Abstract: A method of manufacturing a wall panel for a caravan, the wall panel having a first face and a second face, comprises printing a first design onto the first face of the wall panel for example using a first direct-to-substrate printer. A second design may be printed onto the second face of the wall panel, for example using a second direct-to-substrate printer (which may be the same printer as, or a different printer to, the first printer). Alternatively, the first design may be printed onto a first skin for the wall panel. The second design may be printed onto a second skin for the wall panel. The first and second skins, with the designs printed thereon, may then be assembled into a wall panel.

Abstract: Methods and a processing device are provided for restoring pixels damaged by artifacts caused by dust, or other particles, entering a digital image capturing device. A user interface may be provided for a user to indicate an approximate location of an artifact appearing in a digital image. Dust attenuation may be estimated and an inverse transformation, based on the estimated dust attenuation, may be applied to damaged pixels in order to recover an estimate of the underlying digital image. One or many candidate source patch may be selected based on having smallest pixel distances, with respect to a target patch area. The damaged pixels included in the target patch area may be considered when calculating the pixel distance with respect to candidate source patches. RGB values of corresponding pixels of source patches may be used to restore the damaged pixels included in the target patch area.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.

Abstract: A winder for winding a web to produce a rolled product is provided. The winder includes a web transport apparatus that is used for conveying the web. Also included in one exemplary embodiment is a plurality of independent winding modules. The winding modules are independently positioned to independently engage the web as the web is conveyed by the web transport apparatus. The winding modules may be configured to wind the web to form a rolled product by center winding, surface winding, and combinations of center and surface winding. The winding modules are structurally and operationally independent of one another where if one module is disabled, another may still operate to produce the rolled product without shutting down the winder.

Abstract: Described herein are systems and methods of enhancing channel bandwidth in an optical system having a number of wavelength selective switching (WSS) devices. The method includes the steps of passing the optical signals through the WSS devices by: (i) spatially dispersing the wavelength channels of the optical signals; (ii) projecting the spatially dispersed channels onto corresponding predetermined regions of an optical manipulation matrix including a plurality of individually addressable manipulating elements; (iii) determining a modification function that specifies a state for each manipulating element within the predetermined region; and (iv) driving the elements of the corresponding regions at states specified by the function to selectively modify the channel band shape such that the received channel's bandwidth is substantially enhanced, and to spatially direct the wavelength channels to predetermined output ports of the WSS devices.

Abstract: Systems and Methods for Negotiated Accelerated Block Option for Trivial File Transfer Protocol are provided. In one embodiment, a method for implementing a negotiated accelerated Trivial File Transfer Protocol (TFTP) file transfers, the method comprising: transmitting a TFTP request packet for accelerated transfer from a requesting device to a serving device; receiving a response from the serving device; determining whether to initiate an accelerated transfer by evaluating the response packet from the serving device; and when evaluating the response packet indicates that the serving device accepts acceleration, initiating an accelerated TFTP file transfer using a negotiated block acceleration value, wherein the negotiated block acceleration value is negotiated by the client device and the Accelerated TFTP Server Engine based on one or both of hardware constraint factors and transmission statistics.

Abstract: A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7 including R3?, p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.

Abstract: An apparatus and method for providing navigation and other information via a motor driven dial in response to the operator's voice commands.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (I) wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

Abstract: There are provided inter alia compounds of formula (I) useful as cyclophilin inhibitors.

Abstract: Thermally insulating layer incorporating a distinguishing agent and method for inspecting the insulating layer are provided. The distinguishing agent may be used for determining a remaining thickness of the thermally insulating layer.

Abstract: A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1, R2, R3, R4, R5, m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.

Abstract: An interior light assembly for use in a vehicle includes a housing having a light transmission end constructed to pass light out of the housing. A light source is located in the housing and arranged to emit light in a direction to pass out of the light transmission end of the housing. A visor extends from the light transmission end of the housing for blocking light from the light source in directions transverse to the light transmission end of the housing into a passenger compartment of the vehicle. The visor has an end remote from the housing shaped to engage a windshield of the vehicle. The visor may be pivotably mounted on the housing to facilitate flush engagement of the remote visor end with the windshield. The visor can flare outwardly from the housing to the remote end so light can be seen at greater off-angles by persons outside the vehicle.

Abstract: Described herein is a laser (1) having a cavity for supporting oscillation of an electromagnetic signal to provide lasing action. A gain element (5) provides a source of stimulated emission for amplifying the oscillating signal. The laser also includes a wavelength selective element (7), which includes a reflecting element and a polarization modifying element. The reflecting element selectively defines a predetermined wavelength and the polarization modifying element selectively modifies the polarization of the signal component at the predetermined wavelength so as to provide high selectivity. The wavelength selective element (7) rotates the signal polarization at the predetermined wavelength into an orthogonal state. A polarization filter (9) filters out the signal components having wavelengths not corresponding to the predetermined wavelength and a polarization rotation element (11) again rotates the polarization of the signal into an orthogonal state.

Abstract: Described herein is an optical channel monitor (100), including a plurality of input ports in the form of optical fibers (102) disposed in a vertical “port displacement” dimension. Each fiber (102) inputs a respective optical beam (103) having a plurality of individual wavelength channels. A lens (104) collimates each beam and converges the beams in the port displacement dimension to a focal plane (105). The collimated and converged beams are incident onto a rotatable micro-electromechanical system (MEMS) mirror (106), which selectively directs each optical beam onto a wavelength dispersion element in the form of a grism (108) at a predetermined angle (denoted by ?) in a horizontal “dispersion” plane. The grism (108) spatially separates, in the dispersion plane, the wavelength channels contained within each optical beam (103) by diffraction. The angle at which each channel is diffracted is controlled by the angle ?.

Abstract: A system and method for inventory management is provided. An indication of a removal of a first resource at a first location is received, and a risk value associated with the first resource at the location is calculated. A determination is made if the risk value is less than a predetermined threshold, and a request to transfer a second resource from a second location to the first location is generated.

Abstract: A worksurface assembly includes a worksurface member having an upper surface, a bottom surface, a forward edge, a rearward edge, and an aperture that opens both upwardly and forwardly from the worksurface member, and a storage member including a pair of sidewalls, a rear wall and a bottom wall that cooperate to form an interior storage area having a height to width ratio of greater than or equal to about 1:1 at at least one position along a length of the storage member, wherein the storage member has a forwardly facing opening and an upwardly facing opening, and wherein the storage member is readily detachably secured to the worksurface member such that the interior storage of the storage member is accessible through the aperture of the worksurface member and such that access to the interior space is uninterrupted between the forwardly facing opening and the upwardly facing opening of the storage member.

Abstract: Automatic organ localization is described. In an example, an organ in a medical image is localized using one or more trained regression trees. Each image element of the medical image is applied to the trained regression trees to compute probability distributions that relate to a distance from each image element to the organ. At least a subset of the probability distributions are selected and aggregated to calculate a localization estimate for the organ. In another example, the regression trees are trained using training images having a predefined organ location. At each node of the tree, test parameters are generated that determine which subsequent node each training image element is passed to. This is repeated until each image element reaches a leaf node of the tree. A probability distribution is generated and stored at each leaf node, based on the distance from the leaf node's image elements to the organ.