Patents Issued in December 14, 2004
  • Patent number: 6831136
    Abstract: Improved amine-terminated polybutadienes (ATPBs) having one or two terminal amino groups, are prepared by cyanoalkylating a hydroxyl-terminated polybutadiene by Michael addition of acrylonitrile in the presence of a base, forming nitrile termination, followed by hydrogenation in the presence of a Group VIII metal as catalyst. The ATPBs may be hydrogenated or partially hydrogenated, either prior to or after the amination, to saturate or partially saturate the polymers. Polyureas, polyurethanes, crosslinked epoxies, polyamides, and other derivatives with improved properties can be prepared from the ATPBs. The resultant derivatives are useful in liquid binders for braking systems, electric potting compositions, coatings, adhesives, sealants, and water proofing membranes, for example.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: December 14, 2004
    Assignee: Sartomer Technology Company, Inc.
    Inventors: Herbert Chao, Nan Tian, Alain Drexler, John Schmidhauser
  • Patent number: 6831137
    Abstract: The invention concerns a transparent polyamide alloy, produced by compounding it from 30-98% by weight of a transparent, amorphous, rigid and brittle polyamide A with at least 35 mole % cyclo-aliphatic diamine and a glass transition point of at least 150° C., and 2-70% by weight of a transparent, impact resistant polyamide B with at least 40-80 mole % of at least one long-chain polyamide-forming monomer, with more than 10 carbon atoms and at least 10 mole % terephthalic acid and a glass transition point of under 70° C.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: December 14, 2004
    Assignee: EMS Inventa AG
    Inventors: Hans Dalla Torre, Manfred Hewel
  • Patent number: 6831138
    Abstract: The invention relates to polymer-containing catalysts (e.g., polymer-containing organo-metal catalysts) that may be useful in various applications (e.g., polymerization of macrocyclic oligoesters). Advantages of these catalysts include the improved ability to prepare, store, and handle the catalyst in open air; higher molar volume and molecular weight; and the ability to produce a blend of reactants and a catalyst (e.g., a macrocyclic oligoester and a polymerization catalyst) for subsequent one-step reaction (e.g., polymerization of macrocyclic oligoesters).
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: December 14, 2004
    Assignee: Cyclics Corporation
    Inventor: Yi-Feng Wang
  • Patent number: 6831139
    Abstract: The present invention provides a method for manufacturing an ethylene-vinyl acetate copolymer (EVA) in a polymerization solution in a vessel. The polymerization solution includes ethylene, vinyl acetate, methanol and a polymerization initiator. This method includes: cooling a gas including a vapor evaporated from the polymerization solution whereby to produce a condensate of at least a portion of said gas, and introducing said condensate into the polymerization solution whereby to evaporate at least one component in said condensate. Said vapor includes said at least one component.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: December 14, 2004
    Assignee: Kuraray Co., Ltd.
    Inventors: Takaharu Kawahara, Masato Takai
  • Patent number: 6831140
    Abstract: The invention relates to a method for evaluating the condition of a fluidized bed reactor by examining the condition of the reactor wall. Specifically, the invention relates to a method for measuring static in the reactor using a static probe that is located at the distributor plate and comprises a distributor plate cap. The invention also relates to methods of determining a static level using a radio frequency (rf). The static measurements are provided to indicate or predict major continuity disturbances in the fluidized bed gas phase reactor.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: December 14, 2004
    Assignee: Univation Technologies, LLC
    Inventors: Michael Elroy Muhle, Robert Olds Hagerty, John Francis Szul, Mark Gregory Goode, Laurence G. Britton
  • Patent number: 6831141
    Abstract: A process of using a catalyst composition to polymerize at least one monomer to produce a polymer. The process comprises contacting the catalyst composition and at least one monomer in a polymerization zone under polymerization conditions to produce the polymer. The catalyst composition is produced by a process comprising contacting at least one organometal compound, at least one treated solid oxide compound, and at least one organoaluminum compound.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: December 14, 2004
    Assignee: Phillips Petroleum Company
    Inventors: Max P. McDaniel, Elizabeth A. Benham, Shirley J. Martin, Kathy S. Collins, James L. Smith, Gil R. Hawley, Christopher E. Wittner, Michael D. Jensen
  • Patent number: 6831142
    Abstract: The invention relates to absorptive, crosslinked polymers which are based on partly neutralized, monoethylenically unsaturated monomers carrying acid groups, and have improved properties, in particular in respect of their capacity for transportation of liquids in the swollen state, and which have been after-crosslinked on their surface at temperatures of at least 150° C. with a combination of polyol as after-crosslinking compound and a cation in the form of an aqueous solution.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: December 14, 2004
    Assignee: Stockhausen GmbH & Co. KG
    Inventors: Richard Mertens, Harren Jörg
  • Patent number: 6831143
    Abstract: Catalyst systems useful for the polymerisation of 1-olefins are disclosed, which contain nitrogen-containing transition metal compounds comprising the skeletal unit depicted in Formula (B), wherein M is Fe[II], Fe[III], Ru[II], Ru[III] or Ru[IV]; X represents an atom or group covalently or ionically bonded to the transition metal M; T is the oxidation state of the transition metal M and b is the valency of the atom or group X; R1, R2, R3, R4 and R6 are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl; R5 and R7 are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: December 14, 2004
    Assignee: BP Chemicals Limited
    Inventors: George Johan Peter Britovsek, Birgit Angelika Dorer, Vernon Charles Gibson, Brian Stephen Kimberley, Gregory Adam Solan
  • Patent number: 6831144
    Abstract: In anionic polymerization using an anionic polymerization initiator, a tertiary organoaluminum compound (A) having in the molecule thereof a chemical structure represented by a general formula: Al—O—Ar wherein Ar represents an aromatic ring, and at least one Lewis base (B) selected from the group consisting of an ether compound and a tertiary polyamine compound are caused to be present in the polymerization system. In this way, the polar monomer can be polymerized with a high polymerization initiation efficiency and a high living polymerization property and at a high polymerization rate even if the used polymerization initiator is suitable for industrial use and a relatively mild cooling condition or a temperature condition near room temperature is adopted as a polymerization temperature condition.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: December 14, 2004
    Assignee: Kuraray Co., Ltd.
    Inventors: Kenichi Hamada, Kazushige Ishiura, Masaji Kato, Sachie Yaginuma
  • Patent number: 6831145
    Abstract: A silicone composition for preparing a cured silicone product, the composition prepared by mixing: (A) an organopolysiloxane containing an average of at least two epoxy-functional organic groups per molecule; (B) a curing agent in an amount sufficient to cure the composition, provided the curing agent is free of phenolic hydroxy groups; (C) an electrically conductive filler in an amount sufficient to impart electrical conductivity to the silicone product, wherein the filler comprises particles having at least an outer surface of a metal selected from silver, gold, platinum, palladium, and alloys thereof; and (D) an effective amount of a hydroxy-functional organic compound having a molecular weight up to about 1000 and containing at least one hydroxy group per molecule, provided the compound does not substantially inhibit cure of the composition. A cured silicone product and a multi-part silicone composition.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: December 14, 2004
    Assignee: Dow Corning Corporation
    Inventors: Don Lee Kleyer, Michael Andrew Lutz
  • Patent number: 6831146
    Abstract: A resin composition for wet friction materials contains as a main component a phenolic resin formed as a result of the reaction between phenols and aldehydes in the presence of a basic catalyst, and a particulate filler having a specific surface area of 35 to 410 m2/g as an additive. A wet friction material is formed using the resin composition for wet friction materials described above as a binder. The thus formed wet friction material exhibits a small initial rate of change in friction coefficient, a large positive gradient of &Dgr;&mgr;-V characteristic, and excellent durability.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: December 14, 2004
    Assignees: Sumitomo Bakelite Company Limited, NSK-Warner K.K.
    Inventors: Hiroshi Aiba, Masahiro Mori
  • Patent number: 6831147
    Abstract: The present invention provides UV-stable polycarbonates, optionally mixed with known aromatic polycarbonates, the production and use thereof, wherein the polycarbonates contain terminal groups of the formula (Ia)
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: December 14, 2004
    Assignee: Bayer AG
    Inventors: Thomas Scholl, Peter Bier
  • Patent number: 6831148
    Abstract: A photoactive polymer from the class of polyimides, polyamide acids and esters thereof comprises as a side-chain a photocrosslinkable group of the general formula (I) wherein the broken line indicates the point of linkage to the polyimide main chain and wherein: B is a straight-chain or branched alkyl residue which is optionally substituted, wherein one or more non-adjacent CH2 groups may independently be replaced by a group Q; D represents an oxygen atom or —NR1— wherein R1 represents a hydrogen atom or lower alkyl; and S3 represents a spacer unit. The polymers may be used as orientation layers for liquid crystals and in the construction of unstructured and structured optical elements and multi-layer systems.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: December 14, 2004
    Assignee: Rolic AG
    Inventors: Richard Buchecker, Guy Marck, Olivier Muller
  • Patent number: 6831149
    Abstract: The present invention is directed to a process for making an absorbable polylactone copolymer prepared in part from about 2 to about 80 mole percent glycolide, which process utilizes a combination of a monofunctional polymerization initiator and a di-functional polymerization initiator, to achieve rates of crystallization of the copolymer of at least about 2 times faster than the rate of crystallization of a copolymer made by a similar process utilizing either the mono-functional or the di-functional polymerization initiator alone. Absorbable polylactone copolymers prepared by such processes and medical devices containing such copolymers are also disclosed.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: December 14, 2004
    Assignee: Ethicon, Inc.
    Inventors: Hugh D. Newman, Jr., Sasa Andjelic, Brian M. Kelly, Dennis D. Jamiolkowski, Rao S. Bezwada
  • Patent number: 6831150
    Abstract: The invention provides a novel reductive alkylation method useful for selectively alkylating saccharide-amines of glycopeptide antibiotics.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: December 14, 2004
    Assignee: Theravance, Inc.
    Inventor: Martin S. Linsell
  • Patent number: 6831151
    Abstract: The present invention provides a signal transducer specifically expressed in mouse mast cells that has the amino acid sequence of SEQ ID No. 2, a signal transducer specifically expressed in human mast cells that has the amino acid sequence of SEQ ID No. 4, polynucleotides encoding these proteins, an expression vector involving these polynucleotides, transformed cells induced by these expression vectors, and antibodies against the foregoing proteins. The signal transducer provided in the present invention is useful for screening of novel medicines against allergic diseases.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: December 14, 2004
    Assignee: Japan Science and Technology Corporation
    Inventor: Ryo Goitsuka
  • Patent number: 6831152
    Abstract: Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are disclosed.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: December 14, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Craig Rosen
  • Patent number: 6831153
    Abstract: A mammalian 22444 gene and gene products which are predictive of a susceptibility or predisposition to various neuropsychiatric disorders are provided. Methods of predicting an individual's susceptibility to developing or having a neuropsychiatric disorder via detection of these diagnostic markers are also provided. In addition, compositions and methods for identifying compositions for use in the treatment of neuropsychiatric disorders via these genes and gene products are described.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: December 14, 2004
    Assignee: Trustees of the University of Pennsylvania
    Inventor: Wade H. Berrettini
  • Patent number: 6831154
    Abstract: Protein complexes are provided comprising MAP17 and SCAMP2. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and disorders associated with MAP17 and SCAMP2. In addition, methods for detecting the protein complexes and modulating the functions and activities of the protein complexes or interacting members thereof are also provided.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: December 14, 2004
    Assignee: Myriad Genetics, Inc.
    Inventor: Paul Bartel
  • Patent number: 6831155
    Abstract: The invention provides compositions and methods for inhibiting degradation of p53, thereby enhancing p53-mediated tumor suppressor activity.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: December 14, 2004
    Assignee: President and Fellows of Harvard College
    Inventors: Zhi-Min Yuan, JiJie Gu
  • Patent number: 6831156
    Abstract: The present invention relates to a molecular motor actin binding protein, in particular, to Nuclear Myosin I&bgr; (NMI&bgr;) containing a 16 amino acid N-terminal extension involved in transcription. More particularly, this invention is directed to a molecule with oligonucleotide sequence coding for a protein nuclear Myosin I&bgr; (NMI&bgr;) containing a 16 amino acid N-terminal extension that co-localizes with, and forms functional complexes with, RNA polymerase II. This invention is also directed to polyclonal and monoclonal antibodies to the 16 amino acid N-terminal extension that block in vitro RNA synthesis. This invention is also directed to administration to a cell of polyclonal or monoclonal antibodies to the NMI&bgr; 16 amino acid N-terminal extension sequence or to an epitope within that sequence to inhibit transcription. Other inhibitors are also suitable. This invention may be used to treat illness through targeted inhibition of cell proliferation.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: December 14, 2004
    Inventors: Primal de Lanerolle, Grzegorz Nowak, Lidija Pestic-Dragovich, Ljuba Stojilkovic, Pavel Hozak
  • Patent number: 6831157
    Abstract: Recombinantly produced serum albumin is purified in a series of steps, optionally by incubation with an anion-exchange adsorbent, followed by affinity chromatography employing a hydrophobic solid phase and using a water-soluble lipid anion as desorbens in the aqueous phase. Said immobile phase comprises a carrier coupled to a 2-mercapto or 2-hydroxy alkanoic acid.
    Type: Grant
    Filed: December 30, 2002
    Date of Patent: December 14, 2004
    Assignee: DSM IP Assets B.V.
    Inventors: Cornelis Jacobus Van Der Laken, Marcellinus Petrus Johannes Piët
  • Patent number: 6831158
    Abstract: Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a low in vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils than non-conjugated recombinant human G-CSF.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: December 14, 2004
    Assignee: Maxygen Holdings Ltd.
    Inventors: Torben Lauesgaard Nissen, Kim Vilbour Andersen, Christian Karsten Hansen, Jan Moller Mikkelsen, Hans Thalsgaard Schambye
  • Patent number: 6831159
    Abstract: Methods for recovering factor VIII/vWF-complex that involve binding factor VIII/vWF-complex from a protein solution to a cation exchanger and recovering factor VIII/vWF-complex by step-wise elution are disclosed. The recovered complex contains high-molecular vWF multimers. Compositions containing factor VIII/vWF-complex as purified by cation exchange chromatography are also provided.
    Type: Grant
    Filed: May 8, 2000
    Date of Patent: December 14, 2004
    Assignee: Baxter Aktiengesellschaft
    Inventors: Artur Mitterer, Bernhard Fischer, Öyvind L. Schönberger, Kathrin Thomas-Urban, Friedrich Dorner, Johann Eibl
  • Patent number: 6831160
    Abstract: The present invention features methods for purifying polypeptides of interest using a modified Fluorescein arsenical helix binder (FlAsH) compound immobilized on a solid support. An exemplary FlAsH target sequence motif is also presented. Examples of modification of the FlAsH compound which allow immobilization to a solid support are also provided. The present invention also provides DNA constructs for producing a dual affinity tagged polypeptide and methods for purification thereof.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: December 14, 2004
    Assignee: The Regents of the University of California
    Inventors: Ronald D. Vale, Kurt Thorn, Roger Cooke, Marija Matsuka, Nariman Naber
  • Patent number: 6831161
    Abstract: Methods of affinity separation wherein the affinity ligand is an immobilized proteinaceous ligand wherein one or more of its asparagine (Asn) residues has been modified. Methods of making a stabilized combinatorial protein by a) modification of Asn residues within a protein molecule to increase stability of the protein in alkaline conditions, and b) randomization of a protein molecule to modify its binding characteristics, and combinatorial proteins wherein in a step separate from the randomization step, the stability of the protein in alkaline conditions has been increased by modifying one or more of its Asn residues.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: December 14, 2004
    Assignee: Affibody AB
    Inventors: Mathias Uhlén, Sophia Hober
  • Patent number: 6831162
    Abstract: The invention relates to a novel and highly effective hypoglycemic protein called polypeptide-k, extracted from Momordica charantia, provides a method for the extraction of said polypeptide-k from Momordica charantiaand provides novel hypoglycemic compositions employing the said extract, and useful in the treatment of diabetes mellitus.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: December 14, 2004
    Inventor: Pushpa Khanna
  • Patent number: 6831163
    Abstract: Disclosed is a molecule containing a first chromophore that exhibits a first absorption maximum above 700 nm and a second chromophore that exhibits a second absorption maximum different from the first absorption maximum, wherein the absorption of the first and second chromophores are substantially independent of each other. The molecule exhibits improved stability.
    Type: Grant
    Filed: December 26, 2002
    Date of Patent: December 14, 2004
    Assignee: Eastman Kodak Company
    Inventors: Ruizheng Wang, Ann L. Carroll-Lee, Kevin W. Williams, Linda A. Kaszczuk, Charles H. Weidner
  • Patent number: 6831164
    Abstract: The invention relates to a process for the production of peracylated 1-O-glycosides of general formula I or salts thereof in which sugar1 is a monosaccharide that is functionalized in 1-OH-position, R represents methyl, ethyl, propyl, isopropyl, tbutyl, phenyl, n means 2, 3 or 4, X means —COO— or —NH—and L means a straight-chain, branched, saturated or unsaturated C1-C30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of peracylated saccharides with 1-O-functionalized side chains on an enlarged scale.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: December 14, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Klaus-Dieter Graske, Ulrich Niedballa
  • Patent number: 6831165
    Abstract: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: December 14, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Burkhard Kröger, Hartwig Schröder, Oskar Zelder, Gregor Haberhauer
  • Patent number: 6831166
    Abstract: Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, a lipid soluble vitamin, an RNA cleaving complex, a metal chelator, a porphyrin, an alkylator, a pyrene, a hybrid photonuclease/intercalator, or an aryl azide photo-crosslinking agent exhibit increased cellular uptake and other properties. The substituent can be attached at the 2′-position of the functionalized nucleoside via a linking group.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: December 14, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Phillip Dan Cook, Clarence Frank Bennett
  • Patent number: 6831167
    Abstract: Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: December 14, 2004
    Assignee: Aventis Behring GmbH
    Inventors: Juergen Roemisch, Hans-Arnold Stoehr, Annette Feussner, Wiegand Lang, Thomas Weimer, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann
  • Patent number: 6831168
    Abstract: There is provided an aldehyde oxidase gene which is a 4.4 kbp gene obtainable from a plant and which encodes an amino acid sequence of an enzyme capable of oxidizing an aldehyde compound to a carboxylic acid and utilization thereof.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: December 14, 2004
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Tomokazu Koshiba
  • Patent number: 6831169
    Abstract: Nucleic acid molecule that comprise an incomplete hepatitis C viral genome are provided. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein operably linked to regulatory elements functional in human cells are provided. Methods of immunizing individuals susceptible to or infected by hepatitis C virus comprising the step of administering such pharmaceutical compositions are provided.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: December 14, 2004
    Assignee: The General Hospital Corporation
    Inventors: Catherine J. Pachuk, Jack Wands, Takaji Wakita, Vincent R. Zurawski, Jr., Leslie R. Coney
  • Patent number: 6831170
    Abstract: A novel gene designated as FRAG1 from and its encoded protein is disclosed. A fusion protein called FGFR2-ROS, which is formed by chromosomal rearrangement of rat FRAG1 with FGFR2 is also disclosed. Methods of producing FRAG1 protein, related fusion proteins, and antibodies against FRAG1 are disclosed, as are related pharmaceuticals and methods of using such nucleic acids, polypeptides, and antibodies are also disclosed.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: December 14, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Matthew V. Lorenzi, Toru Miki
  • Patent number: 6831171
    Abstract: The present invention relates to novel Nucleic acid catalysts, methods of synthesis, and uses thereof.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: December 14, 2004
    Assignees: Yale University, Sirna Therapeutics, Inc.
    Inventors: Ronald Breaker, Leonid Beigelman
  • Patent number: 6831172
    Abstract: Cross-linked hyaluronic acids produced by the reaction of the carboxylic acid groups of hyaluronic acid and a polyamine and the sulfated and hemisuccinylated derivates thereof. The cross-linked hyaluronic acids are useful for various pharmaceutical and medical purposes.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: December 14, 2004
    Assignee: Farmila-Thea Farmaceutici S.p.A.
    Inventors: Rolando Barbucci, Roberto Rappuoli
  • Patent number: 6831173
    Abstract: A process for producing aldehydes, and/or carboxylic acids is described, in which a primary alcohol, especially a carbohydrate, is oxidized using a catalytic amount of a nitrosonium compound obtained by oxidizing a nitroxyl compound in the presence of an enzyme compound capable of oxidation. Further described are oxidized carbohydrates containing at least 1 cyclic monosaccharide chain group carrying a carbaldehyde group per 25 monosaccharide units and per molecule.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: December 14, 2004
    Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
    Inventors: Jan Matthijs Jetten, Ronald Tako Marinus Van Den Dool, Wim Van Hartingsveldt, Mario Tarcisius Raymundus Van Wandelen
  • Patent number: 6831174
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: December 14, 2004
    Assignee: Shire BioChem Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Patent number: 6831175
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: December 14, 2004
    Assignee: Abbott Laboratories
    Inventors: Qun Li, Keith W. Woods, Gui-Dong Zhu, John P. Fischer, Jianchun Gong, Tongmei Li, Virajkumar Gandhi, Sheela A. Thomas, Garrick K. Packard, Xiaohong Song, Jason N. Abrams, Robert B. Diebold, Jürgen Dinges, Charles W. Hutchins, Vincent S. Stoll, Saul H. Rosenberg, Vincent L. Giranda
  • Patent number: 6831176
    Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: December 14, 2004
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Gabriela Pistia-Brueggeman
  • Patent number: 6831177
    Abstract: Industrial and commercial processes for the preparation of 2-acyl-5-benzylfuran derivatives, 1,2,4-triazole-3-carboxylic acid ester derivatives or propenone derivatives having an anti-HIV activity; and useful crystals of the derivatives. A deblocking: (III-2), (IV-10), (VI-1), wherein R1, R2 and R4 are each independently hydrogen or the like; A is CR6 or N; R6 is hydrogen or the like; Q is a protecting group; and L is a leaving group.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: December 14, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Masaaki Uenaka, Kyozo Kawata, Masahiko Nagai, Takeshi Endoh
  • Patent number: 6831178
    Abstract: A process for the preparation of a compound of the formula (I′): which comprises reacting in a solvent a compound of the formula (III): wherein X is halogen, with p-tolylacetylene, a copper (I) salt, a catalyst, and a base, and then treating the resulting reaction mixture with an acid.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: December 14, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshiro Konoike, Akira Okuyama, Yoshiyuki Masui, Teruo Sakata
  • Patent number: 6831179
    Abstract: A process for the stereoselective preparation of insecticide 6,7,8,9,10,10-hexahalo-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide of the general formula I: wherein X is a halogen such as fluorine, chlorine or bromine. The process comprises reacting 1,4,5,6,7,7-hexahalo-5-norbornene-2,3-dimethanol of the general formula IV: wherein X is as defined above, with a cyclic sulfite ring forming reagent optionally in an inert organic solvent at ambient to 139° C., wherein the reaction is carried out in the presence of a stereo isomer directing agent comprising an isomer of the compound of the formula I different from the desired isomer. The molar ratio of the stereoisomer directing agent to the dimethanol compound of the formula IV is at least 0.07.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: December 14, 2004
    Assignee: Excel Industries Limited
    Inventors: Ashwin Champraj Shroff, Abhijit Premvallabh Purohit, Sanjay Dhirajlal Vadodaria
  • Patent number: 6831180
    Abstract: The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloids used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: December 14, 2004
    Assignee: Stragen Pharma SA.
    Inventors: Jean-Pierre Robin, Julie Blanchard, Sylvie Cavoleau, Ludovic Chauviat, Sandra Charbonnel, Robert Dhal, Gilles Dujardin, Florence Fournier, Chrystelle Gilet, Laurent Girodier, Laurence Mevelec, Sandrine Poutot, Sylvie Rouaud
  • Patent number: 6831181
    Abstract: A process for recycling reaction byproducts in the manufacture of dianhydro sugar alcohols, such as isosorbide, from corresponding sugar alcohols.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: December 14, 2004
    Assignee: E. I. Dupont de Nemours and Co.
    Inventor: Kamlesh Kumar Bhatia
  • Patent number: 6831182
    Abstract: The present invention relates to a process for the gas-phase hydrogenation of C4-dicarboxylic acids and/or their derivatives over a catalyst based on copper oxide to give substituted or unsubstituted &ggr;-butyrolactone and/or tetrahydrofuran, which comprises, which a first reaction zone in which the C4-dicarboxylic acid and/or its derivatives is/are reacted to give a mixture comprising a substituted or unsubstituted &ggr;-butyrolactone as main product and a subsequent second reaction zone in which the substituted or unsubstituted &ggr;-butyrolactone present in the mixture from the first hydrogenation step is reacted at a temperature lower than the temperature in the first hydrogenation step to give substituted or unsubstituted tetrahydrofuran.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: December 14, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Holger Borchert, Stephan Schlitter, Rolf-Hartmuth Fischer, Markus Rösch, Frank Stein, Ralf-Thomas Rahn, Alexander Weck, Gerd Kaibel
  • Patent number: 6831183
    Abstract: The present invention provides crystals of the compound represented by formula (I): ;crystals of a vitamin D derivative which are obtained by purifying a crude or preliminarily purified product of the vitamin D derivative through a reverse phase chromatography and then crystallizing the purified derivative from an organic solvent; novel compounds which are formed during the synthesis of a vitamin D derivative as by-product; and a method for purifying a vitamin D derivative or the precursor thereof. The method of the present invention makes it possible to supply a highly purified vitamin D derivative, especially ED-71, in bulk and steadily.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: December 14, 2004
    Assignee: Chugai Seiy aku Kabushiki Kaisha
    Inventor: Tsuyoshi Yamauchi
  • Patent number: 6831184
    Abstract: The present invention relates to a process for the skeletal isomerization of unsaturated linear fatty acids to branched fatty acids which comprises contacting said unsaturated linear fatty acids with at least one large pore zeolite catalyst wherein said at least one zeolite catalyst comprises a material having a three dimensional channel structure having a pore diameter of at least 6.0 Å. In another embodiment, the invention relates to a process for the skeletal isomerization and hydrogenation of unsaturated linear fatty acids to saturated branched fatty acids which comprises contacting said unsaturated linear fatty acids with at least one metal-zeolite catalyst.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: December 14, 2004
    Assignee: Akzo Nobel N.V.
    Inventors: Shuguang Zhang, Zongchao Zhang, Dale Steichen
  • Patent number: 6831185
    Abstract: Oil and fat compositions containing at least 0.01% by mass of one or more polyglycerol fatty acid esters having an average degree of polymerization of 6 to 30 and an average degree of substitution of 4 to 32 have an antifoaming effect and they are usable as general-purpose oil and fat compositions having controlled foaming properties in the course of the frying, good cooking properties and a long deep-frying life.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: December 14, 2004
    Assignee: The Nisshin Oillio, Ltd.
    Inventors: Junichi Ikuina, Shin Arimoto