Patents Issued in October 21, 2008
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Patent number: 7439288Abstract: The invention relates to flame retardants which comprise titanium phosphinates and/or titanyl phosphinates of the formulae (I) and (II) where R1 and R2 are identical or different and are unsubstituted or substituted linear or branched or cyclic C1-C10-alkyl groups or C6-C10-aryl, C7-C18-alkylaryl, or C7-C18-arylalkyl groups, and R3 is an unsubstituted or substituted linear or branched or cyclic C1-C10-alkylene group, C6-C10-arylene, C7-C18-alkylarylene, or C8-C18-arylalkylene group, and x is a number from 0 to 1.9. The invention also relates to molding compositions which comprise the inventive flame retardant.Type: GrantFiled: May 20, 2004Date of Patent: October 21, 2008Assignee: Clariant Produkte (Deutschland) GmbHInventors: Martin Sicken, Elke Schloβer
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Patent number: 7439289Abstract: Benzoylresorcinol-based phosphate esters are obtained by reacting a benzoylresorcinol compound with a chlorophosphate. The benzoylresorcinol-based phosphate esters can function as flame retardants and/or UV stabilizers for polycarbonates (PC), poly(phenylene oxide) (PPO), polyesters (e.g., PET and PBT), polycarbonate and acrylonitrile-butadiene-styrene terpolymer (PC/ABS) blends, poly(phenylene oxide) and high-impact polystyrene (PPO/HIPS) blends and other polymers. The benzoylresorcinol-based phosphate ester flame retardants may possess enhanced thermal stability compared to resorcinol based phosphate ester (RDP). Synthetic procedures and applications of the benzoylresorcinol-based phosphate esters compounds are provided.Type: GrantFiled: September 21, 2005Date of Patent: October 21, 2008Assignee: Indspec Chemical CorporationInventors: Raj B. Durairaj, Gary A. Jesionowski
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Patent number: 7439290Abstract: Linear low density polyethylene compositions suitable for the production of films having improved breathability are provided. The compositions which are comprised of a linear low density polyethylene base resin, a functionalized polyolefin and a polyester polyol are melt blended under conditions of mixing and shear to increase their melt elasticity.Type: GrantFiled: January 12, 2005Date of Patent: October 21, 2008Assignee: Equistar Chemicals, LPInventors: Chun D. Lee, Manivakkam J. Shankernarayanan
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Patent number: 7439291Abstract: A solvent-resistant polymeric membrane comprising a solvent-inert polymer having a solubility parameter greater than 18 (J/cm3)0.5, such as a polyketone, a polyether ketone, polyarylene ether ketone ketone, a polyimide, a polyetherimide, or a polyphenylene sulfide, is described. The solvent-resistant polymeric membrane can be prepared by methods in which solvent-inert polymers form a solution at room temperature.Type: GrantFiled: September 14, 2005Date of Patent: October 21, 2008Assignee: General Electric CompanyInventors: Hua Wang, Anatoli Kogan, Jared Paul Ray, Gary William Yeager
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Patent number: 7439292Abstract: The invention relates to the use of a block copolymer having at least one block that comprises phosphate and/or phosphonate functions, as an additive for film-forming compositions, such as paint, latex or mastic which is optionally siliconised in order to ensure or promote the adhesion of the aforementioned compositions on a metallic surface or to protect said metallic surface against corrosion. The invention also relates to film-forming compositions comprising the abovementioned block copolymers.Type: GrantFiled: March 13, 2003Date of Patent: October 21, 2008Assignee: Rhodia ChimieInventors: Mathias Destarac, Cécile Bonnet-Gonnet, Arnaud Cadix
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Patent number: 7439293Abstract: A fire retardant slotwall panel material having multiple slots forming multiple slats on which brackets and other devices can be mounted. The composition of the material for extruding the slotwall panels comprises CPVC, PVC and a fire retardant so that the resulting product will meet at least one of the ASTM E84-01 and UL 723 fire retardant standards. The composition can comprise 60-100 PHR of CPVC, 40-0 PHR of PVC and 20-50 PHR of fire retardant that can be AL Trihydrate. The composition of the material can include other ingredients such as: 2.7-3.3 PHR Zeolite, 0.36-0.44 PHR Blowing Agent, 9-11 PHR Process Aid, 2.475-2.525 PHR Tin Stabilizer, 0.9-1.1 PHR Exter Wax, 0.9-1.1 PHR OPE Wax, 2.7-3.3 PHR Impact Modifier, and 2.7-3.3 PHR TiO2.Type: GrantFiled: December 29, 2003Date of Patent: October 21, 2008Assignee: Whirlpool CorporationInventors: Travis M. Perkins, Randall Jay Brown
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Patent number: 7439294Abstract: Polyester compositions are disclosed that include polyester polymers or copolymers having incorporated therein metallic titanium particles that improve the reheat properties of the compositions. Processes for making such compositions are also disclosed. The titanium particles may be incorporated in the polyester by melt compounding, or may be added at any stage of the polymerization, such as during the melt-phase of the polymerization. A range of particle sizes may be used, as well as a range of particle size distributions. The polyester compositions are suitable for use in packaging made from processes in which a reheat step is desirable.Type: GrantFiled: August 11, 2006Date of Patent: October 21, 2008Assignee: Eastman Chemical CompanyInventor: Zhiyong Xia
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Patent number: 7439295Abstract: An inkjet-receptive coating composition for efficacious inkjet printing which is a synergistic composition of swellable, water-insoluble polyvinylpolypyrrolidone particles and (fumed) silica or silica gel particles.Type: GrantFiled: February 14, 2005Date of Patent: October 21, 2008Assignee: ISP Investments Inc.Inventors: Robert Gibbison, Andrew Mint, Sarah Orton, Edward Johnson
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Patent number: 7439296Abstract: Disclosed is a polypropylene resin composition including from 50 to 93% by weight of polypropylene resin including propylene-ethylene block copolymer satisfying given requirements, from 1 to 25% by weight of ethylene-?-olefin copolymer rubber made up of ethylene units and units of C4-12 ?-olefin having a density of 0.850 to 0.870 g/cm3 and an MFR of 0.05 to 1 g/10 min, from 1 to 25% by weight of another type of ethylene-?-olefin copolymer rubber made up of ethylene units and units of C4-12 ?-olefin having a density of 0.850 to 0.870 g/cm2 and an MFR of 2 to 20 g/10 min, and from 5 to 25% by weight of inorganic filler. Molded articles made from the composition have good balance between rigidity and impact resistance and have good appearance.Type: GrantFiled: January 12, 2006Date of Patent: October 21, 2008Assignee: Sumitomo Chemical Company, LimitedInventor: Susumu Kanzaki
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Patent number: 7439297Abstract: A composition comprising: A) 50-99.9% by weight of at least a copolymer (1) of ethylene (E) with chlorotrifluoroethylene (CTFE) wherein CTFE is comprised between 53 and 70% by moles, having a crystallinity in the range 5-45%; B) 0.1-50% by weight of a fine powder of a nucleating agent, having an average particle size lower than 50 micron and a melting temperature higher than 300° C.Type: GrantFiled: September 24, 2004Date of Patent: October 21, 2008Assignee: Solvay Solexis S.p.A.Inventors: Julio A. Abusleme, Claudia Manzoni
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Patent number: 7439298Abstract: Pyrogenically produced silicon dioxide powder in the form of aggregates of primary particles having a BET surface area of 150±15 m2/g, wherein the aggregates display an average surface area of 12000 to 20000 nm2, an average equivalent circle diameter (ECD) of 90 to 120 nm and an average circumference of 1150 to 1700 nm. It is produced by a pyrogenic process in which silicon tetrachloride and a second silicon component comprising H3SiCl, H2SiCl2, HSiCl3, CH3SiCl3, (CH3)2SiCl2, (CH3)3SiCl and/or (n-C3H7)SiCl3 are mixed with primary air and a combustion gas and burnt into a reaction chamber, secondary air also being introduced into the reaction chamber, and the feed materials being chosen such that an adiabatic flame temperature of 1670 to 1730° C. is obtained. Silicone sealing compound containing the pyrogenically produced silicon dioxide powder.Type: GrantFiled: March 21, 2005Date of Patent: October 21, 2008Assignee: Degussa AGInventors: Kai Schumacher, Dieter Kerner, Uwe Diener, Mario Scholz
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Patent number: 7439299Abstract: An aqueous coating composition having a 60° gloss of ?40 upon drying comprising a self-crosslinkable polyurethane obtained by the reaction of: (A) an isocyanate-terminated pre-polymer formed from components which comprise (i) 5 to 65 wt % of at least one organic polyisocyanate; (ii) 0.Type: GrantFiled: December 16, 2003Date of Patent: October 21, 2008Assignee: DSM IP Assets B.V.Inventors: Richard G Coogan, Nikos J Georgakakis, Anthony Pajerski
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Patent number: 7439300Abstract: The present invention provides polyvinyl alcohol based (PVA) whose solubility in water varies with a small temperature change to a sufficiently great degree. In manufacturing a polyvinyl alcohol based polymer by: progressing a transesterification reaction of a polyvinyl ester based polymer with alcohol in a liquid reaction mixture including the polyvinyl ester based polymer, the alcohol, and a basic compound; precipitating the polyvinyl ester based polymer, at least a part of which has been transesterified with the alcohol, out of the liquid reaction mixture; and further progressing the transesterification reaction in the liquid reaction mixture including the polyvinyl ester based polymer that has precipitated, the liquid reaction mixture has a temperature of 75° C. to 150° C. when the polyvinyl ester based polymer, at least a part of which has been transesterified, starts precipitating.Type: GrantFiled: September 10, 2004Date of Patent: October 21, 2008Assignee: Kuraray Co., Ltd.Inventors: Hisamichi Yanai, Yoshihiro Tokuda, Jin Tokuyasu, Kimiko Miyata, Naoki Fujiwara, Takeshi Kusudou
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Patent number: 7439301Abstract: Disclosed is an elastomeric hydrogenated block copolymer capable of being directly extruded or molded with a minimum of additives and having both high elasticity and low permanent set. The hydrogenated block copolymers have high melt flows allowing for ease in processing the hydrogenation block copolymers in melt processes such as extrusion and molding.Type: GrantFiled: March 1, 2005Date of Patent: October 21, 2008Assignee: Kraton Polymers U.S. LLCInventor: Dale L. Handlin, Jr.
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Patent number: 7439302Abstract: A new underlayer composition that exhibits high etch resistance and improved optical properties is disclosed. The underlayer composition comprises a vinyl or acrylate polymer, such as a methacrylate polymer, the polymer comprising at least one substituted or unsubstituted naphthalene or naphthol moiety, including mixtures thereof. Examples of the polymer of this invention include: where each R1 is independently selected from an organic moiety or a halogen; each A is independently a single bond or an organic moiety; R2 is hydrogen or a methyl group; and each X, Y and Z is an integer of 0 to 7, and Y+Z is 7 or less. The organic moiety mentioned above may be a substituted or unsubstituted hydrocarbon selected from the group consisting of a linear or branched alkyl, halogenated linear or branched alkyl, aryl, halogenated aryl, cyclic alkyl, and halogenated cyclic alkyl, and any combination thereof.Type: GrantFiled: August 2, 2005Date of Patent: October 21, 2008Assignee: International Business Machines CorporationInventors: Wu-Song Huang, Sean D. Burns, Mahmoud Khojasteh
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Patent number: 7439303Abstract: According to the present invention, a pressure-sensitive adhesive for a motor vehicle brake disc antirust film, which comprises an acrylic resin based pressure-sensitive adhesive prepared by crosslinking an acrylic copolymer containing a unit based on a (meth)acrylamide based monomer and having a weight average molecular weight of 500,000 to 1,100,000 with a polyisocyanate compound by the utilization of the unit based on a (meth)acrylamide based monomer as a crosslinking base point. The pressure-sensitive adhesive for a motor vehicle brake disc antirust film can provide a motor vehicle brake disc antirust film which is hardly peeled off when adhered onto a motor vehicle wheel.Type: GrantFiled: March 22, 2005Date of Patent: October 21, 2008Assignee: Lintec CorporationInventors: Huminori Ikeda, Atsushi Tezuna, Yumiko Matsubayashi, Osamu Kanazawa
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Patent number: 7439304Abstract: A composition comprising (i) a dynamically-cured rubber, (ii) from about 20 to about 300 parts by weight of a thermoplastic resin per 100 parts by weight rubber, (iii) from 0.2 to 0.9 parts by weight stannous chloride per 100 parts by weight rubber, and (iv) from 0.25 to 4.0 parts by weight metal oxide per 100 parts by weight rubber.Type: GrantFiled: September 1, 2004Date of Patent: October 21, 2008Assignee: Advanced Elastomer Systems, L.P.Inventors: Maria D. Ellul, Christopher Hrbacek
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Patent number: 7439305Abstract: Hot-melt adhesives containing at least one aromatic modified polyethylene and/or polypropylene (co)polymer, a further ethylene or propylene/C4 to C20 alpha-olefin copolymer, and at least one tackifying resin are useful for the adhesive bonding of package and paperboard products.Type: GrantFiled: June 18, 2007Date of Patent: October 21, 2008Assignee: Henkel Kommanditgesellschaft Auf AktienInventors: Gunter Hoffmann, Ralf Grauel, Richard Scholta, Thomas Moeller, Ralf Eberhardt
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Patent number: 7439306Abstract: A method of selecting polyethylene components for a polyethylene composition having an improved Vicat softening point comprising blending at least a first polyethylene having a first density and a second polyethylene having a second density to form the polyethylene composition, wherein the first density is greater than the second density, and determining a first Vicat softening point (V1) of the composition measured, and calculating a second Vicat softening point (V2) of the composition using the formula V2=[?n1{W1(Vicat softening point of the first polyethylene)+W2(Vicat softening point of the second polyethylene) . . . Wn(Vicat softening point of the nth polyethylene)}], wherein W1 is the weight fraction of the first polyethylene, W2 is the weight fraction of the second polyethylene and Wn is the weight fraction of the nth polyethylene, n ranges from 2 to 10 and W1+W2 . . . +Wn=1.0; comparing V1 and V2; selecting the polyethylene components such that V1 is less than V2 for the polyethylene composition.Type: GrantFiled: November 23, 2004Date of Patent: October 21, 2008Assignee: ExxonMobil Chemical Patents Inc.Inventor: Donna Sue Davis
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Patent number: 7439307Abstract: Articles made from propylene ethylene copolymers with an ethylene content between 8 and 32 mole % have been grafted with maleic anhydride and a peroxide. The functionality level is higher than what is reported with polypropylene.Type: GrantFiled: March 8, 2005Date of Patent: October 21, 2008Assignee: ExxonMobil Chemical Patents Inc.Inventors: Jean-Roch H. Schauder, Sudhin Datta
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Patent number: 7439308Abstract: A method for producing a (meth)acrylic polymer having crosslinkable silyl groups at the termini, comprising a step of adding a hydrosilane compound having a crosslinkable silyl group to an alkenyl-terminated (meth)acrylic polymer (A), which is prepared by atom transfer radical polymerization, in the presence of a platinum hydrosilylation catalyst. The amount of the platinum hydrosilylation catalyst is 0.1 to 10 mg on a platinum metal basis per kilogram of the alkenyl-terminated (meth)acrylic polymer (A). An object of the invention is to provide a method for producing a (meth)acrylic polymer having terminal crosslinkable silyl.Type: GrantFiled: April 18, 2003Date of Patent: October 21, 2008Assignee: Kaneka CorporationInventors: Shigeki Ohno, Yoshiki Nakagawa, Kenichi Kitano, Masanao Takeda, Nao Fujita
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Patent number: 7439309Abstract: Disclosed is a silver halide photographic light-sensitive material, which has at least one polymer compound having a nitrogen-containing aromatic ring having a mercapto group represented by the formula Z-SH wherein Z represents a nitrogen-containing aromatic ring as a partial structure. This silver halide photographic light-sensitive material can stably contain silver halide grains of a high aspect ratio showing high sensitivity and superior planarity, shows superior pressure resistance and can be stably prepared.Type: GrantFiled: March 22, 2005Date of Patent: October 21, 2008Assignee: Fujifilm CorporationInventors: Terukazu Yanagi, Makiko Yokoi, Mamoru Sakurazawa, Yoshihisa Tsukada, Seiji Hatano
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Patent number: 7439310Abstract: The present invention can provide a resin composition comprising epoxy-modified polyphenylene ethers which show good solubility in MEK or acetone which has been conventionally used in a manufacturing process for printed boards of epoxy resins, and has high heat resistance originating from polyphenylene ethers. Specifically, the resin composition of the present invention contains (C) an epoxy-modified polyphenylene ether obtained by reacting (A) a polyphenylene ether having a content of volatile components of 0.1-5.0% by weight and a number of average molecular weight of 500 or more and less than 1.0×104 and (B) a cresol-novolac type epoxy resin at a modification ratio of component (A) of 5-95%, wherein (B?) a cresol-novolac type epoxy resin is contained in an amount of 10-900 parts by weight based on 100 parts by weight of the total of the reaction products (C), and (A?) a polyphenylene ether.Type: GrantFiled: July 6, 2006Date of Patent: October 21, 2008Assignee: Asahi Kasei Chemicals CorporationInventors: Tetsuji Tokiwa, Tomohiro Kondo
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Patent number: 7439311Abstract: The present invention provides a method for producing a polymer by conducting polymerization in a polymerization reactor having an inner wall covered with an anti-fouling agent comprising an aqueous solution containing a polyvinyl alcohol obtained through saponification of a polyvinyl ester that contains monomer units having a silyl group. In the present invention, the polyvinyl alcohol satisfies the following formulae (I) and (II): 370<P×S<9000 ??(I) where P indicates the viscosity-average degree of polymerization of the polyvinyl alcohol, and S indicates the content (mole %) of the monomer units having a silyl group of formula (1) in the polyvinyl alcohol; 0.2/100?(A?B)/(B)?75/100 ??(II) where A indicates the content (ppm) of silicon atoms in the polyvinyl alcohol, and B indicates the content (ppm) of silicon atoms in the polyvinyl alcohol that was washed with sodium hydroxide-containing methanol and then washed with methanol by Soxhlet extraction.Type: GrantFiled: January 18, 2008Date of Patent: October 21, 2008Assignee: Kuraray Co., Ltd.Inventors: Masaki Kato, Kazuyuki Somemiya, Takeshi Kusudou, Naoki Fujiwara
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Patent number: 7439312Abstract: Branched crystalline polypropylene compositions and methods for the preparation of branched crystalline polypropylene compositions are provided. For example, described herein is a process of preparing a branched crystalline polypropylene composition that includes combining two or more different metallocene catalyst compounds with a polymerization medium that includes propylene, for a time sufficient to provide branched crystalline polypropylene that has from 0.0 wt % to 2.0 wt % ethylene and a heat of fusion of 70 J/g or more.Type: GrantFiled: October 10, 2003Date of Patent: October 21, 2008Assignee: ExxonMobil Chemical Patents Inc.Inventors: Palanisamy Arjunan, Thottinal A. Mathew, Patrick Brant, James C. Vizzini
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Patent number: 7439313Abstract: A MgCl2.mEtOH.nH2O adducts, where 3.4<m?4.4, 0?n?0.7, characterized by an X-ray diffraction spectrum, taken under the condition set forth above, in which, in the range of 2? diffraction angles between 5° and 10°, at least two diffraction lines are present at diffraction angles 2? of 9.3±0.2°, and 9.9±0.2°, the most intense diffraction lines being the one at 2? of 9.3±0.2°, the intensity of the other diffraction line being less than 0.4 times the intensity of the most intense diffraction line. Catalyst components obtained from the adducts of the present invention are capable to give catalysts for the polymerization of olefins characterized by enhanced activity and/or porosity with respect to the catalysts prepared from the adducts of the prior art.Type: GrantFiled: February 13, 2006Date of Patent: October 21, 2008Assignee: Basell Poliolefine Italia S.p.A.Inventors: Daniele Evangelisti, Gianni Collina, Ofelia Fusco, Mario Sacchetti
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Patent number: 7439314Abstract: Transition metal complexes of selected monoanionic phosphine ligands, which also contain a selected Group 15 or 16 (IUPAC) element and which are coordinated to a Group 3 to 11 (IUPAC) transition metal or a lanthanide metal, are polymerization catalysts for the (co)polymerization of olefins such as ethylene and ?-olefins, and the copolymerization of such olefins with polar group-containing olefins. These and other nickel complexes of neutral and monoanionic bidentate ligands copolymerize ethylene and polar comonomers, especially acrylates, at relatively high ethylene pressures and surprisingly high temperatures, and give good incorporation of the polar comonomers and good polymer productivity. These copolymers are often unique structures, which are described.Type: GrantFiled: September 16, 2004Date of Patent: October 21, 2008Assignee: E. I. du Pont de Nemours and CompanyInventors: Linda Kaye Johnson, Stephan J. McClain
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Patent number: 7439315Abstract: A copolymer film having a decreased dielectric constant which is produced by supplying at least two organic monomers as raw materials, forming a film of a copolymer comprising a backbone based on said at least two monomers on a surface of a substrate, and heating the copolymer film at a temperature higher than a temperature at which the copolymer film is formed.Type: GrantFiled: July 22, 2005Date of Patent: October 21, 2008Assignee: NEC CorporationInventors: Nobutaka Kunimi, Jun Kawahara, Akinori Nakano, Keizo Kinoshita
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Patent number: 7439316Abstract: A process for the preparation of stable aqueous polycarbodiimide dispersions, to be used as crosslinking agent, which are free of organic solvents is described. Sid process is characterized in: reacting a polyisocyanate in the presence of a carbodiimide catalyst to form a polycarbodiimide, terminating and/or chain extending the polycarbodiimide chain by the addition of formation dispersion of the resulting compound in water, wherein pH is adjusted to a value between 9 and 14 by the addition of a base and/or a buffer to the water used for the dispersion and/or to the obtained aqueous dispersion. According to the present process said terminating or chain extending with the compound containing a hydrophylic group and one or more amine functions may also occur during or after the dispersion of the polycarboiimide in water. The preferred pH of the polycarbodiimide dispersions is between 11 and 13.Type: GrantFiled: December 28, 2005Date of Patent: October 21, 2008Assignee: Stahl International B.V.Inventors: Laurentius Cornelius Josephus Hesselmans, Andries Johannes Derksen, Jacob Christiaan Munneke
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Patent number: 7439317Abstract: An amorphous polyester chip having superior processing ability is characterized by a moisture content of not more than 300 ppm and a fine particle content of not more than 500 ppm. A preferred embodiment is a copolymerized polyester chip comprising a main repeating unit consisting of ethylene terephthalate, and 1,4-dimethylene-cyclohexane terephthalate or neopentyl terephthalate, wherein the glycol component of the copolymerized polyester has a specific composition of 50 to 85 mol % of ethylene glycol, 12 to 45 mol % of 1,4-cyclohexanedimethanol or neopentyl glycol and 1.5 to 7.0 mol % of diethylene glycol. Such amorphous polyester chip can be obtained by cooling an amorphous polyester obtained by melt polymerization, cutting the polyester to give a chip, feeding the chip in a treatment tank, drying the chip and removing fine particles.Type: GrantFiled: June 30, 2004Date of Patent: October 21, 2008Assignee: Toyo Boseki Kabushiki KaishaInventors: Keisuke Suzuki, Hiroki Fukuda, Hideki Shimizu, Tsuyoshi Matsunaga
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Patent number: 7439318Abstract: An analytical technique for the accurate and precise measurement of trace water in chemical reagents, comprising the steps of combining a chemical reagent comprising ?5 ppm water, with hexafluoroacetone (HFA), to form a sample mixture comprising at least the chemical reagent and a water derivative of hexafluoroacetone; and measuring the concentration of the water derivative of hexafluoroacetone by gas chromatography.Type: GrantFiled: March 13, 2007Date of Patent: October 21, 2008Assignee: Advanced Technology Materials, Inc.Inventors: Alexander S. Borovik, Ziyun Wang, Chongying Xu, Thomas H. Baum
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Patent number: 7439319Abstract: The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selective substrate polypeptides contain SEQ ID NOS:28-35, and MT1-MMP selective substrate polypeptide contain SEQ ID NOS:36-40. In addition, the invention provides a method of preferentially directing a moiety to a site of MMP-2 activity by administering to a subject an effective amount of an isolated MMP-2 selective substrate polypeptide containing SEQ ID NOS:45-47 linked to a moiety.Type: GrantFiled: September 13, 2002Date of Patent: October 21, 2008Assignee: Burnham Institute for Medical ResearchInventors: Jeffrey W. Smith, Emily I. Chen, Steven J. Kridel
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Patent number: 7439320Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung, colon, colorectal and breast cancer, are disclosed. Illustrative compositions comprise one or more Cripto tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung, colon, colorectal and breast cancer.Type: GrantFiled: August 20, 2001Date of Patent: October 21, 2008Assignee: GlaxoSmith Kline Biologicals s.a.Inventors: Jean-Pol Cassart, Thierry Coche, Remi M Palmantier, Carlota Vinals Y De Bassols
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Patent number: 7439321Abstract: The invention provides compositions and methods for the detection and quantification of A. phagocytophilum (formerly known as Ehrlichia equi) antibodies and antibody fragments.Type: GrantFiled: January 11, 2005Date of Patent: October 21, 2008Assignee: IDEXX Laboratories, Inc.Inventors: Thomas O'Connor, Ramaswamy Chandrashekar
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Patent number: 7439322Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.Type: GrantFiled: March 27, 2003Date of Patent: October 21, 2008Assignee: Eli Lilly and CompanyInventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
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Patent number: 7439323Abstract: Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-IMilano (R173C) and apoA-IParis, (R151C) were found to exhibit potent antioxidant activity on phospholipid surfaces. The addition of a free thiol, at the hydrophobic/hydrophilic interface of an amphipathic alpha helix of synthetic peptides that mimic HDL-related proteins, imparts a unique antioxidant activity to these peptides which inhibits lipid peroxidation and protects phospholipids from water-soluble free radical initiators. These peptides can be used as therapeutic agents to combat cardiovascular disease, ischemia, bone disease and other inflammatory related diseases.Type: GrantFiled: July 7, 2005Date of Patent: October 21, 2008Assignee: The Regents of the University of CaliforniaInventor: John K. Bielicki
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Patent number: 7439324Abstract: The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent is used to detect protein with target epitope that was inaccessible during contact with the blocking agent. The invention also relates to novel amyotrophic lateral sclerosis-specific epitopes and their uses to make antibodies, and to the novel antibodies and uses thereof.Type: GrantFiled: March 3, 2006Date of Patent: October 21, 2008Assignee: Amorfix Life Sciences, LtdInventor: Neil Cashman
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Patent number: 7439325Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: May 13, 2002Date of Patent: October 21, 2008Assignee: Genentech, Inc.Inventors: Kevin P. Baker, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
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Patent number: 7439326Abstract: Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment, mutations in PAMP are diagnostic for Alzheimer's Disease or spina bifida. The invention further relates to screening, particularly using high-throughput screens and transgenic animal models, for compounds that modulate the activity of PAMP and presenilins. Such compounds, or gene therapy with PAMP, can be used in treating neurodegenerative diseases, particularly Alzheimer's Disease. In addition, the invention provides PAMP mutants, nucleic acids encoding for PAMP mutants, and transgenic animals expressing PAMP mutants, which in a preferred aspect result in biochemical changes similar to those induced by mutations in ?APP, PS1, or PS2, associated with familial Alzheimer's disease.Type: GrantFiled: January 22, 2004Date of Patent: October 21, 2008Assignee: The Governing Council of the University of TorontoInventors: Peter H. St. George-Hyslop, Paul E. Fraser
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Patent number: 7439327Abstract: The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.Type: GrantFiled: January 17, 2006Date of Patent: October 21, 2008Assignee: Nuvelo, Inc.Inventors: Bryan J. Boyle, Peter C. R. Emtage, Walter Funk, Y. Tom Tang, Jingsong Zhao
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Patent number: 7439328Abstract: A polypeptide may include an amino acid sequence having at least about 95% identity to the amino acid sequence of SEQ ID NO: 42, wherein a residue at position 94 of the polypeptide is an amino acid other than threonine or wherein a residue at position 82 of the polypeptide is an amino acid other than serine. A polypeptide may include at least the first 14 residues and at most the first 92 residues of an amino acid sequence starting with residue 1 of, and having at least about 95% identity to, the amino acid sequence of SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 16, or 17. Such polypeptide may stimulate neurite outgrowth or neurogenesis. A nucleic acid may encode the polypeptide. A vector may include the nucleic acid. A host cell, such as an embryonic stem cell, may include the vector.Type: GrantFiled: June 30, 2006Date of Patent: October 21, 2008Assignee: Cornell Research Foundation, Inc.Inventors: Ching-Hwa Sung, Jen-Zen Chuang
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Patent number: 7439329Abstract: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.Type: GrantFiled: July 2, 2003Date of Patent: October 21, 2008Assignee: Sugen, Inc.Inventors: Tod R. Smeal, Marinella G. Callow, Bahija Jallal, Sergey Zozulya, Mikhail L. Gishizky
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Patent number: 7439330Abstract: The invention includes antibodies or antigen-binding fragments thereof which bind specifically to glycated CD59, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of producing and using the antibodies or antigen-binding fragments thereof for diagnosis and treatment of diabetic conditions and diabetic-associated conditions.Type: GrantFiled: June 17, 2004Date of Patent: October 21, 2008Assignee: President and Fellows of Harvard CollegeInventor: Jose Halperin
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Patent number: 7439331Abstract: The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab?)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.Type: GrantFiled: June 29, 2006Date of Patent: October 21, 2008Assignee: Genentech, Inc.Inventors: Michael S. C. Fung, William N. C. Sun, Cecily R. Y. Sun
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Patent number: 7439332Abstract: A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.Type: GrantFiled: April 25, 2003Date of Patent: October 21, 2008Assignee: Kirin Pharma Kabushiki KaishaInventor: Mitsuo Nishikawa
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Patent number: 7439333Abstract: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.Type: GrantFiled: February 28, 2005Date of Patent: October 21, 2008Assignee: Human Genome Sciences, Inc.Inventors: Jing-Shan Hu, Craig A. Rosen, Liang Cao
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Patent number: 7439334Abstract: A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided. The method for arranging ferritin of the present invention is characterized in that ferritin is selectively bound on titanium on a substrate by modifying the N-terminal part of ferritin with a peptide which specifically binds to titanium. Also, the method for arranging ferritin of the present invention is characterized in that selectivity for titanium can be markedly improved by adding a nonionic surface activating agent.Type: GrantFiled: February 16, 2006Date of Patent: October 21, 2008Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Ichiro Yamashita, Kiyotaka Shiba
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Patent number: 7439335Abstract: The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.Type: GrantFiled: April 8, 2004Date of Patent: October 21, 2008Assignee: The Scripps Research InstituteInventors: Susan R. Webb, Ola Winqvist, Lars Karlsson, Michael R. Jackson, Per A. Peterson
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Patent number: 7439336Abstract: The invention relates to a process for the purification of IL-18 binding protein (IL-18BP) from a fluid using aqueous two-phase partitioning.Type: GrantFiled: June 27, 2005Date of Patent: October 21, 2008Assignee: Ares Trading S.A.Inventors: Henri Kornmann, Gianni Baer
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Patent number: 7439337Abstract: The present invention is a kit and method for purifying a protein of interest.Type: GrantFiled: August 2, 2007Date of Patent: October 21, 2008Assignee: Rutgers, the State University of New JerseyInventor: William W. Ward