Abstract: An electronic device may include a glass housing member that includes an upper portion defining a display area, a lower portion defining an input area, and a transition portion joining the upper portion and the lower portion and defining a continuous, curved surface between the upper portion and the lower portion. The electronic device may include a display coupled to the glass housing member and configured to provide a visual output at the display area. The electronic device may include an input device coupled to the glass housing member and configured to detect inputs at the input area. The electronic device may include a support structure coupled to the glass housing member and configured to support the computing device.

Abstract: A system may include an electronic device such as a head-mounted device and a handheld controller for controlling the electronic device. The handheld controller may have a housing with an elongated shaft extending between first and second tip portions. The handheld controller may have power receiving circuitry configured to receive power from a power source. The power source may be incorporated into an electronic device such as a wireless charging dock or stick, a battery case, or a head-mounted device. The power source may supply power through terminals that form ohmic contacts with mating terminals in the finger device or may transmit power wirelessly using capacitive coupling or inductive charging arrangements. Magnets may be used to hold and align the elongated shaft of the handheld controller on the power source.

Abstract: A finger-mounted device may include finger-mounted units. The finger-mounted units may each have a body that serves as a support structure for components such as force sensors, accelerometers, and other sensors and for haptic output devices. The body may have sidewall portions coupled by a portion that rests adjacent to a user's fingernail. The body may be formed from deformable material such as metal or may be formed from adjustable structures such as sliding body portions that are coupled to each other using magnetic attraction, springs, or other structures. The body of each finger-mounted unit may have a U-shaped cross-sectional profile that leaves the finger pad of each finger exposed when the body is coupled to a fingertip of a user's finger. Control circuitry may gather finger press input, lateral finger movement input, and finger tap input using the sensors and may provide haptic output using the haptic output device.

Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.

Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.

Abstract: Methods for identifying compounds that positively regulate connexin 43 hemichannels.

Abstract: A system may include an electronic device such as a head-mounted device and a handheld input device for controlling the electronic device. The handheld input device may include a stylus and a removable sleeve on the stylus. The input-output capabilities of the handheld input device may be shared between the stylus and the removable sleeve. The stylus may include touch sensor circuitry, a force-sensitive tip, and a motion sensor. The sleeve may include conductors for translating touch input on the sleeve to the touch sensor circuitry on the stylus, a deformable member for translating forces on the sleeve to the force-sensitive tip of the stylus, and visual markers that can be detected by an external camera and used with motion sensor data from the stylus to track the handheld input device. The removable sleeve may include haptic output devices and a battery and may be attached to an item without electronics.

Abstract: An apparatus includes a display, a facial interface, and a connector between the display and the facial feature. The connector can include a stop.

Abstract: A head-mountable device can operate in concert with one or more optical assemblies thereof to provide multiple users with shared experiences and content enjoyment. Such operations can be facilitated by a connection between the head-mountable device and one or both of its optical assemblies to allow different users to receive content. Such a connection can be made possible by a communication link that directly and/or physically connects the head-mountable device and one or both of its optical assemblies when the one or both of the optical assemblies is removed from the head-mountable device for operation by a separate user. The ability to provide multiple outputs on separate components allows separate users to participate in a shared experience.

Abstract: A robotic joint system is provided that facilitates efficient movement of a ground-contacting robotic system, such as during a gait cycle. The robotic joint system can comprise a first support member, a second support member, and a joint assembly rotatably coupling the first support member to the second support member about an axis of rotation. The joint assembly can comprise a passive actuation system coupled between the first and second support members. The passive actuation system can comprise a passive actuator operable to store energy and to release energy to apply a torque to the joint assembly and the first and second support members, and a length adapter coupled to the passive actuator operable to selectively direct the output of the stored energy of the passive actuator.

Abstract: A head-mountable device can have multiple cameras, which may be used to generate graphical content, provide a video passthrough of the environment, and/or sense objects, people, or events in the environment. The cameras of the head-mountable device can capture views that are output to a display. Other sensors and/or detectors can detect the presence or motion of objects and/or events in an environment of the user and provide outputs that call the user's attention to such objects and/or events. The outputs can include notifications, selectable features of a visual display output, and/or a view that includes the objects and/or events. The cameras can be integrated in a way that provides a low profile, such as by incorporation with other features of the head-mountable device.

Abstract: A method is disclosed for autonomously routing data using relay nodes pre-selected from a group of distributed computer nodes based on measured one-way latencies. One-way latencies between a plurality of nodes in a pulse group are automatically measured. A sending bucket of nodes are automatically selected from the pulse group based on the one-way latencies. A receiving bucket of nodes are automatically selected from the pulse group based on the one-way latencies. In response to a command to transfer data from the first node to the second node, a relay node that is both in the first sending bucket and in the first receiving bucket is automatically selected, wherein data is automatically routed from the first node to the second node via the relay node.

Abstract: Systems of the present disclosure can provide a head-mountable device that distributes forces along the user's head. A head-mountable device can include head securement element with a support element to engage the head of the user. The support element can be coupled to the frame or light seal module of the head-mountable device. The support element can be attachable or deployable from the head-mountable device. A head-mountable device can also distribute forces with a support portion extending from a band.

Abstract: The present technology provides large mode area optical fibers engineered to have normal dispersion around 1600 nm, enabling high power Raman amplification at eye safer wavelengths. The fibers can have a main core and one or more side cores disposed relative to the main core so that modes of the main core and the one or more side cores hybridize into supermodes with modified dispersion.

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

Abstract: A touch sensor device (TSD) includes TSD electrodes associated with a surface of the TSD. Also, an overlay that includes marker electrode(s) is also associated with at least a portion of the surface of the TSD. The TSD also includes drive-sense circuits (DSCs) operably coupled to the plurality of TSD electrodes. A DSC is configured to provide a TSD electrode signal to a TSD electrode and simultaneously to sense a change of the TSD electrode signal based on a change of impedance of the TSD electrode caused by capacitive coupling between the TSD electrode and the marker electrode(s) of the overlay. Processing module(s) is configured to process a digital signal generated by the DSC to determine characteristic(s) of the overlay that is associated with the at least a portion of the surface of the TSD.

Abstract: An electronic device may have a display mounted in a housing. The display may be mounted on a front side of the device and the housing may have a housing wall on the rear side of the device. The display may be formed from an array of pixels configured to display an image for a user. Pixel-free border areas that run along the edges of the array of pixels may be provided with an edge illuminator. The edge illuminator may provide illumination to the border areas during operation of the device. The edge illuminator may have crystalline semiconductor light-emitting diode dies, backlit liquid crystal devices or electrophoretic display components, or may have a light guide that is supplied with illumination from a light-emitting diode.

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

Abstract: A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.

Abstract: A radio-frequency (RF) push-pull amplifier circuit that includes: a first transistor; a transformer; and a first matching circuit comprising at least one capacitor and at least one inductor, in which an input of the first matching circuit is coupled to an output of the first transistor, an output of the first matching circuit is coupled to an input of the transformer, and the first matching circuit is configured to transform an impedance at the input of the transformer into a first predefined impedance at the output of the first transistor.