Abstract: A memory circuit (14) having features specifically adapted to permit the memory circuit (14) to serve as a video frame memory is disclosed. The memory circuit (14) contains a dynamic random access memory array (24) with buffers (18, 20) on input and output data ports (22) thereof to permit asynchronious read, write and refresh accesses to the memory array (24). The memory circuit (14) is accessed both serially and randomly. An address generator (28) contains an address buffer register (36) which stores a random access address and an address sequencer (40) which provides a stream of addresses to the memory array (24). An initial address for the stream of addresses is the random access address stored in the address buffer register (36).

Abstract: A method for forming a gate array substrate contact and the contact resulting therefrom includes the steps of etching off polysilicon gate layers at the same time as cutting the polysilicon to form the gate array base cell (10). The method includes forming openings (40, 42, and 44) in the second insulating layer (34) and insulating layer (30) to connect a lead (46, 48, and 50) to the underlying substrate.

Abstract: A gate array base cell which can easily be configured as high conductivity transistor device or a low conductivity transistor device comprises a moat region of first conductivity type, typically heavily doped n-type silicon or heavily doped p-type silicon, for example. A channel region of a different conductivity type separates the moat region into at least three portions. An insulating layer, such as silicon dioxide, for example, and a gate are formed above the channel region. The gate may be formed of polysilicon, for example. Modifications, variations, circuit configurations and an illustrative fabrication method are also disclosed.

Abstract: A compound of the formula: ##STR1## in which R.sup.3 is hydrogen or lower alkyl, R.sup.4 is pyridyl (lower) alkyl; andR.sup.1, R.sup.2, R.sup.5 and A are defined in the description;or a pharmaceutically acceptable salt thereof, which have endothelin antagonistic activity.

Abstract: A general neuro-computer and system using it is capable of executing a plurality of learning algorithms, providing an instruction execution speed comparable with a hard wired system, and practically neglecting a time required for rewriting microprograms. The neuro-computer is constituted by a neuron array having a plurality of neurons, a control storage unit for storing microinstructions, a parameter register, a control logic, and a global memory. A host computer as a user interface inputs information necessary for the learning and execution of the neuro-computer to the system, the information including learning algorithms, neural network architecture, the number of learnings, the number of input patterns, input signals, and desired signals. The information inputted from the host computer is transferred via a SCSI to the neuro-computer to perform a desired neural network operation.

Abstract: This invention relates to pyrrolidine derivatives and pharmaceutically acceptable salts, their pharmaceutical compositions, and methods of use as thromboxane A.sub.2 antagonists and/or thromboxane A.sub.2 synthetase inhibitors in the treatment of thrombotic diseases, asthma or nephritis, e.g. of the formula: ##STR1## wherein R.sup.1 is thienyl(lower)alkyl, furyl(lower)alkyl or pyrrolyl(lower)alkyl.

Abstract: This invention relates to new amino acid derivatives and pharmaceutically acceptable salts thereof, wherein the amino acid derivatives are useful in the treatment and/or prevention of hypertension, heart failure, renal diseases or glaucoma.

Abstract: A gate array device (10) includes a plurality of static random access memory cells (11). Each memory cell (11) comprises n-channel pass gate transistors (12, 14), n-channel drive transistors (16, 18), and p-channel transistors (20, 22). All transistors within the memory cell (11) are approximately of the same size. A resistance element (23) connects to the p-channel transistors (20, 22) in each memory cell (11), generating a new supply voltage (V.sub.cr ). The resistance element (23) effectively reduces the size of the p-channel transistors (20, 22) to below the size of the drive transistors (16, 18). By effectively reducing the size of the p-channel transistors (20, 22), the speed, accuracy, and stability of the memory cell (11) are enhanced despite the similar sizes of the transistors in the gate array device (10).

Abstract: Peptide compounds of the formula (I') ##STR1## in which R.sup.1 is acyl,R.sup.2 is lower alkyl, cyclo(lower)alkyl(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.3 is optionally substituted heterocyclic(lower)alkyl or optionally substituted ar(lower)alkyl,R.sup.4 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.6 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, or heterocyclic(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylimino or lower alkylene, or a pharmaceutically acceptable salt thereof are disclosed. The compounds can be used to treat and prevent endothelin mediated diseases such as hypertension.

Abstract: A memory circuit (14) having features specifically adapted to permit the memory circuit (14) to serve as a video frame memory is disclosed. The memory circuit (14) contains a dynamic random access memory array (24) with buffers (18, 20) on input and output data ports (22) thereof to permit asynchronious read, write and refresh accesses to the memory array (24). The memory circuit (14) is accessed both serially and randomly. An address generator (28) contains an address buffer register (36) which stores a random access address and an address sequencer (40) which provides a stream of addresses to the memory array (24). An initial address for the stream of addresses is the random access address stored in the address buffer register (36).

Abstract: A signal receiver (20) for converting a small swing signal into a full swing signal. The signal receiver (20) includes an input stage (22), having a first power input terminal (32), a second power input terminal (34), a small swing signal input terminal (30), and an intermediate signal output terminal (36), wherein the input stage (22) generates an intermediate signal on the intermediate signal output terminal (36). Signal receiver (20) further includes an output stage (28), having an intermediate signal input terminal (50) for receiving the intermediate signal, and an output terminal (56), wherein the output stage (28) generates the full swing signal on the output terminal (56). A first feedback stage (24) is provided, which includes a first power supply terminal (38), a first feedback terminal (42), and a first control signal terminal (40) coupled to the first power input terminal (32), wherein the first feedback stage (24) generates a first control signal to the first power input terminal (32).

Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is carboxy or pharmaceutically acceptable salts and esters thereof;R.sup.2 is hydrogen, lower alkyl or halogen;R.sup.3 is phenyl, naphthyl, phenyl or naphthyl each substituted by from one to three C.sub.1-6 alkyl groups, mono-, di- or triphenyl (C.sub.1-6)alkyl; or substituted mono-, di- or triphenyl (C.sub.1-6) alkyl;A is lower alkylene which may be substituted by oxo or lower alkenylene,Q is carbonyl or lower alkylene,X is ##STR2## in which R.sup.4 is hydrogen or C.sub.1-6 alkyl, andR.sup.5 is hydrogen, C.sub.1-6 alkyl or Y--Z--R.sup.3,Y is a bond or lower alkylene,Z is lower alkylene ##STR3## in which R.sup.6 is hydrogen, (C.sub.1 -C.sub.6) alkyl, mono-, di- or triphenyl(C.sub.1-10) alkyl, C.sub.1-6 alkyl or lower alkoxycarbonyl substituted mono-, di- or triphenyl(C.sub.1-6)alkyl or pharmaceutically acceptable carboxylic acid acyl, and pharmaceutically acceptable salts thereof. The compound is useful as a testosterone 5.alpha.-reductase inhibitor.

Abstract: An encoder for generating a position signal in accordance with a position of a conductive slider comprises a non-conductive substrate, a first conductive pattern formed on the substrate, and at least three second conductive patterns formed on the substrate. The second patterns are independent from the first pattern. Each of the second patterns has a lead wire extending to an edge of the substrate. The slider is slidable on the substrate, and produces a conductive state signal when it abuts against the first pattern and produces a non-conductive state signal when it abuts against the second pattern or the substrate. The position signal is generated in accordance with the conductive state signal and the non-conductive state signal. One of the second patterns is surrounded by the first pattern, and the lead wire extending therefrom passes between the other two second patterns and extends to the exterior of the first pattern.

Abstract: A compound of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen, halogen, nitro, amino, protected amino, hydroxyamino, lower alkyl, hydroxy, protected hydroxy, sulfamoyl, carboxy, protected carboxy, mercapto, optionally substituted heterocyclic-carbonyl, optionally substituted heterocyclic-(lower)alkyl, lower alkylthio, hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.3 is aryl which may have suitable substituent(s), andA is lower alkylene,or pharmaceutically acceptable salts thereof.

Abstract: Novel peptides of the formula (I") ##STR1## in which R.sup.1 is hydrogen or acyl,R.sup.2.sub.c is lower alkyl,R.sup.3.sub.c is optionally N-substituted indolylmethyl,R.sup.4 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl, amino(lower)alkyl, protected amino (lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic (lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylamino or lower alkylene,or a pharmaceutically acceptable salt thereof are disclosed.Additionally, the preparation of such peptides is described. The peptides are used to treat endothelin mediated diseases such as hypertension.

Abstract: Indole derivatives of the following formula: ##STR1## wherein R.sup.1 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.2 is hydrogen, lower alkyl or halogen,R.sup.3 and R.sup.4 are each hydrogen or lower alkyl,R.sup.5 is ar(lower)alkyl which may have suitable substituent(s), andA is carbonyl, sulfonyl or lower alkylene, or a pharmaceutically acceptable salt thereof, which are useful as a testosterone 5.alpha.-reductase inhibitor.

Abstract: A method of forming a semiconductor gate array structure on a semiconductor substrate comprises the steps of forming a plurality of moat regions 12 and 14 where each of the moat regions 12 and 14 includes a channel region 22 and 28 and an insulating layer formed over the channel region 22 and 28. The moat regions separated by an insulating region 16. A plurality of gates 30 are formed wherein each of said gates 30 includes a first portion 30a over one of said channel regions 22, a second portion 30b over a channel region 28 adjacent to said one of said channel regions, and a third portion 30c over the insulating region 116 between said one of said channel regions. The gates 30 are formed such that each channel region is beneath one gate. The third portion 30a of a selected number of the gates is then etched to form the desired gate configuration.

Abstract: Compounds of the formula: ##STR1## are described wherein R.sup.1, R.sup.2, R.sup.3 and A are described in the claims. These compounds show significant dopamine receptor agonist activity.

Abstract: This invention relates to pyrrolidine derivatives and pharmaceutically acceptable salts thereof of the structure ##STR1## where R.sup.1, R.sup.2, and R.sup.3 are as defined herein. These compounds are for pharmaceutical use in treating thrombotic diseases, asthma or nephritis.

Abstract: This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity and represented by the general formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, aryl, ar(lower)alkoxy or a heterocyclic group, each of which may be substituted with halogen,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is cyclo(lower)alkyl, aryl or ar(lower)-alkyl, each of which may be substituted with halogen,A is ##STR2## or lower alkylene, and Y is ##STR3## and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.