Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

Abstract: A system and method identify a set of rules for determining a commonality of attributes across different behavior changes for a network. The system performs the method by receiving a set of data correlating network triggers to performance changes of one or more network devices. The set of data further includes an indication of a sign of the performance change for each of the network devices based on the triggers. The method further includes extracting a set of rules relating to a set of relationships between the triggers and the performance changes. The rules identify a commonality of the performance changes for multiple network devices based on the triggers.

Abstract: The present invention relates to a method for the selective hydrogenation of an unsaturated compound, particularly a method in an unsaturated compound or a mixture containing unsaturated compounds for increase of the light sulphides weight, hydrogenation of a polyunsaturated compound and isomerization of a monounsaturated compound. The method uses a supported catalyst. The supported catalyst contains at least one Group VIB non-noble metal oxide and at least one Group VIII non-noble metal oxide deposited on a carrier; and the catalyst has an optimized acid distribution on the surface of the catalyst, and more preferably has an optimized Group VIII/VIB metal ratio and a Group VIII non-noble metal density per unit of catalyst surface area.

Abstract: The present invention relates to antibodies that bind blood brain barrier receptors (BBB-R) and methods of using the same.

Abstract: A method for disseminating content over an overlay network having a plurality of routers in communication with providers and consumers of content is disclosed. A router in the overlay network receives a content descriptor corresponding to a query for content from a node, and generates a subscriber interface list based on the query for the content. The subscriber interface list is transmitted to a plurality of subsequent routers in the overlay network, wherein a content identified by the subsequent routers that correspond to the query will be routed to the router based on the subscriber interface list. The router receives first and second documents corresponding to the query for the content from the node. If the second document is the duplicate, the router deletes the second document and transmits the first document to the node or if not the router transmits both the first and second documents to the node.

Abstract: Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating autoimmune and/or glomerulonephritis-associated diseases, and in particular, Systemic Lupus Erythematosus (SLE).

Abstract: Inhibitors of protein tyrosine phosphatases are disclosed. The inhibitors include hydroxyindole carboxylic acids having a linker and an amine scaffold that are potent inhibitors of Src homology 2-domain containing protein tyrosine phosphatase-2.

Abstract: A method for disseminating content over an overlay network having a plurality of routers in communication with providers and consumers of content is disclosed. A router in the overlay network receives a content descriptor corresponding to a query for content from a node, and generates a subscriber interface list based on the query for the content. The subscriber interface list is transmitted to a plurality of subsequent routers in the overlay network, wherein a content identified by the subsequent routers that correspond to the query will be routed to the router based on the subscriber interface list. The router receives first and second documents corresponding to the query for the content from the node. If the second document is the duplicate, the router deletes the second document and transmits the first document to the node or if not the router transmits both the first and second documents to the node.

Abstract: A system and method identify a network upgrade from a data set including a plurality of configuration sessions. The system performs the method by receiving a plurality of configuration sessions. Each of the configuration sessions comprises a plurality of configuration commands. The configuration commands are generated by a same user identifier and within a time threshold. The method further includes identifying one of the configuration sessions as a network upgrade session. The identification is based on a rareness of the configuration session or a skewness of the configuration session.

Abstract: A variety of benzofurans and indole derivatives some with an alkynyl linker are disclosed herein. These compounds are not highly charged at physiological pH and have good bioavailability characteristics. These compounds exhibit selective or at least preferential affinity for the active sites of various sub-sets of protein tyrosine phosphatases. Some of these compounds are excellent inhibitors of Mycobacterium protein tyrosine phosphatase B (mPTPB) a protein tyrosine phosphatase expressed in Mycobacterium tuberculosis and characterized as a virulence factor in the causal agent of tuberculosis. Accordingly, many of these compounds and pharmaceutically acceptable salts thereof are useful for the treatment of diseases such as tuberculosis.

Abstract: An article is described that includes at least one fibrous support surface coated by at least two successive layers including: an inner layer, in contact with the fibrous support, which is a coating including a silicone elastomer, polyurethane or silicone-polyurethane; and a topcoat outer layer, in contact with the inner layer, which is a coating obtained by crosslinking a composition described herein. The first layer, that is in contact with the fibrous support, is a layer based on a silicone elastomer, polyurethane or silicone-polyurethane composition that was crosslinked. The second layer, that is in contact with the first layer, is a layer obtained by crosslinking as described herein.

Abstract: The present invention is concerned with a staining dye for staining a biological cell, comprising dye molecules with a positively charged polar head group for attraction to cell membrane of the cell and for refraining the dye molecules from entering the cytoplasm, and one or more hydrophobic groups for interaction with phospholipids of the cell membrane. The dye molecules are phosphorescent transition metal polypyridine complexes having a metal center and ligands which are non-organic fluorophores.

Abstract: A system and method identify a network upgrade from a data set including a plurality of configuration sessions. The system performs the method by receiving a plurality of configuration sessions. Each of the configuration sessions comprises a plurality of configuration commands. The configuration commands are generated by a same user identifier and within a time threshold. The method further includes identifying one of the configuration sessions as a network upgrade session. The identification is based on a rareness of the configuration session or a skewness of the configuration session.

Abstract: The present invention relates to a selective hydrogenation catalyst for an unsaturated compound. The supported catalyst contains at least one Group VIB non-noble metal oxide and at least one Group VIII non-noble metal oxide deposited on a carrier; and the catalyst has an optimized acid distribution on the surface of the catalyst, and more preferably has an optimized Group VIII/VIB metal ratio and a Group VIII non-noble metal density per unit of catalyst surface area. Using the catalyst of the present invention can have the following advantages: the weight increase of light sulphides in an unsaturated compound or a mixture containing unsaturated compounds, the hydrogenation of a polyunsaturated compound, the isomerization of a monounsaturated compound, high operation flexibility and a significant improvement in the effects of a hydrogenation treatment.

Abstract: The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same.

Abstract: Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

Abstract: Systems and processes for real-time instant funding solutions for miscellaneous income are disclosed. The method of funding miscellaneous income includes securely transmitting a funding information file or a real time funding transaction request with miscellaneous funding information to a funding card processing system using real-time web services APIs which are externally accessible by an external computing system, e.g., point of sale, time and labor or payroll system. The method further includes processing the funding information file with the funding card processing system, which includes at least identifying client information and a user receiving miscellaneous income contained within the miscellaneous funding information. The method further includes funding a payroll card of the identified user with the miscellaneous income received with the miscellaneous funding information of the funding information file.

Abstract: Novel protein tyrosine phosphatase (PTP) inhibitor compounds synthesized from phosphonodifluoromethyl phenylalanine (F2Pmp) are provided. Use of these compounds for inhibiting a PTP enzyme (such as PTP-MEG2), as well as treating a disease, disorder, or condition associated with inappropriate activity of a PTP (such as type 2 diabetes), is also provided.

Abstract: Recommendation systems are widely used in Internet applications. In current recommendation systems, users only play a passive role and have limited control over the recommendation generation process. As a result, there is often considerable mismatch between the recommendations made by these systems and the actual user interests, which are fine-grained and constantly evolving. With a user-powered distributed recommendation architecture, individual users can flexibly define fine-grained communities of interest in a declarative fashion and obtain recommendations accurately tailored to their interests by aggregating opinions of users in such communities. By combining a progressive sampling technique with data perturbation methods, the recommendation system is both scalable and privacy-preserving.