Abstract: A method includes obtaining a source image of a user and obtaining a driving video in which a face or a head of the user is moving. The method also includes generating metadata identifying animations to be applied to the source image so that the source image mimics at least some movements of the user's face or head in the driving video. The method further includes transmitting the source image and the metadata to an end user device configured to animate the source image based on the metadata. Generating the metadata includes suppressing one or more artifacts associated with one or more objects that temporarily occlude at least a portion of the user's head or body in the driving video or that temporarily appear in the driving video.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: This application provides a positioning method, apparatus, and device. The method includes: receiving a first positioning reference signal PRS on a first frequency domain resource, where the first frequency domain resource is a frequency domain resource in an unlicensed spectrum; receiving a second PRS on a second frequency domain resource, where the second frequency domain resource is a frequency domain resource in a licensed spectrum; determining, based on the first PRS and the second PRS, a first positioning measurement result corresponding to the first PRS and a second positioning measurement result corresponding to the second PRS; and determining a location of a terminal based on the first positioning measurement result and the second positioning measurement result. The method may be applicable to quickly and accurately determining the location of the terminal without occupying a large quantity of frequency domain resources in the licensed spectrum.

Abstract: A light condensing device for inspecting the quality inside fruits and vegetables, resolving problems in which manually holding fruits for inspection is inefficient and cannot be used in large-scale fruit packaging production. The device comprises a housing, a halogen lamp, a diaphragm, a plano-convex lens support a first plano-convex lens, a reflector lens fixing plate, a reflector, a plano-convex lens fixing plate, and a second plano-convex lens. The housing is a sealed and non-transparent housing. The halogen lamp is fixedly disposed at a left end of the housing, and extends into an inner portion of the housing. A pluggable diaphragm is disposed at the right side of the halogen lamp, and is used to guide a lighting direction of the halogen lamp. The diaphragm passes through the inner portion of the housing. The plano-convex lens support is fixedly disposed inside the housing at the right side of the diaphragm.

Abstract: A method for presenting a virtual representation of a real space is provided. The method includes: obtaining a plurality of color images and a plurality of depth images respectively corresponding to the plurality of color images; for any of the plurality of observation points, superimposing a color image corresponding to the observation point and a depth image corresponding to the color image, to obtain a superimposed image; respectively mapping respective superimposed images corresponding to the plurality of observation points to a plurality of spheres in a virtual space; performing spatial transformation on vertices of the plurality of spheres in the virtual space; and for any vertex of any of the spheres, performing spatial editing and shading, so as to obtain and present respective virtual representations, in the virtual space, of respective partial scenes of a real space.

Abstract: A louver awning with a hidden louver opening and closing driving structure includes an awning frame assembly, a plurality of louvers rotatably mounted on a top portion of the awning frame assembly, linkage bars for linking the louvers, and a louver opening and closing driving structure. The awning frame assembly includes a plurality of columns and ring beams fitted together. The louver opening and closing driving structure comprises a hand-operated mechanism, a transmission assembly and a louver transmission mechanism. The transmission assembly is used to transmit power input by the hand-operated mechanism to the louver transmission mechanism, and the louver transmission mechanism is used to drive the louvers to rotate so as to realize opening and closing of the louvers.

Abstract: The invention discloses a deuterated camptothecin derivative and its antibody-drug conjugate (ADC), and combines the deuteration technology with camptothecin ADC to discover improved deuterated camptothecin ADC drug, so that it has higher safety and efficacy and can better meet the clinical challenge.

Abstract: A bispecific tetravalent antibody having a binding specificity to a human epithelium growth factor receptor (EGFR), comprising, from N terminus to C terminus, a Fab region having a first binding specificity to human EGFR, wherein the Fab region comprises a variable region having an amino acid sequence having at least 90% of sequence identity to the sequences as disclosed herein; a Fc domain, and a scFv domain having a second binding specificity to HER3.

Abstract: A method of preventing, reducing a risk of, or treating a virus infection, or preventing or treating a symptom caused by the virus in a subject, said method comprising administering to said subject an effective amount of a fusion protein, wherein the fusion protein comprises a variant angiotensin converting enzyme 2 (ACE2) domain covalently fused to a Fc domain. The variant ACE2 domain comprises a N-terminal deletion, a C-terminal deletion, or both, relative to a full-length wildtype ACE2 having a SEQ ID NO. 1, and the variant ACE2 domain has ACE2 activity. The virus may be SARS-CoV, SARS-CoV-2, or MERS-CoV. The symptom comprises Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), Acute Respiratory Distress Syndrome (ARDS), Pulmonary Arterial Hypertension (PAH), or Coronavirus Disease 2019 (COVID-19).

Abstract: A method for video processing is provided. The method comprises obtaining an image of a scene, obtaining a video that records an area included in the scene, determining one or more frames from the plurality of frames of the video, determining pairs of matched features, generating a plurality of composite frames by combining each of the selected one or more frames with the image of the scene based on the pairs of matched features, and generating a composite video based on the plurality of composite frames. Each of the pairs of matched features is related to an object that is in both the image and the one or more frames. Each of the pairs of matched features is associated with one or more pixels of the image of the scene and one or more pixels of a selected frame of the one or more frames.

Abstract: The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.

Abstract: The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.

Abstract: Example embodiments relate to Doherty amplifiers. One example includes a radiofrequency (RF) power amplifier. The RF power amplifier includes an input lead. The RF power amplifier also includes a first output lead. Additionally, the RF power amplifier includes a first semiconductor die arranged in between the input lead and the first output lead. The first semiconductor die includes a first edge arranged adjacent to the input lead and an opposing second edge arranged adjacent to the first output lead. Further, the RF power amplifier includes a field-effect transistor integrated on the first semiconductor die. The field-effect transistor includes a gate bondpad assembly and a drain bondpad assembly. The field-effect transistor also includes a plurality of gate bondwires and a plurality of drain bondwires. In addition, the field-effect transistor includes a plurality of gate fingers extending in a first direction and a plurality of drain fingers extending in a second direction.

Abstract: A method for navigating in a simulated environment is disclosed herein. A navigation device determines a search space associated with a plurality of viewpoints other than the current viewpoint in a three-dimensional (3D) space for a current viewpoint. The search space comprises a set of 3D coordinates for each of the plurality of viewpoints. The navigation device determines a field of view at the current viewpoint, which is an area associated with a viewing angle and a visible distance. The navigation device determines a target viewpoint in the search space of the current viewpoint based on the field of view at the current viewpoint. The target viewpoint is outside the area of the field of view at the current viewpoint. The navigation device causes display of a guidance user interface (UI) comprising an indicator corresponding to the target viewpoint in the field of view at the current viewpoint.

Abstract: Example embodiments relate to Doherty amplifiers. One Doherty amplifier includes a packaged main amplifier that includes a main input lead for receiving a main RF signal, a main power transistor for amplifying the main RF signal, and a main output lead for outputting the main RF signal amplified by the main power transistor. The Doherty amplifier also includes a packaged peak amplifier that includes a peak input lead assembly for receiving a peak RF a first peak power transistor configured for amplifying a part of the peak RF signal, a second peak power transistor configured for amplifying a remaining part of the peak RF signal, and a peak output lead for combining the part of the peak RF signal amplified by the first peak power transistor and the remaining part of the peak RF signal amplified by the second peak power transistor into an amplified peak RF signal.

Abstract: A fusion protein, comprising a variant angiotensin converting enzyme 2 (ACE2) domain covalently fused to a Fc domain. The variant ACE2 domain has a N-terminal deletion, a C-terminal deletion, or both, relative to a full-length wildtype ACE2 having a SEQ ID NO: 1. The variant ACE2 domain has ACE2 activity.

Abstract: The present disclosure relates to antibodies, in particular monoclonal antibodies of murine, chimeric, and humanized origin, that specifically bind to the human TROP2 protein, and to the amino acid and nucleotide sequences encoding these antibodies. The disclosure also discloses the use of these antibodies as a diagnostic reagent or a drug in the diagnostic and/or therapeutic management of malignancies or any lesion related to the overexpression of said receptor.

Abstract: A camptothecin drug having a highly stable hydrophilic connecting unit and its conjugate, or its pharmaceutically acceptable salt thereof, including methods for preparation thereof, and its applications in preventing and/or treating cancer. The conjugate can specifically bind to receptors highly expressed in tumor cells. The conjugates have excellent water solubility, stability, and homogeneity, and can be used for preventing and/or treating tumors and/or other diseases.

Abstract: Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflanunatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.