Patents Issued in August 19, 2008
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Patent number: 7413695Abstract: A resin infusion mold tool system for use in a vacuum assisted resin transfer molding process with a subsequent pressure bleed step. The mold tool system includes a mold assembly having an outer mold line tool connected to resin supply lines and supplying resin to the preform. A plurality of inner mold line tools form a hard interface with the inner mold line of the fiber preform and are held to within tight tolerances by an external locating fixture. Excess resin is drawn out of the fiber preform using a vacuum bag connected to vacuum lines and disposed over the inner mold line tools but not between the tools and the fiber preform. The mold assembly is placed in an autoclave, the resin supply lines are detached and the autoclave pressurized to bleed additional resin out of the preform to raise the fiber volume of the composite structure.Type: GrantFiled: January 7, 2004Date of Patent: August 19, 2008Assignee: The Boeing CompanyInventors: Patrick J. Thrash, Roger Alan Burgess, Alan M. Markus
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Patent number: 7413696Abstract: A method for the production of elastomer and duromer molded items in an injection molding process using an injection molding machine with a respectively separately heatable filling unit, injection unit and cross-linking tool. The filling unit is heated to a temperature which is non-critical with regard to the cross-linking reaction of the plastic to be treated. The injection unit is heated to a temperature which is slightly below the cross-linking temperature of the molding material used.Type: GrantFiled: August 28, 2002Date of Patent: August 19, 2008Assignee: Carl Freudenberg KGInventors: Christop Malig, Udo Eping, Volker Schroiff, Heinz Gross, Peter Steinl
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Patent number: 7413697Abstract: Methods for making processable rubber compositions containing fluorocarbon elastomers cured by polyol or phenol curative agents include an optional heat treating step before thermoplastic processing. In one aspect, a dynamic vulcanizate of a fluorocarbon elastomer containing an excess of un-reacted polyol curative agent is subject to a pre-molding heat treatment at a temperature of 150° C. or above, but preferably below the thermoplastic processing temperature, for a time sufficient to drive off or decompose at least part of the un-reacted or excess polyol curative agent. After part or all of the curative agent is driven off or decomposed by the heat treatment, the heat treated material may be thereafter processed by thermoplastic techniques to form shaped articles. Advantageously, articles produced by thermoplastic processing of the heat treated dynamic vulcanizates are characterized by a low permeability to gases and vapors.Type: GrantFiled: June 21, 2004Date of Patent: August 19, 2008Assignee: Freudenberg-NOK General PartnershipInventor: Edward Hosung Park
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Patent number: 7413698Abstract: Load-bearing articles are manufactured from shape defining compressible cores and thermoplastic shells. The manufacture of these articles requires specific methods and tools. Articles that can be manufactured using these methods include relatively lightweight pallets with high load-bearing capacity.Type: GrantFiled: June 1, 2004Date of Patent: August 19, 2008Assignee: Novo Foam Products LLCInventors: Ed Bearse, Thomas Bohan, David Hedley, Alan Lewis
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Patent number: 7413699Abstract: A ceramic electronic element having improved the continuity of inner electrode layers while suppressing the decrease in adhesion between its dielectric layers and inner electrode layers and the deterioration in functions of the inner electrode layers, and a method of making the same are provided. In the method of making a ceramic capacitor (10) in accordance with the present invention, an electrode paste (22) is applied to a surface (20a) of a green sheet (20) and fired, so as to form a dielectric layer (12) laminated with an electrode layer (14). Since the electrode paste (22) is doped with a BaTiO3 powder, the adhesion between the dielectric layer (22) and inner electrode layer (14) after firing is significantly restrained from lowering, and the sintering start temperature of the electrode paste (22) is close to that of the green sheet (20).Type: GrantFiled: September 17, 2004Date of Patent: August 19, 2008Assignee: TDK CorporationInventors: Shuichi Miura, Tetsuji Maruno, Kazuhiko Oda, Akira Sasaki, Kouji Tanaka
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Patent number: 7413700Abstract: A composite material (10) formed of a ceramic matrix composite (CMC) material (12) protected by a ceramic insulating material (14). The constituent parts of the insulating material are selected to avoid degradation of the CMC material when the two layers are co-processed. The CMC material is processed to a predetermined state of shrinkage before wet insulating material is applied against the CMC material. The two materials are then co-fired together, with the relative amount of shrinkage between the two materials during the firing step being affected by the amount of pre-shrinkage of the CMC material during the bisque firing step. The shrinkage of the two materials during the co-firing step may be matched to minimize shrinkage stresses, or a predetermined amount of prestress between the materials may be achieved. An aluminum hydroxyl chloride binder material (24) may be used in the insulating material in order to avoid degradation of the fabric (28) of the CMC material during the co-firing step.Type: GrantFiled: January 3, 2007Date of Patent: August 19, 2008Assignee: Siemens Power Generation, Inc.Inventors: Gary B. Merrill, Jay E. Lane, Steven C. Butner, Robert Kreutzer, Jay A. Morrison
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Patent number: 7413701Abstract: Clutch linings comprising fiber-reinforced ceramic materials which contain short carbon fibers and whose matrix has a mass fraction of at least 40% of silicon carbide, process for producing them and their use in clutch systems, in particular for motor vehicles.Type: GrantFiled: August 17, 2004Date of Patent: August 19, 2008Assignee: SGL Carbon AGInventors: Andreas Kienzle, Mario Krupka, Gustavo Cabello, Jens Rosenloecher
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Patent number: 7413702Abstract: Tools and methods are provided for use in a process for sintering a metal injection molded body where the body comprises a material and having a first end, a second end, and a flowpath extending therebetween, the flowpath having a diameter. The tool assembly comprises an insert and an endcap. The insert is configured to be disposed in the body flowpath and has an inner surface, an outer surface, a first end, a second end, a channel, a slot having a width, an inner diameter and an outer diameter. The endcap is configured to be inserted at least partially into the channel at the insert first end when the slot width is increased, and at least a portion of the endcap has an outer diameter that is substantially equal to or larger than the insert inner diameter.Type: GrantFiled: June 30, 2005Date of Patent: August 19, 2008Assignee: Honeywell International Inc.Inventors: Jyh-Woei J. Lu, Richard L. Bye, John N. Tervo, Jerry C. LaSalle
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Patent number: 7413703Abstract: Processes for making rigid, binder free agglomerates of powdered metal are disclosed. The agglomerates have a low tap density. Articles that contain binder free agglomerates made from electrochemically active powder are also disclosed.Type: GrantFiled: January 17, 2003Date of Patent: August 19, 2008Assignee: Eveready Battery Company, Inc.Inventors: Peter Ru-Feng Tsai, Ning Ciu
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Patent number: 7413704Abstract: A case hardening bearing steel having an excellent rolling contact fatigue life in intermediate temperature, in addition, excellent toughness at room temperature is provided. Specific means for solving the problems are as follows. The composition contains, by mass percent, C of 0.15 to 0.30 mass percent, Si of 0.5 to 2.0 mass percent, Mn of 0.3 to 2.0 mass percent, Cr of 1.3 to 2.5 mass percent, Mo of 0.3 to 1.0 mass percent, and O of not more than 0.0012 mass percent in a range where (Si+Mo)?1.0 mass percent is satisfied, and contains iron and inevitable impurities as remnant; the maximum size of oxide nonmetallic inclusion is not more than 12.5 ?m when examined area is 320 mm2; number of the oxide nonmetallic inclusion having a diameter of equivalent circle of 3 ?m or more is not more than 250 when the examined area is 320 mm2; in addition, C density of an outer layer is adjusted to be in a range from 0.7 to 1.2 mass percent by carburization.Type: GrantFiled: April 9, 2003Date of Patent: August 19, 2008Assignees: JFE Steel Corporation, Koyo Seiko Co., Ltd.Inventors: Akihiro Matsuzaki, Takashi Iwamoto, Masao Goto, Katsuhiko Kizawa
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Patent number: 7413705Abstract: Improved 14-karat rose-colored gold alloy compositions include: about 58.5% gold; about 9.0-12.0% silver; about 0.0-0.2% zinc; about 0.3-0.4% cobalt; about 0.0-0.02% iridium; and about 29.0-33.0% copper. Improved 18-karat rose-colored gold alloy compositions include: about 75.2% gold; about 7.0% silver; about 0.0-0.2% zinc; about 0.3-0.4% cobalt; about 0.0-0.02% iridium; and about 17.0-17.5% copper. The hardness of these compositions are capable of being selectively changed between their respective annealed-hardness and age-hardness values. The color of these compositions is between about 5-7 CieLab a* color units and between about 17-21 CieLab b* color units.Type: GrantFiled: May 9, 2005Date of Patent: August 19, 2008Assignee: Leach & Garner CompanyInventors: Dwarika P. Agarwal, Grigory Raykhtsaum
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Patent number: 7413706Abstract: A measurement operation, such as a calorimetry measurement, is performed using a measurement array and a replaceable passivation membrane (e.g., a parylene membrane). The passivation membrane is used to cover the measurement array to provide temporary electrical and chemical passivation, while still allowing measurement of the parameter of interest (e.g., temperature, in a calorimetry measurement). By only replacing the membrane instead of the entire measurement array between measurement operations, the cost of the measurements can be significantly reduced over conventional methods. The passivation membrane can be mounted on a frame to simplify handling of the membrane.Type: GrantFiled: December 19, 2003Date of Patent: August 19, 2008Assignee: Palo Alto Research Center IncorporatedInventors: Eric Peeters, Gregory B. Anderson
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Patent number: 7413707Abstract: Provided is a microchip assembly including a base holder, a microchip installed on the base holder and having at least one input hole into which a reaction sample is input and at least one microchamber accommodating the input reaction sample, a flipper rotatably installed at the outside of the microchip on the base holder and opening and closing the input hole of the microchip while flipping up in a vertically erected state or flipping down in a horizontal state, and slider installed at the outside of the flipper on the base holder to be capable of sliding and supporting the flipper in the erected state and flipping down the flipper while moving inside.Type: GrantFiled: May 9, 2006Date of Patent: August 19, 2008Assignee: Samsung Electronics Co., Ltd.Inventors: Kwang-wook Oh, Yu-jin Seo
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Patent number: 7413708Abstract: An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5??3? exonuclease activity of a polymerase and the 5??3? extension of by a polymerase. The invention also includes methods for performing combined PCR amplification and hybridization probing, one such method including the steps of contacting a target nucleic acid sequence with PCR reagents and an oligonucleotide probe as described above, and subjecting these reagents to thermal cycling. One preferred refinement of the above method further includes the addition of a strand displacer to facilitate amplification.Type: GrantFiled: July 9, 2007Date of Patent: August 19, 2008Assignee: Applied Biosystems Inc.Inventor: Paul E. Mayrand
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Patent number: 7413709Abstract: A polyaryl-ether-ketone (PAEK)-based microfluidic device having an integrated electrospray emitter is disclosed. Bonding of at least one PAEK substrate forming the microfluidic device is accomplished using a solvent-resistant adhesive, such as a polyimide-based adhesive, in combination with an adhesion enhancement treatment. By providing the PAEK-based microfluidic device with an integrated electrospray emitter, efficient and effective analysis of fluid samples is enabled.Type: GrantFiled: February 12, 2003Date of Patent: August 19, 2008Assignee: Agilent Technologies, Inc.Inventors: Daniel B. Roitman, Kevin Killeen, Hongfeng Yin, Karen L. Seaward
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Patent number: 7413710Abstract: A pipette system including a pipette capillary tube and an actuator, with the actuator serving to set the position of a phase boundary between a system medium and a second medium in the pipette capillary is described. A sensor element is also provided for measuring the position of the phase boundary, in such a way that the actuator is controlled by a regulating element in response to an output signal from the sensor element.Type: GrantFiled: October 23, 2001Date of Patent: August 19, 2008Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Thomas Lisec, Sascha Mühlmann, Sven Grünzig
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Patent number: 7413711Abstract: A dispensing system delivers a precise amount of fluid for biological or chemical processing and/or analysis. Dispensing means moves the fluid. The dispensing means is operated by a pneumatic force. Connection means delivers the fluid to the desired location. An actuator means provides the pneumatic force to the dispensing means. Valving means transmits the pneumatic force from the actuator means to the dispensing means.Type: GrantFiled: July 16, 2003Date of Patent: August 19, 2008Assignee: Lawrence Livermore National Security, LLCInventors: William J. Benett, Peter A. Krulevitch, Steven R. Visuri, John M. Dzenitis, Kevin D. Ness
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Patent number: 7413712Abstract: A microfluidic device comprises a matrix of rotary flow reactors. The microfluidic matrix device offers a solution to the “world-to-chip” interface problem by accomplishing two important goals simultaneously: an economy of scale in reagent consumption is achieved, while simultaneously minimizing pipetting steps. N2 independent assays can be performed with only 2N+1 pipetting steps, using a single aliquot of enzyme amortized over all reactors. The chip reduces labor relative to conventional fluid handling techniques by using an order of magnitude less pipetting steps, and reduces cost by consuming two to three orders of magnitude less reagents per reaction. A PCR format has immediate applications in medical diagnosis and gene testing. Beyond PCR, the microfluidic matrix chip provides a universal and flexible platform for biological and chemical assays requiring parsimonious use of precious reagents and highly automated processing.Type: GrantFiled: April 30, 2004Date of Patent: August 19, 2008Assignee: California Institute of TechnologyInventors: Jian Liu, Carl L. Hansen, Stephen R. Quake
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Patent number: 7413713Abstract: A reaction apparatus comprises a first supply flow channel having a fine flow channel cross sectional area for a liquid pressurized by a pressurizing device, a gas supply flow channel having a fine flow channel cross sectional area for supplying a gas, a two-phase flow channel having a fine flow channel cross sectional area in communication with a joined portion for the first supply flow channel and the second supply flow channel for flowing a gas/liquid two-phase fluid, a gas bubble reaction flow channel in communication with the exit of the gas/liquid two-phase channel and having a flow channel cross sectional area larger than that of the gas/liquid two-phase flow channel, and a liquid discharge flow channel for discharging the liquid in the gas bubble reaction flow channel. Therefore, in the reaction apparatus, a stable mixing ratio of a gas to a liquid can be obtained and the mixing speed of the gas to the liquid is increased.Type: GrantFiled: October 30, 2002Date of Patent: August 19, 2008Assignee: Hitachi, Ltd.Inventors: Tadashi Sano, Ryo Miyake, Akira Koide, Norihide Saho, Akiomi Kono, Takeshi Harada
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Patent number: 7413714Abstract: An automated sequential reaction system that can be used to either sequentially produce a plurality of different products each requiring a single reaction, or to produce a desired product that requires a series of sequential reactions. A system controller controls an automated reactant supply, a solvent supply, a reaction module, a detector, and a product collector. Prior to initiating any reaction, the system is flushed with solvent and a heat exchanger supplies the reaction module with a temperature-conditioned fluid to maintain the reaction module at a desired temperature. For single reactions, a plurality of reactants are injected into a chemical reactor included in the reaction module. As fluid exits the chemical reactor, the detector determines if the fluid is a desired chemical product or solvent, and routes the fluid to the appropriate receptacle.Type: GrantFiled: July 16, 2000Date of Patent: August 19, 2008Assignee: YMC Co. Ltd.Inventors: Thomas Schwalbe, Klaus Golbig, Michael Hohmann, Andreas Oberbeck, Shahriyar Taghavi-Moghadam
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Patent number: 7413715Abstract: The present invention is to provide a catalyst for removing nitrogen oxides which is capable of keeping sufficient denitrification performance, i.e., a high removal rate of nitrogen oxides in exhaust gas having a high NO2 content especially under conditions where the ratio of NO2/NO in exhaust gas is 1 or higher, a catalyst molded product therefor, and an exhaust gas treating method. The catalyst is designed for removing nitrogen oxides, which is used to denitrify exhaust gas containing nitrogen oxides having a high NO2 content, which comprises: at least one kind of oxide selected from the group consisting of copper oxides, chromium oxides, and iron oxides as a component for reducing NO2 to No; and which further comprises: at least one kind of titanium oxide; at least one kind of tungsten oxide; and at least one kind of vanadium oxide as components for reducing NO to N2.Type: GrantFiled: April 12, 2004Date of Patent: August 19, 2008Assignee: itsubishi Heavy Industries, Ltd.Inventors: Shigeru Nojima, Kozo Iida, Yoshiaki Obayashi, Masashi Kiyosawa, Masanori Demoto
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Patent number: 7413716Abstract: A muffler with a housing for receiving exhaust gasses from an engine is disclosed. The muffler includes a housing with an inlet and an exit, a baffle plate partitioning the housing into first and second chambers. The baffle plate includes a catalyst receptacle in the first chamber, the second chamber includes the exit of the housing. A catalytic converter element with a longitudinal axis is housed within the catalyst receptacle, the catalytic converter element is positioned within the catalyst receptacle such that exhaust gas passes through the catalytic converter element in a direction transverse to the longitudinal axis of the catalytic converter element and through the second chamber to exit the housing.Type: GrantFiled: April 8, 2005Date of Patent: August 19, 2008Assignee: Homelite Technologies, Ltd.Inventors: Nagesh S. Mavinahally, Fabio T. Romero, David R. Brower
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Patent number: 7413717Abstract: The ceramic honeycomb structure according to the present invention includes a cell group having a plurality of cells which are divided each other by porous partition walls and functioning as a fluid channel, and porous outer wall surrounding and holding outermost peripheral cells located at a circumference of the cell group. In the partition walls, a part located at least one opening end of the cells of the cell group constitutes a reinforced partition wall part having higher strength than the other part of the partition walls (normal partition wall part) as well as having a variation of porosity per unit volume within ±2%. Uniform and excellent erosion resistance is achieved throughout the reinforced partition wall part.Type: GrantFiled: February 25, 2003Date of Patent: August 19, 2008Assignee: NGK Insulators, Ltd.Inventors: Sadaaki Hirai, Takayuki Kawae, Yasushi Kato
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Patent number: 7413718Abstract: A silicon production reactor including a reaction vessel and heating element, the reaction vessel has a vertically extending wall and a space surrounded by the wall, the heating element being capable of heating at least a part, including lower end portion, of the wall's surface facing the space to a temperature of not lower than the melting point of silicon, the silicon production reactor being adapted to flow raw gas for silicon deposition from an upper part of the space of the reaction vessel toward a lower part thereof, characterized in that the space of the reaction vessel is of slit form in cross-sectional view. This silicon production reactor is capable of attaining improvement with respect to problems encountered at apparatus scale-up, such as decrease of reactivity of raw gas and generation of by-products, thereby accomplishing a striking enhancement of production efficiency.Type: GrantFiled: June 17, 2003Date of Patent: August 19, 2008Assignee: Tokuyama CorporationInventors: Yasuo Nakamura, Satoru Wakamatsu
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Patent number: 7413719Abstract: The invention can be summarized as follows. There is provided a method for oxidizing elemental mercury in a combustion process comprising, adding a composition comprising an aluminum silicate to a combustion chamber, boiler or kiln downstream from the burner region combustion zone. There is further provided a method for reducing the emission of one or more heavy metals in a combustion process by adding a composition comprising an aluminum silicate to a combustion chamber downstream from the burner region combustion zone. There is also provided a composition comprising an aluminum silicate that may be employed to oxidize elemental mercury generated in a combustion process. The composition also may be employed to reduce the emission of one or more heavy metals generated in a combustion process.Type: GrantFiled: March 26, 2007Date of Patent: August 19, 2008Inventor: William Troy Digdon
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Patent number: 7413720Abstract: A Selective Catalytic Reduction (SCR) catalyst was prepared by slurry coating ZSM-5 zeolite onto a cordierite monolith, then subliming an iron salt onto the zeolite, calcining the monolith, and then dipping the monolith either into an aqueous solution of manganese nitrate and cerium nitrate and then calcining, or by similar treatment with separate solutions of manganese nitrate and cerium nitrate. The supported catalyst containing iron, manganese, and cerium showed 80 percent conversion at 113 degrees Celsius of a feed gas containing nitrogen oxides having 4 parts NO to one part NO2, about one equivalent ammonia, and excess oxygen; conversion improved to 94 percent at 147 degrees Celsius. N2O was not detected (detection limit: 0.6 percent N2O).Type: GrantFiled: March 20, 2006Date of Patent: August 19, 2008Assignee: Los Alamos National Security, LLCInventor: Kevin C. Ott
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Patent number: 7413721Abstract: A method for forming ammonia is disclosed and which includes the steps of forming a plasma; providing a source of metal particles, and supplying the metal particles to the plasma to form metal nitride particles; and providing a substance, and reacting the metal nitride particles with the substance to produce ammonia, and an oxide byproduct.Type: GrantFiled: July 28, 2005Date of Patent: August 19, 2008Assignee: Battelle Energy Alliance, LLCInventors: Peter C. Kong, Robert J. Pink, Larry D. Zuck
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Patent number: 7413722Abstract: A method and apparatus for manufacture of NF3 by gas-liquid phase reaction of fluorine and ammonia in molten ammonium acid fluoride (AAF) in a static reactor in which the reactants are conveyed primarily by thermal conduction or siphon. Optimally, the reactor contains one or more static mixing elements with little, if any, mechanical agitation. Reactant flow rate and reaction temperature are regulated by the rate of introduction of ammonia and cooling, as necessary The ratio of hydrogen fluoride (generated by the reaction) to ammonia in the reactor is significantly lower than taught in the prior art. This allows a lower reaction temperature. The present invention is an improved synthetic method that offers enhanced selectivity and higher yields, improved control of reaction kinetics, reduced operational and energy costs, and a greater margin of safety.Type: GrantFiled: August 4, 2005Date of Patent: August 19, 2008Assignee: Foosung Co., Ltd.Inventor: Yuichi Iikubo
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Patent number: 7413723Abstract: Methods of oxidizing multiwalled carbon nanotubes are provided. The multiwalled carbon nanotubes are oxidized by contacting the carbon nanotubes with gas-phase oxidizing agents such as CO2, O2, steam, N2O, NO, NO2, O3, and ClO2. Near critical and supercritical water can also be used as oxidizing agents. The multiwalled carbon nanotubes oxidized according to methods of the invention can be used to prepare rigid porous structures which can be utilized to form electrodes for fabrication of improved electrochemical capacitors.Type: GrantFiled: November 9, 2005Date of Patent: August 19, 2008Assignee: Hyperion Catalysis International, Inc.Inventors: Chunming Niu, David Moy, Asif Chishti, Robert Hoch
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Patent number: 7413724Abstract: Method for producing nano-particles from a precursor material. One embodiment of the method comprises vaporizing the precursor material to produce a vapor, directing the vapor into an isolation chamber, contacting the vapor contained in the isolation chamber with a quench fluid stream, the quench fluid stream cooling the vapor to produce the nano-particles, and removing the nano-particles from the isolation chamber.Type: GrantFiled: August 20, 2002Date of Patent: August 19, 2008Assignee: Cyprus Amax Minerals CompanyInventors: Mohamed H. Khan, James A. Cole, Joel A. Taube
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Patent number: 7413725Abstract: A method of making Cu, Zn, and/or Cu/Zn alloy nanoparticles subjects one or more targets to laser energy to form a vapor and condenses the vapor to form nanoparticles having an average particle size of less than 20 nm. The optional application of an electric field results in nanoparticles with aspect ratios greater than 1.0. The target(s) can be a single target or separate targets comprising a mixture of copper, zinc, and/or copper/zinc. When separate targets are used, the laser beam can be split to form two separate beams each of which is made incident upon one of the targets. The nanoparticles can be formed in a chamber having an inert atmosphere or a reactive atmosphere and a convection current is created in the chamber by maintaining the top plate at a lower temperature than the bottom plate.Type: GrantFiled: August 11, 2004Date of Patent: August 19, 2008Assignee: Philip Morris USA Inc.Inventors: M. Samy El-Shall, Sarojini Deevi, Yezdi B. Pithawalla, Seetharama C. Deevi, A. Clifton Lilly, Jr.
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Patent number: 7413726Abstract: The present invention provides a low temperature process for the synthesis of ultrafine rutile phase titanium dioxide particles through vapor phase hydrolysis of titanium tetra chloride.Type: GrantFiled: March 26, 2004Date of Patent: August 19, 2008Assignee: Council of Scientific and Industrial ResearchInventors: Gerald D. Surender, Ani K. John, Kumara P. Rajendra Prasad, Savithri Sivaraman
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Patent number: 7413727Abstract: The invention provides a composition of matter of the formula (I): V-L-R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterised in that V is a non-peptidic organic group, or V is peptidic and R is a macromolecular or particulate species providing a multiplicity of labels detectable in in vivo imaging.Type: GrantFiled: June 17, 2003Date of Patent: August 19, 2008Assignee: GE Healthcare ASInventors: Jo Klaveness, Anne Naevestad, Helge Tolleshaug
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Patent number: 7413728Abstract: Use of an immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and Nocardioides, for use in the manufacture of a medicament for the treatment of an autoimmune disease or autoimmune disorder, including certain vascular disorders.Type: GrantFiled: November 12, 2004Date of Patent: August 19, 2008Assignee: UCL Biomedica PLCInventors: Graham McIntyre, John Lawson Stanford, Cynthia Ann Stanford, Oscar Adelmo Bottasso
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Patent number: 7413729Abstract: This invention relates to purified sialic acid permease systems, and inhibitory agents of sialic acid permease systems.Type: GrantFiled: January 13, 2006Date of Patent: August 19, 2008Assignee: University of Iowa Research FoundationInventors: Michael A. Apicella, Anthony Zaleski, Bradford W. Gibson, Simon Allen
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Patent number: 7413730Abstract: The invention is a light protective cosmetic or dermatological preparation, comprising (a) PEG-30 dipolyhydroxystearate, (b) 2-ethylhexyl 2-cyano-3,3-diphenylacrylate, (c) at least one dibenzoylmethane derivative and (d) at least 2% by weight of titanium dioxide particles, based on the total weight of the preparation, and is free from water-soluble UV-A filter substances.Type: GrantFiled: January 19, 2005Date of Patent: August 19, 2008Assignee: Beiersdorf AGInventors: Kerstin Hoop, Heike Lerg, Anja Sabine Mueller, Bente Nissen, Melanie Steinforth, Martin Sugár
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Patent number: 7413731Abstract: The present invention relates to a composition comprising: (a) a fragrance oil wherein the fragrance oil comprises: (i) greater than about 50%, by weight of the fragrance oil, of perfume raw materials with high odour impact perfume raw materials which have an odour detection threshold of less than, or equal to, about 50 parts per billion; (ii) less than about 5%, by weight of the fragrance oil, of top note perfume raw materials wherein the top note perfume raw materials have a boiling point of less than about 250° C. at 1 atmosphere pressure (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules, and nanocapsules; liposomes; pro-perfumes; film formers; absorbents; cyclic oligosaccharides and mixtures thereof. (c) greater than about 50%, by weight, of a volatile solvent.Type: GrantFiled: April 24, 2003Date of Patent: August 19, 2008Assignee: The Procter and Gamble CompanyInventors: Gabor Heltovics, Jerome Anthony Janszen, Jill Maureen Mattila, Lynette Anne Makins Holland, Jane Margaret Warwick
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Patent number: 7413732Abstract: The application relates for method for cloning the gene comprising the steps of: 1. Providing a replication-deficient baculovirus vector, 2. Providing a rescue vector comprising (a) nucleic acid sequence which is capable of restoring replication in the replication-deficient baculovirus vector and (b) at least one gene to be cloned; 3. Causing the replication-deficient baculovirus vector and rescue vector to recombine to produce a replication-enabled baculovirus vector comprising the at least one gene to be cloned; and 4. Growing the replication-enabled baculovirus vector within a suitable invertebrate cell, such as an insect cell. Preferably the baculovirus vector is based upon AcMNPV. Also disclosed are replication-deficient baculovirus vectors, rescue vectors, cells containing such vectors and kits comprising such vectors.Type: GrantFiled: August 14, 2000Date of Patent: August 19, 2008Assignees: Oxford Brookes University, Natural Environment Research CouncilInventors: Robert David Possee, Linda Anne King
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Patent number: 7413733Abstract: A delivery system comprising a T cell comprising at least one antigen capable of loading antigen-presenting-cells with the antigen.Type: GrantFiled: October 21, 2003Date of Patent: August 19, 2008Assignee: MolMed SpAInventors: Catia Traversari, Claudio Bordignon
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Patent number: 7413734Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.Type: GrantFiled: June 25, 2004Date of Patent: August 19, 2008Assignee: Ethicon, IncorporatedInventors: Sanjay Mistry, Darin J. Messina, Ian Ross Harris, Alexander M. Harmon, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
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Patent number: 7413735Abstract: The present invention relates to a pharmaceutical composition for inhibiting angiogenesis which comprises arginine deiminase as an active ingredient, where the arginine deiminase, obtained from Mycoplasma arginini or prepared by a genetic recombination technique, may be conjugated to an activated polymer to lower its immunogenecity and increase its life time. The pharmaceutical composition of the present invention exhibits an excellent inhibitory activity against angiogenesis.Type: GrantFiled: June 20, 2005Date of Patent: August 19, 2008Assignee: Angio Lab, Inc.Inventors: Bon-Hong Min, Myung-Ok Park, Min-Young Kim, Byung-Young Park, Boe-Gwun Chun, Sang-Wook Kang, Chang-Hee Moon
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Patent number: 7413736Abstract: A humanized form of an anti-idiotype antibody to CEA, e.g., hWI2, has conserved immunoreactivity. The clinical benefits of anti-CEA antibodies are maximized by using the humanized anti-idiotype as a clearing agent for anti-CEA antibodies or antibody fragments. The humanized anti-idiotype also can be used as an immunogenic vaccine.Type: GrantFiled: July 25, 2007Date of Patent: August 19, 2008Assignee: Immunomedics, Inc.Inventors: Shui-on Leung, Michele J. Losman, Hans Hansen
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Patent number: 7413737Abstract: Antibodies, or antigen-binding portions thereof, to aspartyl (asparaginyl) ?-hydroxylase are provided. The anti-aspartyl (asparaginyl) ?-hydroxylase antibodies, or antigen-binding portions thereof, can modulate activity of aspartyl (asparaginyl) ?-hydroxylase.Type: GrantFiled: November 15, 2004Date of Patent: August 19, 2008Assignee: Massachusetts Institute of TechnologyInventors: K. Dane Wittrup, Yik Andy Yeung, Jack R. Wands
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Patent number: 7413738Abstract: Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.Type: GrantFiled: December 14, 2004Date of Patent: August 19, 2008Assignee: Enzon Pharmaceuticals, Inc.Inventors: Hong Zhao, Susan Adler, legal representative, Richard B. Greenwald
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Patent number: 7413739Abstract: The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.Type: GrantFiled: October 25, 2005Date of Patent: August 19, 2008Assignees: Eidgenossische Technische Hochschule Zurich, Universitat ZurichInventors: Jeffrey A. Hubbell, Donald Elbert, Ronald Schoenmakers
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Patent number: 7413740Abstract: Secondary bile acid production inhibitors and cholesterol-lowering agents containing a yeast as the active ingredient.Type: GrantFiled: July 8, 2005Date of Patent: August 19, 2008Assignee: Kabushiki Kaisha Yakult HonshaInventors: Haruji Sawada, Yasuto Yoshida, Yasue Wada, Kenji Ohishi, Masahiko Itoh, Wakae Yokoi, Tunekazu Watanabe
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Patent number: 7413741Abstract: The invention relates to recombinantly or synthetically produced HCV E1 envelope proteins or parts thereof comprising disulfides between specific cysteine residues. The invention further relates to viral-like particles and compositions comprising said HCV E1 envelope proteins or parts thereof as well as to methods using said HCV E1 envelope proteins or parts thereof, and to kits comprising said HCV E1 envelope proteins or parts thereof.Type: GrantFiled: March 8, 2005Date of Patent: August 19, 2008Assignee: Innogenetics N.V.Inventors: Stany Depraetere, Erik Depla, Gert Verheyden, Alfons Bosman
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Patent number: 7413742Abstract: Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.Type: GrantFiled: August 22, 2006Date of Patent: August 19, 2008Assignee: Allergan, Inc.Inventor: Stephen Donovan
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Patent number: 7413743Abstract: The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.Type: GrantFiled: June 8, 2005Date of Patent: August 19, 2008Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub
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Patent number: 7413744Abstract: A cosmetic comprising the organopolysiloxane wax represented by the following formula (1), wherein R1 is a group selected from the group consisting of alkyl groups having 1 to 20 carbon atoms, alicyclic groups, aryl groups, aralkyl groups and fluorinated alkyl groups; R2 is a group having a pentaerythritol higher fatty acid polyester residue represented by the following formula (2), (CH2OCOR8)mC(CH2O—X—)4-m??(2) wherein 1?m<4 or a group having a dipentaerythritol higher fatty acid polyester residue represented by the following formula (3), O(CH2C)2(CH2OCO R8)n (CH2O—X—)6-n??(3) wherein 1?n<6, R8in the formulae (2) and (3) being a linear, saturated or unsaturated, aliphatic group having 17 to 30 carbon atoms, —X— in the formulae (2) and (3) being anyone of the following moieties, —R3—, —COR4—, wherein R3 is a C3-C8 alkylene group or a cycloalkylene group, R4 is a C4-C20 aliphatic or alicyclic group having at least one group selected from the group consisting of carboxyl, carbonyloxy and hydrType: GrantFiled: June 10, 2003Date of Patent: August 19, 2008Assignee: Shin-Etsu Chemical Co., Ltd.Inventor: Shoji Ichinohe