Abstract: An applicator tool for applying a liquid onto a surface of a floor includes an applicator and a handle connected to the applicator. The applicator includes a housing having a bottom surface and a plurality of sidewalls. The bottom surface is connected to the sidewalls to define a reservoir. The bottom surface has at least one opening in fluid for substantially continuously dispensing the liquid.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.

Abstract: A method is provided including determining a first power level required from a diesel powered system. The first power level corresponds to a first proportion of a maximum power. The method also includes determining an emission output for a mission based on the first power level. The method further includes determining a second power level corresponding to a second proportion of the maximum power, wherein alternate use of the second power level and at least one of the first power level or a third power level results in a lower emission output for the mission, with the overall resulting power being proximate the minimum power required. The method also includes automatically controlling operation of the diesel powered system by using the second power level alternately with at least one of the first power level or the third power level.

Abstract: Systems and methods for multiple computer dataloading using a standard dataloader are provided. In one embodiment, a method for simultaneously uploading duplicate data to a plurality of computers comprises: performing a handshake message exchange with a dataloader to determine a MAC address for a target node; conducting a data transfer between the dataloader and the target node by forwarding a file transfer protocol message having the MAC address for the target node from the dataloader to the target node; forwarding the file transfer protocol message to at least one node other than the target node, wherein the at least one node and the target node both consume the file transfer protocol message; and selectively suppressing one or more response messages generated by the at least one node from reaching the dataloader.

Abstract: A pulse of laser light is switched out of a pulse train and spatially dispersed into its constituent wavelengths. The pulse is collimated to a suitable size and then diffracted by high groove density multilayer dielectric gratings. This imparts a different angle to each individual wavelength so that, when brought to the far field with a lens, the colors have spread out in a linear arrangement. The distance between wavelengths (resolution) can be tailored for the specific laser and application by altering the number of times the beam strikes the diffraction gratings, the groove density of the gratings and the focal length of the lens. End portions of the linear arrangement are each directed to a respective detector, which converts the signal to a 1 if the level meets a set-point, and a 0 if the level does not. If both detectors produces a 1, then the pulse train is allowed to propagate into an optical system.

Abstract: There is provided inter alia a compound of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.

Abstract: The invention relates to a method for the continuous production of a powdered product from a product in the liquid state in the form of a solution-, suspension- or emulsion-type mixture in an aqueous medium. According to the invention, during the first step (E1) of the method, the product in the liquid state is transformed into a product in the viscous state. The invention is characterised in that it includes at least one overrun step (E2, E4) and at least one product-drying step (E3, E6) comprising at least a first step (E3) involving thermomechanical treatment with at last one thermomechanical treatment machine into which the viscous state product and a determined amount of powered product from the same family as the liquid state product are injected simultaneously. The treatment machine is configured to mix the viscous state product and the powdered product such as to produce solidified particles of the product upon contact with the ambient air.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (1): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

Abstract: A winder for winding a web to produce a rolled product is provided. The winder includes a web transport apparatus that is used for conveying the web. Also included in one exemplary embodiment is a plurality of independent winding modules. The winding modules are independently positioned to independently engage the web as the web is conveyed by the web transport apparatus. The winding modules may be configured to wind the web to form a rolled product by center winding, surface winding, and combinations of center and surface winding. The winding modules are structurally and operationally independent of one another where if one module is disabled, another may still operate to produce the rolled product without shutting down the winder.

Abstract: Systems and methods for access security for dataloading are provided. In one implementation, a system comprises a first computer that transmits a packet, the first computer comprising: an authentication code memory that stores an authentication code for the packet; a first processing unit that executes communication instructions in a first memory, the communication instructions attaching the authentication code to the packet; and a first communication port that transmits the packet.

Abstract: A muffler mechanism that reduces the volume of an acoustic piano without altering the feel of the piano to a human pianist. One embodiment includes a highly configurable piano muffler kit that may be mounted into pianos of various models. The muffler mechanism includes a cushioning member, which muffles the sound of the hammer striking the string and reduces the volume of the sound made by the string's vibration. The muffler mechanism also includes shims that may be used to position the cushioning member between a hammer let-off position and the string. This may allow for muffled piano playing without a noticeable change in the resistance of the keys. The muffler mechanism is mounted using brackets with a relatively small footprint. This allows the piano muffler to be installed without removing all of the dampers.

Abstract: A fuel vapor recovery system and method for an automotive vehicle are disclosed. The vehicle fuel tank is vented to atmosphere via a passageway having a carbon canister to remove fuel vapors, a bladder, and a normally-closed isolation valve. When fueling the vehicle, the gases in the fuel tank displaced by entering fuel are introduced into the carbon canister where the fuel vapors are stored. The isolation valve is commanded to open to allow such flow through the carbon canister. When the vehicle is parked for a period of a day, it undergoes a diurnal temperature change which causes fuel to vaporize into the fuel system. According to an aspect of the present development, the isolation valve remains closed and the gases are contained within the bladder as it expands or contracts as the volume of gases increases or decreases in response to temperature changes.

Abstract: A method and system for generating and processing barcoded documents such that a safety net may be implemented to catch barcode errors. Barcodes may be generated for placement on the first and last page of documents. Each barcode may be associated with a document. During processing of barcoded documents, if a barcode is missing or misread, the safety net will catch the error and mark the affected pages for further review.

Abstract: A controller system for detecting and matching link speeds. The present invention provides for a controller system. The controller system is a first controller and a first port. The first port is located in the first controller and has a first link speed. The first controller is adapted to match the first link speed to a second link speed of a second port of a first controlled device that is connectable to the first controller.

Abstract: Systems and methods authenticate a device to operate within an enterprise system with an enterprise policy. An agent, installed on the device, analyzes the device to determine profile information of the device. The determined profile information is sent to a type 2 super peer that verifies whether the profile information conforms to the enterprise policy. If the profile information conforms to the enterprise policy, an agent trust credential is generated, within the type 2 super peer, for the agent, based upon the profile information, and issued to the agent. Authenticity of the device is verified based upon the agent trust credential. If the device is authenticated, communications with the device are permitted. If the device is not authenticated, communications with the device is prevented. In another embodiment, a method restores a device to conform to a system policy. A snapshot of critical components of the device is taken while the device is in compliance with the system policy.