Abstract: Systems and methods are described herein for analyzing the performance of a communications network (e.g., a mobile telecommunications network) using customer-centric and/or subscriber-centric data and information. In some embodiments, the systems and method may determine key performance indicators for a communications network by accessing call detail records from multiple communications network sources, generating a database of one or more customer stats table (CSTs) based on the accessed call records, wherein the CSTs include records for each individual customers of the communications network, and determining one or more key performance indicators (KPIs) for the overall network based on the records stored by the one or more customer stats tables.

Abstract: An additive manufacturing apparatus utilizing combined electron beam selective melting and electron beam cutting. One electron beam emitting, focusing, and scanning device (6) is capable of emitting electron beams (67, 68) in three modes of heating, selective melting, and electron beam cutting. The electron beam in the heating mode is emitted to scan and preheat a powder bed (7). The electron beam (67) in the selective melting mode is emitted to scan and melt powder (71) in a section outline to form a section layer of a component. The electron beam (68) in the electron beam cutting mode is emitted to perform one or more cutting scans on inner and outer outlines (74, 75) of a section of the component to obtain accurate and smooth inner and outer outlines of the section. The heating, melting deposition, and outline cutting processes are repeated to obtain a required three-dimensional physical component.

Abstract: Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins.

Abstract: A breast pump comprising: a container comprising a deformable body and a lid, the container further comprising an inlet and a vent, wherein the vent is provided with a vent valve which is configured to allow air flow out of the container through the vent but not into the container through the vent; a nipple shield for receiving milk expressed from a user's breast; and a flexible conduit fluidly connecting the nipple shield and the inlet of the deformable container, wherein, in use, milk expressed from the breast flows from the nipple shield through the conduit to the container.

Abstract: The present invention relates to a method of semi-solid indirect squeeze casting for Mg-based composite material, which aims at improving the mechanical property of the cast by adding magnesium zinc yttrium quasicrystal of high hardness, high elastic modulus and excellent matrix binding property acting as the reinforcement into the magnesium alloy matrix and manufacturing the cast through smelting using a vacuum atmosphere smelting furnace, agitating with ultrasonic wave assisted vibration in the rotating impeller jet agitation furnace and indirect squeeze casting against the problem of poor wettability, easy agglomeration, inhomogeneous distribution between the reinforcement particles and the matrix materials and poor properties of the manufactured cast. The manufacturing method of the present invention has advanced technologies and detailed and accurate data.

Abstract: Provided herein are compositions and methods for the treatment and prevention of cancer, including melanoma.

Abstract: An intelligent sensing device and a sensing system are disclosed. The sensing device comprises a sensor unit provided with a plurality of sensors, and a wireless communication module, a memory module and a processing module connected with a data platform, wherein the processing module is connected with the sensor unit, the wireless communication module and the memory module; the processing module acquires the motion condition of a user by means of a preset detection algorithm according to a detection result of the acceleration sensor; and the sensing device has multiple different modes corresponding to different preset detection algorithms, and the user selects the preset detection algorithm by setting the mode of the sensing device. The sensing device is extremely low in power consumption, good in stability and sensitivity and high in storage capacity, can be interconnected with the data platform, and allows various sensors to be accessed thereto.

Abstract: Disclosed is a method of inhibiting growth of a melanoma cancer cell. The method includes contacting the melanoma cancer cell with an effective amount of a composition and the composition contains polymethoxyflavone. The polymethoxyflavone can be applied in an amount of 0.1 ?mol/L-1000 ?mol/L. A method of treating a subject having melanoma with the above discussed composition is also included.

Abstract: The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: A signal processing unit performs preprocessing, demosaic processing and color reproduction processing on an image signal. A control unit detects an image area having undergone a characteristic change exceeding a predetermined change amount, by using an image signal before the reproduction processing and an image signal after the color reproduction processing. The control unit associates area information indicating the detection result of the image area having undergone a characteristic change exceeding a predetermined change amount with the image signal after the color reproduction processing, and records the area information on a recording medium, or outputs the area information to an external device. Thus, it becomes possible to detect an image area where a control change caused by color reproduction processing is unnatural.

Abstract: Various methods and systems are provided for scanning an image subject along a scan axis. The method includes stitching sectional datasets acquired from different anatomical sections of the image subject based on locations of a landmark in the sectional datasets.

Abstract: Systems and methods are described herein for determining dropped call rates (DCR) for various communications networks, such as IP Multimedia Networks (IMS), which include Voice over LTE (VoLTE) networks. For example, the systems and methods utilize data (e.g. abnormal cause codes) generated by layers of the IMS networks, such as a Session Initiation Protocol (SIP) layer of the IMS network, when determining dropped call rates for IMS networks.

Abstract: Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.

Abstract: The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.

Abstract: The embodiment of the present application discloses a method, device, system and storage medium for displaying a holographic portrait in real time, applicable to reducing latency and achieving real-time display. A method in the application embodiment comprises: acquiring portrait data of a figure through somatosensory equipment; acquiring portrait data within a preset range as effective portrait data; blurring and storing the effective portrait data; sending the blurred effective portrait data to holographic display equipment frame by frame based on a first-in first-out principle, so as to display the effective portrait data of the figure on holographic projection of the holographic display equipment in real time, achieve real-time display of the holographic portrait, have a lower latency and improve user experience.

Abstract: Described herein are one or more self-organizing network (SON) components configured to determine QoS factors associated with QoS classes for a node of a telecommunication network based at least in part on performance metrics, network configuration, or network fault information. The one or more SON components may receive the performance metrics, network configuration, or network fault information from the node, and the performance metrics, network configuration, or network fault information may be associated with communication of traffic of the QoS classes by the node. Upon determining the QoS factors, the one or more SON components may transmit indications of the QoS factors to the node.

Abstract: Apparatuses and methods are disclosed for cluster switching. An exemplary method may include synchronizing original data on a first cluster to a second cluster after starting to switch clusters. A priority of the original data on the second cluster is set to a lower priority. The method may also include responding to a write operation request on the second cluster in the period of synchronizing the original data on the first cluster to the second cluster. A priority of new data corresponding to the write operation request is set to a higher priority. A version of data with a higher priority can overwrite another version of data. The method may further include responding to the write operation request on the second cluster after synchronizing the original data on the first cluster to the second cluster.

Abstract: Systems and methods are described herein for determining dropped call rates (DCR) for various communications networks, such as IP Multimedia Networks (IMS), which include Voice over LTE (VoLTE) networks. For example, the systems and methods utilize data (e.g. abnormal cause codes) generated by layers of the IMS networks, such as a Session Initiation Protocol (SIP) layer of the IMS network, when determining dropped call rates for IMS networks.

Abstract: A real-time multimodal image perception system to transform the standard lab blood smear image for persons with BVI to perceive, employing a combination of auditory, haptic, and vibrotactile feedbacks. These sensory feedbacks are used to convey visual information in appropriate perceptual channels, thus creating a palette of multimodal, sensorial information. A Bayesian network is provided to characterize images through two groups of features of interest: primary and peripheral features. A method is provided for optimal matching between primary features and sensory modalities.