Patents Issued in March 6, 2014
  • Publication number: 20140065130
    Abstract: Methods for treating premature ejaculation and prolongation of climax time in a patient in need thereof by local administration of a Clostridial neurotoxin, such as a botulinum toxin, are provided.
    Type: Application
    Filed: August 20, 2013
    Publication date: March 6, 2014
    Applicant: Allergan, Inc.
    Inventor: Anders N. Nilsson Neijber
  • Publication number: 20140065131
    Abstract: The present invention provides an aqueous extract of a myceliated agricultural substrate for use as a nutraceutical or food composition for human consumption comprising at least one small molecule compound, wherein mycelia is grown on an agricultural substrate by inoculating the agricultural substrate with a pure strain of a fungal culture selected from the group comprising Basidiomycota and Ascomycota derived from a liquid fermentation, under optimum growth conditions. The present invention further provides methods of formation of an aqueous extract and nutraceutical or food compositions obtained from the extract. The aqueous extract and the nutraceutical compositions obtained from the extract thereof have neuroprotective and neuroregenerative properties amongst many other therapeutic properties.
    Type: Application
    Filed: May 1, 2013
    Publication date: March 6, 2014
    Applicant: Mycotechnology, Inc.
    Inventors: Brooks John Kelly, Jonathan Freestone Phillips, Jim Langan
  • Publication number: 20140065132
    Abstract: Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or more of the symptoms of ASD.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 6, 2014
    Inventors: Elaine Hsiao, Sarkis K. Mazmanian, Paul H. Patterson, Sara McBride
  • Publication number: 20140065133
    Abstract: The present invention concerns a method for treating or reducing the likelihood of developing a respiratory syncytial virus (RSV) infection in a subject by administering an effective amount of an inhibitor of the janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway or the mitogen-activated kinase (MAPK)/extracellular signal-regulated kinase (ERK1/2) signaling pathway to the subject. Another aspect of the invention concerns a pharmaceutical composition that includes an inhibitor of JAK/STAT or MAPK/ERK signaling to the subject; and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: November 6, 2013
    Publication date: March 6, 2014
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventor: SHYAM S. MOHAPATRA
  • Publication number: 20140065134
    Abstract: The present invention is directed to a pharmaceutical composition comprising: (A) a type II anti-CD20 antibody with increased antibody dependent cellular cytotoxicity (ADCC); and (B) a chemotherapeutic agent selected from the group consisting of: cyclophosphamide, vincristine and doxorubicine. The present invention is also directed to a method for the treatment of a CD20 expressing cancer, comprising administering to a patient in need of such treatment (i) an effective first amount of a type II anti-CD20 antibody with increased antibody dependent cellular cytotoxicity; and (ii) an effective second amount of one or more chemotherapeutic agents selected from the group consisting of cyclophosphamide, vincristine and doxorubicine.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 6, 2014
    Applicant: ROCHE GLYCART AG
    Inventors: CHARLES DUMONTET, THOMAS FRIESS, FRANK HERTING, CHRISTIAN KLEIN, PABLO UMANA
  • Publication number: 20140065135
    Abstract: The present application relates to methods of using anti-PD-L1 antibodies to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
    Type: Application
    Filed: July 30, 2013
    Publication date: March 6, 2014
    Applicant: Genentech, Inc.
    Inventors: Bryan Irving, Henry Chiu, Heather Maecker, Sanjeev Mariathasan, Sophie M. Lehar, Yan Wu, Jeanne Cheung
  • Publication number: 20140065136
    Abstract: Dioxino- and oxazin-[2,3-d]pyrimidine PI3K inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions.
    Type: Application
    Filed: August 29, 2013
    Publication date: March 6, 2014
    Applicant: Genentech, Inc.
    Inventors: Robert Andrew Heald, Neville James McLean
  • Publication number: 20140065137
    Abstract: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
    Type: Application
    Filed: September 20, 2013
    Publication date: March 6, 2014
    Applicant: GENENTECH, INC.
    Inventors: Arthur Huang, Robert Kelley, Henry Lowman, Menno Van Lookeren Campagne, Charles Winter
  • Publication number: 20140065138
    Abstract: The present invention provides anti-N3pGlu A? antibodies or antigen-binding fragment thereof. In addition, the present invention provides the use of the anti-N3pGlu A? antibodies or antigen-binding fragment thereof for the treatment of Alzheimer's disease.
    Type: Application
    Filed: September 27, 2013
    Publication date: March 6, 2014
    Applicant: Eli Lilly and Company
    Inventors: Jirong LU, Ying TANG, Ronald Bradley DEMATTOS
  • Publication number: 20140065139
    Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.
    Type: Application
    Filed: October 1, 2013
    Publication date: March 6, 2014
    Applicant: Virginia Commonwealth University
    Inventors: Ruey-min Lee, Peck-sun Lin
  • Publication number: 20140065140
    Abstract: Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. The treatment can also include administration of a monoclonal antibody against epidermal growth factor receptor, for example cetuximab.
    Type: Application
    Filed: November 11, 2013
    Publication date: March 6, 2014
    Applicant: Wellstat Biologics Corporation
    Inventors: Robert M. LORENCE, Michael Scot ROBERTS
  • Publication number: 20140065141
    Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.
    Type: Application
    Filed: May 4, 2012
    Publication date: March 6, 2014
    Applicant: Novartis AG
    Inventors: Dylan Daniel, Johanna Joyce, James Sutton
  • Publication number: 20140065142
    Abstract: Compositions containing multivalent and monovalent multispecific complexes having scaffolds such as antibodies that support such binding functionalities are described. The use of and methods of compositions containing multivalent and monovalent multispecific complexes having scaffolds, such as antibodies, that support such binding functionalities are also described.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 6, 2014
    Applicant: Zyngenia, Inc.
    Inventors: Viktor ROSCHKE, David Lafleur, David M. Hilbert, Peter Kiener
  • Publication number: 20140065143
    Abstract: Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6.
    Type: Application
    Filed: July 24, 2013
    Publication date: March 6, 2014
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Amato J. Giaccia, Erinn Bruno Rankin, Jennifer R. Cochran, Douglas Jones, Mihalis Kariolis, Katherine Fuh, Yu Miao
  • Publication number: 20140065144
    Abstract: Promoting bone fracture healing in a subject having a bone fracture using an IL-20 antagonist, which can be an antibody that blocks an IL-20-mediated signaling pathway. Such antibodies include anti-IL-20 antibodies and anti-IL-20R1 antibodies capable of blocking the IL-20-mediated signaling pathway.
    Type: Application
    Filed: August 30, 2012
    Publication date: March 6, 2014
    Applicant: National Cheng Kung University
    Inventor: Ming-Shi Chang
  • Publication number: 20140065145
    Abstract: Methods for preparing solid formulations of immunoglobulin single variable domains are provided. The methods are based on contacting solid carrier(s) with a liquid comprising the immunoglobulin single variable domains, e.g. by spraying the liquid onto the solid carrier(s), to cause granulation or coating of the carrier(s). During contacting the carrier is agitated, e.g. in a fluid bed, and the mixture of carrier and liquid is exposed to heat, e.g. a heated air stream, to evaporate the liquid.
    Type: Application
    Filed: March 28, 2012
    Publication date: March 6, 2014
    Applicant: ABLYNX N.V.
    Inventor: Ann Debunne
  • Publication number: 20140065146
    Abstract: Provided is a pharmaceutical composition for treating and/or preventing abnormal bone metabolism targeting a protein encoded by a gene strongly expressed in osteoclasts. Specifically provided is a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation, and the like.
    Type: Application
    Filed: September 30, 2013
    Publication date: March 6, 2014
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Yoshiharu Hiruma, Eisuke Tsuda, Takeshi Takizawa, Makiko Nakayama
  • Publication number: 20140065147
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
    Type: Application
    Filed: June 19, 2013
    Publication date: March 6, 2014
    Inventors: ROBERT A. KASTELEIN, TERRILL K. MCCLANAHAN, ERIN MURPHY, JASON R. CHAN
  • Publication number: 20140065148
    Abstract: Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor blood vessels, and that the administration of an anti-aminophospholipid antibody alone is sufficient to induce thrombosis, tumor necrosis and tumor regression in vivo. This invention therefore provides anti-aminophospholipid antibody-based methods and compositions for use in the specific destruction of tumor blood vessels and in the treatment of solid tumors. Although various antibody conjugates and combinations are thus provided, the use of naked, or unconjugated, anti-phosphatidylserine antibodies is a particularly important aspect of the invention, due to simplicity and effectiveness of the approach.
    Type: Application
    Filed: July 8, 2013
    Publication date: March 6, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Sophia Ran
  • Publication number: 20140065149
    Abstract: Methods of inhibiting melanoma tumor growth, methods of treating melanoma and metastatic melanoma, and methods of reducing the frequency of tumor initiating cells (or cancer stem cells) in melanoma tumors are described. The methods described comprise administering a DLL4 antagonist (e.g., an antibody that specifically binds the extracellular domain of human DLL4) to a subject. Related polypeptides and polynucleotides, compositions comprising the DLL4 antagonists, and methods of making the DLL4 antagonists are also described.
    Type: Application
    Filed: September 6, 2013
    Publication date: March 6, 2014
    Applicant: OncoMed Pharmaceuticals, Inc.
    Inventors: Timothy C. HOEY, Lucia Beviglia
  • Publication number: 20140065150
    Abstract: Disclosed are methods and apparatuses for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using ex vivo treatment with an anti-sFlt-1 receptor (sFlt-1) antibody bound to a solid support in order to reduce blood levels of sFlt-1. Further disclosed are the sequences of the heavy chain and light chain CDRs of the anti-sFlt-1 antibodies.
    Type: Application
    Filed: February 7, 2012
    Publication date: March 6, 2014
    Applicant: AGGAMIN PHARMACEUTICALS, LLC
    Inventors: Paul Kussie, Woo S. Joo
  • Publication number: 20140065151
    Abstract: The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2). The present invention also relates to a method for preventing metastasis in a patient suffering from primary cancer comprising administering, to a patient in need of such preventative treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2).
    Type: Application
    Filed: July 13, 2012
    Publication date: March 6, 2014
    Inventors: Ulrich Brinkmann, Remko Albert Griep, Klaus Kaluza, Anita Kavlie, Christian Klein, Joerg Thomas Regula, Werner Scheuer
  • Publication number: 20140065152
    Abstract: The present invention relates to a novel epitope that converts T cell to type 1 helper T (TH1) cell. Specifically, the present invention relates to an epitope constituting the 56th to 65th amino acids (SEQ ID No. 2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to TH1 cell and a method for converting T cell to TH1 cell, a pharmaceutical composition comprising the antibody for preventing or treating cancer, a method for treating cancer using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody.
    Type: Application
    Filed: April 12, 2013
    Publication date: March 6, 2014
    Applicant: National Cancer Center
    Inventor: Byoung Se KWON
  • Publication number: 20140065153
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a JAK/STAT inhibitor.
    Type: Application
    Filed: May 2, 2013
    Publication date: March 6, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20140065154
    Abstract: The invention provides anti-TLR3 antibodies as well as methods of making and using them. The antibodies are particularly adapted to the treatment of autoimmune or inflammatory diseases using anti-TLR3 antibodies.
    Type: Application
    Filed: January 10, 2012
    Publication date: March 6, 2014
    Applicant: INNATE PHARMA
    Inventors: Laurent Gauthier, Catherine Massacrier, Yannis Morel, Carine Paturel, Cecile Bonnafous, Mette Dahl Andersen, Benjamin Rossi
  • Publication number: 20140065155
    Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
    Type: Application
    Filed: August 29, 2013
    Publication date: March 6, 2014
    Inventors: Mario Mezler, Achim Moeller, Reinhold Mueller, Bernhard K. Mueller, Tariq Ghayur, Eve H. Barlow, Martin Schmidt, Axel Meyer, Nicole Teusch
  • Publication number: 20140065156
    Abstract: Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
    Type: Application
    Filed: October 1, 2013
    Publication date: March 6, 2014
    Applicant: Crucell Holland B.V.
    Inventors: Edward N. van den Brink, Cornelis A. de Kruif, Mark Throsby
  • Publication number: 20140065157
    Abstract: Gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages. Gene-modified, inflammation-specific macrophages that comprise a 1-alpha-hydroxylase gene. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages.
    Type: Application
    Filed: November 8, 2013
    Publication date: March 6, 2014
    Applicant: LOMA LINDA UNIVERSITY
    Inventors: David J. Baylink, Kin-Hing William Lau, Xuezhong Qin
  • Publication number: 20140065158
    Abstract: Provided are a wide concentration range, especially high concentration, substantially salt-free anti-prolactin receptor antibody formulations that are substantially isosmotic and of low viscosity.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 6, 2014
    Inventors: Xinghang Ma, Jun Xiang, Jianjie Niu
  • Publication number: 20140065159
    Abstract: Provided are salt-free antibody and other protein formulations that are substantially isosmotic and of low viscosity. Also provided are methods for the treatment of diseases using the disclosed formulations.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 6, 2014
    Inventors: Xinghang Ma, Jun Xiang
  • Publication number: 20140065160
    Abstract: The invention provides for the treatment of diseases or disorders characterized by cells expressing the CD40 membrane glycoprotein. The invention provides methods for the treatment of various diseases or disorders characterized by cells expressing CD40 with a combination of an agent causes the depletion of cells expressing CD40 and a second agent which causes the depletion of cells expressing the CD20 membrane antigen. Pharmaceutical compositions and articles of manufacture such as kits comprising the agents and combinations thereof are also provided.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 6, 2014
    Applicant: Genentech, Inc.
    Inventor: Igbal GREWAL
  • Publication number: 20140065161
    Abstract: A treatment composition for treating or preventing bovine mastitis, the treatment composition characterised in that it includes at least two components which have an isoelectric point of or above substantially 6.8 and is extracted from milk, or a milk derived substance.
    Type: Application
    Filed: September 4, 2013
    Publication date: March 6, 2014
    Applicant: DEC International NZ Limited
    Inventor: Judith Mary Bragger
  • Publication number: 20140065162
    Abstract: The present invention relates to methods and medicaments useful for the treatment of brain tumors by administering anti-CTGF agents, particularly anti-CTGF antibodies. Methods and medicaments are provided for reducing tumor cell proliferation and tumor growth, reducing tumor vascularity, inhibiting tumor cell invasion, improving tumor surgical margins and prolonging survival of patients with brain tumors.
    Type: Application
    Filed: November 8, 2012
    Publication date: March 6, 2014
    Applicant: FibroGen, Inc.
    Inventor: FibroGen, Inc.
  • Publication number: 20140065163
    Abstract: The present invention relates to antibodies with specificity for granulocyte-macrophage colony stimulating factor (GM-CSF). More particularly, the invention relates to humanized monoclonal antibodies that bind specifically to human GM-CSF with high affinity. The invention also relates to nucleic acids encoding the antibodies, vectors for expression of these nucleic acids, and host cells for producing said antibodies. Further, the invention relates to the use of said antibodies in the diagnosis or treatment of autoimmune or inflammatory diseases.
    Type: Application
    Filed: November 17, 2011
    Publication date: March 6, 2014
    Inventors: Laurent Magnenat, Olivier Leger, Charles MacKay, David Georges Zahra
  • Publication number: 20140065164
    Abstract: In certain embodiments, the present invention provides a method of treating an IP10-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IPIO antibody; (b) detecting the level of the anti-IPIO antibody in a sample of the subject; and (c) if the level of the anti-IPIO antibody from step (b) is below a threshold exposure level, increasing the dosage of the anti-IPIO antibody in the subject such that the IP-10 related disease in the subject is treated.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 6, 2014
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Allison Y. Luo, Wendy L. Trigona, Jinshan Shen, Li-An Xu, Yan Zhang, Bruce Stouffer, Haibin Chen, Haichun Huang, Xiaolu Tao, Catherine Brockus
  • Publication number: 20140065165
    Abstract: Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses. These binding molecules do not bind to hemagglutinin of influenza A viruses. Further provided are nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis of, prophylaxis against, and/or treatment of influenza B virus infections.
    Type: Application
    Filed: October 10, 2013
    Publication date: March 6, 2014
    Applicant: Crucell Holland B.V.
    Inventors: Ronald Vogels, Theodorus H. J. Kwaks
  • Publication number: 20140065166
    Abstract: The invention described herein provides novel peptides. The novel peptides are useful alone or as portions of larger molecules, such as antibodies or antibody fragments, that can be used to treat or prevent infection of Nipah virus and/or Hendra virus.
    Type: Application
    Filed: April 9, 2013
    Publication date: March 6, 2014
    Applicant: The Henry M. Jackson Foundation for the Advancemen t of Military Medicine, Inc.
    Inventors: Christopher C. Broder, Deborah L. Fusco, Kai Hu, Dimitar B. Nikolov
  • Publication number: 20140065167
    Abstract: Antibodies, particularly human antibodies, are disclosed having activity in treatment of demyelinating diseases and diseases of the central nervous system. Neuromodulatory agents are provided comprising a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, and active fragments, monomers and combinations thereof having one or more of the following characteristics: capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, and active fragments thereof.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 6, 2014
    Inventors: Moses Rodriguez, David J. Miller, Larry R. Pease
  • Publication number: 20140065168
    Abstract: Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-associated disorder or disease and methods of diagnosing a KIT-associated disorder or disease using the antibodies described herein.
    Type: Application
    Filed: July 24, 2013
    Publication date: March 6, 2014
    Applicant: KOLLTAN PHARMACEUTICALS, INC.
    Inventors: Yaron Hadari, Elizabeth M Mandel-Bausch, Francis Joseph Carr, Timothy David Jones, Laura Clare Alexandra Perry
  • Publication number: 20140065169
    Abstract: Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
    Type: Application
    Filed: July 12, 2013
    Publication date: March 6, 2014
    Inventors: Siddhartha Jaiswal, Irving L. Weissman, Ravindra Majeti, Mark P. Chao
  • Publication number: 20140065170
    Abstract: The present invention relates to biomarkers for preeclampsia as well as treatment of this disease. In particular, the invention relates to methods for diagnosis or aiding in the diagnosis of preeclampsia of a pregnant female mammal to detect elevated levels of free haemoglobin, particularly free fetal haemoglobin. This facilitates and makes possible early diagnosis and clinical intervention when a preeclamptic condition is found. In addition, the invention relates to a method to treat female mammals with preeclampsia with the purpose to reverse the pathological conditions associated with this disease.
    Type: Application
    Filed: September 17, 2013
    Publication date: March 6, 2014
    Applicant: A1M Pharma AB
    Inventors: Stefan Hansson, Bo Akerström
  • Publication number: 20140065171
    Abstract: The present invention provides methods of site-specific labeling of antibodies, using proteins having 4?-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates.
    Type: Application
    Filed: May 31, 2013
    Publication date: March 6, 2014
    Inventors: Bernhard Hubert GEIERSTANGER, Jan GRUNEWALD, Badry BURSULAYA
  • Publication number: 20140065172
    Abstract: The present invention relates to a delivery system that comprises a conjugate that facilitates the delivery of a compound such as a biologically-active macromolecule, a nucleic acid or a peptide in particular, into a cell. The present invention also relates to said conjugate for delivery of a compound, such as a biologically-active macromolecule, a nucleic acid or a peptide, into a cell. The present invention further relates to a pharmaceutical composition comprising said conjugate and to its use. The present invention also relates to a method of delivering a compound to a cell or an organism, preferably a patient.
    Type: Application
    Filed: January 26, 2012
    Publication date: March 6, 2014
    Inventors: Christophe J. Echeverri, Birte Sönnichsen, Reinhard Wähler, Mike Werner Helms, Brian S. Sproat
  • Publication number: 20140065173
    Abstract: Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
    Type: Application
    Filed: September 5, 2013
    Publication date: March 6, 2014
    Applicant: Orbis Health Solutions LLC
    Inventor: Thomas E. Wagner
  • Publication number: 20140065174
    Abstract: A pharmaceutical composition is used to enhance immunity of the human body. The composition contains potent components of lanostane compounds. A method is devised to obtain an extract from metabolite, sclerotium, or fermentation product of Poria cocos (Schw) Wolf. The extract contains 5-60% of the lanostane compounds by weight of the extract. The extract is devoid of secolanostane capable of inhibiting immunity development.
    Type: Application
    Filed: November 1, 2013
    Publication date: March 6, 2014
    Applicant: Sinphar Pharmaceutical Co., Ltd.
    Inventors: Hang-Ching Lin, Jerming Tseng, Hsiou-Yu Ding, Wen-Liang Chang, Chien-Lian Chao, Hsin-Wen Huang
  • Publication number: 20140065175
    Abstract: The invention relates to the technological sector of the transport and delivery of molecules into cells, either at cytoplasm or at nucleus or inter-cells (cell to cell transport), using peptides binding proteins from the cell microtubule motor complex, preferably dynein-binding peptides, as carrier/delivery peptides; or functionalized structures, as nanoparticles, linked to said carrier/delivery peptides. This delivery can be useful in many technical fields comprising, among some others: diagnosis, therapy and pharmacology.
    Type: Application
    Filed: February 17, 2012
    Publication date: March 6, 2014
    Inventors: M. Covadonga Alonso Martí, José Ángel Martínez Escribano
  • Publication number: 20140065176
    Abstract: Cell death-inducing epitopes and polypeptides containing same. Also disclosed are compounds for inducing death of activated T-cells, a method of producing antibodies to the epitopes, a method of identifying compounds that bind to the epitopes, a method of inducing death of activated T-cells, and pharmaceutical compositions containing the compounds.
    Type: Application
    Filed: August 29, 2013
    Publication date: March 6, 2014
    Applicant: AbGenomics Cooperatief U.A.
    Inventors: Rong-Hwa Lin, Chung Nan Chang
  • Publication number: 20140065177
    Abstract: Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin.
    Type: Application
    Filed: June 28, 2013
    Publication date: March 6, 2014
    Applicant: VaxInnate Corporation
    Inventors: Langzhou Song, Ge Liu, Scott Umlauf, Uma Kavita, Hong Li, Xiangyu Liu, Bruce Weaver, Lynda Tussey
  • Publication number: 20140065178
    Abstract: The present invention provides pseudoinfectious alphavirus particles and methods of making them and using them to produce an immune response to an alphavirus in a subject.
    Type: Application
    Filed: February 1, 2012
    Publication date: March 6, 2014
    Applicant: UAB RESEARCH FOUNDATION
    Inventors: Ilya Frolov, Elena Frolova
  • Publication number: 20140065179
    Abstract: A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.
    Type: Application
    Filed: March 9, 2012
    Publication date: March 6, 2014
    Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
    Inventors: Chikateru Nozaki, Kazuyoshi Kaminaka, Junichi Matsuda