Abstract: A method for identifying prospective purchasers of battery electric vehicles (BEVs) may include defining a predetermined time frame associated with vehicle ownership, receiving a first dataset including a first subset of drivers are drivers who have owned or leased any first internal combustion engine (ICE) vehicle followed by any second ICE vehicle within the predetermined time frame, a second subset of drivers are drivers who have owned or leased any first ICE vehicle followed by any second BEV within the predetermined time frame, and a third subset of drivers are drivers who have not changed vehicles within the predetermined time frame, receiving a second dataset including a set of drivers who own or lease any first ICE vehicle which is in a same vehicle class as a target BEV, and identifying a target set of prospective purchasers of BEVs.

Abstract: A system and method for providing point of interest related notifications within a vehicle that include receiving sensor data associated with an operation of the vehicle or a use of a component of the vehicle. The system and method also include storing a first geo-location of the vehicle based on the sensor data and determining if a subsequent geo-location of the vehicle is within a predetermined vicinity of at least one point of interest. The system and method further include providing at least one point of interest related notification associated with the at least one point of interest if it is determined that the subsequent geo-location of the vehicle is within the predetermined vicinity of the at least one point of interest.

Abstract: The present invention relates to heteroaryl amide compounds, a preparation method therefor, pharmaceutical compositions thereof and applications thereof, and specifically, relates to a type of compounds having broad-spectrum tumor resistant activity, a preparation method therefor, pharmaceutical compositions containing the compounds, and uses of the compounds in the preparation of drugs for treating tumors.

Abstract: The present invention relates to a method of semi-solid indirect squeeze casting for Mg-based composite material, which aims at improving the mechanical property of the cast by adding magnesium zinc yttrium quasicrystal of high hardness, high elastic modulus and excellent matrix binding property acting as the reinforcement into the magnesium alloy matrix and manufacturing the cast through smelting using a vacuum atmosphere smelting furnace, agitating with ultrasonic wave assisted vibration in the rotating impeller jet agitation furnace and indirect squeeze casting against the problem of poor wettability, easy agglomeration, inhomogeneous distribution between the reinforcement particles and the matrix materials and poor properties of the manufactured cast. The manufacturing method of the present invention has advanced technologies and detailed and accurate data.

Abstract: Various methods and systems are provided for scanning an image subject along a scan axis. The method includes stitching sectional datasets acquired from different anatomical sections of the image subject based on locations of a landmark in the sectional datasets.

Abstract: The present disclosure generally relates to methods and systems for determining usage of a vehicle. A vehicle monitoring system may include a memory, at least one processor coupled to the memory, and a sensor system that generates vehicle trip data. The system may periodically determine a location of the vehicle during a trip while an ignition of the vehicle remains on. The system may determine that a duration of the trip is at least a threshold duration. The system may determine a direction of travel for segments between consecutive locations during the trip. The system may determine a ratio of a most common direction of travel for the trip to at least a second most common direction of travel for the trip. The system may determine that the vehicle has been used for commercial purposes in response to the ratio being less than a threshold ratio.

Abstract: The present disclosure generally relates to methods and systems for determining usage of a vehicle. A vehicle monitoring system may include, a memory, at least one processor coupled to the memory, and a sensory system that generates vehicle trip data during a monitoring window. The vehicle monitoring system may partition the trip data into a base group and a contrast group. The vehicle monitoring system may calculate a similarity score between the contrast group and the base group. The vehicle monitoring system may determine that the vehicle has been used for commercial purposes in response to the similarity score satisfying a threshold.

Abstract: The invention relates to a method for preparing high-melting-point metal powder through multi-stage deep reduction, and belongs to the technical field of preparation of powder. The method includes the following steps of mixing dried high-melting-point metal oxide powder with magnesium powder and performing a self-propagating reaction, placing an intermediate product into a closed reaction kettle, leaching the intermediate product with hydrochloric acid as a leaching solution so as to obtain a low-valence oxide MexO precursor of the low-valence high-melting-point metal; uniformly mixing the precursor with calcium powder, pressing the mixture, placing the pressed mixture into a vacuum reduction furnace, heating the vacuum reduction furnace to 700-1200° C., performing deep reduction for 1-6 h, leaching a deep reduction product with hydrochloric acid as a leaching solution and performing treatment, so as to obtain the high-melting-point metal powder.

Abstract: A serum/plasma LncRNA marker composition associated with auxiliary diagnosis of intrahepatic cholestasis of pregnancy and application thereof. The marker is selected from any one of ENST00000449605.1, ASO3480 and ENST00000505175.1. The serum/plasma LncRNA screening and auxiliary diagnosis kit is a LncRNAs diagnostic kit developed based on the specific serum/plasma LncRNA of ICP cases and healthy controls.

Abstract: Systems and methods are described herein for analyzing the performance of a communications network (e.g., a mobile telecommunications network) using customer-centric and/or subscriber-centric data and information. In some embodiments, the systems and method may determine key performance indicators for a communications network by accessing call detail records from multiple communications network sources, generating a database of one or more customer stats table (CSTs) based on the accessed call records, wherein the CSTs include records for each individual customers of the communications network, and determining one or more key performance indicators (KPIs) for the overall network based on the records stored by the one or more customer stats tables.

Abstract: An additive manufacturing apparatus utilizing combined electron beam selective melting and electron beam cutting. One electron beam emitting, focusing, and scanning device (6) is capable of emitting electron beams (67, 68) in three modes of heating, selective melting, and electron beam cutting. The electron beam in the heating mode is emitted to scan and preheat a powder bed (7). The electron beam (67) in the selective melting mode is emitted to scan and melt powder (71) in a section outline to form a section layer of a component. The electron beam (68) in the electron beam cutting mode is emitted to perform one or more cutting scans on inner and outer outlines (74, 75) of a section of the component to obtain accurate and smooth inner and outer outlines of the section. The heating, melting deposition, and outline cutting processes are repeated to obtain a required three-dimensional physical component.

Abstract: Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins.

Abstract: A breast pump comprising: a container comprising a deformable body and a lid, the container further comprising an inlet and a vent, wherein the vent is provided with a vent valve which is configured to allow air flow out of the container through the vent but not into the container through the vent; a nipple shield for receiving milk expressed from a user's breast; and a flexible conduit fluidly connecting the nipple shield and the inlet of the deformable container, wherein, in use, milk expressed from the breast flows from the nipple shield through the conduit to the container.

Abstract: The present invention relates to a method of semi-solid indirect squeeze casting for Mg-based composite material, which aims at improving the mechanical property of the cast by adding magnesium zinc yttrium quasicrystal of high hardness, high elastic modulus and excellent matrix binding property acting as the reinforcement into the magnesium alloy matrix and manufacturing the cast through smelting using a vacuum atmosphere smelting furnace, agitating with ultrasonic wave assisted vibration in the rotating impeller jet agitation furnace and indirect squeeze casting against the problem of poor wettability, easy agglomeration, inhomogeneous distribution between the reinforcement particles and the matrix materials and poor properties of the manufactured cast. The manufacturing method of the present invention has advanced technologies and detailed and accurate data.

Abstract: Provided herein are compositions and methods for the treatment and prevention of cancer, including melanoma.

Abstract: An intelligent sensing device and a sensing system are disclosed. The sensing device comprises a sensor unit provided with a plurality of sensors, and a wireless communication module, a memory module and a processing module connected with a data platform, wherein the processing module is connected with the sensor unit, the wireless communication module and the memory module; the processing module acquires the motion condition of a user by means of a preset detection algorithm according to a detection result of the acceleration sensor; and the sensing device has multiple different modes corresponding to different preset detection algorithms, and the user selects the preset detection algorithm by setting the mode of the sensing device. The sensing device is extremely low in power consumption, good in stability and sensitivity and high in storage capacity, can be interconnected with the data platform, and allows various sensors to be accessed thereto.

Abstract: Disclosed is a method of inhibiting growth of a melanoma cancer cell. The method includes contacting the melanoma cancer cell with an effective amount of a composition and the composition contains polymethoxyflavone. The polymethoxyflavone can be applied in an amount of 0.1 ?mol/L-1000 ?mol/L. A method of treating a subject having melanoma with the above discussed composition is also included.

Abstract: The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: A signal processing unit performs preprocessing, demosaic processing and color reproduction processing on an image signal. A control unit detects an image area having undergone a characteristic change exceeding a predetermined change amount, by using an image signal before the reproduction processing and an image signal after the color reproduction processing. The control unit associates area information indicating the detection result of the image area having undergone a characteristic change exceeding a predetermined change amount with the image signal after the color reproduction processing, and records the area information on a recording medium, or outputs the area information to an external device. Thus, it becomes possible to detect an image area where a control change caused by color reproduction processing is unnatural.