Abstract: A watercraft having a propulsion mechanism extending through an opening in the bottom of the watercraft having a propulsion mechanism adapted to be inserted in an opening in the bottom of a watercraft comprising a pair of pedals each coupled to a flexible fin extending below the water line, the pair of fins oscillate through an arcuate path on a horizontal axis to propel the watercraft. The horizontal axis is preferably continuously rotatable in either direction through 360° on a vertical axis disposed at a substantially right angle to the longitudinal axis of the watercraft to propel the watercraft in any direction.

Abstract: A method includes obtaining power and performance data for each storage device of a plurality of storage devices, and adjusting, based on the power and performance data for the plurality of storage devices, a power consumption level of a particular storage device of the plurality of storage devices.

Abstract: Disclosed is an apparatus (1) and method for treating contaminated waste water (2). The apparatus comprises a heater (30), a feed apparatus (11, 12, 13, 14), for supplying contaminated waste water (2) to the heater (30) and a centrifuge (50, 60) downstream of the heater (30). A heat exchanger (20) is also provided which has a first channel (22) and a second channel (24). The first channel (22) is connected in a flow path extending between the feed apparatus (11, 12, 13, 14) and the centrifuge (50, 60); and a waste water outlet (9) from the main centrifuge (60) is fluidly coupled to an inlet of the second channel (24) of the heat exchanger (20).

Abstract: Dust accumulation monitors are provided to autonomously monitor dust accumulations. The dust accumulation monitors include a casing having a translucent portion, a light sensor configured to output a sensing signal based on sensed light penetrating through the translucent portion, a controller coupled to the light sensor to receive the sensing signal and configured to output a dust alert signal based on the received sensing signal, and a communication interface coupled to the controller and configured to output an alert based on the dust alert signal output by the controller. A dust accumulation monitoring system includes a plurality of dust accumulation monitors, and a central monitor communicatively connected to each of the plurality of dust accumulation monitors and configured to receive dust sensing signals from each of the plurality of dust accumulation monitors. The dust accumulation monitors may communicate through wired or wireless links with the central monitor.

Abstract: A watercraft having a propulsion mechanism extending through an opening in the bottom of the watercraft having a propulsion mechanism adapted to be inserted in an opening in the bottom of a watercraft comprising a pair of pedals each coupled to a flexible fin extending below the water line, the pair of fins oscillate through an arcuate path on a horizontal axis to propel the watercraft. The horizontal axis is preferably continuously rotatable in either direction through 360° on a vertical axis disposed at a substantially right angle to the longitudinal axis of the watercraft to propel the watercraft in any direction.

Abstract: A sealing system for a rotary machine is provided. The sealing system includes a pair of circumferentially adjacent rotary components. Each of the rotary components includes a platform, a shank, and a radial seal. The shank extends radially inwardly from the platform and includes a radially extending first side channel and an opposite radially extending second side channel. The radial seal includes a first leg received in the first side channel of a first of the pair of rotary components, a second leg received in the second side channel of a second of the pair of rotary components (201), and a resiliently deformable body extending therebetween, the body including a U-shaped portion located generally centrally between the first leg and the second leg.

Abstract: The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motoneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

Abstract: The invention is directed to a triazolopyridazine compound of formula (I): N-oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: A method of custom labeling products in which users specify, via a purchasing interface, product label images in correspondence with products. A label group is generated for each of the users. The label group includes an indicator label image providing a purchase identifier and product identifiers, and the product label images arranged in a sequence specified by the product identifiers. The label groups are printed to produce printed label groups. The printed label groups are transferred to a labeling machine. A conveyor system is controlled to release, for each of the printed label groups, the sequence of the products specified by the product identifiers. Printed product labels of each of the printed label groups are applied to the corresponding sequence of the products.

Abstract: An microelectromechanical switch uses electrostatic attraction to draw a beam toward a contact and electromagnetic repulsion to disengage and repel the beam from the contact. The electrostatic attraction is generated by a gate electrode. The electromagnetic repulsion is generated between the beam and a magnetic coil positioned on the same side of the beam as the contact. The magnetic coil produces a magnetic field, which induces a current in the beam that repels the magnetic coil. The gate electrode and the magnetic coil may be co-planar or in different planes. A circuit may also operate a coil-shaped structure act as the gate electrode and the magnetic coil, depending on the configuration.

Abstract: The present invention relates generally to methods of making surfactant compositions and detergent compositions.

Abstract: The present invention relates generally to surfactant and detergent compositions and, more specifically, to surfactant and detergent compositions containing an ethoxylated glycerine.

Abstract: Methods of treating a head and neck cancer are disclosed.

Abstract: The invention is directed to a triazolopyridazine compound of formula (I), N-oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: The present invention relates to a system and method for facilitating property management and in particular to a system and method for facilitating maintenance of property. A computer implemented system is provided comprising a server system arranged to communicate with remote inspector systems. The inspector systems facilitate inspection of properties. A report generator is provided to generate a report on maintenance from a repairer required for maintenance and repair of the property. Repairer modules facilitate tradesmen interacting with the system and carrying out maintenance tasks.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: Novel RET fusion molecules and uses are disclosed.

Abstract: A method includes receiving, by virtual machine manager and from a virtual machine, a request for a set of namespace identifiers corresponding to a set of namespaces associated with one or more storage devices. The method also includes determining, by the virtual machine manager, one or more namespaces associated with the virtual machine from the set of namespaces associated with the one or more storage devices. The method further includes, in response to determining the one or more namespaces associated with the virtual machine, sending, by the virtual machine manager and to the virtual machine, a subset of the set of namespace identifiers, the subset of namespace identifiers corresponding to the one or more namespaces associated with the virtual machine.