Abstract: An integrated reactor shield structure includes radially adjacent layers. Each layer includes radially extending walls defining cells and a sheet surrounding the radially extending walls. Biologic shielding material is disposed in each of the cells. Integrated pressure vessel structures are also disclosed.

Abstract: An apparatus that facilitates and/or supports stabilizing apparent azimuth angles of audio signals in environments of varying acoustic fidelity may include an eyewear frame dimensioned to be worn by a user. The apparatus may also include circuitry coupled to the eyewear frame and configured to (1) obtain an audio signal originating from a sound source in an environment of the user, (2) manipulate an azimuthal angle of the audio signal relative to a location of the sound source in the environment toward a midline feature of the user, and (3) provide the audio signal for auditory display to the user such that the manipulated azimuthal angle causes the user to perceive the audio signal as originating from the location of the sound source. Various other apparatuses, systems, and methods are also disclosed.

Abstract: A device and method for shutting off fluid-flow in a pipe. The device includes a moveable sealing member inside a pipeline, a longitudinal spring configured to bias against the sealing member in a first direction, and a lateral spring at an angle to the longitudinal spring wherein the lateral spring is configured to bias against the sealing member in a second direction. The device includes a housing with a passage configured to be positioned inline with a pipeline, and a sealing seat. A locking element is biased against the sealing member using the lateral spring to maintain an open position with the sealing member off of the sealing seat. The locking element is configured to move from the sealing member upon a fluid overpressure in the passage, whereby the sealing member extends into the seal seat to close off the pipeline upon the overpressure.

Abstract: A broadband network gateway (BNG) controller is described that includes a network subscriber database (NSDB) and one or more core applications. The NSDB is configured to store vBNG instance information for one or more subscriber devices. The vBNG instance information specifies vBNG instances operable by one or more edge routers. The vBNG instances are configured to receive requests to access service provider services from the one or more subscriber devices and to selectively authenticate the one or more subscriber devices for network services based on authentication information included in the requests to access services provider services. The one or more core applications include a network instance and configuration manager (NICM). The NICM is configured to modify the vBNG instance information at the NSDB to include an additional vBNG instance and to output, to an edge router, an instruction to generate the additional vBNG instance at the edge router.

Abstract: Disclosed herein is an input device having adjustable input mechanisms. The input mechanisms of the input device may be dynamically adjusted based on one or more input characteristics associated with a user. Accordingly, the input device may be customized to fit a user's input preferences.

Abstract: A method comprises: determining that a vehicle is at a first location; controlling motion of the vehicle using an advanced driver assistance system (ADAS); determining a second location for the vehicle based on lane sensing information of a lane monitoring system of the vehicle and a first travel distance of the vehicle since the first location, the lane sensing information reflecting a lane curvature; determining a third location for the vehicle based on a heading angle of the vehicle and a second travel distance of the vehicle since the first location; determining a fourth location for the vehicle by fusing the second and third locations with each other; and controlling the motion of the vehicle using the ADAS based on the fourth location.

Abstract: This Application sets forth techniques for cellular service management of cellular wireless service subscriptions for a set of wireless devices, including switching one or more cellular wireless service subscription among different wireless devices in the set of mobile wireless devices based on user-initiated triggers and/or autonomously when one or more cellular service switching criteria are satisfied.

Abstract: Embodiments disclosed herein provide a surgical cassette including a housing having a base and a cover coupled to the base, wherein the cover and the base each at least partially define one or more channels. The housing further includes a plurality of ports formed in the base and in fluid communication with at least one of the one or more channels, a plurality of bores formed in the base and configured to receive one of a plurality of valve assemblies, and at least one pump landing formed in the base and configured to receive at least one pump assembly. A plurality of valve assemblies is disposed within the plurality of bores and configured to control fluid flow in the one or more channels of the housing. At least one pump assembly is disposed within the at least one pump landing and configured to provide a source of pressure or vacuum to the one or more channels of the housing.

Abstract: A method comprises: determining that a vehicle is at a first location; controlling motion of the vehicle using an advanced driver assistance system (ADAS); determining a second location for the vehicle based on receiving a first sensor return indicating at least a first static object and a second static object; determining a third location for the vehicle based on a heading angle of the vehicle and a first travel distance of the vehicle since the first location; determining a fourth location for the vehicle by fusing the second and third locations with each other, and controlling the motion of the vehicle using the ADAS based on the fourth location.

Abstract: A method comprises: determining that a vehicle is at a first location; controlling motion of the vehicle using an advanced driver assistance system (ADAS); determining a second location for the vehicle based on receiving a first sensor return indicating at least a first static object and a second static object, and based on a first travel distance of the vehicle since the first location; determining a third location for the vehicle based on lane sensing information of a lane monitoring system of the vehicle and a second travel distance of the vehicle since the first location, the lane sensing information reflecting a vehicle curvature; determining a fourth location for the vehicle by fusing the second and third locations with each other; and controlling the motion of the vehicle using the ADAS based on the fourth location.

Abstract: An airfoil wall that includes a wishbone-shaped fiber layup structure that has first and second arms that merge into a single leg. The leg includes fiber tows from each of the arms and the tows are interwoven in the leg. Each of the arms includes a first section that is distal from the leg and a second section that is proximal to the leg. The first section defines a first thickness and a first fiber tow count. The second section defines a second thickness that is greater than the first thickness and a second fiber tow count that is greater than the first fiber tow count. The single leg defines a third thickness that is greater than the second thickness and a third fiber tow count that is greater than the second fiber tow count.

Abstract: Some embodiments described in this disclosure are directed to electronic devices that present indications of changes to a shared document and/or to the users in a messaging conversation while displaying the messaging conversation. Some embodiments described in this disclosure are directed to electronic devices that present options to update the users with access to shared documents and/or messaging conversations. Some embodiments described in this disclosure are directed to electronic devices that participate in communication sessions associated with a shared document.

Abstract: The present disclosure provides an isolated monoclonal antibody or an antigen-binding fragment thereof that binds specifically to leukocyte immunoglobulin-like receptor 4 (LILRB4). In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, modulates the activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, activates LILRB4. In certain embodiments, the antibody or antigen binding fragment, when bound to LILRB4, suppresses activation of LILRB4. In certain embodiments, the antibody or antigen-binding fragment, when bound to LILRB4, specifically blocks binding of ApoE to LILRB4. In another aspect, there is provided a method of treating or ameliorating the effects of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the antibody or an antigen-binding fragment thereof or an engineered cell as provided herein.

Abstract: An ingestible device comprising a capsule, a camera, an antenna, and a propulsion component id disclosed. The camera can capture images of various in vivo environments as the ingestible device traverses the gastrointestinal tract, and these images can be wirelessly transmitted to an electronic device located outside of the living body. The images may be transmitted to the electronic device for review by an operator responsible for controlling the ingestible device.

Abstract: A head-mounted device may have a head-mounted housing containing rear-facing displays that display images for a user when the head-mounted housing is worn by the user. The head-mounted housing may be coupled to the user's head using an upper headband and a lower headband that are attached to a support member. The upper headband and/or the lower headband may rotate relative to the support member to adjust the position of the headband on the user's head. The adjustable headband may rotate about a friction hinge, in a recess of the support member, or about a rotating member of the support member. Additionally or alternatively, the adjustable headband may be coupled to an attachment on the support member that can slide along a portion of the support member. The adjustable headband may be further moved on the user's head by sliding the attachment on the support member.

Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.

Abstract: A computing device can be reconfigurable to include one or more electrical devices in various configurations. The computing device can include a base forming an input surface configured to receive user input. The base can receive one or more input devices, such as, displays or keyboards. The base can include a hinge rotatably attached to the base and configured to removably retain an electronic device, such as, a display. The computing device can include a coupling mechanism having a first retaining portion and a second retaining portion rotatably coupled to an intermediate portion. The first and second retaining portions can be configured to removably retain electrical devices to the coupling mechanism.

Abstract: The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

Abstract: An electronic device may include a glass housing member that includes an upper portion defining a display area, a lower portion defining an input area, and a transition portion joining the upper portion and the lower portion and defining a continuous, curved surface between the upper portion and the lower portion. The electronic device may include a display coupled to the glass housing member and configured to provide a visual output at the display area. The electronic device may include an input device coupled to the glass housing member and configured to detect inputs at the input area. The electronic device may include a support structure coupled to the glass housing member and configured to support the computing device.

Abstract: An electronic watch may include a housing at least partially defining an interior cavity divided into at least a first volume and a second volume, a pressure-sensing component positioned within the first volume, a speaker positioned within the first volume, a processor positioned within the second volume, a battery positioned within the second volume, and a barometric vent that allows air pressure equalization between the first volume and an external environment.