Abstract: A fuel injector is provided that creates variable spray characteristics to effectively reduce emissions, such as NOx emissions and particulate matter. The injector includes a nozzle valve element of the outwardly opening type including a fuel delivery passage and spray holes. The nozzle valve element is operable to move to a low lift position to cause fuel flowing from the spray holes to impinge on the injector body and to deflect toward the combustion chamber, and to move to a high lift position to cause fuel flowing from the spray holes to avoid impingement on injector body and flow in an obstructed manner directly into the combustion chamber. An annular chamber may be formed in the nozzle valve element adjacent the spray holes to receive fuel.

Abstract: Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGF?), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGF?1, TGF?2 and TGF?3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).

Abstract: An injector, comprising, an injector body comprising, an inner wall that defines an injector cavity for fluid, at least one inlet channel into the injector cavity, and at least one outlet channel from the injector cavity, a plunger that defines at least one passageway between the injector cavity and the at least one outlet channel, the plunger being movable longitudinally in the injector cavity between at least: a first open arrangement in which the at least one passageway is positioned to direct fluid into the at least one outlet channel at a first position, and a second open arrangement in which the at least one passageway is positioned to direct fluid into the at least one outlet channel at a second position different from the first position.

Abstract: A linkage mapping process incorporating an RBF non-linear classifier pattern-matching approach for use in the genetic analysis and modification of botanical organisms by comparing infrared mass spectroscopy, isomeric-level quantitative chemical analysis patterns, with single-molecule real-time genetic and genomic isoform analysis sequence patterns to build a searchable pattern library of those phenotype patterns producing commercially desirable traits for directed selection of desirable attributes and identification of their associated phenotype patterns.

Abstract: A fuel injector is provided that creates variable spray characteristics to effectively reduce emissions, such as NOx emissions and particulate matter. The injector includes a nozzle valve element of the outwardly opening type including a fuel delivery passage and spray holes. The nozzle valve element is operable to move to a low lift position to cause fuel flowing from the spray holes to impinge on the injector body and to deflect toward the combustion chamber, and to move to a high lift position to cause fuel flowing from the spray holes to avoid impingement on injector body and flow in an obstructed manner directly into the combustion chamber. An annular chamber may be formed in the nozzle valve element adjacent the spray holes to receive fuel.

Abstract: A flow limiter for a fuel system is provided. The flow limiter includes a self-contained portion that enables testing of the flow limiter prior to assembly into a fuel system. A housing of the flow limiter is arranged to provide reduced or no pressure differential across a wall of the housing, permitting the housing to be reduced in size and thickness and providing improved consistency of operation.

Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

Abstract: The present disclosure provides an improved system and method of operating a fuel injector of an engine to provide at least two different types of fuel spray in a combustion chamber of the engine by application of ultrasonic pulses to fuel in the fuel injector during an injection event. A first type of spray includes larger droplets that reduce the effective diffusion combustion area around the droplets and a second type of spray includes relatively small droplets that increase the effective diffusion combustion area around the droplets.

Abstract: The disclosure provides an improved fuel injector and method of operating the fuel injector to provide at least two different types of fuel spray to a combustion chamber of an internal combustion engine. The two types of spray are formed by providing a first fuel pressure to the fuel injector during a first portion of an injection event at a first pressure and providing a second fuel pressure to the fuel injection during a second portion of the injection event, and maintaining a substantially constant fuel flow rate throughout the injection event.

Abstract: A fluid control device for use in a high pressure fluid system, the device including a device body with a cavity and a high pressure circuit, a plunger positioned for reciprocal movement in the cavity, and a leakage reduction cap mounted to the plunger for reducing fluid leakage flow. In one implementation, the leakage reduction cap includes a flexible portion positioned between the device body and the plunger, and defining an annular clearance gap between the leakage reduction cap and the device body. The flexible portion of the leakage reduction cap resiliently flexes radially outwardly in response to fluid pressure forces to reduce the annular clearance gap so as to minimize fluid leakage flow through the annular clearance gap.

Abstract: A system that includes computer hardware, computer software, apparatus, and methodology that enables individuals, businesses, and all types of organizations (both for profit and non-profit) to capture and securely transmit check images (including, but not limited to, personal checks, business checks, travelers checks, money orders, merchant coupons, food coupons, line of credit checks, etc.), deposit information, and other information from remote locations (i.e., locations that could include the financial institution's remote locations, other financial institution's locations, businesses, private residences, etc.), for the purpose of having those checks credited to the depositing individual's or organization's bank account(s) and having the check images (and/or physical checks) entered into the bank check clearing channels for ultimate delivery to the maker bank for payment out of the maker's account.

Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGF?), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGF?1, TGF?2 and TGF?3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).

Abstract: A system that includes computer hardware, computer software, apparatus, and methodology that enables individuals, businesses, and all types of organizations (both for profit and non-profit) to capture and securely transmit check images (including, but not limited to, personal checks, business checks, travelers checks, money orders, merchant coupons, food coupons, line of credit checks, etc.), deposit information, and other information from remote locations (i.e., locations that could include the financial institution's remote locations, other financial institution's locations, businesses, private residences, etc.), for the purpose of having those checks credited to the depositing individual's or organization's bank account(s) and having the check images (and/or physical checks) entered into the bank check clearing channels for ultimate delivery to the maker bank for payment out of the maker's account.

Abstract: A payment management platform for brokering consumer-pay transactions is provided.

Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGF?), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGF?1, TGF?2 and TGF?3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).

Abstract: A fuel injector is provided that includes various precise configuration parameters, including dimensions, shape and/or relative positioning of fuel injector features, resulting in improved efficiency of fuel flow through the fuel injector.

Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind. Transforming Growth Factor beta (TGF?), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TG?1, TGF?2 and TGF?3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).

Abstract: Systems and methods for managing computer-assisted communications channels based on relationships between users who wish to communicate with one another are described. The relationship-managed communications system allows users to retain control over whom they permit to communicate with them and under what conditions such communications may take place, for example when they take place and/or using which communications channels, by allowing pairs of users to establish relationships which specify communications permissions. Users of the system provide their contact information to the relationship-managed communications system, and the system uses the securely stored information to mediate the establishment of communications channels between users. Embodiments of the system may intelligently route communications to substitute channels based on relationship-related and other information.

Abstract: The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.