Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: The invention provides antibodies to tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: In some embodiments, a humidification system includes a heater base having a heater plate, a humidification chamber, and circuit. The circuit can include various conduits, including an inspiratory conduit, expiratory conduit, Y-piece, patient conduit, and/or dry conduit. In use, the chamber contains a quantity of liquid. The heater base heats the heater plate, which in turn heats the liquid to a temperature that causes at least some of the liquid to become vapor, thereby humidifying the gases within the chamber. The gas is delivered to the patient via the inspiratory conduit. Various features can help control the system and ensure the patient receives gases having the desired conditions. These features can be used individually or in various combinations and subcombinations both in existing humidification systems and improved systems for respiratory humidification, laparoscopy, and other purposes.

Abstract: In some implementations, windows can be displayed based on a global z-order. The global z-order can be maintained for all open windows. The global z-order can include windows that are not currently displayed. The global z-order can define a display order of windows across multiple workspaces. In some implementations, workspaces can be associated with respective levels. The workspace levels can be used to determine how to display windows associated with each workspace when multiple workspaces are displayed simultaneously.

Abstract: A system generates screenshots of a graphical user interface (GUI) of an application that is displayed by target devices testing the application. Each screenshot includes an image of the GUI and metadata indicative of elements of the GUI present in the image or a state of the application or target device when the image is generated. The system determines, based on the metadata of a screenshot from a first set of the screenshots and the metadata of a screenshot from a second set of the screenshots, whether the screenshots are similar and if so, the system assigns the screenshot from the second set of screenshots to a cluster that includes the screenshot from the first set of screenshots. The system outputs an indication of the cluster (e.g., a notification or graphical indication) indicative of the similarity or discrepancy between the screenshots.

Abstract: A digital hydrometer and methods of digitally displaying a specific gravity measured by a hydrometer are provided. The digital hydrometer can comprise a base, a displacement vessel, an inductive distance sensor, an output circuit, and a hydrometer float. The displacement vessel and inductive distance sensor can be mounted in or on the base. The displacement vessel can hold a displacement fluid. The hydrometer float can float in the displacement fluid. The output circuit can be in electrical communication with the inductive distance sensor and comprise a digital display device configured to display a digital value that is commensurate with a change in impedance attributable to the proximity of a metallic object, in the hydrometer float, to the sensor or its inductor. The digital value can be a specific gravity of the displacement fluid.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A comfortable low-leak mask assembly for use with Non-Invasive Positive Pressure Ventilation (NIPPV) is provided to improve patient compliance and/or treatment. The mask system may include headgear having straps that are substantially inextensible and/or micro-adjustable; and/or a mask and/or cushion that includes various structures to allow enhanced/tailored sealing and/or fit at selected locations on the patient's face.

Abstract: In some examples, a storage device includes a first non-volatile memory array configured to store data from a host device and the storage device and a second non-volatile memory array configured to store data from the storage device, wherein the second non-volatile memory array is separate from the first non-volatile memory array. The storage device also includes a controller configured to store a virtual-to-physical mapping table to the first non-volatile memory array and store a portion of the virtual-to-physical mapping table to the second non-volatile memory array.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: Methods are provided of identifying a male fertility condition in a subject. Methods of performing a fertility treatment and an in vitro fertilization procedure are also provided. The methods may comprise determining the DNA methylation pattern of DNA extracted from a semen sample of a subject.

Abstract: A watercraft having a propulsion mechanism extending through an opening in the bottom of the watercraft having a propulsion mechanism adapted to be inserted in an opening in the bottom of a watercraft comprising a pair of pedals each coupled to a flexible fin extending below the water line, the pair of fins oscillate through an arcuate path on a horizontal axis to propel the watercraft. The horizontal axis is preferably continuously rotatable in either direction through 360° on a vertical axis disposed at a substantially right angle to the longitudinal axis of the watercraft to propel the watercraft in any direction.

Abstract: A method includes obtaining power and performance data for each storage device of a plurality of storage devices, and adjusting, based on the power and performance data for the plurality of storage devices, a power consumption level of a particular storage device of the plurality of storage devices.

Abstract: Dust accumulation monitors are provided to autonomously monitor dust accumulations. The dust accumulation monitors include a casing having a translucent portion, a light sensor configured to output a sensing signal based on sensed light penetrating through the translucent portion, a controller coupled to the light sensor to receive the sensing signal and configured to output a dust alert signal based on the received sensing signal, and a communication interface coupled to the controller and configured to output an alert based on the dust alert signal output by the controller. A dust accumulation monitoring system includes a plurality of dust accumulation monitors, and a central monitor communicatively connected to each of the plurality of dust accumulation monitors and configured to receive dust sensing signals from each of the plurality of dust accumulation monitors. The dust accumulation monitors may communicate through wired or wireless links with the central monitor.

Abstract: A watercraft having a propulsion mechanism extending through an opening in the bottom of the watercraft having a propulsion mechanism adapted to be inserted in an opening in the bottom of a watercraft comprising a pair of pedals each coupled to a flexible fin extending below the water line, the pair of fins oscillate through an arcuate path on a horizontal axis to propel the watercraft. The horizontal axis is preferably continuously rotatable in either direction through 360° on a vertical axis disposed at a substantially right angle to the longitudinal axis of the watercraft to propel the watercraft in any direction.

Abstract: A sealing system for a rotary machine is provided. The sealing system includes a pair of circumferentially adjacent rotary components. Each of the rotary components includes a platform, a shank, and a radial seal. The shank extends radially inwardly from the platform and includes a radially extending first side channel and an opposite radially extending second side channel. The radial seal includes a first leg received in the first side channel of a first of the pair of rotary components, a second leg received in the second side channel of a second of the pair of rotary components (201), and a resiliently deformable body extending therebetween, the body including a U-shaped portion located generally centrally between the first leg and the second leg.

Abstract: The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

Abstract: The invention is directed to a triazolopyridazine compound of formula (I): N-oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.