Abstract: The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: The invention is directed to a triazolopyridazine compound of formula (I): N-oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: A method of custom labeling products in which users specify, via a purchasing interface, product label images in correspondence with products. A label group is generated for each of the users. The label group includes an indicator label image providing a purchase identifier and product identifiers, and the product label images arranged in a sequence specified by the product identifiers. The label groups are printed to produce printed label groups. The printed label groups are transferred to a labeling machine. A conveyor system is controlled to release, for each of the printed label groups, the sequence of the products specified by the product identifiers. Printed product labels of each of the printed label groups are applied to the corresponding sequence of the products.

Abstract: An microelectromechanical switch uses electrostatic attraction to draw a beam toward a contact and electromagnetic repulsion to disengage and repel the beam from the contact. The electrostatic attraction is generated by a gate electrode. The electromagnetic repulsion is generated between the beam and a magnetic coil positioned on the same side of the beam as the contact. The magnetic coil produces a magnetic field, which induces a current in the beam that repels the magnetic coil. The gate electrode and the magnetic coil may be co-planar or in different planes. A circuit may also operate a coil-shaped structure act as the gate electrode and the magnetic coil, depending on the configuration.

Abstract: Methods of treating a head and neck cancer are disclosed.

Abstract: The present invention relates generally to methods of making surfactant compositions and detergent compositions.

Abstract: The present invention relates generally to surfactant and detergent compositions and, more specifically, to surfactant and detergent compositions containing an ethoxylated glycerine.

Abstract: The invention is directed to a triazolopyridazine compound of formula (I), N-oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: The present invention relates to a system and method for facilitating property management and in particular to a system and method for facilitating maintenance of property. A computer implemented system is provided comprising a server system arranged to communicate with remote inspector systems. The inspector systems facilitate inspection of properties. A report generator is provided to generate a report on maintenance from a repairer required for maintenance and repair of the property. Repairer modules facilitate tradesmen interacting with the system and carrying out maintenance tasks.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: Novel RET fusion molecules and uses are disclosed.

Abstract: A method includes receiving, by virtual machine manager and from a virtual machine, a request for a set of namespace identifiers corresponding to a set of namespaces associated with one or more storage devices. The method also includes determining, by the virtual machine manager, one or more namespaces associated with the virtual machine from the set of namespaces associated with the one or more storage devices. The method further includes, in response to determining the one or more namespaces associated with the virtual machine, sending, by the virtual machine manager and to the virtual machine, a subset of the set of namespace identifiers, the subset of namespace identifiers corresponding to the one or more namespaces associated with the virtual machine.

Abstract: A system generates screenshots of a graphical user interface (GUI) of an application that is displayed by target devices testing the application. Each screenshot includes an image of the GUI and metadata indicative of elements of the GUI present in the image or a state of the application or target device when the image is generated. The system determines, based on the metadata of a screenshot from a first set of the screenshots and the metadata of a screenshot from a second set of the screenshots, whether the screenshots are similar and if so, the system assigns the screenshot from the second set of screenshots to a cluster that includes the screenshot from the first set of screenshots. The system outputs an indication of the cluster (e.g., a notification or graphical indication) indicative of the similarity or discrepancy between the screenshots.

Abstract: Various examples are directed to systems and methods for formatting stitched panoramic frames for transmission to a remote image processing system, the method comprising. A control circuit of a panoramic camera may receive first and second frames captured by first and second image sensors having partially overlapping fields-of-view. The control circuit may identify a first overlap region of the first frame and a second overlap region of the second frame. The first and second overlap region may comprise pixel values from portions of the fields-of-view of the image sensors that overlap. The control circuit may generate a panoramic frame from based at least in part on the first and second frames. The control circuit may generate a transmission frame comprising the panoramic frame, the first overlap region and the second overlap region.

Abstract: The present invention relates generally to surfactant and detergent compositions and, more specifically, to surfactant and detergent compositions containing an ethoxylated glycerine.

Abstract: The present invention relates generally to methods of making surfactant compositions and detergent compositions.

Abstract: A coal combustion process is described using cleaned coal and processed biomass to reduce adverse by-products in a coal combusting apparatus including the reduction of carbon dioxide by at least 50 volume %. The coal feedstock comprises an aggregate blend of cleaned coal and processed biomass. The biomass feedstock comprises processed biomass pellets. The total energy density is predetermined and can be similar to the coal component or higher than the coal component. The intracellular salt in the processed biomass is at least 60 wt % less for the processed organic-carbon-containing feedstock used to make the processed biomass pellets than that of the starting un-processed processed organic-carbon-containing feedstock. The cleaned coal has a sulfur content that is 50 wt % less than that of un-cleaned coal before it passed through the coal-cleaning sub-system.

Abstract: A process for making a renewable processed biochar pellet composition made with a pelletizing sub-system followed with a heating sub-system from a processed organic-carbon-containing feedstock made with a beneficiation sub-system is described. Renewable biomass feedstock passed through a beneficiation sub-system to reduce water content to below at least 20 wt % and an intracellular water-soluble salt reduction of at least 60% from that of unprocessed organic-carbon-containing feedstock on a dry basis. The processed feedstock is introduced into a pelletizing sub-system and then into a heating sub-system to result in renewable processed biochar pellets having an energy density of at least 21 MMBTU/ton (24 GJ/MT), a water content of less than 10 wt %, and an intracellular water-soluble salt content that is decreased by at least 60 wt % on a dry basis for the processed organic-carbon-containing feedstock from that of the unprocessed organic-carbon-containing feedstock.