Abstract: The present invention relates to a composition containing ATRP polymers and dispersible inorganic or organic pigment particles. The pigment composition is useful for preparing coating compositions, prints, images, inks or lacquers and other disperse systems.

Abstract: A process for preparing copolymer dispersions that includes subjecting A) one or more vinyl monomer mixtures containing a) OH-free (meth)acrylic esters and/or vinylaromatics, b) hydroxy-functional vinyl monomers and/or hydroxy-functional (meth)acrylic esters, c) ionic and/or potentially ionic monomers capable of free-radical copolymerization, and d)optionally further monomers, other than the compounds of components a)–c), capable of free-radical copolymerization; to free-radical polymerization in the presence of e) compounds according to formula (I) where R1 is an aliphatic, araliphatic or aromatic radical having 1 to 18 carbon atoms, R2 is H or CH3, R3, R4 are identical or different aliphatc radicals having 1 to 7 carbon atoms and n is 1 to 4; and subsequently dispersing the resultant copolymer B) before or after addition of a neutralizing agent C) in water. The resulting dispersions can be used to coat substrates.

Abstract: A curable aqueous composition including (a) a polyacid including at least two carboxylic acid groups, anhydride groups, or salts thereof; (b) a polyol including at least two hydroxyl groups; and (c) an emulsion polymer including, as copolymerized units, greater than 30% by weight, based on the weight of the emulsion polymer solids, ethylenically unsaturated acrylic monomer including a C5 or greater alkyl group; wherein the ratio of the number of equivalents of the carboxylic acid groups, anhydride groups, or salts thereof to the number of equivalents of the hydroxyl groups is from 1/0.01 to 1/3, and wherein the carboxylic acid groups, anhydride groups, or salts thereof are neutralized to an extent of less than 35% with a fixed base is provided. Also provided is a method for treating heat-resistant fibers or a heat-resistant nonwoven formed therefrom with the curable aqueous composition and the article prepared thereby.

Abstract: Disclosed are adhesives and processes for preparing the same, comprising at least one first homogeneous ethylene/?-olefin interpolymer, and optionally at least one tackifier, and optionally at least one plasticizer. The claimed adhesives are useful as adhesives such as are employed in various applications, such as in masking tape, clear office tape, labels, decals, bandages, decorative and protective sheets (such as shelf and drawer liners), floor tiles, sanitary napkin/incontinence device placement strips, sun control films, the joining of gaskets to automobile windows, packaging, bookbinding, construction of nonwoven articles, and insulation bonding.

Abstract: A stabilizer composition is described and comprises a 2-cyano-3,3-diarylacrylate, a sterically hindered monomeric amine, a sterically hindered phenol and, where appropriate, a chromane derivative and/or an organic phosphite and/or phosphonite. The stabilizer composition is particularly suitable for stabilizing thermoplastic polyurethane with respect to light, oxygen, and heat.

Abstract: An aqueous resin composition is provided which does not use a high boiling point solvent, and yet displays favorable long term stability and excellent film formation, and does not suffer from problems such as skin generation. The aqueous resin composition comprises a water soluble magnesium salt (A) and an aqueous polyurethane (B).

Abstract: There is provided a primer composition capable of effectively enhancing anti-plasticizer property and water resistance even without curing of the primer layer, and a bonded structure. A primer composition forms a primer layer, containing a polymer, of a paint film formed by painting and drying on a surface to be painted; and a bonded structure includes: a base material, a primer layer containing a polymer sticking fast to the base material, and an adhesive sheet having an adhesive layer stuck fast to the primer layer. The polymer contains a polycarbonate polyurethane having a repeated unit derived from polycarbonate polyol in a molecule thereof.

Abstract: Aqueous stoving enamels containing resins A which have hydroxyl groups and are made hydrophilic by partially neutralized acid groups, and highly etherified aminoplasts B, characterised in that the aqueous solutions or dispersions of the resin have a pH value of 6 or below, a method for the preparation thereof, and a method of use comprising coating thermally sensitive substrates.

Abstract: Reactive polymeric surfactants are disclosed, and their use in processes for preparation of microcapsules, and in stabilising emulsions. The surfactants are random graft polymers or block copolymers which contain both hydrophobic and hydrophilic units and in which the hydrophobic unit includes a hydrophilic cross-linking unit which reacts with (a) a wall forming ingredient in a microencapsulation process, or (b) an ingredient in the disperse phase of an emulsion.

Abstract: A carbon-phenol resin molding compound is provided, which is preferably used to obtain molded articles having high electrical and thermal conductivities as well as good mechanical strength. The resin molding compound is prepared by reacting a phenol with an aldehyde in the presence of a catalyst, while mixing them with a carbon powder such that a content of the carbon powder in the molding compound is 75 wt % or more. The catalyst is at least one selected from tertiary amines, carbonates, hydroxides and oxides of alkali metals or alkali earth metals.

Abstract: A sheet excellent in mechanical performance such as folding endurance is provided. A sheet having a substrate layer using an impact-resistant styrene type resin containing 2 to 15 wt % of rubber particles having a peak at less than 2 ?m and an impact-resistant styrene type resin containing 0.2 to 10 wt % of rubber particles having a peak at 2 ?m or more in a distribution of volume-based particle diameters, or a sheet having a substrate layer comprising an impact-resistant styrene type resin (A) containing 10 to 15 wt % of rubber having a volume average particle diameter of from 0.5 ?m to 1.5 ?m and an impact-resistant styrene type resin (B) containing 5 to 10 wt % of rubber having a volume average particle diameter of from 2.0 ?m to 3.0 ?m wherein (A) is from 50 to 95 wt % and (B) is from 5 to 50 wt % on the basis of the total amount of both components, and a surface layer formed on at least its one surface, is provided.

Abstract: The present invention is a composition useful as an impact modifier for polyamide compositions. In one embodiment, impact modifiers of the present invention are ethylene maleic anhydride copolymers having at least 3% maleic anhydride functionality.

Abstract: This invention relates generally to polymers suitable for making elastomeric films, membranes or sheets. More specifically, this invention is directed to polymers of the ethylene, alpha-olefin, diene terpolymer type that are reactor blends of two components, an amorphous major component and semicrystalline minor component, wherein the viscosity of the major component is less than one fourth the viscosity of minor component. These polymers are particularly suitable for elastomeric membranes such as roofing membranes.

Abstract: A golf ball-which is formed from a crosslinked rubber compound composed of, as essential components, (A) a rubber base material composed of (a) a polybutadiene containing no less than 60 wt % of cis-1,4 bonds and having a Mooney viscosity (ML1+4 (100° C.)) of 50 to 120, which is synthesized by using a group VIII element catalyst and/or a rare earth element-based catalyst, and (b) a solid isoprene rubber containing no less than 60 wt % of cis-1,4 bonds and having a Mooney viscosity (ML1+4 (100° C.)) of 70 to 90, with the ratio of (a) to (b) being from 70/30 to 98/2 by weight; (B) an unsaturated carboxylic acid and/or a metal salt thereof; and (C) an organic peroxide. The golf ball is characterized by good rebound resilience and good workability with which it is produced.

Abstract: Physical blends of solid particulates of chlorinated polyolefins and elastomeric ethylene copolymers yield a blended product with anti-blocking characteristics superior to that defined by the weight proportion-based linear interpolation of either blend component. The blend compositions are useful as impact modifiers for polyvinyl chloride compositions.

Abstract: An elastomeric composition for forming a golf ball or a component thereof is disclosed that includes the use of a non-conjugated diene monomer having two or more vinyl (CH2?CH—) terminal end groups. The composition produces a molded product exhibiting an enhanced combination of increased compression (i.e., softness) and resilience (C.O.R.).

Abstract: A process for making substituted polyethylene glycol compound. The compound has the formula RO(C2H40)nH wherein R represents a C1–7 hydrocarbon group and n represents the average number of moles of C2H40 groups, ranging from 500 to 2000. The compound has a ratio of weight average molecular weight to a number average molecular weight in the range of from 1 to 1.1. The compound contains less than ten weight percent polyethylene glycol. The gist of the process is the use of a polyether solvent, wherein the n value of the compound ranges from 600 to 2000.

Abstract: This invention relates to rapid curing coating compositions that are particularly useful for automotive OEM and refinish applications. The coating composition includes a binder component that contains a novel highly branched copolyester polyol, and a crosslinking component that contains conventional crosslinking agents, such as polyisocyanate and melamine. This invention is also directed to a process for producing coatings from the rapid curing coating compositions. These compositions are especially useful in providing for mar resistant and flexible coatings.

Abstract: The invention provides ethylene/?-olefin copolymers exhibiting improved environmental stress cracking resistance properties, and methods for the production of the copolymers in a single reactor by means of a bimetallic catalyst including a Ziegler component and a metallocene component.

Abstract: The present invention provides a method of preparing an aqueous dispersion of poly(perfluorovinyl ether) homopolymers. The present invention further relates to a method of making an aqueous fluoropolymer dispersion comprising bicomponent particles of poly(perfluorovinyl ether) homopolymers and a second fluoropolymer. The dispersions of the present invention may be used for rendering fibrous substrates oil repellent, water repellent and/or stain repellent.

Abstract: Fluoroacrylates comprise the reaction product of: (a) at least one fluorochemical alcohol represented by the formula: CnF2n+1—X—OH wherein: R=hydrogen or an alkyl group of 1 to 4 carbon atoms, m=2 to 8, Rf=CnF2n+1, y=0 to 6, and q=1 to 8; (b) at least one unbranched symmetric diisocyanate; and (c) at least one hydroxy-terminated alkyl (meth)acrylate or 2-fluoro acrylate monomer having 2 to about 30 carbon atoms in its alkylene portion.

Abstract: A fluororubber sealant composition includes 100 parts by weight of a fluororubber, which is a copolymer having a cross-linking site derived from a bromine-containing and/or iodine-containing compound, capable of crosslinking with peroxide and having a component unit composition comprising 20 to 23% by mol of a perfluoromethyl vinylether component unit, 60 to 70% by mol of a vinylidene fluoride component unit, 10 to 20% by mol of a tetrafluoroethylene component unit, 0 to 10% by mol of hexafluoropropylene component unit (based on 100% of the total of the above component units), and a small amount of a bromide and/or iodide unsaturated fluorohydrocarbon component unit as a crosslinking site based on 100% by mol of the total of the above component units; and further comprising, based on 100 parts by weight of the fluororubber, 2 to 50 parts by weight of a bituminous fine powder; 0.5 to 6 parts by weight of an organoperoxide; and 1 to 10 parts by weight of a polyfunctional monomer.

Abstract: Amorphous perfluorinated homopolymers and copolymers of perfluorodioxoles of formula (IA): wherein R?F is equal to RF or ORF wherein RF is a linear or branched perfluoroalkyl radical having 1–5 carbon atoms; X1 and X2, equal to or different from each other, are F, CF3; said polymers having a dioxole content ?95% by moles, having the following property combination: Tg, measured according to the ASTM 3418 (DSC) method, from 180° C. to 195° C.; intrinsic viscosity, measured at the temperature of 30° C. in perfluoroheptane (Galden® D80) according to the ASTM D2857-87 method, from 13 cc/g to 100 cc/g.

Abstract: A process is described for producing homo-, co- and block copolymers by controlled radical polymerization in aqueous solution, wherein a monomer component (A) consisting of at least one radically polymerizable monomer, an initiator component (B) consisting of at least one radical initiator, a polysaccharide component (C) consisting of at least one cyclic polysaccharide (derivative) and a regulator component (D) consisting of at least one compound of the general formula (Ia) or/and (Ib) are reacted in the presence of water, in which R1 to R6 can each independently denote hydrogen, an optionally substituted C1–C20 alkyl residue, C3–C8 cycloalkyl residue, C7–C34 aralkyl residue or optionally an aromatic C6–C14 hydrocarbon residue and R2 and R5 can additionally denote polymer residues having an average molecular mass (number average) of 100 to 50,000 Daltons, and at least two but at most four of the residues R1 to R6 represent an aromatic hydrocarbon residue.

Abstract: The neodymium catalyst system prepared by the technique of this invention can be used in the polymerization of isoprene monomer into synthetic polyisoprene rubber having an extremely high cis-microstructure content and high stereo regularity. This polyisoprene rubber will crystallize under strain and can be compounded into rubber formulations in a manner similar to natural rubber. This invention more specifically discloses a process for the synthesis of polyisoprene rubber which comprises polymerizing isoprene monomer in the presence of a neodymium catalyst system, wherein the neodymium catalyst system is prepared by a process that comprises (1) reacting a neodymium carboxylate with an organoaluminum compound in an organic solvent to produce neodymium-aluminum catalyst component, and (2) subsequently reacting the neodymium-aluminum catalyst component with an elemental halogen to produce the neodymium catalyst system, wherein the neodymium catalyst system is void of nickel-containing compounds.

Abstract: A propylenic polymer according to the present invention or a composition thereof have an excellent melt flowability and contains a less amount of stickiness-causing components, and also has a low modulus and is pliable, and is capable of providing a transparent molded article, thus being useful as a substitute for a pliable vinyl chloride resin. In addition, a molded article made therefrom exhibits an excellent heat seal performance at a low temperature, and is excellent in terms of transparency and rigidity. Specifically, it has an isotactic pentad fraction (mmmm), which indicates a stereoregulariry, of 30 to 80%, a molecular weight distribution (Mw/Mn) of 3.5 or less and an intrinsic viscosity [?] of 0.8 to 5 dl/g.

Abstract: Fibers comprising a propylene homopolymer or a copolymer of propylene and at least one of ethylene and one or more unsaturated comonomers exhibit desirable properties. The homopolymers are characterized as having 13C NMR peaks corresponding to a regio-error at about 14.6 and about 15.7 ppm, the peaks of about equal intensity. The copolymers are characterized as (A) comprising at least about 60 weight percent (wt %) of units derived from propylene, and (B) having at least one of the following properties: (i) 13C NMR peaks corresponding to a regio-error at about 14.6 and about 15.7 ppm, the peaks of about equal intensity, (ii) a B-value greater than about 1.4 when the comonomer content of the copolymer is at least about 3 wt %, (iii) a skewness index, Six, greater than about ?1.

Abstract: A hot melt adhesive comprising an adhesive polymer and a modified rosin-terpene, preferably a phenol modified rosin terpene. The adhesive is particularly useful in packaging applications.

Abstract: An organopolysiloxane-modified polysaccharide prepared by esterification reacting (A) an organopolysiloxane having residual carboxylic anhydride groups and (B) a polysaccharide having hydroxyl groups, wherein the organopolysiloxane is bonded to the polysaccharide through half ester groups, and a process for the preparation of organopolysiloxane-modified polysaccharide, in which component (A) and component (B) are subjected to an esterification reaction in the presence of (C) a non-protonic polar solvent. The organopolysiloxane-modified polysaccharide comprising polysaccharide and organopolysiloxane bonded thereto through half ester groups is novel. The process for the preparation of organopolysiloxane-modified polysaccharide permits introduction of organopolysiloxane into polysaccharide at a high introduction ratio.

Abstract: A cross-linkable and cross-linked organosilicon polymer which is prepared from a mixture of a reactive polysiloxane resin having both reactive carbon-carbon double bonds and silicone-hydrogen groups, characterized by alternating structures of polycyclic polyene residue and cyclic (or tetrahedral) polysiloxane residue, and either vinyl terminated fluorine-containing polysiloxane or vinyl terminated phenyl-substituted siloxane. In an alternative embodiment, the polymer comprises a mixture of vinyl terminated phenyl-substituted polysiloxane and vinyl functional fluorosilicone elastomer with the cross-linkable and cross linked organosilicon polymer. In an alternative embodiment, the polymer comprises vinyl functional polydimethyl siloxane, and preferably high molecular weight methyl divinyl siloxane, with or without phenyl substituted siloxane.

Abstract: A polyurethane prepolymer obtainable by reacting at least one aromatic polyisocyanate having symmetrical substitution of NCO groups and at least one aromatic polyisocyanate having asymmetric substitution of NCO groups, the fraction of aromatic polyisocyanate having symmetrical substitution of NCO groups being higher than the fraction of polyisocyanate having asymmetric substitution of NCO groups, and at least one polyol having an OH functionality of more than 2.5 and at least one polyol having an OH functionality of less than 2.5.

Abstract: A thermoplastic molding composition comprising a linear (co)polyformal is disclosed. The (co)polyformal corresponds to formulae (Ia) or (Ib), in which A independently denotes hydrogen or phenyl, —O-D-O— and —O-E-O— independently denote a diphenolate residue, in which -E- and -D- independently denote an aromatic radical having 6 to 40 C atoms, wherein at least one of —O-D-O— and —O-E-O— denotes 1,1-bis(4-hydroxyphenyl)cyclohexane residue. The composition is characterized in its restricted water absorption. Also disclosed is a process for the preparation of the composition.

Abstract: The invention relates to a compound of formula I: where: X is equal to NR5; R4 is equal to a C1–C12 alkyl group, aryl group, aralkyl group or cycloalkyl group, R1, R2, R3, R5 are equal to an H, alkyl, cycloalkyl, aryl of heterocyclic group; where R1, R2, and R5 or R1, R2, and R3 may together form a heterocyclic group. The invention also relates to a method for the preparation of this compound by reaction of an amino compound with an alkanol hemiacetal. The invention also relates to amino-aldehyde resins containing this compound and the application of these resins in adhesive compositions, laminates, shaped articles and transparent coatings.

Abstract: A process for the preparation of polyethylene terephthalate by making use of non antimony catalysts is described. The Ti complex catalyst is pre-dispersed in the polymer matrix selected from PET, PBT, PCTG, PETG, PCT, PEN, PPT, PTT or any other related polyesters and prepared as a master batch. The key feature of the process is that the polyester obtained is having good whiteness, as against the yellowness normally encountered with Ti based catalysts, and also the polyester has very good clarity with minimum haze.

Abstract: The present invention relates to novel (meth)acrylic esters of polyalkoxylated trimethylolpropane of the formula where AO is for each AO independently at each instance EO, PO or BO where EO is O—CH2-CH2- PO is independently at each instance O—CH2-CH(CH3)- or O—CH(CH3)-CH2- BO is independently at each instance O—CH2-CH(CH2-CH3)- or O—CH(CH2-CH3)-CH2- p1+p2+p3 is 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 or 75, R1, R2 and R3 are independently H or CH3, a simplified process for preparing these esters and the use of reaction mixtures thus obtainable.

Abstract: A novel polymerization catalyst for polyesters, which does not contain any germanium or antimony compound as the main component; polyesters produced with the catalyst; and a process for producing polyesters. This polymerization catalyst is excellent in catalytic activity, little causes thermal degradation of polyesters in melt molding even when neither deactivated nor removed, and can give thermally stable polyesters which little generate foreign matter and are excellent in transparency and color. The polymerization catalyst is one which contains as the first metal-containing component at least one member selected from the group consisting of aluminum and aluminum compounds and which gives polyethylene terephthalate (PET) having a thermal stability parameter (TS) satisfying the relationship: (1) TS<0.3.

Abstract: A curable composition includes a poly(arylene ether) and a fused alicyclic (meth)acrylate monomer. Also described are a method of preparing the composition, a cured composition derived from the curable composition, and an article comprising the cured composition. The composition is useful, for example, as a bulk molding compound.

Abstract: The present invention is directed to a process for the preparation of polyalkoxyaminies from monoalkoxyamine(s) of formula (I) and of at least one polyunsaturated compound of formula (II): and the preparation of polyfunctional living (co)polymers by polymerization by the radical route of one or more vinyl monomers in the presence of the polyalkoxyamines thus prepared.

Abstract: The invention concerns a pseudopeptide of at least 6 amino acids comprising at least a unit selected among the general formulae (I) and/or (II) wherein: R1, R2 and R3 each independently of one another represent a side-chain of amino acids and can be identical or different; X represents an oxygen or sulphur atom. The invention also concerns its synthesis process, a reagent containing it, a detection kit comprising such a reagent, a method for detecting an antigen or an antibody using said pseudopeptide, and antibody or and anti-idiotype and finally a therapeutic composition.

Abstract: Conjugated peptides include a first peptide component which is an antigen associated with autoimmune disease, allergy, asthma or transplantation rejection and binds to an antigen-specific receptor on a T cell, and a second peptide component which corresponds to an “antigen presenting molecule”, namely, a peptide binding to a T cell surface receptor, which would normally promote T cell activation when the first peptide is bound to its antigen-specific T cell receptor. However, in this invention, the second peptide component has an amino acid sequence which is a modification of an antigen presenting T cell binding peptide, such modification blocking or inhibiting the engagement of receptor sites on the T cell surface (other than the antigen-specific T cell receptor). As a result, T cell activation is prevented, and is directed through antigen-specific T cell receptor occupation, without T cell activation, leading to antigen-specific T cell anergy and cell death.

Abstract: The present invention encompasses a GLP-1 analog and compositions and formulations thereof useful for the treatment of hyperglycemia and other various diseases and conditions in mammals.

Abstract: The invention concerns a novel ICBP90 (Inverted CCAAT box binding protein 90) and its fragments, polynucleotides coding for said polypeptides and specific antibodies directed against said polypeptides. The invention also concerns methods and kits for diagnosing cell proliferation and compounds useful as medicine for preventing and/or treating pathology involving cell proliferation and in particular cancer.

Abstract: Polypeptides derived from vitamin D nuclear receptor, which nuclear receptor comprises a ligand-binding domain, or LBD, which contains a flexible insertion domain. The polypeptides are charactarised in that the LBD flexible insertion domain is modified by substituting or suppressing at least 30 acids. The invention also concerns the use of the polypeptides in particular for screening synthetic vitamin D analogues or for producing tests (double or triple hybrid) for identifying other proteins (activator, repressor, . . . ) interacting with the vitamin D receptor using constructs containing the polypeptide used with Gal4 for example, or for analyzing three dimensional structures of complexes formed between the polypeptides and a particular molecule by crystallography or NMR.

Abstract: A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.

Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.

Abstract: A metalloprotease that converts TNF-? from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.

Abstract: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

Abstract: The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.