Hyperpolarizable compounds and devices fabricated therefrom
Substituted compounds having relatively large molecular first order hyperpolarizabilities are provided, along with devices and materials containing them. In general, the compounds bear electron-donating and electron-withdrawing chemical substituents on a polyheterocyclic core.
Latest Trustees of the University of Pennsylvania Patents:
- COMPOSITIONS AND METHODS FOR TREATMENT OF FABRY DISEASE
- COMPOSITIONS AND METHODS FOR T CELL TARGETED DELIVERY OF THERAPEUTIC AGENTS
- Scalable purification method for AAV1
- Extracellular vesicle proteins and their use for cancer diagnosis, predicting response to therapy, and treatment
- Enhanced antigen presenting ability of RNA car T cells by co-introduction of costimulatory molecules
Claims
2. The compound of claim 1 wherein said electron-donating group is an alkyl group, an alkylamino group, an arylamino group, NH.sub.2, an alkoxyl group, OH, an alkylthio group, SH, --OC(O)-(alkyl), a cycloheptatriene, or a heterocycle.
3. The compound of claim 1 wherein said electron-withdrawing group is haloalkyl, N-(alkyl).sub.3.sup.+, S-(alkyl).sub.2.sup.+, NH.sub.3.sup.+, NO.sub.2, SO.sub.2 -(alkyl), CN, SO.sub.2 -(aryl), C(O)OH, F, Cl, Br, I, cyclopentadienyl, C(O)O-(alkyl), C(O)-(alkyl), CHO, or a heterocycle.
4. The compound of claim 1 having formula: ##STR8## wherein each R.sub.L, R.sub.T, R.sub.R, and R.sub.B is, independently, an electron-donating group or an electron-withdrawing group, provided that at least one of R.sub.L, R.sub.T, R.sub.R, and R.sub.B is an electron-donating group and at least one of R.sub.L, R.sub.T, R.sub.R, and R.sub.B is an electron-withdrawing group.
5. The compound of claim 4 wherein:
- one pair of R.sub.L and R.sub.T, R.sub.L and R.sub.B, R.sub.R and R.sub.T, or R.sub.R and R.sub.B are chemical groups that are electron-donating; and
- the other pair of R.sub.L and R.sub.T, R.sub.L and R.sub.B, R.sub.R and R.sub.T, and R.sub.R and R.sub.B is a chemical group that is electron-withdrawing.
6. The compound of claim 1 having formula (1) or (2): ##STR9## wherein: M is a metal atom;
- R.sub.P1 is --R.sub.A, --R.sub.T or aryl having 3 to about 60 carbon atoms;
- R.sub.P2 is --R.sub.A, --R.sub.R;
- R.sub.P3 is --R.sub.A, --R.sub.B or aryl having 3 to about 60 carbon atoms;
- R.sub.P4 is --R.sub.A, --R.sub.L;
- R.sub.A, is a covalent bond, cumulenyl, polyenyl, or polyynyl; and
- each R.sub.L, R.sub.T, R.sub.R, and R.sub.B is, independently, an electron-donating group or an electron-withdrawing group, provided that at least one of R.sub.L, R.sub.T, R.sub.R, and R.sub.B is an electron-donating group and at least one of R.sub.L, R.sub.T, R.sub.R, and R.sub.B is an electron-withdrawing group.
7. The compound of claim 1 having formula (3) or (4): ##STR10## wherein: M is a metal atom;
- R.sub.P1 is --R.sub.A, --R.sub.T or aryl having 3 to about 60 carbon atoms;
- R.sub.P3 is --R.sub.A, --R.sub.B or aryl having 3 to about 60 carbon atoms;
- R.sub.A, is a covalent bond, cumulenyl, polyenyl, or polyynyl;
- each R.sub.L, R.sub.T, R.sub.R, and R.sub.B is, independently, an electron-donating group or an electron-withdrawing group, provided that at least one of R.sub.L, R.sub.T, R.sub.R, and R.sub.B is an electron-donating group and at least one of R.sub.L, R.sub.T, R.sub.R, and R.sub.B is an electron-withdrawing group; and
- q is 1-5 and n is 0-50.
8. The compound of claim 7 wherein:
- one pair of R.sub.L and R.sub.T, R.sub.L and R.sub.B, R.sub.R and R.sub.T, and R.sub.R and R.sub.B are electron-donating chemical groups; and
- the other pair of R.sub.L and R.sub.T, R.sub.L and R.sub.B, R.sub.R and R.sub.T, and R.sub.R and R.sub.B is an electron-withdrawing chemical group.
9. The compound of claim 7 wherein said electron-donating group is an aromatic hydrocarbon bearing at least one electron-donating substituent or a heterocycle bearing at least one electron-donating substituent.
10. The compound of claim 9 wherein said electron-donating substituent is an alkyl group, an alkylamino group, an arylamino group, NH.sub.2, an alkoxyl group, OH, an alkylthio group, SH, or --OC(O)-(alkyl).
11. The compound of claim 7 wherein said electron-withdrawing group is an aromatic hydrocarbon bearing at least one electron-withdrawing substituent or a heterocycle bearing at least one electron-withdrawing substituent.
12. The compound of claim 11 wherein said electron-withdrawing substituent is haloalkyl, N-(alkyl).sub.3.sup.+, S-(alkyl).sub.2.sup.+, NH.sub.3.sup.+, NO.sub.2, SO.sub.2 -(alkyl), CN, SO.sub.2 -(aryl), C(O)OH, F, Cl, Br, I, C(O)O-(alkyl), C(O)-(alkyl) or CHO.
13. The compound of claim 7 wherein said electron-donating group is 4-dimethylaminophenyl or julolidinyl.
14. The compound of claim 7 wherein said electron-withdrawing group is 4-nitrophenyl, 4-cyanophenyl, N,N'-diethylthiobarbituric acid, or 3-phenyl-5-isoxazolone.
15. The compound of claim 1 having a.beta. value greater than 500.times.10.sup.-30 esu at 1906 nm or 1064 nm incident radiation.
18. A device comprising a substrate and at least one layer on said substrate, said layer including a compound according to claim 1.
19. The device of claim 18 further comprising a superstrate on said layer.
20. The device of claim 18 further comprising means for establishing an electric field across said layer.
21. The device of claim 18 further comprising sensing means for detecting light transmitted by said layer.
22. A composition comprising synthetic organic polymer and at least one compound according to claim 1.
23. The composition of claim 22 wherein said polymer is in admixture with said compound.
24. The composition of claim 22 wherein said polymer is covalently bound with said compound.
25. The composition of claim 22 wherein said polymer constitutes a major proportion of said composition and said compound constitutes a minor proportion of said composition.
26. The composition of claim 22 wherein said polymer is a polyimide, a polyacrylate, a polymethacrylate, a polyester, a polycarbonate, a polystyrene, a polyolefin, a polyvinyl ether, or a mixture thereof.
27. A process for preparing a device, comprising the steps of:
- providing a substrate; and
- placing upon said substrate at least one layer that includes a compound according to claim 1.
5171741 | December 15, 1992 | Dougherty |
5371199 | December 6, 1994 | Therien et al. |
5493017 | February 20, 1996 | Therien et al. |
5599924 | February 4, 1997 | Therien et al. |
WO 94/04614 | March 1994 | WOX |
WO 95/29916 | November 1995 | WOX |
- Boyle et al., "Iodination and Hek Alkynylation . . . " in J. Chem. Soc., Chem. Commun., p. 527, no month, 1995. Imahori et al., "Synthesis and Properties . . . " in Bull. Chem. Soc. Jpn. 67, 2500, p. 2500, Sep. 1994. Imahori et al., "Polyphytine-Quinone . . . " in Chem. Letters, pp. 1215-1218, no month, 1993. DiMagno et al., "Catalytic Conversion . . . " in J. Am. Chem. Soc. 115, p. 2513, no month, 1993. Anderson, "Meso-Alkynyl Porphyrins" in Tetrahedron Letts. vol. 33, p. 1101, no month, 1992. Blanchard-Desce and Lehn, "Chain-length dependence of the quadratic hyperpolarizability of push-pull polyenes and carotenoids. Effect of end groups and conjugation path", Chem. Phys., 1994, (no month) 181, 281-289. Burland, et al., "Second-Order Nonlinearity in Poled-Polymer Systems", Chem. Rev., (no month) 1994, 94, 31-75. Cadiot and Chodkiwicz, "Couplings of Acetylenes", Chapter 9, pp. 597-647, Marcel Dekker, 1964 (no month). Clays, et al., "Hyper-Rayleigh Scattering in Solution", Phys. Rev. Lett., (Jun.) 1991, 66, 2980-2983. Clays, et al., "Nonlinear Optical Properties of Proteins Measured by Hyper-Rayleigh Scattering in Solution", Science, (Nov.) 1993, 262, 1419-1422. Dehu, et al., "Donor-Acceptor Diphenylacetylenes: Geometric Structure, Electronic Structure, and Second-Order Nonlinear Optical Properties", J. Am. Chem. Soc., (no month) 1993, 115, 6198-6206. Dhenaut, et al., "Chiral metal complexes with large octupolar optical nonlinearities", Nature, (Mar.) 1995, 374, 339-342. DiMagno, et al., "Catalytic Conversion of Simple Haloporphyrins into Alkyl-, Pyridyl-, and Vinyl-Substituted Porphyrins", Am. Chem. Soc., (no month) 1993, 115, 2513-2515. DiMagno, et al, "Facile Synthesis of meso-Tetrakis(perfluoroalkyl) porphyrins: Spectroscopic Properties and X-ray Crystal Structure of Highly Electron-Deficient 5,10,15,20-tetrakis (heptafluoropropyl) porphyrin", J. Org. Chem., (no month) 1994, 59, 6943-6948. DiMagno, et al., "Facile Elaboration of Polphyrins via Metal-Mediated Cross-Coupling", J. Org. Chem., (no month) 1994, 59, 5983-5993. Eglinton and McCrae, "The Coupling of Acetylenic Compounds", Adv. Org. Chem., (no month) 1963, 4, 225-277. Gilmour, et al., "Synthesis of Diarylthiobarbituric Acid Chromophores with Enhanced Second-Order Optical Nonlinearities and Thermal Stability", Chem. Mater, (no month), 1994, 6, 1603-1604. Laidlaw, et al., "Large second-order optical polarizabilities in mixed-valency metal complexes", Nature, (May) 1993, 363, 58-60. Lin, et al., "Highly Conjugated, Acetylenyl Bridged Porphyrins: New Models for Light-Harvesting Antenna Systems", Science, (May) 1994, 264, 1105-1111. Marder, et al., "Large First Hyperpolarizabilities in Push-Pull Polyenes by Tuning of the Bond Length Alternation and Aromaticity", Science, (Jan.) 1994, 263, 511-514. Patai, et al., The Chemistry of Functional Groups, Supplement C, Part 1, pp. 529-534, Wiley, 1983 (no month). Pauley and Wang, "Hyper-Rayleigh scattering studies of first order hyperpolarizability of tricyanovinylthiophene derivatives in solution", J. Chem. Phys., (Apr.) 1995, 102, 6400-6405. Peng, et al., "Large Photorefractivity in an Exceptionally Thermostable Multifunctional Polyamide", J. Am. Chem. Soc., (no month) 1994, 116, 6003-6004. Rao, et al., "Dramatically Enhanced Second-order Nonlinear Optical Susceptibilities in Tricyanovinylthiophene Derivatives", J. Chem. Soc. Chem. Commun., (no month) 1993, 1118-1119. Scamporrino, "Main-Chain Porphyrin Polymers. 1. Synthesis and Characterization of Polyethers Containing Porphyrin Units and Their Metal Derivatives", Macromolecules, (Mar.) 1992, 25, 1625-1632. Sessler, et al., "A Expanded Porphyrin: The Synthesis and Structure of a New Aromatic Pentadentate Ligand", J. Am. Chem. Soc., (no month) 1988, 110, 5586-5588. Sessler, et al., "Sapphyrins and Heterosapphyrins", Tetrahedron, (no month) 1992, 48, 9661-9672. Sessler, et al., "Synthesis and Characterization of Diaryl Sapphyrins Prepared under Lindsey-Type Conditions", J. Org. Chem., (no month) 1995, 60, 5975-5978. Sessler, et al., "Synthesis and Structural Studies of Sapphyrin a 22-.pi.-Electron Pentapyrrolic Expanded Porphyrin", J. Am. Chem. Soc., (no month) 1990, 112, 2810-2813. Stiegman, et al., "The Electronic Structure and Second-Order Nonlinear Optical Properties of Donor-Acceptor Acetylenes: A Detailed Investigation of Structure-Property Relationships", J. Am. Chem. Soc., (no month) 1991, 113, 4658-7666. Terhune, et al., "Measurements of Nonlinear Light Scattering", Phys. Rev. Lett., (Apr.) 1965, 14, 6861-684. Imahori, et al., "Porphyrin-Quinone Compounds with a Spacer of Diacetylene Unit", Chemistry Leeters, (no month) 1993, 1215-1218. Suslick, et al., "Push-Pull Porphyrins as Nonlinear Optical Materials", J. Am. Chem. Soc., (no month) 1992, 114, 6928-6930. LeCours, et al., "Push-Pull Arylethynyl Porphyrins: New Chromophores That Exhibit Large Molecular First-Order Hyperpolarizabilities", J. Am. Chem. Soc., (no month) 1995, 118, Issue 3, pp. A-H.
Type: Grant
Filed: Jan 26, 1996
Date of Patent: Jul 21, 1998
Assignee: Trustees of the University of Pennsylvania (Philadelphia, PA)
Inventors: Michael J. Therien (Philadelphia, PA), Stephen G. DiMagno (Lincoln, NE)
Primary Examiner: John J. Zimmerman
Assistant Examiner: Michael LaVilla
Law Firm: Woodcock Washburn Kurtz Mackiewicz & Norris, LLP
Application Number: 8/592,049
International Classification: C07B 4700; C07D48722; H03G 100; A01N 5502;