Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: A TIM-3 antibody, an antigen-binding fragment thereof, and medical uses thereof are described. More specifically, the present invention provides a rat-derived antibody containing a CDR region of the TIM-3 antibody, a chimeric antibody or a human-derived antibody thereof, and a pharmaceutical composition containing the TIM-3 antibody and the antigen-binding fragment thereof, as well as uses thereof serving as a drug. In particular, the present invention provides uses of a human-derived TIM-3 antibody in the preparation of drugs for treating TIM-3-related conditions.

Abstract: The disclosed system identifies and resolves telecommunication network problems and/or problems with devices utilizing the network. The system segments the user devices into groups having similar characteristics, by grouping together devices more likely to leave the network, and devices less likely to leave the network. Each group of devices has a trained machine learning model, to predict the NEX score for each device. The system focuses on devices with a low NEX score. The system determines whether the problem is with the network and/or the problem is with the device. The system gathers information from network monitoring software and determine which tower caused, for example, the call to drop. The system determines technological capability of the device from the device TAC number. The system suggests solutions to the network problems by suggesting adding a sector, tuning an antenna, etc., or if the device has problems, adjusting phone settings.

Abstract: Presented here is a method to predict whether a user of a wireless telecommunication network will report a problem associated with the wireless telecommunication network. A processor can obtain multiple key performance indicators (KPIs) describing a user experience with the wireless telecommunication network. The processor can calculate at least a daily value of each KPI according to a rule specific to the KPI. The processor can create an image representing a color-coded value of each KPI, where a first axis of the image identifies the KPI, and where a second axis of the image represents the daily value of the KPI. The processor can predict whether the user of the wireless telecommunication network will report the problem by providing the image to a machine learning model and receiving a prediction from the machine learning model whether the user of the wireless telecommunication network will report the problem.

Abstract: The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.

Abstract: The present disclosure provides a method for preparing resorcinol through micro-channel reaction. In the method, resorcinol is prepared through micro-channel reaction using m-aminophenol as a raw material, a diazo salt is synthesized at 0° C. or more, hydrolysis of the diazo salt is performed at 90° C. or less, and then reaction conditions are reduced; the reaction time is decreased from traditional 10 hours to less than 2 minutes, and therefore the reaction time is significantly shortened; the purity of a product is 75% or more, which is significantly improved.

Abstract: Provided is a nursing bottle. The nursing bottle includes a bottle body and a bottle bottom. The bottle body is detachably connected to the bottle bottom. Both the bottle body and the bottle bottom are made of silica gel, and the bottle body has an arc shape imitating a woman's breast. An outer side of the bottle body is provided with a nipple. The nipple is provided with a water outlet. The bottle body is provided with a containing cavity and a first opening. A storage bin for storing liquid is provided in the containing cavity. The water outlet is in communication with the storage bin. A side of the storage bin facing towards the bottle bottom is provided with a second opening. Reinforcing ribs are provided between the cavity wall of the containing cavity and the outer periphery of the storage bin.

Abstract: A server for machine learning model based recommendations for vehicle remote application is provided. The server includes circuitry configured to retrieve customer subscription data associated with a first set of customers related to a set of vehicles. The set of vehicles are controlled with one or more remote applications associated with the server. The circuitry extracts the first set of features from the customer subscription data and trains a machine learning model based on the first set of features and a first feature of the first set of features. The first feature corresponds to a paid subscription of a remote application. The circuitry determines an importance score for each of the first set of features based on the trained machine learning model. The circuitry generates recommendation information related to the remote application, based on the determined importance score and transmits the recommendation information to electronic devices associated with the server.

Abstract: Described herein are one or more self-organizing network (SON) components configured to determine QoS factors associated with QoS classes for a node of a telecommunication network based at least in part on performance metrics, network configuration, or network fault information. The one or more SON components may receive the performance metrics, network configuration, or network fault information from the node, and the performance metrics, network configuration, or network fault information may be associated with communication of traffic of the QoS classes by the node. Upon determining the QoS factors, the one or more SON components may transmit indications of the QoS factors to the node.

Abstract: The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: A location adjustment method and apparatus provide for improved control. In a virtual environment picture, a temporary entry control and a function prompt information about location customization are displayed. A location adjustment operation is triggered on the temporary entry control, and a drag operation on the temporary entry control is provided in an editing state, with the temporary entry control dragged from a first location to a second location. The temporary entry control is displayed at the second location. When the temporary entry control is displayed for the first time, a location of the temporary entry control is adjusted by directly dragging the temporary entry control, which simplifies location adjustment and improves efficiency.

Abstract: Disclosed is a milk suction and collection device integrally manufactured and formed by silicone. The milk suction and collection device includes a main body which is hollow inside to define a milk storage chamber and is further provided with a milk pouring port operative to be selectively blocked. A breast protecting film is provided on a side in a thickness direction of the main body and is configured to be fitted with an outer periphery of a breast, and is further provided with a milk collecting port communicating with the milk storage chamber. The side of the main body of the milk suction and collection device provided with the breast protecting film is operative to be fitted with the breast because the milk suction and collection device is integrally manufactured and formed by silicone. When the milk pouring port is closed, a breast pumping function is achieved by squeezing the main body. When the milk pouring port is opened, a milk collecting function is achieved.

Abstract: An intelligent sensing device and a sensing system are disclosed. The sensing device comprises a sensor unit provided with a plurality of sensors, and a wireless communication module, a memory module and a processing module connected with a data platform, wherein the processing module is connected with the sensor unit, the wireless communication module and the memory module; the processing module acquires the motion condition of a user by means of a preset detection algorithm according to a detection result of the acceleration sensor; and the sensing device has multiple different modes corresponding to different preset detection algorithms, and the user selects the preset detection algorithm by setting the mode of the sensing device. The sensing device is extremely low in power consumption, good in stability and sensitivity and high in storage capacity, can be interconnected with the data platform, and allows various sensors to be accessed thereto.

Abstract: The present disclosure generally relates to methods and systems for determining usage of a vehicle. A vehicle monitoring system may include a memory, at least one processor coupled to the memory, and a sensor system that generates vehicle trip data. The system may periodically determine a location of the vehicle during a trip while an ignition of the vehicle remains on. The system may determine that a duration of the trip is at least a threshold duration. The system may determine a direction of travel for segments between consecutive locations during the trip. The system may determine a ratio of a most common direction of travel for the trip to at least a second most common direction of travel for the trip. The system may determine that the vehicle has been used for commercial purposes in response to the ratio being less than a threshold ratio.

Abstract: The invention relates to a method for preparing high-melting-point metal powder through multi-stage deep reduction, and belongs to the technical field of preparation of powder. The method includes the following steps of mixing dried high-melting-point metal oxide powder with magnesium powder and performing a self-propagating reaction, placing an intermediate product into a closed reaction kettle, leaching the intermediate product with hydrochloric acid as a leaching solution so as to obtain a low-valence oxide MexO precursor of the low-valence high-melting-point metal; uniformly mixing the precursor with calcium powder, pressing the mixture, placing the pressed mixture into a vacuum reduction furnace, heating the vacuum reduction furnace to 700-1200° C., performing deep reduction for 1-6 h, leaching a deep reduction product with hydrochloric acid as a leaching solution and performing treatment, so as to obtain the high-melting-point metal powder.