Abstract: The present invention relates to 1,4-dihydro-4-oxo-1,8-napthpyridine analogs of the formula and pharmaceutically acceptable salts, esters, and prodrugs thereof, wherein A, X, W and Y are substituents. The present invention relates to methods for using such compounds.

Abstract: Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R1–R8 for compounds of each of the formulae IA, IB, IC, ID, IE and IF are as described herein. Said compounds are particularly useful in the treatment of various neurological and psychiatric disorders, e.g., ADHD.

Abstract: According to the first aspect of the invention, a composition for reversing malarial resistance to quinolines is disclosed. The composition includes a surfactant, such as nonylphenolethoxylate (NPE) in an admixture with a pharmaceutically acceptable carrier, excipient, or diluent. According to a second aspect of the invention, a composition for the prevention or treatment of malaria is provided. The composition comprises a pharmaceutically effective amount of a quinoline in combination with a surfactant, such as NPE, for reversing malarial resistance to quinolines. According to a third aspect of the invention, a method of preventing or treating malaria in a person is provided. The method comprises administering to a patient in need thereof one or both of the compositions described above.

Abstract: N-Biarylmethylaminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

Abstract: The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR7, —X1-A1-COOR7 (R7 is H, alkyl) or tetrazolyl; R1, R2, R3 and R4 are H and the like; A is —(CH2)m—X— (X is —N(R8)—, —C(R9)(R10)—, —CO— or —CO—N(R8)—); B is aryl or aromatic heterocyclic group; R5 is H and the like; R6 is —(Y)s1-(A2)s-Z (Y is —O—, —S(O)t—, —N(R13)—, —N(R14)—CO—, —N(R14)—SO2—, —SO2—N(R14)— and the like, A2 is alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.

Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Abstract: The present invention relates generally to substituted naphthyl benzothiophene acids and methods of using them.

Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)–(VI) as recited throughout the application.

Abstract: This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fullerene core; (ii) from 1 to 18 —X3 groups bonded to the fullerene core; (iii) from 1 to 6 —X4— groups bonded to the fullerene core; or (iv) from 1 to 6 dendrons bonded to the fullerene core.

Abstract: The invention provides compounds of the formula: wherein (a) is a single or double bond; W is CH, CH2, CHCH3, CCH3, C(CH3)2, C(CH2)2 or C(CH2)3, provided that when (a) is a double bond, then W is CH or CCH3, and when (a) is a single bond, then W is CH2, CHCH3, C(CH3)2, C(CH2)2 or C(CH2)3; X is CH or N; and Y is H or F, and salts, hydrates, tautomers, pure enantiomers, and enantiomeric mixtures; and a method of treating schizophrenia comprising administering same.

Abstract: The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent.

Abstract: The invention relates to ophthalmological compositions for topical treatment of glaucoma or ocular hypertension comprising an effective intraocular pressure reducing amount of a prostaglandin derivative of PGA, PGB, PGD, PGE or PGF, in which the omega chain contains a ring structure, in an ophthalmologically compatible carrier. The invention further relates to the preparation of said compositions and their use for treatment of glaucoma or ocular hypertension.

Abstract: The invention relates to methods of treating and preventing disorders associated with elevated TNF-? and/or IL-1? by administering therapeutic amounts of stearidonic acid. Further provided are methods for down-regulating TNF-? and/or IL-1? and assays for determining the presence, absence, or quantity of TNF-? and/or IL-1? in a subject in conjunction with a regimen of stearidonic acid administration.

Abstract: The present invention provides a composition for preventing or treating diseases accompanied by a decrease in bone weight, hypertension and diseases resulting from hypertension, the composition containing, as an active component, at least one member selected from the a compound represented by formula (I) wherein A and B are the same or different and are independently selected from the group consisting of halogen, amino, amidino, anilinoamide, mercapto, sulfonic acid, phosphate, carboxy, hydroxy C1–C5 alkyl, sugar residue, —OR1, and —OCOR2; wherein R1 is selected from the group consisting of hydrogen, C1–C5 alkyl, hydroxy C1–C5 alkyl, and C2–C5 alkenyl; and R2 is selected from the group consisting of C1–C5 alkyl, hydroxy C1–C5 alkyl, and C2–C5 alkenyl; n is number of substituents A present and is a number from 0 to 5; and m is number of substituents B present and is a number from 0 to 5.

Abstract: A more controllable acoustic ceiling patch or textured material in the form of a sprayable composition includes a base, a filler, an adhesive binder, an anti-foaming agent, a suspension agent, and rubber particulates or polyethylene particulates forming an aggregate suitable for spraying in the presence of volatile organic compound (VOC) propellants without melting or deterioration. The more controllable acoustic ceiling patch is storable and dispensable from a pressurized dispenser having a delivery nozzle. An aerosol system with a spray nozzle is included on the container for selective discharge of the textured material onto a prepared patch area, which may be on a drywall or support panel so as to match and blend with the surrounding acoustic ceiling surface area in order to provide a continuous and unbroken coextensive surface texture of mechanically and visually matched material.

Abstract: This invention is generally related to the field of Fischer-Tropsch catalysts. In particular, the present invention is related to a Fischer-Tropsch catalyst and method of making same. More particularly, the present invention discloses a catalyst comprising a support and at least one catalytically active metal wherein the support comprises a transition alumina including theta-alumina, delta-alumina, or combinations thereof, and a surface coverage comprising at least one rare-earth oxide.

Abstract: This invention presents an ion exchange media including a plurality of cation exchange zones and anion exchange zones in flow paths that are contained in a substantially nonporous resin transport framework. During electrodeionization and other potential applications the ion exchange media of the invention prevents unfavorable water splitting at resin-membrane interfaces and encourages water splitting at resin—resin interfaces where the water splitting may be constructively used to regenerate the resin.

Abstract: This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant. The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability. Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.

Abstract: The invention relates to a superabsorbent polymer wherein an increased rate of water absorption is obtained by the addition of an encapsulated blowing agent. The invention relates to a superabsorbent polymer including an encapsulating blowing agent and having a vortex time of 40 seconds or less. In particular, the superabsorbent polymer includes from about 55 to about 99.9 wt. % of polymerizable unsaturated acid group containing monomers; from about 0.001 to about 5.0 wt. % of internal crosslinking agent; wherein the wherein the composition has a degree of neutralization of more than about 20%; and from about 0.05 to about 10.0 wt. % of an encapsulated blowing agent.

Abstract: A method of increasing the gas transmission rate of a packaging film comprises providing a packaging film that comprises at least about 0.001 weight % of single-walled carbon nanotube material based on the weight of the film. The packaging film is exposed to an amount of radiation energy effective to increase the oxygen transmission rate of the packaging film by at least about 100 cc (STP)/m2. day (1 atm, 0% RH, 23° C.).

Abstract: UV curable adhesives are provided that comprise epoxidized monohydroxylated polydiene polymers, hydrogenated hydroxylated polydiene polymers, and selectively hydrogenated starblock copolymers. The adhesive formulations provide both excellent room temperature properties of tack and peel and excellent holding power at temperatures as high as 95° C.

Abstract: The present invention is directed to an aqueous superabsorbent polymer paste comprising from about 1 to about 5 wt % of superabsorbent particles and from about 95 to about 99 wt % of an aqueous water-soluble solution having from about 0.5 to about 5%, preferably from about 1 to about 3% solid level. The present invention is also directed to a coated substrate comprising a substrate material and an aqueous superabsorbent polymer paste comprising a blend of i) from about 1 to about 5 wt % of superabsorbent particles and ii) from about 95 to about 99 wt % of an aqueous water-soluble solution. The present invention is also directed to a method for reducing the loss of circulation fluids into flow passages of a subterranean formation during well drilling, completion or work over operations, by using the aqueous superabsorbent polymer paste of the present invention.

Abstract: Actinic ray curable inks is disclosed. The ink contains at least one kind of epoxidized fatty acid ester or epoxidized fatty acid glyceride, as well as by further containing an oxetane compound, a cation polymerization initiator and a colorant.

Abstract: Disclosed are methods for anchoring materials in or to concrete. The methods preferably comprise delivering to the concrete or masonry, the material to be anchored to the concrete or masonry or both an anchor composition comprising alkylacrylate ester monomer and a copolymer of alkylacrylate ester and methacrylic acid monomers, and free-radical catalyst.

Abstract: The present invention provide methods for producing a low moisture organophyllosilicate composition using monomers, oligomers, or polymers to displace water associated with the organophyllosilicates in an aqueous organophyllosilicate slurry or filter cake. The invention additionally provides methods for producing organophyllosilicate nanocomposites from the concentrated organophyllosilicate compositions by dispersing the compositions in a polymer matrix.

Abstract: A molding composition or encapsulant for an electronic component and its method of preparation provides reduced moisture uptake without undue swelling and comprises melt-blending an epoxy resin, hardener and clay, cooling, adding a catalyst to form an epoxy-clay nano-composite, and combining it with a bulk amount of a filler.

Abstract: Lignocellulosic-based woodfiber-plastic composite products containing a pesticidal amount of calcium borate is resistant to attack by wood destroying fungi and insects. The preferred calcium borates are the calcium polytriborates having a CaO:B2O3 molar ratio of about 2:3 and calcium hexaborates, having a CaO:B2O3 ratio of 1:3. Composites can be produced by combining the calcium borate with particles of the lignocellulosic material and the thermoplastic resin binder, and heating and extruding the resultant mixture through a die to form the composite product.

Abstract: The invention relates to a tire having at least one component (e.g. tread) of a rubber composition comprised of a composite of styrene/butadiene elastomer and functionalized styrene/butadiene elastomer containing an internal silanol and/or siloxy group therein with pendent silanol and/or alkoxy groups of a polymodal (e.g. bimodal) molecular weight distribution and a dispersion therein of silica aggregates of which a portion thereof contain a plurality of hydroxyl groups on their surface in a form of geminal hydroxyl groups. In one aspect, said silica aggregates may be pre-treated to reduce said hydroxyl groups on their surface prior to blending with said silanol and/or siloxy functionalized elastomer.

Abstract: The addition of pulverulent monosaccharides, disaccharides or oligosaccharides to plastisols based on pulverulent organic polymers and plasticizers results in plastisols with good adhesion properties on a large number of substrates employed in automobile construction. These plastisols are distinguished by good adhesion properties and a high resistance to ageing, and can be employed in automobile construction both in shell construction and in the lacquering line and in the trim shop for adhesive, sealing and coating tasks.

Abstract: Methods to decrease aldehyde content of a polymer are provided. An effective amount of an additive that contains a P—H functionality is incorporated into the polymer in the presence of an acidic of basic catalyst compositions are also provided.

Abstract: A waterborne coating composition comprising fine polymer particles dispersed in an aqueous medium and an inorganic filler, wherein the fine polymer particles comprise (A) 50 to 90% by weight of synthetic rubber polymer particles containing 50 to 90% by weight of a repeating unit derived from a conjugated diolefin monomer and having a glass transition temperature of ?20° C. or lower and (B) 10 to 50% by weight of acrylic polymer particles containing 50% by weight or more of a repeating unit derived from an acrylic ester and/or a methacrylic ester and having a glass transition temperature of 0° C. or lower.

Abstract: A water based intercoat coating composition containing (A) a polyester resin comprising, as essential components, an alicyclic polybasic acid (a1) and/or an alicyclic polyhydric alcohol (a2), other polybasic acid (a3) and other polyhydric alcohol (a4), (B) a crosslinking agent, and (C) a water based urethane resin emulsion.

Abstract: It is an object of the present invention to provide a resin composition which has a low hardness, is favorable in high loss properties (vibration absorbing properties) and gas permeation resistance, is excellent in injection moldability, thereby enabling itself to be injection molded with stable dimensional accuracy, and which is particularly suitable for constituting an elastic member for an ink jet printer, an insulator for a recording medium drive, a gasket for an HDD and an impact absorbing material for an HDD. The above object has been achieved with a resin composition which comprises 100 parts by weight of a thermoplastic elastomer containing an isobutylenic block copolymer composed of isobutylenic polymer blocks and aromatic vinylic polymer blocks, and 1 to 50 parts by weight of a polyolefin resin.

Abstract: An object of the present invention is to easily provide an aqueous paint composition which is excellent in the low-temperature curability and can give a coated film that, while retaining a suitable texturability, further combines the water resistance, the marring resistance and the beef tallow staining resistance with good balance. In addition, another object of the present invention is to provide a coated article which is coated with this aqueous paint composition.

Abstract: There is provided a method of forming a fine pattern by using a practicable fluorine-containing polymer which has a high transparency to exposure light having a short wavelength such as F2 laser and can undergo resolution of a fine pattern.

Abstract: An olefin thermoplastic elastomer sheet which has the same or similar rubber elasticity, flexibility and molding and processability as those of the conventional olefin thermoplastic elastomer sheets, and is good in mechanical properties and excellent in mar resistance in particular, and a production process thereof, and a laminate having a surface layer composed of this sheet. The olefin thermoplastic elastomer sheet according to the present invention is composed of an elastomer material comprising an olefin random copolymer formed by copolymerizing ethylene, an ?-olefin having 3 to 10 carbon atoms and an unsaturated monomer having a functional group, and optionally a non-conjugated diene, and metal ions crosslinking the olefin random copolymer.

Abstract: The invention provides curable waterborne coating compositions comprising an aqueous dispersion (A) comprising an organic binder component (A1) comprising at least 5% by weight of a reactive component (a), based on the total weight of organic binder component (A1), and at least one crosslinking component (B). The reactive component (a) is substantially free of any heteratoms and is a not a crystalline solid at room temperature and comprises from (i) 12 to 72 carbon atoms, and (ii) at least two functional groups. The curable waterborne coating compositions of the invention show significantly improved pop resistance while also providing improved chip resistance, weathering resistance, flexibility, and/or scratch & mar resistance.

Abstract: The present invention relates to stable polymer systems comprising anionic and modified polyamine polymers. When such polymer systems are employed in cleaning compositions, such cleaning compositions exhibit unexpectedly improved anti-soil re-deposition and situs whitening capabilities.

Abstract: Novel siloxane copolymers have a structure as shown below. They can be applied and heat treated at relatively low temperatures into cured resin coatings which have satisfactory solvent resistance, durability, and good adhesion and bond to metal substrates such as copper even under humid conditions.

Abstract: The present invention relates to molding compositions comprising A) from 39 to 99% by weight of at least one polyarylene ether sulfone built up from bifunctional monomer units, B) from 1 to 20% by weight of at least one polyarylene ether sulfone containing, based on the total weight of component B, from 0.1 to 10% by weight of units which derive from 1,1,1-tris(4-hydroxyphenyl)ethane, C) from 0 to 60% by weight of at least one filler, D) from 0 to 40% by weight of at least one impact-modifying rubber, and E) from 0 to 40% by weight of one or more various additives, where the percentages by weight of components A to E give 100% in total, and also to a process for preparing these molding compositions, to their use, and to moldings, films, fibers, or foams obtainable from these molding compositions.

Abstract: Disclosed is an aromatic sulfonic acid ester derivative represented by the formula (1); in the formula, X is an atom or a group selected from a halogen atom excluding fluorine, —OSO3CH3 and —OSO3CF3, A is a divalent electron attractive group, B is a divalent electron donating group or a direct bonding, Ra is a hydrocarbon group of 1 to 20 carbon atoms, Ar is an aromatic group having a substituent of —SO3Rb (wherein Rb is a hydrocarbon group of 1 to 20 carbon atoms), m is an integer of 0 to 10, n is an integer of 0 to 10 and k is an integer of 1 to 4. Also disclosed is a process for producing a polyarylene having a sulfonic acid group, which process comprises the steps of coupling polymerization of an aromatic compound containing the derivative of the formula (1), to prepare a polyarylene and hydrolysis of the polyarylene, and which process has high safety and is easily capable of controlling the amount of sulfonoc acid group introduced into a polymer and the introducing position thereof.

Abstract: This invention relates to processes and plants for continuous solution polymerization. Such plan and process include a pressure source, a polymerization reactor, downstream of said pressure source, pressure let-down device, downstream of said polymerization reactor, and a separator, downstream of said pressure let-down device, wherein said pressure source is sufficient to provide pressure to said reaction mixture during operation of said process plant to produce a single-phase liquid reaction mixture in said reactor and a two-phase liquid-liquid reaction mixture in said separator in the absence of an additional pressure source between said reactor and said separator.

Abstract: A complex of transition metal Ti, Fe, Co, Ni, Cr, Mn, Ta, Rh, Y, Sc, Ru, Pd, Zr, Hf, V or Nb and a mono-, bi-, tri-, or tetra-dentate ligand, wherein at least one of the donor atoms of the ligand is a nitrogen atom N with a 5-membered heterocyclic substituent joined to the N by a carbon atom. The complex is preferably formula (I) wherein R5—N-G-X1 is a bi-, tri, or tetra-dentate ligand, N is joined to G by an imine linkage; G is a bridging group which can contain a third or fourth donor atom; X1 is —O or —S if the X1-M bond is covalent, or if the X1-M bond is dative X1 is ?S, —PR7R8, —PR8R9, ?NR7, ?NR8, —NR7R8 or —NR8R9; R5 and R7 are 5-membered heterocyclic substituents joined to the nitrogen (or phosphorus) atoms via a carbon atom: R8 and R9 are hydrocarbyl or heterohydrocarbyl, substituted hydrocarbyl or aryl substituent; X represents an atom or group covalently or ionically bonded to the transition metal M; L is a group datively bound to M, and n is from 0 to 5; q is 1 or 2.

Abstract: A catalyst composition and method for olefin polymerization are provided. In one aspect, the catalyst composition is represented by the formula ?a?b?gMXn wherein M is a metal; X is a halogenated aryloxy group; ? and ? are groups that each comprise at least one Group 14 to Group 16 atom; ? is a linking moiety that forms a chemical bond to each of ? and ?; and a, b, g, and n are each integers from 1 to 4.

Abstract: A process for producing a copolymer which comprises reacting a vinyl monomer with a macromonomer composition containing a macromonomer. The macromonomer composition is obtained by polymerizing at a temperature of 160 to 350° C. a monomer mixture comprising 10 to 80 wt. % first vinyl monomer having an alkyl group in the ?-position, 0 to 30 wt. % styrene as an optional ingredient, and 0 to 90 wt. % one or more other vinyl monomers based on the total amount of all monomers.

Abstract: This invention relates to olefin polymers particularly suited to satisfying the dielectric properties required in electrical device use. The olefin polymers can be prepared by contacting polymerizable olefin monomers with catalyst complexes of Group 3–11 metal cations and noncoordinating or weakly coordinating anion compounds bound directly to the surfaces of finely divided substrate particles or to polymer chains capable of effective suspension or solvation in polymerization solvents or diluents under solution polymerization conditions. Thus, the invention includes polyolefin products prepared by the invention processes, particularly ethylene-containing copolymers, having insignificant levels of mobile, negatively charged particles as detectable by Time of Flight SIMS.

Abstract: Golf ball compositions, and components formed therefrom, including trifunctional materials, such as trifunctional isocyanates, polyols, and amines, that have improved performance and durability characteristics, e.g., improved heat resistance, improved resiliency, and dimensional stability.

Abstract: The invention concerns a polyisocyanate composition having high functionality, obtained by polycondensation of diisocyanate or triisocyanate monomers, comprising: (a) 0.5 to 30 wt % of compounds bearing a single uretidinedione function; (b) 0.5 to 45 wt. % of compounds bearing a single isocyanurate function; (c) at least 40 wt. % of a mixture of polyisocyanate compounds having a molecular weight not less than three times the average molecular weight of the isocyanate monomers having the smallest molecular weight and bearing at least two isocyanate functions, said mixture having a ratio of carbonyl functions belonging to a uretidinedione cycle/carbonyl functions belonging to an isocyanate cycle+carbonyl functions belonging to a uretidinedione cycle not less than 4%; (d) 0 to 25 wt. % of compounds bearing at least an isocyanate function other than (a), (b) and (c); and (e) 0 to 10% of impurities.

Abstract: Polyamides useful as hotmelt adhesives and having improved resistance to hydrocarbons such as gasoline are obtained by reacting a) an acid component containing at least one C6 to C22 aliphatic dicarboxylic acid and b) an amine component containing at least one straight chain alkylene diamine having from 2 to 8 carbon atoms and at least one heterocyclic secondary diamine. The amine component may optionally also contain at least one branched chain alkylene diamine having from 3 to 10 carbon atoms and/or at least one C24 to C48 dimer amine.

Abstract: The present invention relates to a polyether derivative represented by the following general formula (I): wherein X1 represents —CO— or —SO2—; Ar1 represents unsubstituted arylene, or arylene substituted with a halogen atom, or an alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl aryloxycarbonyl or cyano group; L represents alkylene; m is 1 or 2; A represents —X2—Ar2—(NH2)1, a hydrogen atom, or an alkyl, aryl or acyl group, wherein X2, Ar2 and l have the same meanings as the above-mentioned X1, Ar1 and m, respectively; and n is the average addition mole number of the polyether group, and is a numerical value of 10 to 500.