Abstract: The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.

Abstract: The present disclosure generally relates to user interfaces that include application widgets. In some embodiments, a computer system displays a home screen, where displaying the home screen includes displaying a set of user interface elements based on whether an account that was used to set up the computer system is associated with a first type of content. In some embodiments, a computer system displays a user interface in response to detecting a request to change the orientation of the user interface. Displaying the user interface includes displaying an arrangement of application widgets and application icons, where a set of application widgets has a same spatial organization as in a previous arrangement.

Abstract: Devices, systems, methods, and computer program products for performing medical procedures are disclosed herein. In some embodiments, a system for performing a medical procedure includes a medical instrument configured to be inserted within the anatomic region, the medical instrument including an image capture device. The system can be configured to obtain, from the image capture device, image data of an anatomic landmark within the anatomic region. The system can identify, based on the image data, an association between the anatomic landmark and a corresponding model landmark in a model of the anatomic region. The system can determine a localization state of the medical instrument based on the identified association, the localization state including an estimated location and an uncertainty parameter associated with the estimated location. The system can dynamically update the localization state as the medical instrument navigates within the anatomic region.

Abstract: A technology is described for redundant network communication in a robot. An example of the technology can include a main robotic controller, a local controller in network communication with the main robotic controller, and instructions that, when executed by the processor, transfer first and second data signals between the main robotic controller and the local controller via first and second network channels. The first data signal is sent over the first network channel, and the second data signal is sent over the second network channel. The instructions compare the first data signal with the second data signal to determine signal integrity of the data signals; determine degradation of the first data signal if the signal integrity is less than the signal integrity of the second data signal; and select the second data signal for processing if degradation of the first data signal is determined.

Abstract: Systems and methods are described for selecting User Equipment(s) (UEs) for pairing in a cellular network. A channel orthogonality of one or more UEs located within a radio range of a first Access Node (AN) may be determined. The one or more UEs may be prioritized for Uplink (UL) Multi-User Multiple-Input-Multiple-Output (MU-MIMO) pairing when a channel orthogonality meets a set channel orthogonality condition. A second AN located within the radio range of the first AN may be detected. At least one of the prioritized UEs located within a radio range of the second AN may be selected for de-prioritization. The prioritized UEs may be paired to share a same set of resource blocks.

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

Abstract: A touch sensor device (TSD) includes TSD electrodes associated with a surface of the TSD. Also, an overlay that includes marker electrode(s) is also associated with at least a portion of the surface of the TSD. The TSD also includes drive-sense circuits (DSCs) operably coupled to the plurality of TSD electrodes. A DSC is configured to provide a TSD electrode signal to a TSD electrode and simultaneously to sense a change of the TSD electrode signal based on a change of impedance of the TSD electrode caused by capacitive coupling between the TSD electrode and the marker electrode(s) of the overlay. Processing module(s) is configured to process a digital signal generated by the DSC to determine characteristic(s) of the overlay that is associated with the at least a portion of the surface of the TSD.

Abstract: The present disclosure provides for systems and methods for modifying the epigenome of cells.

Abstract: User equipment receives a GNSS signal that includes a GNSS signal from a satellite. The user equipment also receives a first data input from a motion sensor of the user equipment that is indicative of a motion of the user equipment, receives a second data input from the temperature sensor of the user equipment that is indicative of a temperature of the user equipment, and performs a coherent operation based on the pilot channel of the GNSS signal over a coherent period of time based on the first data input and the second data input to generate a resulting signal. The user equipment performs a non-coherent operation based on the resulting signal to amplify the resulting signal, and outputs a position of the user equipment based on the resulting signal.

Abstract: The present disclosure relates to compounds that are capable penetrating to the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR mediated cancers. The disclosure further relates to methods of treating glioblastoma and other EGFR mediated cancers that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.

Abstract: The present disclosure provides method and apparatus for determining a food item from a photograph and a corresponding restaurant serving the food item. An image is received from a user, the image being associated with a consumable item. One or more ingredients of the consumable item in the image is identified along with a location of the user and using a neural network, determining one or more similar images from a database. A restaurant associated with each of the one or more similar images is determined along with a similarity score indicating a similarity between the restaurant and the identified content of the image. The one or more restaurants and/or associated similar food items are ranked based on the similarity score and a list of ranked restaurants is provided to the user.

Abstract: Keyboards and other input devices are provided with at least one flexible layer that extends over or under the keycaps. The flexible layer spans interkey spaces and lies between inner and outer keycaps. The flexible layer prevents intrusion of invasive material to the keyboard mechanisms and simplifies the appearance of the keyboard area. Some flexible layers help align keycaps by connecting inner and outer keycaps or by providing a mechanical connection interface for the keycaps. Some membranes used in the flexible layer have a layered or composite construction that increases durability and tear resistance by attaching or infusing a mesh material or other tough material to a less durable, elastic material.

Abstract: The present disclosure generally relates to user interfaces that include application widgets. In some embodiments, a computer system displays a home screen, where displaying the home screen includes displaying a set of user interface elements based on whether an account that was used to set up the computer system is associated with a first type of content. In some embodiments, a computer system displays a user interface in response to detecting a request to change the orientation of the user interface. Displaying the user interface includes displaying an arrangement of application widgets and application icons, where a set of application widgets has a same spatial organization as in a previous arrangement.

Abstract: A collection system for collecting outflow from a hysteroscopic surgical procedure includes a plurality of collection vessels each including a flexible body defining an internal volume and transitionable between a collapsed configuration and an expanded configuration. The collection system further includes connection tubing coupling adjacent collection vessels with one another, outflow tubing coupled to at least one of the collection vessels, and a plurality of retention canisters. Each retention canister includes a rigid body. Each collection vessel is configured to engage a corresponding retention canister such that each rigid body at least partially receives one of the flexible bodies therein.

Abstract: Computing systems and input devices can include a chassis with a computing device and an input tool with a sensor, such as a pen- or rod-like input tool, that can be positioned relative to the chassis in multiple configurations. In one configuration, the tool can be spaced away from the chassis and its sensor output can cause a first output signal in response to input provided to the sensor. In another configuration, the tool can be contacting the chassis and its sensor output can cause a second output signal in response to input provided to the sensor. For example, an input tool can be stowed in a recess of a keyboard housing or device chassis, and the input tool can produce a first output when it is in the recess and a second input when it has been removed from the chassis.

Abstract: A system, a wearable device, and a method are provided which can increase the accuracy of physiological metrics while detecting if the patient ingested digital medicine and/or improve performance of the wearable device. The wearable device can comprise machine executable instructions that when executed by the processor, cause the processor to perform various algorithms, such as, for example, at least one of a step count algorithm, a body angle algorithm, a heart rate algorithm, a peak finder algorithm, an adaptive thresholding algorithm, a heart rate variability algorithm, a R-R cleaning Algorithm, a deltaR-R cleaning algorithm, a merge twin interval algorithm, a split tall intervals algorithm, an absorb short intervals algorithm, a bimodal detection algorithm, and a resting algorithm.

Abstract: This application relates to a laptop computer. The laptop computer includes a base portion pivotally coupled to a lid portion is described. The laptop computer includes a display assembly carried by the lid portion, where the display assembly includes a light-transmissive cover, a display layer overlaid by the light-transmissive cover, a display stack electrically coupled to and overlaid by the display layer, and a light pattern recognition module adjacent to the display stack and overlaid by the display layer. The light pattern recognition module includes (i) a light pattern projector that projects a light pattern directly through the display layer.

Abstract: A robot system, comprising a robot capable of gait or gait-like operations, stance or stance-like operations, or a combination of these. The robot can comprise at least one ground-contacting appendage configured to facilitate locomotion of the robot. The system can further comprise a sole supported on the ground-contacting appendage that is operable to interface with a ground surface. The sole can comprise a robot interface facilitating attachment of the sole to the robot, a first sole component having a ground-contacting surface, the first sole component defining a first compliant zone, and a second sole component having a ground-contacting surface, the second sole component defining a second compliant zone. The first sole component can comprise a compliance the same or different than the second sole component.

Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

Abstract: A vitreous enamel coating for an electrosurgical metal cutting blade, in which incident light striking the vitreous enamel coating is diffusely reflected or absorbed, and the vitreous enamel coating exhibits a 60° gloss value less than 100 gloss units as measured according to ASTM D523-14, Standard Test Method for Specular Gloss. The coating reduces glare from light sources such as a nearby plasma-mediated discharge, operating theater lights or lights provided on an electrosurgery apparatus. The coating may also lessen interference with markers, sensors or other instruments designed to measure light emitted by or passing through nearby tissue such as by transillumination.