Abstract: The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.

Abstract: A fuel injector having a nozzle with improved cooling including a retainer and a nozzle housing received therein. The nozzle housing includes a nozzle shank, an outer peripheral surface and at least one injection hole at a tip of the nozzle shank. The nozzle shank is positioned in a nozzle support portion of the retainer. In one embodiment, the outer peripheral surface of the nozzle shank is tapered, and the inner peripheral surface of the nozzle support portion is correspondingly tapered and sized to engage the outer peripheral surface of the nozzle shank along a tapered interface. In another embodiment, the inner peripheral surface of the nozzle support portion has a diameter smaller than a diameter of the outer peripheral surface of the nozzle shank so that an interference fit exists at a seal interface.

Abstract: A fuel injector is provided with a lower nozzle body which is cooled with a small amount of metered fuel. In one embodiment, a blind passage is formed to extend from the upper portion to the lower end of the injector nozzle valve element. A transverse passage is formed in the nozzle valve element connecting the blind passage and the nozzle bore. Rail pressure causes a metered amount of fuel to flow through the nozzle bore, the transverse passage and upwardly along the blind passage to the drain passage. Inward cooling occurs by providing more surface area over which the fuel flows. In another embodiment, a sleeve is formed to fit over an existing nozzle to form a passage surrounding the injector tip. An orifice is located in the nozzle housing to connect the nozzle cavity with the annular passage thereby providing a small amount of fuel to drain.

Abstract: An apparatus for dispensing material during a dental or endodontic procedure includes a housing having a motor with an output. A needle heating member including a chamber may receive a prefilled needle of dispensing material. A heater at least substantially surrounds the chamber for heating the material in the needle. A plunger is used to expel the material from the needle during activation of the motor. A reusable protective sheath is provided for disposition on the outside of the housing. A method of manufacturing a needle for use and dispensing a material during a dental or endodontic procedure includes drawing a blank of metal having a closed distal end, bending the blank at a desired angle, and removing a portion of the drawn metal from the distal end to open the distal end thereby forming the dispensing needle.

Abstract: The invention relates to methods of making carbohydrate and polyol esters suitable for use as plasticizers for polymer compositions. The invention also relates to plasticized polymer compositions comprising such carbohydrate and polyol esters. The invention also relates to articles prepared from such plasticized polymer compositions. The invention further relates to methods of using these compositions.

Abstract: A preferred embodiment EGR valve permits exhaust gas to be induced into the intake line downstream of the compressor, while minimizing the need to reduce the size of the turbocharger. The preferred embodiment EGR valve exploits variations around the mean pressure in the EGR passage created by the engine cycle by selectively opening when the pressure in the EGR valve exceeds the pressure in the intake line. Thus, exhaust gas is recirculated even when the engine is running near torque peak. The preferred embodiment EGR valve also exploits the higher mean pressure in the exhaust line relative to the intake line at higher engine speeds by remaining open, in order to minimize the energy consumed in opening and closing the EGR valve.

Abstract: A series of multi-tapered parabolic implements is disclosed for endodontic use. The instruments comprise different sections: a pilot tip, a first portion adjacent the pilot tip and a second portion adjacent the shank. The two portions have different tapers. The tapers of the two different portions blend into each other along a parabola-shaped surface. The pilot tip is radiussed for ease of entry into a root canal with increased safety.

Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.

Abstract: A head harness for supporting a night vision device is provided. The head harness includes a frame assembly and padding coupled to the frame assembly. The padding is configured to contact at least one of a forehead and a cheek of the face of a user of the head harness.

Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and polycystic kidney disease.

Abstract: A series of multi-tapered files is disclosed for endodontic use. The files comprise at least two sections, a first portion adjacent the tip of the file and a second portion adjacent the shank. The two portions have different tapers. The files are provided in sets of at least four with the tapers of the first portions of all of the files decreasing incrementally from the first to the last file of the set. In some of the sets, the tapers of the second portions are the same from file to file, being fixed at one of two selected tapers. In other sets, the tapers of the second portions increase from file to file as the tapers of the first portions decrease.

Abstract: A fuel injector is provided with a lower nozzle body which is cooled with a small amount of metered fuel. In one embodiment, a blind passage is formed to extend from the upper portion to the lower end of the injector nozzle valve element. A transverse passage is formed in the nozzle valve element connecting the blind passage and the nozzle bore. Rail pressure causes a metered amount of fuel to flow through the nozzle bore, the transverse passage and upwardly along the blind passage to the drain passage. Inward cooling occurs by providing more surface area over which the fuel flows. In another embodiment, a sleeve is formed to fit over an existing nozzle to form a passage surrounding the injector tip. An orifice is located in the nozzle housing to connect the nozzle cavity with the annular passage thereby providing a small amount of fuel to drain.

Abstract: A head harness for supporting a night vision device is provided. The head harness includes a frame assembly and padding coupled to the frame assembly. The padding is configured to contact at least one of a forehead and a cheek of the face of a user of the head harness.

Abstract: The present invention comprises a program product, system and method for deposit processing using check images. In one embodiment of the present invention, the program product comprises machine-readable program code for causing, when executed, a machine to perform the following steps: at least one check processor receiving deposit information for a plurality of different deposit transactions, with the deposit information including original check image data and endorsed and voided check image data for at least one check to be deposited; selecting a print processor that has access to at least one printer based on at least one criterion; sending the electronic check data and check image data to the selected print processor; identifying a clearing end point; generating cash letter data for a maker bank; the print processor or the check processor transmitting the check image data and the cash letter data directly or indirectly to the selected end point and/or to at least one printer.

Abstract: The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.

Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.

Abstract: A system and method for regulating the temperature of a sensor to reduce temperature gradients that form within the sensor. In one embodiment, the temperature gradients are reduced utilizing a temperature regulator with two controlled zones that surround a variable capacitance sensor. Measurements are made for the ambient temperature of at least one of the two temperature controlled zones, and the temperature differential between the two temperature controlled zones. The temperature regulator then adjusts the temperature of the two controlled zones based upon this differential in order to minimize the existing temperature gradient.

Abstract: A system and method for regulating the temperature of a sensor to reduce temperature gradients that form within the sensor. In one embodiment, the temperature gradients are reduced utilizing a temperature regulator with two controlled zones that surround a variable capacitance sensor. Measurements are made for the ambient temperature of at least one of the two temperature controlled zones, and the temperature differential between the two temperature controlled zones. The temperature regulator then adjusts the temperature of the two controlled zones based upon this differential in order to minimize the existing temperature gradient.

Abstract: The invention provides a method of obtaining a cellulose material from corn fiber wherein the method comprises the steps of: (a) heating a mixture of corn fiber and a liquid; (b) contacting the mixture of step (a) with a protease enzyme, thereby providing a proteolyzed corn fiber and a liquid; (c) separating the liquid from the proteolyzed corn fiber; (d) contacting the proteolyzed corn fiber at least once with an alkaline extractant, thereby providing an insoluble cellulose material and a first liquid comprising arabinoxylan; (e) separating the insoluble cellulose material from the first liquid comprising arabinoxylan at a temperature of at or above about 60° C.; and (f) rinsing the insoluble cellulose material to remove essentially all alkali, thereby providing a cellulose material having a cellulose content of at least about 50% and consisting essentially of cellulose I. Cellulose esters and ethers are also prepared from the derivatizable cellulose prepared according to the methods herein.

Abstract: In one aspect, the invention provides a method of separating a corn fiber lipid fraction having phytosterol esters and phytosterols wherein the method comprises the steps of: (a) providing a mixture of unground corn fiber and water; (b) separating the liquid from the corn fiber, thereby providing a water wet corn fiber; and (c) extracting the water wet corn fiber with at least one polar organic solvent, thereby providing a corn fiber lipid fraction/polar organic solvent solution having phytosterol esters and phytosterols.