Patents Issued in October 21, 2008
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Patent number: 7439338Abstract: The present invention provides metal-containing compounds that include at least one ?-diketiminate ligand, and methods of making and using the same. In certain embodiments, the metal-containing compounds include at least one ?-diketiminate ligand with at least one fluorine-containing organic group as a substituent. In other certain embodiments, the metal-containing compounds include at least one ?-diketiminate ligand with at least one aliphatic group as a substituent selected to have greater degrees of freedom than the corresponding substituent in the ?-diketiminate ligands of certain metal-containing compounds known in the art. The compounds can be used to deposit metal-containing layers using vapor deposition methods. Vapor deposition systems including the compounds are also provided. Sources for ?-diketiminate ligands are also provided.Type: GrantFiled: June 28, 2005Date of Patent: October 21, 2008Assignee: Micron Technology, Inc.Inventors: Dan Millward, Timothy A. Quick
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Patent number: 7439339Abstract: A process for forming a diazo compound comprises reacting an organic compound bearing an acidic hydrogen with an aryl-diazonium salt in the presence of an inorganic base and a non-halogenated solvent. The process is simpler and more environmentally friendly than known processes.Type: GrantFiled: April 19, 2005Date of Patent: October 21, 2008Assignee: Eastman Kodak CompanyInventor: Catherine Mineur
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Patent number: 7439340Abstract: A reactive dyestuff containing an alkylthio-s-triazinyl reactive group of the following formula (I) is disclosed, wherein A, X, Y, Z, R, Q, and a are defined the same as the specification. It is suitable for exhaust dyeing, cold batch-up dyeing and continuous dyeing materials that contain hydroxyl group or nitrogen group fibers.Type: GrantFiled: February 15, 2007Date of Patent: October 21, 2008Assignee: Everlight USA, Inc.Inventors: Wen-Jang Chen, Hsien-Chung Shia, Duncan Adrian Sidney Phillips, John Anthony Taylor
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Patent number: 7439341Abstract: Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition.Type: GrantFiled: November 12, 2004Date of Patent: October 21, 2008Assignee: Integrated DNA Technologies, Inc.Inventors: Andrei Laikhter, Mark Aaron Behlke, Joseph Walder, Kevin William Roberts, Yawfui Yong
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Patent number: 7439342Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.Type: GrantFiled: January 8, 2007Date of Patent: October 21, 2008Assignee: Smith Kline Beecham Corp.Inventors: Kevin J. Duffy, Juan I. Luengo
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Patent number: 7439343Abstract: Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R1 is an alkyl group or an azaalkyl group, and R2 is a primary or secondary amino group.Type: GrantFiled: September 1, 2005Date of Patent: October 21, 2008Assignee: Rensselaer Polytechnic InstituteInventors: Kaushal Rege, Shanghui Hu, Jonathan S. Dordick, Steven M. Cramer
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Patent number: 7439344Abstract: The present invention relates to a one-step process for the selective O-acylation of the hydroxy groups of a nucleoside under basic conditions utilizing DMAP and a carboxylic acid anhydride in aqueous heterogenous solvent mixture.Type: GrantFiled: September 22, 2006Date of Patent: October 21, 2008Assignee: Roche Palo Alto LLCInventor: Keshab Sarma
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Patent number: 7439345Abstract: The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula: and oligomers thereof.Type: GrantFiled: December 23, 2003Date of Patent: October 21, 2008Assignee: Nanogen Recognomics GmbHInventors: Christian Miculka, Norbert Windhab, Albert Eschenmoser, Stefan Scherer, Gerhard Quinkert
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Patent number: 7439346Abstract: Compilations of nucleic acids, articles of manufacture which are surfaces comprising multiple blocks of arrays comprising such compilations, methods of use of the compilations and arrays for detection of chromosomal disorders, such as a chromosomal aneuploidies, deletions, amplifications, and diagnosis and prognosis of syndromes associated with a contiguous gene abnormality and kits are provided.Type: GrantFiled: May 17, 2004Date of Patent: October 21, 2008Assignee: Perkinelmer Las Inc.Inventors: Robert C. Johnson, Mansoor Mohammed, Jae Weon Kim, Xan-Yan Lu
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Patent number: 7439347Abstract: Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the invention include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and peptides, as well as, methods of making and using the aforementioned compositions including, but not limited to, diagnostics and medicaments for the treatment and prevention of HCV infection.Type: GrantFiled: October 13, 2005Date of Patent: October 21, 2008Assignee: Tripep ABInventor: Matti Sällberg
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Patent number: 7439348Abstract: The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for an inducible promoter for the gene encoding a maize deoxyhypusine synthase. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method comprises stably incorporating into the genome of a plant cell a nucleotide sequence operably linked to the root-preferred promoter of the present invention and regenerating a stably transformed plant that expresses the nucleotide sequence.Type: GrantFiled: January 10, 2006Date of Patent: October 21, 2008Assignees: Pioneer Hi-Bred International, Inc., E.I. du pont de Nemours and CompanyInventors: Scott Diehn, Albert L. Lu, Billy F. McCutchen, Lynne E. Sims, Kim R. Ward
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Patent number: 7439349Abstract: Method for producing large lots of final sterile Poly-ICLC suitable for clinical use with reduced toxicity at effective dose levels, and method for using Poly-ICLC to regulate genes, and method for using Poly-ICLC to treat certain human and veterinary infectious, neoplastic and autoimmune disorders.Type: GrantFiled: July 1, 2003Date of Patent: October 21, 2008Inventor: Andres Salazar
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Patent number: 7439350Abstract: Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.Type: GrantFiled: June 29, 2004Date of Patent: October 21, 2008Assignee: Gilead Sciences, Inc.Inventors: Norbert W. Bischofberger, Robert J. Jones, Murty N. Arimilli, Kuei-Ying Lin, Michael S. Louie, Lawrence R. McGee, Ernest J. Prisbe, William A. Lee, Kenneth C. Cundy
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Patent number: 7439351Abstract: Method for the sterospecific preparation of 2? or 3? deoxy and 2?,3?-dideoxy-?-L-pentafuranonucleoside compounds. 2? or 3? deoxy and 2?,3?-dideoxy-?-L-pentofuranonucleoside compounds are also described. Finally, the invention concerns the use of these compounds, and particularly 2?,3?dideoxy-?-L-fluorocytidine, as drugs, and especially as anti-viral agents.Type: GrantFiled: September 26, 2003Date of Patent: October 21, 2008Assignees: The UAB Research Foundation, Emory University, Centre National de la Recherche Scientifique (CNSR)Inventors: Gilles Gosselin, Jean-Louis Imbach, Anne-Marie Aubertin, Jean-Pierre Sommmadossi, Raymond F. Schinazi
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Patent number: 7439352Abstract: A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst, and subsequent purification of the anhydrosugar alcohol. In some embodiments of the present invention, film evaporators are used in distillation and purification of the anhydrosugar alcohols. Anhydrosugar alcohols of very high purity are achieved in the practice of the present invention. In some embodiments of the present invention, very high purities of the anhydrosugar alcohols are achieved without the use of organic solvents.Type: GrantFiled: November 14, 2003Date of Patent: October 21, 2008Assignee: Archer-Daniels-Midland CompanyInventors: Kevin M. Moore, Alexandra J. Sanborn, Paul Bloom
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Patent number: 7439353Abstract: This invention relates to a process of manufacturing a cellulose molding, a plant component extracting apparatus and a process of manufacturing cellulose acetate. In one embodiment of the invention, the process of manufacturing a cellulose molding comprises steaming corncob meal at a temperature of 150 to 250° C. and a pressure of 20 to 29 MPa, filtering the steamed corncob meal with a filtering device to obtain a solid and molding the solid.Type: GrantFiled: March 12, 2004Date of Patent: October 21, 2008Assignee: Celjan Co., Ltd.Inventors: Shunichi Matsuo, Takatsugu Takamura
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Patent number: 7439354Abstract: A process for preparing amide acetals represented in Formula I comprising dehydrating a reactant mixture comprising reactants selected from a group consisting of N-acyl dialkanol amines, O-acyl dialkanol amines and mixtures thereof wherein n and m are independently 2 or 3; p is 1, 2 or 3; R1 and R2 can be the same or different and are each independently hydrogen, a linear or branched alkyl, cycloalkyl or aryl group with 1-20 C atoms; R represents hydrogen, a branched or linear alkyl, cycloalkyl, aryl or an alkenyl group with 1-20 C-atoms, each may have one or more substituents.Type: GrantFiled: December 2, 2004Date of Patent: October 21, 2008Assignee: E.I. du Pont de Nemours and CompanyInventors: Christian Peter Lenges, Josef Huybrechts, Douglas J. Adelman
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Patent number: 7439355Abstract: There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4 and R41 to R46 have meanings given in the description, which process comprises the dehydrative cyclisaton of a compound of formula II. (II).Type: GrantFiled: March 25, 2005Date of Patent: October 21, 2008Assignee: AstraZeneca ABInventor: John Pavey
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Patent number: 7439356Abstract: The present invention relates to intermediates of the formula useful in the preparation of piperazinyl-substituted indan derivatives, wherein Y is CONR2 wherein R2 is H or C1-C6 alkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R4 and/or R5, wherein R4 and R5 are as defined in the specification; and R9 is H, C1-C6 alkyl, C3-C6 cycloalkyl, OCF3, OCHF2, OCH2F, halogen, CN, CF3, OH, C1-C6 alkoxy, C1-C6 alkoxy-C1-C6 alkyl, NR6R7, SO3CH3, SO3CF3, SO2NR6R7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C1-C6 alkyl; or COR8; wherein R6, R7 and R8 are as defined in the specification. The invention further relates to a process for the preparation of the intermediates.Type: GrantFiled: October 3, 2006Date of Patent: October 21, 2008Assignee: AstraZeneca ABInventors: Stefan Berg, Lennart Florvall, Svante Ross, Seth-Olov Thorberg
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Patent number: 7439357Abstract: A process for preparing a thiazole compound of formula (3): wherein X1 represents a hydrogen atom or a halogen atom comprising reacting a compound of formula (1): wherein X1 is as defined above, and X2 represents a halogen atom, with ammonia and formaldehyde to obtain a hexahydrotriazine compound of formula (2): wherein X1 is as defined above, and hydrolyzing the compound of formula (2).Type: GrantFiled: June 10, 2005Date of Patent: October 21, 2008Assignee: Sumitomo Chemical Company, LimitedInventors: Naoyuki Takano, Shinzo Seko, Kazuyuki Tanaka
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Patent number: 7439358Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.Type: GrantFiled: January 30, 2007Date of Patent: October 21, 2008Assignee: Boehringer Ingelheim International GmbHInventors: Guenter Linz, Peter Sieger, Matthias Grauert, Rolf Schmid
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Patent number: 7439359Abstract: Structural differences in binding pockets of members of the HSP90 family can be exploited to achieve differential degradation of kinases and other signaling proteins through the use of designed small molecules which interact with the N-terminal binding pocket with an affinity which is greater than ADP and different from the ansamycin antibiotics for at least one species of the HSP90 family. Moreover, these small molecules can be designed to be soluble in aqueous media, thus providing a further advantage over the use of ansamycin antibiotics. Pharmaceutical compositions can be formulated containing a pharmaceutically acceptable carrier and a molecule that includes a binding moiety which binds to the N-terminal pocket of at least one member of the HSP90 family of proteins. Such binding moieties were found to have antiproliferative activity against tumor cells which are dependent on proteins requiring chaperones of the HSP90 family for their function.Type: GrantFiled: November 1, 2001Date of Patent: October 21, 2008Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Gabriela Chiosis, Neal Rosen
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Patent number: 7439360Abstract: Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers,Type: GrantFiled: October 14, 2005Date of Patent: October 21, 2008Assignee: AMGEN Inc.Inventors: Vijay Keshav Gore, Vu Van Ma, Mark H. Norman, Vassil I. Ognyanov, Ning Xi
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Patent number: 7439361Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.Type: GrantFiled: April 20, 2007Date of Patent: October 21, 2008Assignee: Schering CorporationInventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Loc Thanh Tran, Pengyi Zhang, Andrew D. Jones
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Patent number: 7439362Abstract: Piperazinyl- or piperidinylamine-sulfamic acid amides and their use for the manufacture of a medicament in diseases mediated by the action of steriod sulfatase.Type: GrantFiled: March 27, 2003Date of Patent: October 21, 2008Assignee: Novartis AGInventor: Philipp Lehr
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Patent number: 7439363Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): R2 is selected from the group consisting of —C1-8alkyl-Z, —C2-8alkenyl-Z and —C2-8alkynyl-Z; wherein the —C1-8alkyl-Z, —C2-8alkenyl-Z and —C2-8alkynyl-Z and Z is a 5 to 6 member aromatic monocyclic heteroaryl ring having from 2 to 4 heteroatoms. These compounds are useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.Type: GrantFiled: June 1, 2004Date of Patent: October 21, 2008Assignee: Janssen Parmaceutica N.V.Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye
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Patent number: 7439364Abstract: Methods of preparing compounds of Formula I are provided.Type: GrantFiled: December 4, 2006Date of Patent: October 21, 2008Assignee: WyethInventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Greg Feigelson, Zhixian Ding
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Patent number: 7439365Abstract: The present invention relates to the oxalate salt of 1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl]methyl piperidine, commonly known as Donepezil, and its method of preparation.Type: GrantFiled: June 29, 2004Date of Patent: October 21, 2008Assignee: USV, Ltd.Inventors: Venkatasubramanian Radhakrishnan Tarur, Dhananjay Govind Sathe, Avinash Venkatraman Naidu, Umesh Parashram Aher
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Patent number: 7439366Abstract: The present invention relates to a phenacylamine derivative of the formula (I) or a salt thereof: wherein A is alkyl, cycloalkyl, phenyl which may be substituted by Y, pyridyl which may be substituted by Y, or pyrazolyl which may be substituted by Y, R1 and R2 are each alkyl, or R1 and R2 may together form a 3- to 6-membered saturated carbocycle, R3 is hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl or COR4, X is halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkenyloxy, haloalkenyloxy, alkynyloxy, haloalkynyloxy, alkylthio, haloalkylthio, alkenylthio, haloalkenylthio, alkynylthio, haloalkynylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, nitro, cyano, phenyl which may be substituted by Y, phenoxy which may be substituted by Y, benzyloxy which may be substituted by Y, or pyridyloxy which may be substituted by Y, and n is an integer of from 0 to 5.Type: GrantFiled: February 9, 2001Date of Patent: October 21, 2008Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Yuji Nakamura, Masayuki Morita, Kenji Izakura
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Patent number: 7439367Abstract: The present invention relates to an improved process for the preparation of a sulfinyl compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, from a sulfide compound of formula (II), wherein in both formulae (I) and (II) R1 and R3 are selected from the group consisting of hydrogen, methyl or C1-4alkoxy, R2 is selected from the group consisting of substituted or unsubstituted C1-4alkoxy and R4 is selected from the group consisting of hydrogen or substituted or unsubstituted C1-4alkoxy.Type: GrantFiled: January 12, 2004Date of Patent: October 21, 2008Assignee: CIPLA LimitedInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Pathi L. Srinivas
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Patent number: 7439368Abstract: The present invention provides a process of preparing a compound of the formula [I]: wherein X is a group of the formula: —N? or —CH?; R1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cyano group or an amino group optionally substituted by a lower alkyl group; Ring A is a nitrogen-containing heterocyclic group; Ring B is an optionally substituted benzene ring or an optionally substituted pyridine ring; and R3 is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of activated blood coagulation factor X.Type: GrantFiled: June 29, 2004Date of Patent: October 21, 2008Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Masahiko Seki, Shin-ichi Yoshida, Nobuhiro Yagi, Masanori Hatsuda, Mayumi Kimura, Kazuhiko Kondo
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Patent number: 7439369Abstract: A method and system for storing and evolving hydrogen employ chemical compounds that can be hydrogenated to store hydrogen and dehydrogenated to evolve hydrogen. A catalyst lowers the energy required for storing and evolving hydrogen. The method and system can provide hydrogen for devices that consume hydrogen as fuel.Type: GrantFiled: June 10, 2005Date of Patent: October 21, 2008Assignee: Loa Alamos National Security, LLCInventors: David L. Thorn, William Tumas, P. Jeffrey Hay, Daniel E. Schwarz, Thomas M. Cameron
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Patent number: 7439370Abstract: The invention relates to new substituted imidazoles of general formula wherein R1 to R3 and X are defined as claims, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, and processes for preparing them and their use as intermediates for preparing pharmaceutical compositions or pesticides.Type: GrantFiled: May 9, 2005Date of Patent: October 21, 2008Assignee: Boehringer Ingelheim International GmbHInventor: Matthias Eckhardt
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Patent number: 7439371Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: GrantFiled: July 11, 2006Date of Patent: October 21, 2008Assignee: Allergan, Inc.Inventors: Julie A. Wurster, Richard C. Yee
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Patent number: 7439372Abstract: A compound having a structure is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed.Type: GrantFiled: May 1, 2007Date of Patent: October 21, 2008Assignee: Allergan, Inc.Inventors: Donde Yariv, Jeremiah H. Nguyen
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Patent number: 7439373Abstract: Provided are crystalline mycophenolate sodium forms and processes for their preparation.Type: GrantFiled: July 20, 2005Date of Patent: October 21, 2008Assignee: TEVA Gyógyszergyár Zártkörúen Múködö RészvénytársaságInventors: Sandor Molnar, Csaba Szabo, Tivadar Tamas, Janos Hajko, Adrienne Kovacsne-Mezei, Judith Aronhime
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Patent number: 7439374Abstract: The present invention provides compounds of Formula 1, wherein the variables Ar, A1, A2, A3, A4, R5, R6, R7, V, W, X, and Y are defined herein. Certain compounds of Formula 1 described herein possess potent antiviral activity. The invention also provides compounds of Formula 1 that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compounds of Formula 1, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula 1 effective to reduce signs or symptoms of the disease. These infectious diseases include viral infections, particularly HCV infections.Type: GrantFiled: January 5, 2005Date of Patent: October 21, 2008Assignee: Achillion Pharmaceuticals, Inc.Inventors: Andrew Thurkauf, Dawei Chen, Avinash Phadke, Shouming Li, Milind Deshpande
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Patent number: 7439375Abstract: There is provided a catalyst carrier comprising a refractory inorganic material having a sodium solubilization rate no greater than 5 ppmw/5 minutes. There is further a catalyst comprising a refractory inorganic material carrier having a sodium solubilization rate no greater than 5 ppmw/5 minutes; and one or more catalytically reactive metals deposited on said carrier. There is also provided a catalyst suitable for the vapor phase production of alkylene oxide from olefins and oxygen comprising an alumina-based carrier having a sodium solubilization rate no greater than 5 ppmw/5 minutes; and catalytically reactive silver deposited on said carrier.Type: GrantFiled: April 25, 2007Date of Patent: October 21, 2008Assignee: Shell Oil CompanyInventor: John Robert Lockemeyer
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Patent number: 7439376Abstract: A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s and other coatings. The moiety can be have the bromo and nitro groups linked to the same or different carbon atoms. The present invention also relates to urethanes, urea, amides, imides, carbonates, ethers, siloxanes, and many other types of linkages essential to MWF bases.Type: GrantFiled: May 7, 2007Date of Patent: October 21, 2008Assignee: TPAT IP LLCInventor: Thomas Daly
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Patent number: 7439377Abstract: An easy and inexpensive process by which a concentrate of a given unsaturated fatty acid can be obtained from a mixture which has conventionally been difficult to concentrate.Type: GrantFiled: March 16, 2007Date of Patent: October 21, 2008Assignee: The Nisshin OilliO Group, Ltd.Inventors: Hidetaka Uehara, Tomomi Suganuma, Satoshi Negishi
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Patent number: 7439378Abstract: The present invention relates to a novel fulvene compound and a preparation method thereof, and more particularly to a fulvene compound having substituted groups in the 2- and 5-positions, prepared from an unsaturated ketone having a substituted group in the ?-position and a halogen atom in the ?-position, and a preparation method thereof. The present invention also relates to a metallocene catalyst having a substituted group in the ?-position carbon of the bridge of the cyclopentadienyl group only by reaction of a fulvene compound and an anion group including the cyclopentadienyl group, and a preparation method of a polyolefin copolymer using the same.Type: GrantFiled: March 15, 2007Date of Patent: October 21, 2008Assignee: LG Chem, Ltd.Inventors: Young-Whan Park, Si-Geun Lee, Sung-Don Hong, Kwang-Ho Song, Boong-Goon Jeong, Dae-Woo Nam, Bun-Yeol Lee, Choong-Hoon Lee, Hyo-Sun Lee
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Patent number: 7439379Abstract: The present invention relates to a transition metal complex represented by the formula (I): wherein M represents a Group 4 transition metal; —Y— represents (a): —C(R1)(R20)-A-, (b): —C(R1)(R20)-A1(R30)-, (c): —C(R1)=A1-, or (d): —C(R1)=A1-A2-R30; A represents a Group 16 element and A1 and A2 each represents a Group 15 element; R1 to R9, R20, and R30 are the same or different and each represents an optionally substituted hydrocarbon group, etc.; and X1 and X2 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, etc., and an intermediate product thereof, and a catalyst for olefin polymerization which comprises said transition metal complex as a component.Type: GrantFiled: September 12, 2002Date of Patent: October 21, 2008Assignee: Sumitomo Chemical Co., Ltd.Inventors: Hidenori Hanaoka, Eiji Yoshikawa, Yuka Imamoto
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Diarylbutadiene-substituted diorganopolysiloxanes and photoprotective compositions comprised thereof
Patent number: 7439380Abstract: Novel 4,4-diarylbutadiene-substituted diorganopolysiloxanes having the structural formulae (1) or (2): in which A is a radical of formula (3) below: are useful sunscreens for UV-photoprotecting human skin against the damaging effects of UV-radiation, notably UV-A radiation.Type: GrantFiled: May 9, 2007Date of Patent: October 21, 2008Assignee: L'OrealInventor: Herve Richard -
Patent number: 7439381Abstract: A process is described for preparing 3-pentenenitrile by hydrocyanating 1,3-butadiene with hydrogen cyanide over at least one catalyst, wherein the 1,3-butadiene and/or hydrogen cyanide is contacted with at least one microporous solid before the reaction.Type: GrantFiled: January 26, 2005Date of Patent: October 21, 2008Assignee: BASF SEInventors: Tim Jungkamp, Dagmar Pascale Kunsmann-Keitel, Michael Bartsch, Robert Baumann, Gerd Haderlein, Hermann Luyken, Jens Scheidel
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Patent number: 7439382Abstract: The present invention relates to a compound of formula (1), wherein R1, R2, R3, n, and X are as defined in the specification, and a process for producing the same. This compound is useful as an intermediate for the synthesis of compounds useful as pharmaceuticals or agricultural chemicals.Type: GrantFiled: May 16, 2003Date of Patent: October 21, 2008Assignee: Meiji Seika Kaisha, Ltd.Inventors: Toshio Nishizuka, Hiroshi Kurihara
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Patent number: 7439383Abstract: The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis.Type: GrantFiled: April 18, 2003Date of Patent: October 21, 2008Assignee: University of Virginia Patent FoundationInventor: Milton L. Brown
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Patent number: 7439384Abstract: The present invention relates to a process for the preparation of a peroxyester which can be used in particular in polymerizations, such as the polymerization of vinyl chloride, or in the thermosetting of polyester resins. This process comprises the reaction of a hydroxyhydroperoxide salt with an acid halide or an acid anhydride under the following conditions: the molar ratio Rb of the hydroxyhydroperoxide corresponding to the hydroxyhydroperoxide salt to the acid halide is between 0.5 and 1.5; or alternatively the molar ratio Rb? of the hydroxyhydroperoxide corresponding to the hydroxyhydroperoxide salt to the acid anhydride is between 1.0 and 3.0; the hydroxyhydroperoxide salt was prepared beforehand by reaction of the corresponding hydroxyhydroperoxide with a base according to a molar ratio Ra of the base to the hydroxyhydroperoxide of between 0.5 and 1.5; and this process is carried out in aqueous media.Type: GrantFiled: February 7, 2002Date of Patent: October 21, 2008Assignee: ATOFINAInventors: Sandra Grimaldi, Gurusamy Jeyaraj
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Patent number: 7439385Abstract: The present invention provides a novel process for preparation of bisphosphonic acid derivatives or pharmaceutical acceptable salt thereof, by reacting carboxylic acid having structural formula (II) with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 in presence of diphenyl ether.Type: GrantFiled: July 24, 2006Date of Patent: October 21, 2008Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra
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Patent number: 7439386Abstract: Compounds are disclosed herein comprising or a pharmaceutically acceptable salt, or a metabolite or a prodrug thereof; wherein a dashed line indicates the presence or absence of a bond; Y, A, and B are described herein Therapeutic methods, manufacturing methods, compositions, and medicaments related thereto are also disclosed.Type: GrantFiled: April 17, 2006Date of Patent: October 21, 2008Assignee: Allergan, Inc.Inventor: Yariv Donde
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Patent number: 7439387Abstract: The present invention relates to a new industrial feasible process for the preparation of Gabapentin Form-II via a novel intermediate Gabapentin hemisulphate hemihydrate with out forming Gabapentin Form-III by neutralizing the Gabapentin hemisulphate hemihydrate solution with a base at higher temperatures followed by cooling to yield Gabapentin Form II with sulphate ions less than 100 ppm with respect to Gabapentin.Type: GrantFiled: April 16, 2004Date of Patent: October 21, 2008Assignee: Matrix Laboratories Ltd.Inventors: Chava Satyanarayana, Gorantla Seeta Ramanjaneyulu, Indukuri Venkata Sunil Kumar