Abstract: An injector, comprising, an injector body comprising, an inner wall that defines an injector cavity for fluid, at least one inlet channel into the injector cavity, and at least one outlet channel from the injector cavity, a plunger that defines at least one passageway between the injector cavity and the at least one outlet channel, the plunger being movable longitudinally in the injector cavity between at least: a first open arrangement in which the at least one passageway is positioned to direct fluid into the at least one outlet channel at a first position, and a second open arrangement in which the at least one passageway is positioned to direct fluid into the at least one outlet channel at a second position different from the first position.

Abstract: The present disclosure provides a fuel injector for an internal combustion engine with a fuel injector body having a valve chamber, a first conduit in fluid communication with the valve chamber for a first flow of fuel having a first pressure, and a second conduit in fluid communication with the valve chamber for a second flow of fuel having a second pressure. The fuel injector further includes a valve member configured to move between the first conduit and the second conduit. Additionally, an actuator of the fuel injector is configured to move the valve member during a fuel injection cycle. The fuel injector is configured to operate in at least three modes.

Abstract: An injector, comprising, an injector body comprising, an inner wall that defines an injector cavity for fluid, at least one inlet channel into the injector cavity, and at least one outlet channel from the injector cavity, a plunger that defines at least one passageway between the injector cavity and the at least one outlet channel, the plunger being movable longitudinally in the injector cavity between at least: a first open arrangement in which the at least one passageway is positioned to direct fluid into the at least one outlet channel at a first position, and a second open arrangement in which the at least one passageway is positioned to direct fluid into the at least one outlet channel at a second position different from the first position.

Abstract: A fuel injector is provided that includes various precise configuration parameters, including dimensions, shape and/or relative positioning of fuel injector features, resulting in improved efficiency of fuel flow through the fuel injector.

Abstract: The present disclosure provides a fuel injector for an internal combustion engine with a fuel injector body having a valve chamber, a first conduit in fluid communication with the valve chamber for a first flow of fuel having a first pressure, and a second conduit in fluid communication with the valve chamber for a second flow of fuel having a second pressure. The fuel injector further includes a valve member configured to move between the first conduit and the second conduit. Additionally, an actuator of the fuel injector is configured to move the valve member during a fuel injection cycle. The fuel injector is configured to operate in at least three modes.

Abstract: A fuel injector is provided comprising an outer housing, a nozzle housing disposed within the outer housing, a flow path between the outer housing and the nozzle housing, the flow path being coupled to a low pressure fuel source, and a circumferential gap in flow communication with the flow path and extending about a tip of the fuel injector between an outer surface of the nozzle housing and an inner surface of a combustion shield adjacent the injector tip. The circumferential gap is in flow communication with a drain gap between the outer housing and a bore for receiving the fuel injector, the drain gap routing the low pressure fuel away from the injector tip.

Abstract: A fuel injector is provided that creates variable spray characteristics to effectively reduce emissions, such as NOx emissions and particulate matter. The injector includes a nozzle valve element of the outwardly opening type including a fuel delivery passage and spray holes. The nozzle valve element is operable to move to a low lift position to cause fuel flowing from the spray holes to impinge on the injector body and to deflect toward the combustion chamber, and to move to a high lift position to cause fuel flowing from the spray holes to avoid impingement on injector body and flow in an obstructed manner directly into the combustion chamber. An annular chamber may be formed in the nozzle valve element adjacent the spray holes to receive fuel.

Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind. Transforming Growth Factor beta (TGF?), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGF?1, TGF?2 and TGF?3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).

Abstract: An injector combustion shield assembly comprising a bore configured to receive a fuel injector, the bore including a fluid opening in fluid communication with a fluid jacket and a fluid outlet positioned within an annular wall of the bore; and a valve positioned between the fluid jacket and the fluid opening and configured to selectively permit a fluid from the fluid jacket to enter the bore, the valve being movable between an open configuration to permit fluid flow from the fluid jacket into the bore via the fluid opening and a closed configuration to prevent fluid flow from the fluid jacket into the bore.

Abstract: A fuel injector is provided comprising an outer housing, a nozzle housing disposed within the outer housing, a flow path between the outer housing and the nozzle housing, the flow path being coupled to a low pressure fuel source, and a circumferential gap in flow communication with the flow path and extending about a tip of the fuel injector between an outer surface of the nozzle housing and an inner surface of a combustion shield adjacent the injector tip. The circumferential gap is in flow communication with a drain gap between the outer housing and a bore for receiving the fuel injector, the drain gap routing the low pressure fuel away from the injector tip.

Abstract: The disclosure provides an improved fuel injector and method of operating the fuel injector to provide at least two different types of fuel spray to a combustion chamber of an internal combustion engine. The two types of spray are formed by providing a first fuel pressure to the fuel injector during a first portion of an injection event at a first pressure and providing a second fuel pressure to the fuel injection during a second portion of the injection event, and maintaining a substantially constant fuel flow rate throughout the injection event.

Abstract: Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Abstract: The present disclosure provides an improved system and method of operating a fuel injector of an engine to provide at least two different types of fuel spray in a combustion chamber of the engine by application of ultrasonic pulses to fuel in the fuel injector during an injection event. A first type of spray includes larger droplets that reduce the effective diffusion combustion area around the droplets and a second type of spray includes relatively small droplets that increase the effective diffusion combustion area around the droplets.

Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGF?), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGF?1, TGF?2 and TGF?3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).

Abstract: A fuel pump is disclosed wherein a substantially cylindrical plunger bore is provided with an annular drain groove fluidically coupled to a drain duct. A pump plunger is driven by a drive system located in a separate mechanical compartment that holds a reservoir of lubricating oil. An annular seal is provided adjacent the drain groove substantially at the end of the bore and retained in position by a seal support. Exemplary embodiments provide the drain groove and seal as being positioned immediately adjacent one another so that the seal forms a lower wall of the drain groove.

Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

Abstract: The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract: The present disclosure provides a fuel injector for an internal combustion engine with a fuel injector body having a valve chamber, a first conduit in fluid communication with the valve chamber for a first flow of fuel having a first pressure, and a second conduit in fluid communication with the valve chamber for a second flow of fuel having a second pressure. The fuel injector further includes a valve member configured to move between the first conduit and the second conduit. Additionally, an actuator of the fuel injector is configured to move the valve member during a fuel injection cycle. The fuel injector is configured to operate in at least three modes.

Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGF?), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGF?1, TGF?2 and TGF?3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).

Abstract: A fuel pump is disclosed wherein a substantially cylindrical plunger bore is provided with an annular drain groove fluidically coupled to a drain duct. A pump plunger is driven by a drive system located in a separate mechanical compartment that holds a reservoir of lubricating oil. An annular seal is provided adjacent the drain groove substantially at the end of the bore and retained in position by a seal support. Exemplary embodiments provide the drain groove and seal as being positioned immediately adjacent one another so that the seal forms a lower wall of the drain groove.