Abstract: This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR1 and N. X and Y are members independently selected from O, S, CR2, N and NH. R1, R2 and R4 are members independently selected from H and F, provided that at least one member selected from R1, R2 and R4 is F. R6 is a member selected from O?X+ and OH, wherein X+ is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.

Abstract: The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

Abstract: The invention relates to novel indazole derivatives as cited in claim 1, which are inhibitors of CHK1, CHK2 and SGK kinases and can be used to treat cancer and other diseases.

Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ic) wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ic) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ic) in the preparation of medicaments to be applied in such diseases.

Abstract: Process for producing compound of Formula: wherein P2, P3 and R2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7): wherein P3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8): wherein P2 means a protecting group for hydroxy group; and R2 means a phenyl group which may be substituted, in the presence of a base.

Abstract: The present invention is related to an alcohol compound isolated from the extract of Cucurbitaceae family plant having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The compound showed potent reducing activity of body weight, decreasing effect on the blood triglyceride and cholesterol level, activating activity of PPAR ? and preventing activity from the adipogenesis of precursor fat cells with no toxicity, therefore, those extract can be useful in treating or preventing obesity and adipogenesis-involved diseases as a medicine or health care food.

Abstract: The invention relates to a gamma-undecenolactone of formula (i), wherein a lactonic cycle can carry an unsaturation between carbon No. 2 and carbon No. 3 and is preferably saturated, RI is a possibly substituted C7 alkenyl or alkynyl group having at least one unsaturation, and preferably RI is an CH2?CH—CH2—CH2—CH2—CH2—CH2 group, the gamma-undecenolactone contains an asymetric carbon in position 4 having (R) or (S) configuration. The biosynthesis of the gamma-undecenolactone and the use thereon for perfumery and for a food flavoring agent are also disclosed.

Abstract: Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.

Abstract: The present disclosure describes novel standardized citrate replacement fluid solutions and a standardized dialysate solution for use with CRRT methods. The standardized citrate replacement fluid solutions and standardized dialysate solutions do not require modification based on the clinical status of the individual patients. The use of the standardized solutions described herein offers significant advantages over the prior art solutions used in CRRT. The present disclosure describes superior metabolic and electrolyte control and significantly increased dialyzer patency in: (a) 24 intensive care unit (ICU) patients with ARF using a 0.67% trisodium citrate replacement fluid solution, and (b) 32 ICU patients with ARF using a 0.5% trisodium citrate replacement fluid solution. Both groups were treated with Bicarbonate-25 dialysate and achieved effluent rates of 35 mL/kg/hr.

Abstract: Cannabinoid derivatives are known for their function in the central as well as peripheral nervous system. Disclosed are some novel (+)-cannabidiol (CBD) derivatives of the general formula (I) having selective activity in the peripheral, but not in the central nervous system. Use of (+)-CBD derivatives as analgesics, anti-inflammatory and anti-diarrheal agents is also disclosed.

Abstract: The present invention is concerned with an improved method of producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide) comprising the O-methylation of a compound of formula I to produce a compound of formula II in a single step reaction.

Abstract: Methods and compositions comprising modafinil are described for treating premature ejaculation in a male individual.

Abstract: The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.

Abstract: Hydroxyl polyester compounds or compositions which are useful as oilfield demulsifiers are prepared through esterifying carboxylic compounds and epoxide compounds under controlled molar ratios. The hydroxyl polyesters are useful as biodegradable demulsifiers on oil productions.

Abstract: A process is described by which an olefinic naphtha and a hydrogenated distillate fuel are made from a Fischer-Tropsch process. The olefinic naphtha is suitable for use in an ethylene cracker where the olefins enhance the formation of ethylene. Thy hydrogenated distillate fuel is used in jet and or diesel fuels. Optionally the olefinic naphtha has a low content of acids. This low acid content, is obtained by operating the Fischer-Tropsch unit at H2/CO ratios from 1.8 to 2.05 or treating the effluent from the Fischer-Tropsch unit with a metal oxide to remove the acids.

Abstract: The present invention relates to a catalyst comprising particles of a cobalt and zinc co-precipitate, having a volume average particle size of less than 150 ?m. Another aspect of the invention is the use of such a catalyst in a Fischer-Tropsch process. The present invention further relates to a method for preparing a catalyst comprising cobalt and zinc oxide, wherein an acidic solution comprising zinc ions and cobalt ions and a alkaline solution are contacted and the precipitate is isolated.

Abstract: Techniques for creating recycled plastic materials from waste plastic materials are described. A recycled plastic material contains at least a primary polymer, a secondary polymer, and residual additives. Predetermined properties of the recycled plastic material can be controlled by selecting the types of waste plastic materials used in the recycling feed, determining the types and amounts of recycled plastic material recovered from a separation process and blending the recycled plastic material with other materials.

Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a monomeric mixture comprising (a) one or more esterified aminoalcohol monomers; and (b) one or more biomedical device-forming monomers.

Abstract: The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C3-C6 molecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50° C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.

Abstract: The present invention relates to a power and/or telecommunications cable including at least one component element made of a material extruded from an extrudable composition, wherein said extrudable composition comprises a biopolymer selected from polymers of cellulose ester, polymers of starch complexed with a biodegradable polyester, polymers of polyhydroxyalkanoate, and/or polymers of polylactic acid comprising a mixture of polylactic and of polyester.

Abstract: A process in which a mixture is agitated in a substantially oxygen-free environment to produce an agitated emulsion. The mixture comprises water, one or more surfactants, a hydrate inhibitor, and a monomer. The monomer is then polymerized in the emulsion using an initiator and a catalyst to form a hydrate inhibited latex drag reducer.

Abstract: A process for producing filler-containing polytetrafluoroethylene granules by an underwater agitation granulation method, whereby filler-containing polytetrafluoroethylene granules excellent in flowability can be obtained with little detachment of the filler and it is possible to prevent discharge of a polytetrafluoroethylene emulsion into waste liquid, the process characterized in that in a stage of granulating a mixture of polytetrafluoroethylene powder and a filler by agitation in water in the presence of a liquid organic substance hardly soluble in water, a polytetrafluoroethylene emulsion and a coagulant are added to coagulate the polytetrafluoroethylene emulsion as a surface layer of the filler-containing polytetrafluoroethylene granules.

Abstract: A polymer material, containing at least one kind of polymer substance selected from the group consisting of acrylic acid-based polymers, polyester-based polymers, and polycarbonate-based polymers; and a compound represented by formula (2) contained in the polymer substance: wherein A21 and A22 each independently represent an atom other than hydrogen atom and carbon atom; Y21 and Y22 each independently represent a hydrogen atom or a monovalent substituent; at least one of Y21 and Y22 represents a substituent having a Hammett substituent constant ?p of 0.2 or more; Y21 and Y22 may bind to each other to form a ring; and (B) represents a group of atoms necessary for forming a five- or six-membered ring with A21, A22 and the carbon atom.

Abstract: A synergistic stabilizer mixture comprising a component a) and, for example, a component b), where component a) is at least one compound of the formula I in which R1 is hydrogen or methyl, R2 is a direct bond or C1-C10alkylene, and n1 is a number from 2 to 50; component b) is at least one compound of the formulae IIa and IIb in which n2 and n2* are a number from 2 to 50.

Abstract: The present invention provides a resin composition containing a filler poor in affinity for fluororesins as uniformly dispersed therein and a method of producing such resin composition and, further, a resin composition containing, as fillers, a nucleating agent for foaming and suited for producing foamed moldings with fine foam cells uniformly distributed therein and a method of producing such resin composition as well as a foamed molding formed from either of such resin compositions. The present invention is related to a resin composition comprising a fluororesin (A) and a filler (X) low in affinity for said fluororesin (A), wherein the filler (X) has a d99 value of not more than 15 ?m.

Abstract: A nanocomposite material suitable for electrical insulation includes a polymer compounded with a substantially homogeneously distributed functionalized nanoparticle filler. The nanocomposite material is produced by compounding the polymer with the functionalized nanoparticle filler by imparting a shear force to a mixture of the polymer and filler capable of preventing agglomeration of the filler whereby the filler is substantially homogeneously distributed in the nanocomposite material. The electrical insulation may be adapted for AC or DC high voltage, and may also be adapted for low or medium voltage to prevent formation of water tree structures.

Abstract: Flame retardant polymeric blend compositions including a synergistic combination of flame retardants, including a halogenated flame retardant and a nanoparticulate, such as an organically modified clay or a natural nanoclay. The compositions are thermoplastic elastomers, include a polyolefin and a styrenic block copolymer, and exhibit high char formation upon burning as well as desirable vertical burn characteristics. In a preferred embodiment, the flame retardants include at least a halogenated flame retardant and a metal oxide.

Abstract: The manufacturing process of a material of nanocomposites of the resin includes providing a nano-clay platelets liquid; adding a modification agent into the nano-clay platelets liquid, then stirring in a first time in a first temperature for making a cake product; taking the cake product heated in a second temperature and then crumbling the cake product for making a first powder; moving the water out of the first powder for making a second powder; adding a resin into the second powder, then stirring and baking for making the material of nanocomposites of the resin.

Abstract: The present invention relates to a manufacturing method of organic modifier-free exfoliated nano clay-polymer composite. The manufacturing method of organic modifier-free exfoliated nano clay-polymer composite includes (S1) dispersing layered clay nanoparticles and dissolving a thermoplastic polymer in an acidic solvent; (S2) adding the product of step (S1) to a polymer non-solvent incapable of dissolving the polymer, but capable of dissolving the organic modifier separated from the organized layered clay nanoparticles; and (S3) separating an organic modifier-free exfoliated nano clay-polymer composite from the product of step (S2). The inventive manufacturing method can maximally improve the physical properties of composites through the addition of the exfoliated clay nanoparticles by removing the organic modifier that may deteriorate physical properties of the composite from the exfoliated clay nanoparticles dispersed therein.

Abstract: The invention concerns a method for preparing anisotropic silica aggregates comprising the following steps: a) contacting at least one polymer with non-aggregated silica particles and/or highly dispersed in an aqueous medium, with a ratio R, polymer weight to silica particle surface, ranging between 0.03 and 2 mg/m; 2; and whereof the electrostatic value of the silica particle surface is not less than the value of the charge of the silica particle surface measured in an aqueous phase without added salts at a pH not less than 7; b) consolidating the aggregates obtained at step a) either by heat treatment, or by precipitation of a mineral compound.

Abstract: The rubber composition of the invention includes a rubber composition which is a silica compounded rubber composition for tire containing 100 parts by weight of a rubber component made of (a) from 20 to 80% by weight of a vinyl-cis-polybutadiene rubber containing 1,2-polybutadiene having a melting point of 170° C. or higher and a high-molecular substance having at least one unsaturated double bond per a repeating unit and comprising at least one member selected from polyisoprene, crystalline polybutadiene having a melting point of not higher than 150° C.

Abstract: A process for producing a vinyl-cis-polybutadiene rubber, including mixing (A) vinyl-cis-polybutadiene obtained by (1) a step of adding a cis-1,4-polymerization catalyst obtainable from an organoaluminum compound and a soluble cobalt compound to a mixture containing 1,3-butadiene and a hydrocarbon-based organic solvent as the major components and having an adjusted water content, thereby subjecting the 1,3-butadiene to cis-1,4-polymerization and subsequently, (2) a step of making a catalyst obtainable from a soluble cobalt compound, an organoaluminum compound represented by the general formula, AlR3 (wherein R represents an alkyl group having from 1 to 6 carbon atoms, a phenyl group, or a cycloalkyl group), and carbon disulfide present in the resulting polymerization reaction mixture, thereby subjecting the 1,3-butadiene to 1,2-polymerization; and (B) cis-polybutadiene obtained by a step of adding the foregoing cis-1,4-polymerization catalyst, thereby subjecting the 1,3-butadiene to cis-1,4-polymerization and

Abstract: An elastomer composition includes an elastomer and a carbon black, wherein the carbon black is characterized as having a COAN of between about 90 and 150 ml/100 g, a BET of between 50 and 69 m2/g and a distribution index DI that is greater than 1.15, wherein the DI is a ratio of dw to dmode. In particular embodiments, the elastomer may be selected from one or more natural rubbers, one or more synthetic rubbers or combinations thereof. For example, the one or more synthetic rubbers may be selected from styrene butadiene rubber, butadiene rubber, polyisoprene rubber, butyl rubber or combinations thereof. Products made from the elastomer composition include tires and other products, particularly tires that include a sidewall, a carcass, a carcass reinforcement, tread and/or an undertread comprising the elastomeric composition.

Abstract: The invention concerns a process for preparing a block or comb copolymer comprising at least one hydrophilic portion and at least two hydrophobic portions, by anionic solvent-free polymerization of a prepolymer selected from a polyethylene glycol and a polyvinyl alcohol, and of a lactone or dilactone monomer. The process is carried out in the presence of an alkaline-earth metal hydride, in an inert atmosphere, and the polymerization step is not carried out under vacuum. The invention also concerns copolymers obtained by this process.

Abstract: A cosmetic composition containing at least one block copolymer having a hard segment and a soft segment, at least one tackifier component, at least one phenylated silicone, at least one solvent, and optionally, at least one colorant.

Abstract: A propylene polymer resin composition characterized in that it has a flexural modulus in the range of 200 to 1200 MPa and a melt flow rate (MFR) measured at 230° C. in the range of 0.1 to 30 g/min, and a melt tension (MT (mN)) and an MFR (g/10 min) measured at 230° C. satisfy a specific formula, and a sheet or film obtained therefrom. According to the present invention, there is provided a polyolefin film which is excellent in transparency and especially excellent in transparency and low-temperature heat shrinkable properties after stretching.

Abstract: The present invention provides polymeric nanoparticles comprising triblock and optionally diblock copolymer chains. The architecture of the polymeric nanoparticles may be controlled, resulting in nanoparticles having non-spherical shapes. The present invention also provides a method of preparing the polymeric nanoparticles and a rubber article such as a tire manufactured from a formulation comprising the polymer nanoparticles.

Abstract: The present invention provides a method for preparation of an 1-alkene-acrylate based copolymer comprising a step of a radical polymerization reaction of 1-alkene and acrylate based monomer under presence of a metal oxide or Lewis acid, and a method for preparation of an alkene-acrylate based copolymer comprising reacting alkene with an acrylate based monomer under presence of a metal oxide. In the method of preparation according to the present invention, the process is simple and properties of the copolymer can be easily controlled by preparing the copolymer in a mild condition of 100° C. or less and 200 bar or less. In addition, the amount of the polar group of the copolymer prepared by the method is so high that the copolymer can be used for transparent optical products.

Abstract: The present invention provides a copolymer that includes at least one alkene monomer, at least one acrylate monomer and at least one the unsaturated acid anhydride monomer, and a method of preparing the same.

Abstract: Silica-coated alumina activator-supports, and catalyst compositions containing these activator-supports, are disclosed. Methods also are provided for preparing silica-coated alumina activator-supports, for preparing catalyst compositions, and for using the catalyst compositions to polymerize olefins.

Abstract: The present invention relates to a catalyst system for olefin polymerization and a method for olefin polymerization using the same. More particularly, the present invention relates to a Ziegler-Natta catalyst system for olefin polymerization comprising a transition metal compound as a main catalyst component, an organic metal compound as a cocatalyst component, and a cyclic organosilane compound, trioxasilocane as an external electron donor, and a method for olefin polymerization using the same. According to the present invention, a polyolefin having improved various properties such as polymerization activity, melt-flow ability, isotacticity, molecular weight distribution and apparent density can be produced.

Abstract: The present invention provides polymerization catalyst compositions employing half-metallocene compounds with a heteroatom-containing ligand bound to the transition metal. Methods for making these hybrid metallocene compounds and for using such compounds in catalyst compositions for the polymerization and copolymerization of olefins are also provided.

Abstract: An elastic fluorocopolymer comprises repeating units (l) based on a fluoromonomer such as tetrafluoroethylene, hexafluoropropylene, vinylidene fluoride or CF2?CF—O—Rf (wherein Rf is a C1-8 saturated perfluoroalkyl group or a perfluoro(alkoxyalkyl) group) and repeating units (m) based on the formula CR1R2?CR3COOCH?CH2 (wherein each of R1 and R2 is a hydrogen atom, a C1-10 alkyl group or a C1-10 alkoxyalkyl group containing an etheric oxygen atom, and R3 is a hydrogen atom, a fluorine atom or a methyl group) in a molar ratio of (m)/((l)+(n))=0.0001 to 0.1. Further, an elastic fluorocopolymer composition comprises (A) the above elastic fluorocopolymer, (B) an unsaturated multifunctional compound and (C) a bivalent metal oxide and/or hydroxide. The elastic fluorocopolymer and the elastic fluorocopolymer composition are excellent in the crosslinkability and can provide a crosslinked rubber thereof excellent in crosslinked rubber properties.

Abstract: Provided is an easy method for production of a high-performance polyfunctional compound which can be used as an optical recording material, an optical waveguide material, a photo-alignment film material, or the like, in a simple manner. The method for production of a polyfunctional compound includes conducting a Michael addition of a compound (A) having a hydrogen atom of pKa?15 to a (meth)acrylate or a (meth)acrylamide (B), in which at least one of the compounds (A) and (B) has a photoisomerization group and/or a liquid-crystalline group.

Abstract: A heterogeneous rubbery polymer is provided that includes a polymer chain derived from a vinyl aromatic monomer and a conjugated diolefin monomer, wherein from greater than 20 weight percent to about 40 weight percent of units in the rubbery polymer are derived from the vinyl aromatic monomer and from about 60 weight percent to about 80 weight percent of units in the rubbery polymer are derived from the conjugated diolefin monomer. The polymer chain is further characterized by having greater than zero and less than about 30 weight percent of the vinyl aromatic units in sequences containing 1 vinyl aromatic unit, from about 5 weight percent to about 20 weight percent of the vinyl aromatic units in sequences containing 5 to 8 vinyl aromatic units, and greater than zero and less than about 5 weight percent of the vinyl aromatic units in sequences containing 9 or more vinyl aromatic units.

Abstract: A method for producing a thermoplastic cellulose composition according to the present invention includes a process of ring-opening polymerization of cyclic ester with a cellulosic material or oligoesterified cellulose after mechanochemical pretreatment or during mechanochemical treatment, to improve thermoplasticity of the resultant thermoplastic cellulose composition.

Abstract: A stable MQ resin solution with over 50% SiO2 and having viscosity of 50 cps at 25° C. to about 750 cps at 25° C. and which is essential free of monomer is disclosed. The stable resin solution is made by a two step addition of catalysts wherein a hydrolysis catalysts, as for example, hydrochloric acid is added initially and a second catalysts such as Phosphonitrilic chloride trimer is added subsequently.

Abstract: Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer.

Abstract: To provide an epoxy resin giving a cured object having high heat resistance, which is improved in impact resistance and moisture resistance as compared with conventional high-heat-resistance epoxy resins. The epoxy resin is obtained by glycidylating one or more phenol compounds comprising 95% or more 1,1,2,2-tetrakis (hydroxyphenyl)ethane, and is characterized in that in an examination by gel permeation chromatography, the epoxy resin has a tetranucleus-form content of 50 to 90% by area and an octanucleus-form content of at least 5% by area and has a total chlorine content of 5,000 ppm or smaller.

Abstract: To provide an aromatic polyester which is formed into a film having excellent heat resistance, color, mechanical properties, dimensional stability and gas barrier properties and a manufacturing process thereof; the aromatic polyester comprises a dicabroxylic acid component and a diol component, wherein (i) the dicarboxylic acid component contains 50 to 100 mol % of a recurring unit represented by the following formula (A): ?wherein R is an alkylene group having 2 to 10 carbon atoms, (ii) the aromatic polyester has an intrinsic viscosity measured at 35° C. by using a mixed solvent of P-chlorophenol and 1,1,2,2-tetrachloroethane (weight ratio of 40/60) of 0.4 to 3.0; (iii) the aromatic polyester has a content of a recurring unit represented by the following formula (D) of less than 10 mol %: —O—CH2CH2—O—CH2CH2—O—??(D) (iv) the aromatic polyester has a terminal carboxyl group concentration of 200 eq/ton or less; and (v) the aromatic polyester has an alkali metal content of 300 ppm or less.