Patents Issued in October 21, 2008
  • Patent number: 7439188
    Abstract: A reactor for processing semiconductor wafers with electrodes and other surfaces that can be one of heated, textured and/or pre-coated in order to facilitate adherence of materials deposited thereon, and eliminate the disadvantages resulting from the spaulding, flaking and/or delaminating of such materials which can interfere with semiconductor wafer processing.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: October 21, 2008
    Assignee: Tegal Corporation
    Inventors: Stephen DeOrnellas, Leslie Jerde, Kurt Olson
  • Patent number: 7439189
    Abstract: The invention concerns a method of treating wafers comprising at least one surface layer of silicon-germanium (SiGe) and a layer of strained silicon beneath the SiGe layer. The strained silicon layer is denuded by a step of selective etching of the SiGe layer by dispensing an etching solution onto the rotating wafer. Selective etching is then followed by a step of cleaning the surface of the strained silicon layer with an aqueous ozone solution dispensed onto the rotating wafer.
    Type: Grant
    Filed: August 29, 2005
    Date of Patent: October 21, 2008
    Assignee: S.O.I.Tec Silicon on Insulator Technologies
    Inventor: Cécile Delattre
  • Patent number: 7439190
    Abstract: Provided is a fabrication method of a semiconductor device having an improved production yield. An insulating film for forming sidewall insulating films of a gate electrode is deposited on the main surface of a semiconductor wafer and then, subjected to the treatment for equalizing the film thickness distribution. In this treatment, the semiconductor wafer is fixed onto a spin stage of an etching apparatus and rotated; and an etchant is supplied from an etchant nozzle to the main surface of the rotating semiconductor wafer while moving thereabove the etchant nozzle from the peripheral side to the central side on the main surface of the semiconductor wafer. The moving speed of the etchant nozzle is controlled, depending on the thickness distribution of the insulating film and is made lower in a region where a change rate of the thickness of the insulating film in a radial direction of the semiconductor wafer is large than in a region where the change rate is small.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: October 21, 2008
    Assignee: Renesas Technology Corp.
    Inventor: Hiroshi Tanaka
  • Patent number: 7439191
    Abstract: A method of silicon layer deposition using a cyclical deposition process. The cyclical deposition process comprises alternately adsorbing a silicon-containing precursor and a reducing gas on a substrate structure. Thin film transistors, such as for example a bottom-gate transistor or a top-gate transistor, including one or more silicon layers may, be formed using such cyclical deposition techniques.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: October 21, 2008
    Assignee: Applied Materials, Inc.
    Inventors: Kam Law, Quanyuan Shang, William Reid Harshbarger, Dan Maydan
  • Patent number: 7439192
    Abstract: In a method of forming a thin layer for a semiconductor device through an ALD process and a CVD process in the same chamber, a semiconductor substrate is introduced into a processing chamber, and an interval between a showerhead and the substrate is adjusted to a first gap distance. A first layer is formed on the substrate at a first temperature through an ALD process. The interval between the showerhead and the substrate is additionally adjuted to a second gap distance, and a second layer is formed on the first layer at a second temperature through a CVD process. Accordingly, the thin layer has good current characteristics, and the manufacturing throughput of a semiconductor device is improved.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: October 21, 2008
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jung-Hun Seo, Young-Wook Park, Jin-Gi Hong
  • Patent number: 7439193
    Abstract: Provided is a patterning method capable of fabricating high resolution structures without using a high resolution patterning step. The method comprises the steps of: (i) pre-patterning a layer of material (12) on a substrate (10), (ii) spin-coating a solution of a film-forming substance over the pre-patterned substrate, (iii) drying the spin-coated solution to form a film (14) of the film-forming substance on the unpatterned areas of the substrate and on the surface and sides of the pre-patterned material, (iv) etching the dried film in such a way that it remains only around the sides of the pre-patterned material, and (v) removing the pre-patterned material to leave ridges (20) of the film-forming substance on the substrate, the pattern of the ridges corresponding to the outline of the pre-patterned material.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: October 21, 2008
    Assignee: Seiko Epson Corporation
    Inventors: Shunpu Li, Christopher Newsome, David Russell, Thomas Kugler
  • Patent number: 7439194
    Abstract: A dielectric film containing lanthanide doped TiOx and a method of fabricating such a dielectric film produce a reliable gate dielectric having an equivalent oxide thickness thinner than attainable using SiO2. A dielectric film is formed by evaporation of Ti, a lanthanide, and oxidation of the evaporated Ti/lanthanide film using an oxygen plasma.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: October 21, 2008
    Assignee: Micron Technology, Inc.
    Inventors: Kie Y. Ahn, Leonard Forbes
  • Patent number: 7439195
    Abstract: A method of forming (and an apparatus for forming) a metal oxide layer on a substrate, particularly a semiconductor substrate or substrate assembly, using a vapor deposition process and one or more precursor compounds that include aminosilane ligands.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: October 21, 2008
    Assignee: Micron Technology, Inc.
    Inventors: Brian A. Vaartstra, Timothy A. Quick
  • Patent number: 7439196
    Abstract: The main object of the present invention is to provide a method for manufacturing efficiently a pattern formed structure which has a surface having a property-varied pattern and can be used to manufacture a color filter or the like. In order to achieve the object, the present invention provides a method for manufacturing a pattern formed structure, comprising: a patterning substrate preparing process of preparing a patterning substrate having a base material and a photocatalyst-containing property variable layer which is formed on the base material, comprises at least a photocatalyst and a binder, and has a property variable by action of the photocatalyst based on irradiation with energy; and an energy radiating process of radiating energy onto the patterning substrate at an intensity of 0.1 to 10 mW/cm2, thereby forming a property variable pattern in which the property of the photocatalyst-containing property variable layer is varied.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: October 21, 2008
    Assignee: DAI Nippon Printing Co., Ltd.
    Inventors: Hironori Kobayashi, Yusuke Uno
  • Patent number: 7439197
    Abstract: A method of preparing a semiconductor film on a substrate is disclosed. The method includes arranging an insulating substrate in a deposition chamber and depositing a semiconductor film onto the insulating substrate using ion beam deposition, wherein a temperature of the insulating substrate during the depositing does not exceed 250° C. The method can produce a thin film transistor. The disclosed ion beam deposition method forms, at lower temperature and with low impurities, a film morphology with desired smoothness and grain size. Deposition of semiconductor films on low melting point substrates, such as plastic flexible substrates, is enables.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: October 21, 2008
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jang-yeon Kwon, Hyuk Lim, Takashi Noguchi, Young-soo Park, Suk-pil Kim, Hans S. Cho, Ji-sim Jung, Kyung-bae Park, Do-young Kim
  • Patent number: 7439198
    Abstract: A method for fabricating a buried metallic layer at a predetermined vertical position in a semiconductor body having a first and second side includes a step of applying a metal layer to one of the first and second sides at least in sections. The method also includes establishing a positive temperature gradient in a vertical direction of the semiconductor body proceeding from the one side. The temperature in the region of the one side is higher than the eutectic temperatures of system, so that the metal of the metal layer migrates in the vertical direction into the semiconductor body. The method also includes discontinuing the temperature gradient once the metal reaches the predetermined vertical position in the semiconductor body, in order thereby to obtain the metallic layer at the predetermined position.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: October 21, 2008
    Assignee: Infineon Technologies AG
    Inventors: Hans-Joachim Schulze, Helmut Strack
  • Patent number: 7439199
    Abstract: A capacitive element is characterized by including: a base (12); a lower barrier layer (13) formed on the base (12); capacitors (Q1 and Q2) made by forming a lower electrode (14a), capacitor dielectric layers (15a), and upper electrodes (16a) in this order on the lower barrier layer (13); and an upper barrier layer (20) covering at least the capacitor dielectric layers (15a) and the lower barrier layer (13).
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: October 21, 2008
    Assignee: Fujitsu Limited
    Inventors: Takeshi Shioga, John David Baniecki, Kazuaki Kurihara
  • Patent number: 7439200
    Abstract: An improved circuit substrate is provided wherein glass cloth is completely embedded within fluoropolymer by thermocompression to form a composite structure, which when containing an adhesive agent such as the combination of functional groups and liquid crystal polymer is self-adhering to a metal layer such as of copper.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: October 21, 2008
    Assignee: DuPont-Mitsui Fluorochemicals Co. Ltd.
    Inventors: Jeong Chang Lee, Etsuya Taki
  • Patent number: 7439201
    Abstract: The invention is directed to lead-free glass frit compositions that can be used as sealing frits, the compositions being a blend of: (1) at least one of two glass families which are SnO—ZnO—P2O5 and alkali-ZnO—P2O5 glasses; and (2) at least one cerammed filler material having a crystalline phase selected from the group consisting of beta-quartz, beta-eucryptite, cordierite, and beta-spodumene. The blends of the invention have flow characteristics that enable them to be used at sealing temperatures in the range of 450-550° C., and a CTE value in the range of 60-90×10?7/° C.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: October 21, 2008
    Assignee: Corning Incorporation
    Inventors: Melinda Ann Drake, Sasha Marjanovic, Lisa A. Lamberson, Robert Michael Morena
  • Patent number: 7439202
    Abstract: A glass ceramic composition is used for a multilayer ceramic substrate 2 including glass ceramic layers 3 laminated, the multilayer ceramic substrate 2 being used for a multilayer ceramic module 1. The glass ceramic composition includes a first ceramic powder mainly composed of forsterite, a second ceramic powder mainly composed of at least one component selected from CaTiO3, SrTiO3 and TiO2, and a borosilicate glass powder containing Li2O, MgO, B2O3, SiO2, ZnO and Al2O3. The glass ceramic composition contains 3 percent by weight or more of the borosilicate glass powder and further contains at least one additive selected from the group consisting of CaO, BaO and SrO.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: October 21, 2008
    Assignee: Murata Manufacturing Co., Ltd.
    Inventors: Naoya Mori, Yoichi Moriya, Jun Urakawa, Yasutaka Sugimoto
  • Patent number: 7439203
    Abstract: A dielectric ceramic composition comprising a main component including barium titanate and an oxide of Al, wherein the dielectric ceramic composition includes a plurality of dielectric particles, concentration of Al in each of the dielectric particles becomes lower from a particle surface to inside thereof, and each of the dielectric particles has an Al non-dispersed region substantially not including Al at least at a center portion of the particle.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: October 21, 2008
    Assignee: TDK Corporation
    Inventors: Kazushige Ito, Akira Sato
  • Patent number: 7439204
    Abstract: A process for controlling the hydrogenation activity of a catalyst comprised of a crystalline molecular sieve and at least one hydrogenation metal selected from the group consisting of a Group VIIB metal, a Group VIII metal, and mixtures thereof. The process is carried out by contacting the catalyst with hydrogen under sufficient conditions of temperature and pressure and for sufficient time to reduce the hydrogenolysis activity of the catalyst. The catalyst prepared by the process finds application in the catalytic conversion of organic compounds, such as ethylbenzene dealkylation, xylenes isomerization, and the transalkylation of polyalkylaromatic hydrocarbons.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: October 21, 2008
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Timothy E. McMinn, Ronald J. Cimini, Robert A. Crane, Andrew M. Hiester, Teresa A. Jurgens-Kowal, Gary D. Mohr
  • Patent number: 7439205
    Abstract: In accordance with the present invention, there is provided a transition metal olefin polymerization catalyst component characterized by the formula: where, M is a Group IV or a Group IV transition metal, B is a bridge group containing at least two carbon atoms, A? and A? are organogroups, each containing a heteroatom selected from the group consisting of oxygen, sulfur, nitrogen and phosphorus, X is selected from the group consisting of chlorine, bromine, iodine, a C1-C20 alkyl group, a C6-C30 aromatic group and mixtures thereof, and n is 1, 2 or 3. The invention also encompasses a method for the polymerization of an ethylenically unsaturated monomer which comprises contacting a transition metal catalyst component as characterized by formula (1) above and an activating co-catalyst component in a polymerization reaction zone with an ethylenically unsaturated monomer under polymerization conditions to produce a polymer product.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: October 21, 2008
    Assignee: Fina Technology, Inc.
    Inventors: Abbas Razavi, Vladimir Marin, Margarito Lopez
  • Patent number: 7439206
    Abstract: A method of making a composition, said method comprising, spraying a substance comprising platinum and iron into or onto an alumina-containing compound is disclosed. The resulting composition can then be used in a process for oxidizing carbon monoxide with free oxygen.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: October 21, 2008
    Inventors: M. Bruce Welch, Roland Schmidt, Jianhua Yao, Glenn W. Dodwell, Robert W. Morton, Jason J. Gislason, James B. Kimble, David E. Simon, Marvin M. Johnson
  • Patent number: 7439207
    Abstract: The invention relates to novel substituted pyridyl ketones of the formula in which A, R, X, Y, Z and n are as defined in the disclosure, to processes for preparing these novel substances, and to their use as crop treatment agents, in particular as herbicides. The invention further relates to novel intermediates of the formulae and to processes for their preparation.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: October 21, 2008
    Assignee: Bayer CropScience AG
    Inventors: Hans-Georg Schwarz, Dorothee Hoischen, Kristian Kather, Klaus-Helmut Müller, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Patent number: 7439208
    Abstract: A method of forming MgB2 films in-situ on a substrate includes the steps of (a) depositing boron onto a surface of the substrate in a deposition zone; (b) moving the substrate into a reaction zone containing pressurized, gaseous magnesium; (c) moving the substrate back into the deposition zone; and (d) repeating steps (a)-(c). In a preferred embodiment of the invention, the substrate is moved into and out of the deposition zone and the reaction zone using a rotatable platen.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: October 21, 2008
    Assignee: Superconductor Technologies, Inc.
    Inventors: Brian H. Moeckly, Ward S. Ruby
  • Patent number: 7439209
    Abstract: A drilling fluid system comprising a brine and a quantity of cationic copolymers comprising a ratio of acrylamide monomers to cationic derivatives of acrylamide monomers, wherein the quantity and the ratio are effective to maintain effective rheology and fluid loss control in said drilling fluid system at temperatures of at least about 250° C. for at least about 16 hours.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: October 21, 2008
    Assignee: Baker Hughes Incorporated
    Inventors: Billy G. Chesser, Charles Perricone, George W. Bettge
  • Patent number: 7439210
    Abstract: An inhibitive water-based polymer mud system and method for using the system in drilling and in stabilizing wellbores is disclosed for use in water sensitive formations as an alternative to oil-based muds. The system comprises a non-ionic low molecular weight polyacrylamide in combination with a non-ionic high molecular weight polyacrylamide, preferably long chain alcohol and poly anionic cellulose.
    Type: Grant
    Filed: April 24, 2004
    Date of Patent: October 21, 2008
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Gary C. West, Ernest Len Grebe, David Carbajal
  • Patent number: 7439211
    Abstract: The invention concerns a method for preparing a lubricating composition, characterised in that it comprises mixing two previously prepared oil-in-water emulsions (A) and (B): the prior emulsion (A) comprises: (a) at least a non-reactive linear polyorganosiloxane oil comprising per molecule at least 2% in number of organic substituents bound to the silicon atoms which are aryl, alkylarylene and/or arylenealkyl radicals; (b) at least a polyorganosiloxane resin bearing hydroxyl groups and comprising at least two different siloxyl units selected among those formula (R1)3SiO1/2(M), (R1)2SiO2/2(D), R1SiO3/2(T) and SiO4/2(Q), one at least of said units being a unit T or Q, R1 representing an organic substituent; (c) at least a crosslinking agent soluble in the silicone phase comprising at least two functions capable of reacting with the polyorganosiloxane resin(s) (b); (d) a condensation catalyst capable of catalysing the reaction of the constituent (b) with the constituent (c); (e) a surfactant; and (f) water; the
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: October 21, 2008
    Assignee: Rhodia Chimie
    Inventors: Gérald Guichard, Ian Hawkins
  • Patent number: 7439212
    Abstract: The inventive composition comprises compatible combinations of vegetable oils and polar non-chlorine phosphorous-based extreme pressure additives, the composition being either (a) a working strength straight oil, (b) a soluble oil concentrate dilutable to a working strength soluble oil, the composition when at working strength effectively lubricating metal parts during high performance metalworking, and providing environmental and safety advantages.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: October 21, 2008
    Assignee: United Soybean Board
    Inventors: James P. King, Neil Canter
  • Patent number: 7439213
    Abstract: A composition of a major amount of an oil of lubricating viscosity; a secondary or tertiary amine being represented by the formula R1R2NR3 wherein R1 and R2 are alkyl groups of at least 6 carbon atoms and R3 is hydrogen, a hydrocarbyl group, a hydroxyl-containing alkyl group, or an amine-containing alkyl group; and a dispersant, provides high static coefficients of friction and a durable positive slope during oxidative and mechanical stressing, particularly as a friction component of an automatic transmission.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: October 21, 2008
    Assignee: The Lubrizol Corporation
    Inventors: Craig D. Tipton, Mark R. Baker, Shreyasi Lahiri
  • Patent number: 7439214
    Abstract: This invention relates to cationically derivatized polycalactomannans obtained from cassia tora and cassia obtusifolia and to their use in personal care, household care, and institutional care compositions.
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: October 21, 2008
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventors: Ferdinand Utz, Carole A. Lepilleur, Krishnan Tamareselvy, Joseph A. Chiarelli, Julie F. Schmucker-Castner, Michael P. Myers, Daniel F. Hasman, Brian J. Vondruska, William R. Wilber, Hong Luo, Nancy S. Marchant, Francine Shuster
  • Patent number: 7439215
    Abstract: A water-soluble pouch suitable for use in machine dishwashing and which comprises a plurality of compartments in generally superposed or superposable relationship, each containing one or more detergent active or auxiliary components, and wherein the pouch has a volume of from about 5 to about 70 ml and a longitudinal/transverse aspect ratio in the range from about 2:1 to about 1:8, preferably from about 1:1 to about 1:4. The water-soluble pouch allows for optimum delivery of dishwashing detergent. A process for the manufacture of multi-compartment pouches and a pack to contain the pouches are also disclosed.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: October 21, 2008
    Assignee: The Procter & Gamble Company
    Inventors: Tanguy Marie Louis Alexandre Catlin, Rachid Ben Moussa, Timothy Bernard William Kroese, Charles Rupert Gillham, James Iain Kinloch, David John Smith, Alison Lesley Main, Helen Varley
  • Patent number: 7439216
    Abstract: A composition for treating or cleaning fabric articles, especially articles of clothing, linen and drapery, wherein the composition comprises a lipophilic fluid, a polyalkyleneoxide polysiloxane surfactant, and a second surfactant.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: October 21, 2008
    Assignee: The Procter & Gamble Company
    Inventors: Anna Vadimovna Noyes, John Cort Severns, Frederick Anthony Hartman, James Charles Theophile Roger Burckett-St. Laurent, Arseni V. Radomyselski, Paul Amaat France, Jeffrey John Scheibel, Christiaan Arthur Jacques Kamiel Thoen, John Christopher Deak, Phillip Kyle Vinson, Nabil Yaqub Sakkab
  • Patent number: 7439217
    Abstract: The invention is directed to a liquid laundry detergent composition comprising at least one detergent ingredient selected from the group consisting of anionic surfactant, zwitterionic surfactant, amphoteric surfactant, and mixtures thereof; a coacervate phase forming cationic polymer; and one or more fabric care ingredients selected from the group consisting of one or more cationic silicone polymers comprising one or more polysiloxane units and one or more nitrogen moieties; one or more amino silicone polymers; one or more nitrogen-free silicone polymers; and mixtures thereof; and a liquid carrier for providing cleaning and fabric care benefits. A process for preparing such compositions, a method for treating substrates, a method for providing certain fabric care benefits and the use of such compositions are also described.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: October 21, 2008
    Assignee: The Procter & Gamble Company
    Inventors: Jean-Pol Boutique, Patrick Firmin August Delplancke, Roland Wagner, Matthew David Butts, Sarah Elizabeth Genovese, Stefano Scialla
  • Patent number: 7439218
    Abstract: The present invention discloses a highly potent, non-toxic, disinfectant that can be used for a wide breadth of applications. The disinfectant comprises hydrogen peroxide (H2O2), orange terpene oil, orange valencia oil, a non-ionic emulsifier (polysorbate 80), and water (H2O). Applications of the disinfectant include, but are not limited to, uses as a mouthwash, skin cleanser, or as a germicidal for disinfecting surfaces such as foodstuff, plant matter, leather, wood, metal, plastic and fabrics. Methods for using the disinfectant composition of the invention are also provided.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: October 21, 2008
    Assignee: Knockout Technologies, Ltd
    Inventor: Robert Bowker
  • Patent number: 7439219
    Abstract: A modified polyol having alkoxylation and amine capping units, uses of the modified polyol having alkoxylation and amine capping units, and leaning compositions having the modified polyol having alkoxylation and amine capping units.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: October 21, 2008
    Assignee: The Procter & Gamble Company
    Inventors: Jeffrey John Scheibel, Julie Ann Menkhaus
  • Patent number: 7439220
    Abstract: A dispersion including anionic softeners and a process for producing compositions of anionic softeners is provided and obtainable by (a) reacting partial glycerides with maleic anhydride at a temperature above 53° C., wherein maleic anhydride is used in stoichiometric or below stoichiometric quantities to form a reaction product; and, (b) reacting the reaction product with an aqueous solution of sodium sulphite, wherein a quantity of water is selected to form a final product in the form of a 5 to 50 wt % aqueous solution. Powder compositions of anionic softeners may be obtained by drying the final product.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: October 21, 2008
    Assignee: Cognis IP Management GmbH
    Inventors: Juergen Falkowski, Christa Hartschen, Bernd Wahle
  • Patent number: 7439221
    Abstract: Methods and compositions for modulating mammalian gamete adhesion are provided. Representative modulators of gamete adhesion include, but are not limited to polypeptides comprising at least one discoidin/C domain, and optionally at least one EGF domain. A representative polypeptide includes, but is not limited to SED1 polypeptides (SEQ ID NOs. 2-7), prodrugs, fragments, or derivatives thereof. Methods for identifying modulators of SED1-mediated gamete adhesion are also provided.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: October 21, 2008
    Assignee: Emory University
    Inventors: Barry D. Shur, Michael Ensslin
  • Patent number: 7439222
    Abstract: The invention provides methods of synthesizing peptides, involving the steps of providing a composition including a peptide fragment, wherein the peptide fragment has at least one amino acid residue and includes a base-sensitive, N-terminal protecting group; removing the base-sensitive, N-terminal protecting group from the peptide fragment using a deprotection reagent that includes a base, whereby an N-terminal functionality on the peptide fragment is deprotected; removing the base from the composition to provide a residual base content of more than 100 ppm; causing a reactive peptide fragment having a reactive C-terminus and a base-sensitive N-terminal protecting group to react with the deprotected N-terminal functionality of the peptide fragment under conditions such that the reactive peptide fragment is added to the peptide fragment; and optionally repeating the deprotection and coupling steps until a desired peptide is obtained.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: October 21, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Martin R. Guinn, Lewis M. Hodges, David A. Johnston, Hendrick Moorlag, Mark A. Schwindt
  • Patent number: 7439223
    Abstract: The Rev peptide that binds to nucleophosmin/B23 with the highest affinity exhibits the greatest cytotoxicity on Ras-3T3 cells and inhibits tumor growth most effectively in nude mice. The efficiency of colony formation in soft agar of Ras-3T3 cells is significantly inhibited by treatment with Rev peptide. In addition, Rev peptide can potentiate the doxorubicin-induced decrease of cellular viability in U1 bladder cancer cells and inhibition of tumor growth in nude mice. Treatment of Rev peptide increases protein expression and transcriptional activity of p53 and inhibits the nucleophosmin/B23-mediated PCNA promoter activation. Peptides having high affinity of binding to molecular targets such as nucleophosmin/B23 represent a useful approach to anti-cancer biotherapeutics.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: October 21, 2008
    Assignee: Chang Gung University
    Inventor: Benjamin Yat Ming Yung
  • Patent number: 7439224
    Abstract: The present invention relates to the use of a composition comprising at least one mannan-binding lectin (MBL) subunit, or at least one mannan-binding lectin (MBL) oligomer comprising the at least one mannan-binding lectin (MBL) subunit, in the manufacture of a medicament for prophylaxis and/or treatment of infection. In particular the invention relates to prophylaxis and/or treatment of infection in an individual having an immunocompromised condition; and/or an individual being at risk of acquiring an immunocompromised condition resulting from a medical treatment. The present invention is particular relevant for prophylaxis and/or treatment of infection in individuals suffering from neutropenia, in particular as prophylaxis and/or treatment of infection in individuals receiving or going to receive chemotherapy or similar treatment.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: October 21, 2008
    Inventors: Steffen Thiel, Jens Christian Jensenius
  • Patent number: 7439225
    Abstract: The present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or K01-B0171-C substance in a culture fluid and isolating K01-B0171-B substance and/or, K01-B0171-C substance from the culture fluid. The obtained K01-B0171-B substance, K01-B0171-C substance or a composition of these substances is expected to be useful as a medicament of antituberculous agent.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: October 21, 2008
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Hiroshi Tomoda, Masato Iwatsuki, Yoko Takahashi
  • Patent number: 7439226
    Abstract: The present disclosure concerns peptides and peptidomimetics having inhibitory activity against serine proteases. The disclosed peptides and peptidomimetics are particularly useful as selective inhibitors of matriptase and MTSP1. Pharmaceutical compositions comprising serine protease inhibitors and methods for administering the compositions also are disclosed.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: October 21, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Peter P. Roller, Peng Li
  • Patent number: 7439227
    Abstract: This invention relates to the use in the treatment of HCV infection, either as single active agents or in combination with another active agent, of a cyclosporin having increased cyclophilin binding activity and essentially lacking immunosuppressive activity.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: October 21, 2008
    Inventors: Pietro Scalfaro, Jean-Maurice Dumont, Gregoire Vuagniaux, Rolland-Yves Mauvernay
  • Patent number: 7439228
    Abstract: The present invention provides a cytotoxic 7 to 25-mer peptide with three or more catonic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing the peptides, pharmaceutical compositions containing them, and their use as medicaments, particularly as antibacterial or antitumor agents.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: October 21, 2008
    Assignee: Lytix Biopharma AS
    Inventors: John Sigurd Svendsen, Øystein Rekdal, Baldur Sveinbjørnsson, Lars Vorland
  • Patent number: 7439229
    Abstract: The present invention relates to cytokine activity regulator molecules (CARMs) and their use in controlling the action of cytokines, particularly chemokines. In particular, the invention relates to CARMs that are derived from parasite salivary glands. The invention also relates to the use of CARMs in the treatment of diseases and allergies and in the production of vaccines that protect mammals, including humans, against the transmission of pathogenic (disease-causing) micro-organisms by certain parasites.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: October 21, 2008
    Assignee: Evolutec Limited
    Inventors: Norbert Fuchsberger, Valéria Hajnická, Paula Kocákova, Mirko Slovák, Juraj Ga{hacek over (s)}perík
  • Patent number: 7439230
    Abstract: The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: October 21, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert J. Peach, Joseph R. Naemura, Peter S. Linsley, Jurgen Bajorath
  • Patent number: 7439231
    Abstract: The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: October 21, 2008
    Assignee: Provid Pharmaceuticals, Inc.
    Inventors: Gary Olson, Charles Cook, Christopher Self
  • Patent number: 7439232
    Abstract: There is provided a heteroaryl 5-thio-?-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, particularly a prophylactic or therapeutic agent for diabetes, diabetes-related diseases or diabetic complications, which comprises such a compound as an active ingredient.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: October 21, 2008
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Hiroyuki Kakinuma, Masakazu Sato, Hideaki Amada, Hajime Asanuma, Yuko Tsuchiya
  • Patent number: 7439233
    Abstract: Vaccination with the DNA encoding T-cell epitopes to the house dust mite Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f were effective in the inhibition of the allergen induced IgE synthesis. Gene therapy using T-cell epitope encoding DNA is useful in combating allergic disease.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: October 21, 2008
    Inventor: Tai June Yoo
  • Patent number: 7439234
    Abstract: A method for treating cancer patients undergoing chemotherapeutic treatments by administering Product R, a peptide-nucleic acid preparation, is disclosed.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: October 21, 2008
    Assignee: Advanced Viral Research Corporation
    Inventor: Shalom Z. Hirschman
  • Patent number: 7439235
    Abstract: A method for obtaining an extract from a natural mixture of conjugated estrogens from the urine of pregnant mares (PMU) by solid-phase extraction on semipolar adsorption resins in which the resulting extract meets the pharmaceutical specifications for conjugated estrogens and the content of free estrogens is minimized even if old pregnant mares' urine and/or pregnant mares' urine which has been stored or transported at elevated temperatures is used.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: October 21, 2008
    Assignee: Solvay Pharmaceuticals GmbH
    Inventors: Rasche Heinz-Helmer, Rupp Olaf
  • Patent number: 7439236
    Abstract: The present invention relates to compounds of formula I The substituent designations are as disclosed. At least one of B, Q, D and E is nitrogen. The present invention also provides a method of treating disorders of the Central Nervous System such as schizophrenia and cognitive dysfunction.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: October 21, 2008
    Assignee: Pfizer Inc
    Inventors: Brian Thomas O'Neill, Jotham Wadsworth Coe, Christopher J. O'Donnell
  • Patent number: 7439237
    Abstract: The present invention relates to the CGRP antagonists of general formula wherein A, X and R1 to R3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: October 21, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Klaus Rudolf, Stephan Georg Mueller, Philipp Lustenberger, Dirk Stenkamp, Gerhard Schaenzle, Kirsten Arndt, Henri Doods