Abstract: The invention is directed to an input module for microfluidic cartidges comprising: (a) a container for holding a fluid, the container comprising an interior and an inlet thereto; (b) a cap comprising a tubular body with an axial passage such that a first end of the axial passage is capable of being sealingly connected to the inlet of the container and a second end of the axial passage is sealingly covered with a pierceable film and comprises a cap fitting; and (c) an inlet operationally associated with a microfluidic device.

Abstract: Methods, systems, and devices for producing hot fluid from a reactor are disclosed. A mix of moderator particles, fuel particles, and reflector particles are configured to produce heat by nuclear reactions.

Abstract: Aspects of the disclosure relate to a scaling component comprising: a first recess and a second recess, the first recess and the second recess defining a center line; a first volume on a first side of the center line; a second volume on a second side of the center line; and a third volume between the first recess and the second recess such that the center line runs through the third volume. The first recess is outlined by a first recess opening, a first tip section of the first volume, a second tip section of the second volume, and a first wall of the third volume. The second recess is outlined by a second recess opening, a third tip section of the first volume, a fourth tip section of the second volume, and a second wall of the third volume.

Abstract: Embodiments herein describe attaching (or bonding) alignment parts to a photonic die so that these alignment parts can then be used to passively align a FAU to the photonic die. In one embodiment, the alignment part (or parts) is aligned to a photonic die using a mounting FAU. The mounting FAU (along with the mated alignment parts) can then be actively aligned to the photonic die. When aligned, the alignment parts can be bonded (e.g., using cured epoxy) to the photonic die. The mounting FAU can then be lifted off, leaving the alignment parts attached to the photonic die. Later, a final product FAU (which may have a different shape than the mounting FAU) can then be passively aligned to the photonic die using the previously mounted alignment part or parts.

Abstract: A touch sensor device (TSD) includes TSD electrodes associated with a surface of the TSD. Also, an overlay that includes marker electrode(s) is also associated with a region of the surface of the TSD. The TSD also includes drive-sense circuits (DSCs) operably coupled to the plurality of TSD electrodes. A DSC is configured to provide a TSD electrode signal to a TSD electrode and simultaneously to sense a change of the TSD electrode signal based on a change of impedance of the TSD electrode caused by capacitive coupling between the TSD electrode and the marker electrode(s) of the overlay. Processing module(s) is configured to process a digital signal generated by the DSC and other digital signals generated by other DSCs determine the region of the surface of the TSD that is associated with the overlay and to adapt sensitivity of the TSD within that region.

Abstract: A speaker includes a flexible layer, a sensor configured to detect a curvature of the flexible layer, and a transducer configured to vibrate the flexible layer. The vibrations of the flexible layer generate sound waves and output generated by the transducer is based on a curvature of the flexible layer.

Abstract: A wearable electronic device can include optical assemblies for providing visual output to a user. The optical assemblies can include a central display as well as a light track that surrounds at least a portion of the central display. Primary information and images can be provided at the central display to be received at a center region of a user's vision. Supplemental content and/or information can be provided by operation of the light track, which can be operated with relatively simple controls. The supplemental content and/or information can be received at a peripheral region of the user's vision. Accordingly. the inner and outer images produced by the separate mechanisms of the optical assembly can provide a single continuous image for observation by the user.

Abstract: A computing device includes signal generation circuitry and also includes a location on the computing device that is operative to couple a signal generated by the signal generation circuitry into a user. For example, the computing device includes signal generation circuitry that generates a signal that includes information corresponding to a user and/or an application that is operative within the computing device. The signal generation circuitry couples the signal into the user from a location on the computing device based on a bodily portion of the user being in contact with or within sufficient proximity to the location on the computing device that facilitates coupling of the signal into the user. Also, the signal may be coupled via the user to another computing device that includes a touchscreen display that is operative to detect and receive the signal.

Abstract: In accordance with the present disclosure, macrocyclic compounds have been discovered that bind to PD-1 and are capable of inhibiting the interaction of PD-1 and PD-L1. These macrocyclic compounds exhibit in vitro immunomodulatory efficacy thus making them therapeutic candidates for the treatment of various diseases including cancer and infectious diseases.

Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of DNA, RNA, and protein substrates. Each system includes one or more protein components and one or more nucleic acid components that together target DNA, RNA, or protein substrates.

Abstract: This Application describes mechanisms for enterprise remote management of cellular services provided via access credentials, e.g., subscriber identity modules (SIMs) and/or electronic SIMs (eSIMs), for wireless devices. To minimize requirements for user interaction, installation and management of business-supplied cellular service profiles on the wireless device can intercept alert notifications to reduce interruptions and allow for background management of the business-supplied cellular service profiles. Additionally, a business enterprise can use multiple, distinct services to initiate installation of an eSIM to a wireless device. When two different services attempt to install eSIMs on the wireless device in parallel, management software on the wireless device can control an order of installation and disallow duplicate installations of an identical eSIM to the wireless device.

Abstract: Methods for identifying compounds that positively regulate connexin 43 hemichannels.

Abstract: A head-mounted device may have a head-mounted housing containing rear-facing displays that display images for a user when the head-mounted housing is worn by the user. The head-mounted device housing may have housing structures such as elongated housing members with protruding posts. Multiple headbands may be removably coupled to the head-mounted device housing at the protruding posts. A first headband may have a strap with openings configured to receive the posts. Releasable latches may be provided to allow selective engagement and disengagement between the headband and the housing. A second headband may be coupled to the posts between the housing members and the first headband. Alternatively, the first headband may surround the post, and the second headband may be coupled to the post through the opening in the first headband. One or more hair guards and/or one or more keeper loops may be incorporated between the headbands.

Abstract: An apparatus or method for storing records for a plurality of embedded subscriber identity module (eSIM) profiles, wherein a record for each eSIM profile comprises a state of the eSIM profile, receiving, from a first user equipment (UE), a message indicating a first eSIM profile has been deleted from the first UE, changing the state of the first eSIM profile from installed to available, receiving a message requesting the first eSIM profile be allocated to a second UE, changing the state of the first eSIM profile to a state allowing the eSIM profile to be downloaded to the second UE and downloading the first eSIM profile to the second UE.

Abstract: Aqueous inkjet ink compositions are provided which comprise water, a co-medium, pigment particles, and resin particles, wherein the resin particles comprise a polymerization product of reactants comprising: one or more types of hydrophobic monomers; and one or more types of anionic monomers comprising one or more types of crosslinkable anionic monomers.

Abstract: The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease. In particular, the methods encompass techniques for improved diagnosis and/or treatment of an ASM disorder, for example using enzyme replacement therapy.

Abstract: A method for inline resin mixing includes establishing a flow of a mixed resin, initially directing the mixed resin to a first intermediate volume and subsequently directing the mixed resin to a second intermediate volume after a predetermined triggering event relating to a continuing flow of the mixed resin. A mixed resin retention assembly for inline resin mixing includes an inlet spout and an intermediate vessel. The inlet spout receives a flow of the mixed resin. The intermediate vessel includes the first and second intermediate volumes. A valve assembly for inline resin mixing includes an exterior body, an interior body and a cover. The exterior body includes three input ports and an output port. The interior body is disposed within an interior cavity of the exterior body and defines five flow paths extending from a periphery and intersecting at a central portion of the interior body.

Abstract: The controller 13 of the information processing device 1 is configured to acquire measurement data of a feature measured by a lidar 3 provided on a ship and measurement data of a water surface. In addition, the controllers 13 is configured to acquire information regarding a height of the feature from a river map DB 10. Then, the controller 13 is configured to acquire highest point information IH regarding a height of the highest point of the ship from a reference position of the ship. Then, the controller 13 is configured to calculate a ship highest point height based on the measurement data of the feature, the measurement data of the water surface, the information regarding the height of the feature, and the highest point information IH.

Abstract: An electrical stimulation system includes a sheath that includes conductive points that are operative to facilitate electrical stimulation to a bodily portion of a user. Drive-sense circuits (DSCs) generate electrical stimulation signals based on reference signals and provide those electrical stimulation signals via electrodes to the conductive points of the sheath. The electrical stimulation signal is coupled into respective locations of the bodily portion of the user that are in proximity to or in contact with the conductive points of the sheath. In addition, the DSCs sense, via the conductive points of the sheath and via the electrodes, changes of the electrical stimulation signals based on coupling of them into the respective locations of the bodily portion of the user. The DSCs provide digital signals that are representative of the changes of the electrical stimulation signals to one or more processing modules that includes and/or is coupled to memory.

Abstract: A calibration system includes: a reference device including an array of markers at predetermined positions; a camera; and a computing device configured to: store reference data defining the predetermined positions of the markers in a capture volume frame of reference; obtain a calibration image of the reference device captured by the camera; detect image positions of the markers in the calibration image, the image positions defined according to camera frame of reference; based on the image positions of the markers and the reference data, generate calibration data mapping coordinates in the camera frame of reference to coordinates in the capture volume frame of reference.