Abstract: A head-mountable device and/or another electronic device can provide guidance for optimal placement of the head-mountable device. The head-mountable device and/or another electronic device can be operated to guide a user to position the head-mountable device in a manner that will achieve proper alignment of components with respect to the user and maximize user comfort. For example, the head-mountable device and/or another device can include sensors for detecting features of the user's face, forces distributed on the face when worn, and/or alignment with the face (e.g., eyes). By further example, the head-mountable device and/or another device can detect changes in adjustment and infer user discomfort based on the frequency and/or magnitude of such changes. By further example, the head-mountable device and/or another device can detect changes in features of the user's face before, during, and/or after use of the head-mountable device.

Abstract: The present disclosure generally relates to techniques and user interfaces for creating, editing, and using stickers. In some embodiments, a sticker can be created using a media item. In some embodiments, a sticker can be edited to apply a visual effect. In some embodiments, a sticker can be suggested for use in a messaging interface.

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

Abstract: In accordance with the present disclosure, macrocyclic compounds have been discovered that bind to PD-1 and are capable of inhibiting the interaction of PD-1 with PD-L1. These macrocyclic compounds exhibit in vitro immunomodulatory efficacy thus making them therapeutic candidates for the treatment of various diseases including cancer and infectious diseases.

Abstract: Embodiments are directed to an electronic device having a hidden or concealable input region. In one aspect, an embodiment includes an enclosure having a wall that defines an input region having an array of microperforations. A light source may be positioned within a volume defined by the enclosure and configured to propagate light through the array of microperforations. A sensing element may be coupled with the wall and configured to detect input received within the input region. The array of microperforations are configured to be visually imperceptible when not illuminated by the light source. When illuminated by the light source, the array of microperforations may display a symbol.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Abstract: An electronic device may have input-output devices such as sensors, displays, wireless circuitry, and other electronic components mounted within a housing. The housing may have opposing front and rear walls. A display may be formed on a front side of the device and may be overlapped by a front housing wall such as a glass layer. Sensors and other components may be formed on a rear side of the device and may be overlapped by a rear housing wall. The rear housing wall may have a glass portion or other transparent structure through which projectors project images onto nearby surfaces and through which image sensors and other optical sensors receive light. The housing may be supported by a stand. An electrical component in the stand may interact with an electronic device on the stand. Wireless circuitry in an external item may wirelessly couple to wireless circuitry within the housing.

Abstract: A system may include an electronic device such as a head-mounted device and a handheld input device for controlling the electronic device. A tracking device may be removably coupled to the handheld input device to increase the precision with which the head-mounted device tracks the handheld input device. The tracking device may have larger dimensions than the handheld input device and/or may have an expandable housing that expands and retracts. Visual markers on the tracking device may include infrared light-emitting diodes, geometric surface features, or other optical tracking features. The tracking device may serve as a secondary input device for the head-mounted device when the tracking device is decoupled from the input device. The tracking device may have a recess for receiving a shaft of the input device and may have magnets or other attachment structures for attaching the tracking device to the input device.

Abstract: An integrated circuit is provided that comprises a first thermal sink layer, a first ground plane associated with a first set of circuits that have a first operational temperature requirement, a first thermally conductive via that couples the first ground plane to the first thermal sink layer, a second thermal sink layer, a second ground plane associated with a second set of circuits that have a second operational temperature requirement that is higher than the first operational temperature requirement, and a second thermally conductive via that couples the second ground plane to the second thermal sink layer. The first thermal sink layer is cooled at a first temperature to maintain the first set of circuits at the first operational temperature requirement and the second thermal sink layer is cooled at a second temperature to maintain the second set of circuits at the second operational temperature requirement.

Abstract: A pipe segment for thermoset manufacturing includes a pipe body with an exterior surface, a main inlet portion, a main outlet portion, a secondary inlet portion and a secondary outlet portion. The pipe body defines a main chamber and a secondary chamber. A nozzle for thermoset manufacturing includes a nozzle body with an exterior surface, a main inlet portion, a main outlet portion, a secondary inlet portion and a secondary outlet portion. The nozzle body defines a main chamber and a secondary chamber. The main inlet portion includes at least two main inlet orifices. The main outlet portion includes a main outlet orifice. The secondary inlet portion includes a secondary inlet orifice. The secondary outlet portion includes a secondary outlet orifice. A system for thermoset manufacturing includes a pipe segment, a three-way valve and first, second and third fluid subsystems. A method for thermoset manufacturing is also provided.

Abstract: Provided are methods of preparing source identifiable collections of nucleic acids from a plurality of sources, such as cells or cell nuclei, using a combinatorial indexing methodology. Generally, the methods include providing a first set of cellular source sub-portions, each sub-portion comprising multiple cellular sources of the initial plurality of cellular sources. First identifier tagged nucleic acids are then generated in the multiple cellular sources of each sub-portion of the first set using a template switching mediated reaction employing a template switch oligonucleotide comprising a first identifier, wherein the first identifier of the template switch oligonucleotides employed in the different sub-portions of the first set is the same within a given sub-portion but differs between the different sub-portions.

Abstract: A method for amplifying an RF signal is provided. The method includes providing the RF signal to an input of a quadrature coupler. The method includes outputting, from the quadrature coupler, a carrier path signal and a peak path signal. The method includes amplifying the carrier path signal to provide an amplified carrier path signal and amplifying the peak path signal to provide an amplified peak path signal. The method includes generating a first neutralizing signal based on the carrier path signal and generating a second neutralizing signal based on the peak path signal. The method includes modifying the amplified peak path signal based on the first neutralizing signal to provide a neutralized peak path signal and modifying the amplified carrier path signal based on the second neutralizing signal to provide a neutralized carrier path signal. The method also includes combining the neutralized carrier path and peak path signals.

Abstract: A dirt repellant panel coated with a powder coating composition that includes a polymeric binder and an anionic fluorosurfactant present in an amount ranging from about 0.1 wt. % to about 4 wt. %.

Abstract: Head-mounted devices can be formed as a modular system that provides a variety of different components and functions to achieve the results that are desired by a user. The modular configurations allow a user to easily customize a head-mounted device with one or more arm modules to provide features that integrate with other operations of the frame module of the head-mounted device. The arm modules can be easily exchanged with each other to provide different components and functions at different times. Accordingly, a frame module of a head-mounted device need not include permanent components that provide every function that will later be desired by the user. Instead, the head-mounted device can have expanded and customizable capabilities by the use of one or more arm modules.

Abstract: A method of fabricating an airfoil includes providing an airfoil core tube that is made of a rigidized ceramic fabric, using the airfoil core tube as a mandrel by braiding a plurality of ceramic fiber tows around the airfoil core tube to form one or more braided layers, where the airfoil core tube and the one or more braided layers forming an airfoil preform, and densifying the airfoil preform with a ceramic matrix material to thereby form a ceramic matrix composite airfoil.

Abstract: Provided herein are systems and methods for operating carbon oxide (COx) reduction reactors (CRRs) for producing methane (CH4). Embodiments of the systems and methods may also be used for producing other organic compounds including alcohols, carboxylic acids, and other hydrocarbons such as ethylene (CH2CH2). According to various embodiments, the systems and methods may be characterized by one or more of the following features. In some embodiments, a membrane electrode assembly (MEA) includes a cathode catalyst layer with a relatively low catalyst loading. In some embodiments, a bipolar MEA includes a thin cation-conducting layer and a thin anion-conducting layer, with the cation-conducting layer being thicker than the anion-conducting layer. In other embodiments a pure anion exchange polymer only membrane may be used to bridge the cathode catalyst and the anode catalyst. These and other features are described further below.

Abstract: Apparatus, systems, and methods for processing workpieces are provided. An arc lamp can include a tube. The arc lamp can include one or more inlets configured to receive water to be circulated through the arc lamp during operation as a water wall, the water wall configured to cool the arc lamp. The arc lamp can include a plurality of electrodes configured to generate a plasma in a forming gas introduced into the arc lamp via the one or more inlets. The forming gas can be or can include a mixture of a hydrogen gas and an inert gas, the hydrogen gas in the mixture having a concentration less than 4% by volume. The hydrogen gas can be introduced into the arc lamp prior to generating the plasma. The arc lamp may be used for processing workpieces.

Abstract: A computer system detects one or more inputs to subscribe to updates from a first application for a first event and to subscribe to updates from a second application for a second event. The system displays a user interface. Displaying the user interface includes: when the first event is active and the second event is not active, displaying a first representation of the first event in a first region of the user interface, and updating first information contained in the first representation of the first event based on updates received from the first application; and when the second event is active and the first event is not active, displaying a second representation of the second event in the first region of the user interface, and updating second information contained in the second representation of the second event based on updates received from the second application.

Abstract: A system configured to perform acoustic feedback control to enable a device to perform hearing enhancement while suppressing acoustic feedback. During hearing enhancement, the device may amplify environmental noise based on a unique hearing profile associated with the user, personalizing equalization settings, a dynamic range, and/or other characteristics to optimize playback audio for the user. The acoustic feedback control may include an acoustic feedback cancellation (AFC) component that uses an adaptive filter to estimate and cancel a feedback signal. In addition, the AFC component may perform entrainment prevention by detecting periodic signals and adjusting an adaptation rate of the adaptive filter accordingly. Separately, the device may selectively suppress acoustic feedback by detecting frequency bands representing acoustic feedback (e.g., squeal detection) and applying one or more notch filter(s) to suppress the selected frequency bands (e.g., squeal suppression).

Abstract: An enhancement equalizer (EEQ) can be configured to compensate for hearing loss. An app or application can assist a user with measuring hearing loss at various frequencies (e.g., threshold sensitivity versus normal hearing). Using these measurements, the system may compute a set of filters for an EEQ that can boost different frequencies by different amounts corresponding to the user's sensitivity to that frequency. The measurement and resulting EEQ may be earphone specific (e.g., both the measurement and the filter computation may depend on the particular type/model of earphone used). In some implementations, the system may allow the user to select correction strength that controls an amount of correction applied (e.g., 25%, 50%, or 75% of full correction). In some implementations, the system may adjust the EEQ and/or correction strength according to the volume of playback (e.g., by applying less correction at higher playback volumes to avoid triggering earphone limiters).