Abstract: Compositions and methods for treating myotonic dystrophy type 1 (DM1) with SluCas9 and SaCas9 are encompassed.

Abstract: Rotary positive displacement machines can include a rotor having a teardrop-shaped profile that undergoes planetary motion relative to a stator having an elliptical or near-elliptical profile. In some embodiments, these rotary positive displacement machines can be used for a variety of applications including as positive displacement pumps. In some embodiments the rotor and stator are helical. In some embodiments the rotor comprises a dynamic seal. Aspects of the machine geometry can be selected to provide operational and/or durability benefits.

Abstract: A travel kit including a bag containing there within three items selected from the group consisting of: a face sheet mask, multi-pack flushable and biodegradable wet wipes, facial tissues, a pillowcase, facial cleaning towelettes, a hydration mist dispenser, an eye mask, lip and eye covers, foot covers, hand sanitizer, a face mask, one of an N95 or KN95 respirator, lip balm, and spray disinfectant.

Abstract: A method of database recovery includes starting a first database server, starting a second database server, starting a third database server, and starting an application server after starting the first database server, the second database server, and the third. The first, second, and third database servers are configured to store data according to first, second, and third database management systems, respectively, and the application server is configured to run application modules of a set of application modules. The method of database recovery further includes starting a search module, starting a product catalog management module, starting a web connectivity module after starting the search module, starting a graphical user interface module after starting the web connectivity module, and starting at least one business operations module.

Abstract: Example implementations relate to metadata operations in a storage system. An example storage system includes a machine-readable storage storing instructions executable by a processor to determine to generate a synthetic full backup based on data stream representations of a plurality of data streams. The instructions are also executable to, in response to a determination to generate the synthetic full backup, create a logical group including the data stream representations. The instructions are also executable to specify a cache resource allocation for the logical group, and generate the synthetic full backup from data stream representations using an amount of a cache resource limited by the cache resource allocation for the logical group.

Abstract: A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area ci with an outer radius r1. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain value for r1.

Abstract: In some embodiments, a spinal stabilization system may be formed in a patient using quick-connect sleeve assemblies. Each quick-connect sleeve assembly can be coupled to a bone fastener assembly in a fast and intuitive way. In one embodiment, a quick-connect sleeve assembly has a detachable member and a movable member. Both members engage a collar of the bone fastener assembly. In one embodiment, the engagement can be locked via one or more locking features to facilitate screwing a bone fastener of the bone fastener assembly onto a vertebral body in a minimally invasive surgical procedure. Each quick-connect sleeve assembly has a low profile and is particularly shaped for minimally invasive entry.

Abstract: Example implementations relate to provisioning a deduplication data store. An example includes receiving inputs indicating an expected data amount and at least one retention period for the deduplication data store; performing a comparison of the at least one retention period to a stored data structure; determining at least one storage multiplier based on the comparison of the at least one retention period to the stored data structure; and determining an amount of storage to provision for the deduplication data store based on the expected data amount and the at least one storage multiplier.

Abstract: Unlaminated bearings (or Torque Transfer Elements, or TTEs) are disposed to slide and displace within pockets (or “housing cavity receptacles”) provided in the internal periphery of a housing in which an articulating shaft is received. As the shaft “tilts” about its untilted axial centerline during misaligned rotation, convex curved bearing surfaces on shaft pins slidably rotate against corresponding concave curved bearings surfaces on the T as received in the housing cavity receptacles. Further, substantially flat surfaces on the TTEs are disposed to slidably displace against corresponding bearing surfaces on the housing cavity receptacles as the shaft tilts and the convex curved bearing surfaces on the shaft pins slidably rotate against the concave curved bearing surfaces on the TTEs. The sliding displacement of TTEs with respect to the housing cavity receptacles during articulated rotation is in a direction generally parallel to the shaft's untilted axial centerline.

Abstract: Rotary positive displacement machines based on trochoidal geometry that includes a helical rotor that undergoes planetary motion relative to a helical stator are described. The rotor can have a hypotrochoidal-based cross-sectional shape, with the corresponding stator cavity cross-sectional shape being the outer envelope of the rotor cross-sectional shape as it undergoes planetary motion, or the stator cavity can have an epitrochoidal-based cross-sectional shape with the corresponding rotor cross-sectional shape being the inner envelope of the stator cross-sectional shape as it undergoes planetary motion. Such machines can be configured so that the stator axis is spaced from the rotor axis, the rotor is configured to spin about its axis and the stator is configured to spin about its axis, and/or the rotor and the stator are held at a fixed eccentricity so that the rotor undergoes planetary motion relative to the stator, but does not orbit.

Abstract: The invention is a flywheel rotor that includes a number of adjacent laminations, stacked one on top of another, where each of the laminations has the same shape and is rotationally symmetric around a center axis, and where the shape is substantially circular and includes a plurality of protrusions exterior to the circumference, and each of the laminations includes at least one hole for a fastening bolt to pass through. The invention typically includes an endplate at each end of stack of laminations. One of the two endplates may attach to a stubshaft.

Abstract: Tapered stator designs are engineered in a positive displacement motor (PDM) power section to relieve stator stress concentrations at the lower (downhole) end of the power section in the presence of rotor tilt. A contoured stress relief (i.e. a taper) is provided in the stator to compensate for rotor tilt, where the taper is preferably more aggressive at the lower end of the stator near the bit.

Abstract: A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area c1 with an outer radius r1. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain value for r1.

Abstract: A method for producing a container includes identifying a location at a body, with the body at this location having a stress parameter which has a value less than or equal to a threshold value. The identifying includes deriving the threshold value from a simulation result of a simulation based on a finite element method of the stress parameter for a surface area and/or a volume area of the body with or without a marking element present, the identifying also includes obtaining a mean value by the simulation for the stress parameter for at least a part of at least one of the surface area or the volume area of the body. The threshold value is a sum of the mean value and 1000 % or less of an absolute value of the mean value. A marking element is provided which allows identification of the container at the identified location.

Abstract: Examples implementations relate to journals for metadata changes. An example includes detecting, by a storage controller, metadata changes associated with a container index of a deduplication storage system; recording, by the storage controller, the detected metadata changes in a journal associated with the container index, where the journal is included in a journal group comprising a plurality of journals; determining, by the storage controller, whether a filled amount of the journal exceeds a fill threshold; and, in response to a determination that the filled amount of the journal does not exceed the fill threshold, writing the journal group from memory to persistent storage.

Abstract: Example implementations relate to storing manifest portions in a metadata cache. An example includes receiving, by a storage controller, a read request associated with a first data unit. In response to receiving the read request, the storage controller stores a manifest portion in a metadata cache, the stored manifest portion comprising a plurality of records, the plurality of records including a first record associated with the first data unit. The storage controller determines storage information of the first data unit using pointer information included in the first record of the stored manifest portion, and replaces the pointer information in the first record with the determined storage information of the first data unit.

Abstract: Rotary positive displacement machines based on trochoidal geometry and including a helical rotor that undergoes planetary motion relative to a helical stator can be designed and configured so that the axial load or rotor pressure force is positive, negative, or neutral. In some embodiments, a change in axial load, caused by a change in differential pressure across the machine, can be used to trigger a change in a mechanical configuration of the machine.

Abstract: A glass syringe barrel is provided that has an at least partially conically shaped upper portion and a longitudinal axis. The glass syringe barrel has a top end through which a liquid can be ejected and a bottom end into which a plunger stopper can be pushed. The glass syringe barrel includes, in a direction from the top end to the bottom end, a cone, a shoulder region, and a body region. The shoulder region has and outer contour that has a concave and substantially circular arc-shaped area c1 with an outer radius r1. The outer contour of the glass syringe barrel in the shoulder region is defined by a certain minimum value the radius of curvature.

Abstract: A system and method for the dynamic discovery of prices through the use of an auction is provided. In one embodiment, the system allows a seller to auction homogenous assets or liabilities to a plurality of bidders. The assets or liabilities may be organized in baskets by maturity, by geographic location, by type, by a property, etc. The system may determine the eligibility for acceptance of bids submitted by the bidders and a plurality of bids may be determined to be eligible for acceptance using the same or different criteria. Further, a margin by which the bids are acceptable may be determined and a representation of the margin may be communicated to the seller or a bidder. The seller may configure an auction event with auction parameters, such as bid floors and hurdle rates and may alter event parameters while the auction is ongoing.