted gases to traverse through to the detection surface, the diffusion path having a sufficient length and the thermal scrubber being heated by the heater to a sufficient temperature capable of at least partially thermally decomposing the unwanted gas prior to contacting the detection surface to thereby improve the accuracy of the sensor. The system further comprises a heater that is preferably arranged to heat both the detection surface and the thermal scrubber. The invention is particularly useful for improving the performance of an NO2 gas sensor in the presence of ozone (O3).

Abstract: Fused aromatic compounds of Formula I are PPAR gamma agonists or partial agonists and are useful for weekly dosing in the treatment or control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Abstract: A reciprocating drive apparatus for connection to a top end of a rod swing to drive a downhole pump located in a well includes a plate adapted to be fastened to a top end of a well head assembly of the well, and a mast attachable to the plate in a substantially vertical working position. A hydraulic cylinder is attached to the mast such that when the mast is in the working position the hydraulic cylinder is oriented substantially vertically, and such that the hydraulic cylinder can extend and retract in response to a controller. A tether is adapted to be fixed to the well head and to the top end of the rod string and is configured such that the hydraulic cylinder engages the tether to move the rod string up and down as the hydraulic cylinder extends and retracts.

Abstract: The present invention is a security closure for enclosing an opening of a container includes a security lid having openings for lock tabs on the container. The lock tabs mate with openings on the combination lid by inserting and rotating the container. Lock dials are used to maintain the security lid and the container in a closed relationship.