Abstract: This application generally relates to systems and methods of using Radio Frequency Identification (RFID) devices to remotely analyze objects and structures, and more particularly, this application relates to systems and methods of using RFID devices to remotely analyze properties and conditions of a surface of objects and structures.

Abstract: A clamping apparatus for coupling an ultrasonic transducer to a conduit is disclosed. The clamping apparatus comprises a base portion fastened to the conduit and including a bracket for receiving an adapter. The adapter is attached to a housing and allows the housing to be rotated when the adapter is positioned in an upper portion of the bracket, and prevents the housing from being rotated when the adapter is positioned in a lower portion of the bracket. The housing is configured to enclose the ultrasonic transducer except for a housing opening along the bottom of the housing. The ultrasonic transducer extends through the housing opening and is spring biased against the conduit.

Abstract: An ultrasonic mechanical defect and/or fault detection and monitoring system includes at least one ultrasonic fault detection device configured to measure ultrasonic emissions from an object under evaluation and to generate an output signal in response thereto. The system further includes at least one processor configured by code to receive the generated output signal; access a library of stored signal patterns; compare the generated output signal against the library of stored signal patterns; and generate an alert where the generated output signal matches at least one of the library of stored signal patterns.

Abstract: A probe assembly and an inspection system are provided for ultrasonic inspection. Designs for the probe assembly package components to fit into a bore of a hollow target. These designs may incorporate electronics to generate waves and to detect a wide selection of anomalies (e.g., transversal crack, longitudinal crack, and volumetric flaws) that can form in the hollow target. The probe assembly provides support structure to manipulate and operate these electronics in the bore. This support structure facilitates communication of signals, e.g., from transducer elements that operate as a phased array. The probe assembly also includes a fluid circulating system and coupling system that permits the probe device to detach and reattach to match the probe device (and other parts of the probe assembly) to the size of the bore. These systems allow for fluid and electrical signals to circulate through the probe assembly.

Abstract: A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.

Abstract: Systems, methods and devices are taught for providing analytical methods for peak-shaped responses separated in time or space, including quantitation of chromatographic peaks based on a width measurement of a peak trace at a selected height as a quantitation element. Methods of treating a peak trace as a composition of exponential functions representing a leading and a trailing end are included. Methods that facilitate the detection of impurities in peak trace outputs are also included.

Abstract: An electrochemical detector including at least one substance selection structure disposed adjacent or proximate to an electronic device structure, wherein the substance selection structure is arranged to interact with a target substance having a molecular structure so as to alter an electrical characteristic of the electronic device structure.

Abstract: Disclosed herein are a method for analyzing heavy metal removal efficiency using phase difference analysis and an apparatus using the method. The method for analyzing heavy metal removal efficiency using phase difference analysis includes applying a magnetic field to a magnetite onto which a heavy metal is adsorbed, based on a first solenoid coil and a second solenoid coil that have an identical winding direction, applying a high-frequency signal to the magnetite, based on a third solenoid coil having a winding direction that differs from that of the first solenoid coil and the second solenoid coil, detecting a high-frequency signal transformed by the magnetite, and calculating a phase difference between a previously detected default high-frequency signal and the transformed high-frequency signal, and analyzing an efficiency of heavy metal removal by the magnetite by measuring a concentration of the heavy metal based on the phase difference.

Abstract: A standard for testing measurement systems for aqueous chlorine species analysis includes an openable storage vessel and an aqueous composition including a compound having the formula R1R2NCl where R1 and R2 are independently methyl, ethyl or propyl, wherein the aqueous composition is storage stable within the openable storage vessel.

Abstract: A pile testing device for testing ground includes (i) a tubular outer pile member having a helical flight mounted externally thereon, (ii) an inner pile member received within the second pile, (iii) a coupling assembly operable between an inserting position in which the inner pile member and the outer pile member are joined in fixed relation to one another so as to be arranged to be simultaneously driven into the ground and a testing position in which the inner pile member is longitudinally slidable relative to the outer pile member within a prescribed axial range but in which the inner pile member remains coupled to rotate together with the outer pile member, (iv) a jack coupled between top ends of the inner and outer pile members, and (v) a sensor adapted to measure longitudinal displacement of one of the pile members relative to the other pile member or the ground.

Abstract: In one aspect, methods are described herein for the selective detection and quantitative analysis of biological molecule compositions. A method described herein comprises providing a mixture comprising biological molecules, such as DNA, RNA or proteins, complexed with a translocating agent, such as another DNA or protein, and non-complexed biological molecules. The mixture is contacted with a membrane comprising at least one nanopore and an electric field is applied across the nanopore to selectively translocate the biological molecules complexed with the translocating agent through the at least one nanopore. Concentration of the complexed biological molecules is determined based on the translocation rate of said molecules.

Abstract: A system for receiving and ejecting a fluid testing device test strip includes a strip connector having first and second guide rails, and divider walls each having a channel. A sled has first and second legs connected to a cross member. Each leg has a contact leg extending inwardly from a chamfered end. The first and second legs when positioned parallel to the guide rails have the contact leg captured in the divider wall channels retaining the sled in sliding contact with the guide rails for motions in loading and ejection directions. A mechanism assembly is movably connected to the fluid testing device. The cross member is coupled so operation in a first direction displaces the sled in the loading direction positioning the sled in a test strip test position, and opposite operation positions the contact legs in direct contact with and ejects the test strip.

Abstract: A technology of measuring an electrical characteristic of a blood sample is provided that allows easy introduction, into an existing blood test system, a technique of obtaining information on a blood sample from an electrical characteristic of the blood sample. The technology provides a device for measuring an electrical characteristic of a blood sample, the device including: a mixing unit configured to mix a blood cell component and a plasma component on the basis of the composition ratio between the blood cell component and the plasma component in a blood sample; and a blood sample measurement unit configured to measure an electrical characteristic of a blood sample obtained by mixing by the mixing unit.

Abstract: An object of the present invention is to provide a blood analysis method in which a high level of repeatability and reproducibility is achieved with respect to measurement values in a blood sample of 50 ?L or less, and a blood test kit which is used for the blood analysis method. According to the present invention, a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in the blood; and a step of analyzing a concentration of a target component in the blood sample, in which a volume of the blood sample is 50 ?L or less, a dilution factor of blood plasma components in the blood sample is 14 or higher, and the diluent solution is a diluent solution which does not contain the normal component which is homeostatically present in the blood, is provided.

Abstract: Methods for data processing and control for a medical communication system are provided, including determining a sensitivity value for each sensor of a batch of in vivo analyte sensors; determining a sensitivity variation for each sensor of the batch; determining a mean sensitivity based on the sensitivity value determined for each sensor of the batch when it is determined that the determined sensitivity variation does not exceed a tolerance threshold level; associating a sensor code with each sensor of the batch of in vivo analyte sensors when the mean sensitivity is within a predetermined sensitivity range, wherein the sensor code associated with each sensor is based on a characteristic of the associated sensor; and storing the sensor code associated with at least one sensor of the batch configured to generate signals corresponding to monitored analyte level in a memory of a data processing device associated with the sensor.

Abstract: There are disclosed a method for determining binding constants between a substance or a substance mixture and a target, and a kit for carrying out the method according to the invention. The binding constants of the substance for the targets are determined by shifting the binding equilibrium. The concentrations of the immobilised and the dissolved target are varied and the affinities with the targets are determined by shifting the binding equilibria in the individual batches.

Abstract: A blood-glucose meter integrated with a biological test-piece tank includes a biological test-piece tank and a blood-glucose meter. The biological test-piece tank has internally a chamber for providing an accommodation room to store a plurality of biological test pieces, a tank opening located at a top thereof to pair a cover so as to form a sealed structure, and a tank bottom located by opposing to the cover. The blood-glucose meter, connected with the tank bottom, has an inserting hole for receiving a biological test piece that carries thereon a biological specimen to be examined for obtaining a corresponding blood-glucose value.

Abstract: Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.

Abstract: The invention relates to a novel non-obese diabetic (NOD) mouse and its application. Particularly, the invention relates to a NOD mouse specifically expressing anti-polyethylene glycol membrane antibody reporter (anti-PEG reporter) in the NOD mouse.

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

Abstract: Methods of reversibly inducing proximity of first and second target molecules in a sample are provided. Aspects of the methods include contacting the sample with a modifiable chemical inducer of proximity (MCIP) that reversibly induces proximity of the first and second target molecules, upon application of a stimulus that modifies the MCIP. Aspects of the invention further include methods for regulating a biological process in a cell. Aspects of the invention further include compositions, e.g., compounds and kits, etc., that find use in methods of the invention.

Abstract: This invention discloses “Artificially Cleaved Epitope (ACE)” methods, antibodies, reagents, immunoassays, and kits for designing and detecting mutation-specific epitopes/antigens. The ACE methods can detect epitopes that are either absent or poorly recognizable or accessible naturally to antibodies, and thus must be specifically and artificially created (free terminals) and/or exposed in samples and sample preparations for antibody detection. The ACE methods comprise ACE antigen design and ACE antigen detection. The ACE methods, antibodies, reagents, immunoassays, and kits are useful in research and discovery, diagnostic, and therapeutic applications. In another aspect, the ACE methods can artificially and specifically expose hidden antigens while reducing the antibody non-specific bindings in all antibody-based applications.

Abstract: The present invention relates to a composition in which a conducting polymer is doped with a dopant, and a diagnostic apparatus, and more particularly, to a composition which is used to diagnose a disease and detect a biomaterial and also used for qualification and diagnosis by effectively and non-destructively collecting a captured biomaterial. Further, the composition can maximize capturing efficiency by being attached to a surface of a nano-structured scaffold and can be used as an ultrahigh-sensitive sensor using various linked bodies.

Abstract: The invention relates to a method for in situ imaging of samples by cycle multiplexing that enables imaging of various molecular targets through multi-molecular read-outs on the same sample in a rapid, highly sensitive and reliable manner. The invention is further related to imaging buffers preventing the degradation of the sample and of the imaging reagents, which are particularly useful in a method of in situ imaging of samples by cycle multiplexing according to the invention.

Abstract: A device is provided. The device comprises a casing comprising an interior, a first opening, and a second opening; and a porous carrier comprising a sample-receiving zone and a target cell-binding zone. The porous carrier defines a first fluid pathway that extends from the sample-receiving zone to the target cell-binding zone. At least portion of the porous carrier is disposed in the interior of the casing. A second fluid pathway comprising a central axis extends through the casing from the first opening and the second opening, the second fluid pathway intersecting the porous carrier at the target cell-binding zone. The central axis is oriented orthogonally with respect to the porous carrier. Methods of using the device to detect a target microorganism are also provided.

Abstract: A microfluidic device for determining whether an analyte is present in a sample is provided. The microfluidic device includes an elongated flow path having a polymeric medium, where the polymeric medium includes a first analyte detection domain having a first immobilized capture member that specifically binds to a first analyte and a second analyte detection domain having a second immobilized capture member that specifically binds to a second analyte. Also provided are methods, systems and kits in which the subject microfluidic devices find use, as well as methods of producing the same.

Abstract: The present invention relates to a probe for detecting bacteria using a peptidoglycan-binding protein, and a method for preparing the same. Also, the present invention relates to a method for detecting bacteria using the probe. The probe for detecting bacteria according to the present invention can specifically detect bacteria. That is, the probe according to the present invention can clearly distinguish between yeast and bacteria and can detect both Gram-negative and Gram-positive bacteria, and thus is expected to be usable in various fields as a universal probe for detecting bacteria. Further, use of the probe allows bacteria to be detected by identifying only fluorescence development without an additional enzymatic treatment, thereby enabling a simple and quick bacterial detection. In particular, the probe is expected to be effectively usable in the food industry where quick bacterial detection is required.

Abstract: The invention relates generally to immunoassays, and more particularly to monoclonal antibodies and immunoassays for the differential detection and quantitation of a wild-type crystal protein, such as a wild-type-Cry1Ab, from Bacillus thuringiensis and hybrid crystal proteins, which comprise all or a significant portion of the wild-type Cry protein in complex biological samples comprising both the wild-type Cry protein and one or more of the hybrid Cry proteins.

Abstract: Disclosed is a novel means of simultaneously detecting a human parvovirus B19 antigen and an IgM type anti-human parvovirus B19 antibody. The method of simultaneously detecting a human parvovirus B19 antigen and an IgM type anti-human parvovirus B19 antibody in a sample according to the present invention comprises bringing a sample into contact with (1) a 1st probe for detecting the parvovirus B19 antigen and (2) a 2nd probe for detecting the IgM type anti-parvovirus B19 antibody in the presence of a surfactant within the same reaction.

Abstract: Studies in mouse models of Fragile X and preliminary studies in human youth demonstrate that ERK1/2 is biomarker useful to monitoring the treatment of people diagnosed with ASD. Results reported herein demonstrate that acamprosate has the ability to reduce levels of ERK1/2 activation associated with many of the symptoms of ASD. Accordingly, in addition to its utility as a diagnostic marker for ASD ERK1/2 activation levels can be used to monitory patients treated with acamprosate.

Abstract: The present invention relates inter alia to therapeutic agents for use in the treatment of melanoma, methods of diagnosing an increased risk of metastasis in a subject suffering from melanoma, methods of treating such subjects, diagnostic assays and kits. More particularly, in certain embodiments the invention relates to identifying whether a subject suffering from melanoma has an increased risk of metastasis by determining the expression of Ambra-1 and Loricrin in a tissue sample obtained from the subject.

Abstract: Modified Tryptamine, Tryptamine-2?-deoxy-uridine (TrpdU) and TrpdU-phosphoramidites for oligonucleotide synthesis are provided, as well as improved methods of their synthesis and oligonucleotides comprising at least one modified TrpdU nucleotide.

Abstract: Split enzyme reporter systems are disclosed for detecting an analyte in a mixture. Fragments of the split enzyme may be covalently bound to targeting domains that bind to target regions of an analyte, thereby causing formation of an active complex. Some split enzyme reporter systems can be used to detect an analyte without the use of analyte immobilization, blocking, or wash steps. Some reporter systems also enable rapid detection of the analyte of interest.

Abstract: Disclosed are a method for immunologically measuring cardiac troponin in a biological sample, in which the formation of an immunological complex of cardiac troponin with an antibody specifically binding thereto is performed in the presence of a divalent cation at 4 mmol/L or more; and a kit for measuring cardiac troponin, comprising an antibody specifically binding to cardiac troponin, and a buffer containing a divalent cation at a high concentration. According to the method or the kit, a stable and highly-accurate measured value can be obtained without being affected by interfering substances in a specimen regardless of the type of specimen.

Abstract: The present invention relates to a method of visualizing biomolecules, having the steps of: a) providing a sample of immobilized biomolecules in a matrix and carry on the electrophoresis process; b) incubating the matrix of step a) in a solution containing a cyanine-derived molecule, for a time of 5 to 60 minutes, at room temperature, in a container preventing exposure to light, shaking the container at less of 75 rpm; c) transferring the matrix from step b) to a container with a solution having: at least one tetrazolium salt and incubating for a time of 15 to 120 minutes at room temperature under light exposure; d) removing the matrix with immobilized biomolecules from the previous step and washing with distilled water; and e) visualizing directly by the naked eye the biomolecules immobilized in the matrix.

Abstract: The present invention pertains to a method for determining the biological activity of a neurotoxin, the method comprising the steps of: (a) expressing a fusion protein comprising (i) an anchor protein, (ii) a reporter protein and (iii) a neurotoxin cleavage site intervening the anchor protein and the reporter protein, in neurotoxin-sensitive cells; (b) incubating the neurotoxin-sensitive cells of (a) with a neurotoxin and cultivating the cells under conditions which allow the neurotoxin to exert its biological activity; (c) permeabilizing the neurotoxin-sensitive cells of (b) under conditions which allow the release of the reporter protein but not the release of the anchor protein from the permeabilized neurotoxin-sensitive cells; and (d) quantifying the activity of the reporter protein released from the cells, thereby determining the biological activity of the neurotoxin.

Abstract: An object of the present invention is to provide a method for efficiently identifying a polyubiquitinated substrate which is generally not easily identified. The method for identifying a polyubiquitinated substrate includes (1) a step of expressing a trypsin-resistant polyubiquitin chain-binding protein and a ubiquitin ligase in a cell, (2) a step of isolating a complex that contains the trypsin-resistant polyubiquitin chain-binding protein from the cell having undergone the step (1), (3) a step of subjecting the complex isolated by the step (2) to trypsin digestion, and (4) a step of identifying a peptide that has a ubiquitination site from a digested material obtained by the step (3).

Abstract: Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6C, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {?2) glucose 1 (1?3) glucose 2 (1?3) rhamnose (1?3) ribitol (5?phosphate}. This new serotype may be included in pneumococcal vaccines.

Abstract: Disclosed herein are methods of identifying biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) that can be used to predict organ or tissue function or dysfunction. In some embodiments, the methods include ex vivo perfusion of the organ or tissue, collection of samples from the organ or tissue (for example, perfusate, fluids produced by the organ (such as bile or urine), or tissue biopsies) and measuring the level of one or more biomarkers in the sample. It is also disclosed herein that an analysis of biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) present in a biological sample from an organ, tissue, or subject can be used to identify whether the organ, tissue, or subject is at risk for (or has) organ dysfunction or organ failure.

Abstract: Certain embodiments are directed to methods of identifying dementia in subjects comprising, measuring serum levels of one or more of interferon gamma, IL-10, IL-12p40, IL-13, alpha 2 macroglobulin, beta 2 microglobulin, pancreatic polypeptide, prolactin, stem cell factor, thrombopoietin, and Von Willebrand Factor and identifying a subject as having dementia if the levels of the biomarkers is increased.

Abstract: The invention relates to methods and assays for identifying compounds as candidates in the development of a drug for the treatment of various diseases including those associated with pathological Tau. The invention also relates to methods and assays for identifying compounds for the treatment of various diseases including those associated with pathological Tau. The invention also relates to cell lines and constructs for use in an assay of the invention. The methods and assays identify a compound as useful in the treatment of a tauopathy if said compound modulates Sil1 expression or activity.

Abstract: A method for quantification of the concentration of one or more cannabinoid compounds in a liquid sample is provided. The method involves contacting the liquid sample with at least one cannabinoid-sensitive visualization reagent, allowing the at least one cannabinoid-sensitive visualization reagent to develop for a defined amount of time; and comparing the resulting color change of the at least one cannabinoid-sensitive visualization reagent to a calibrated quantification reference chart.

Abstract: According to one embodiment, there is provided an automatic analyzing apparatus which comprises determination processing circuitry, an analyzer mechanism and data processing circuitry. The determination processing circuitry determines whether to continue reaction of a solution mixture based on reaction data. The analyzer mechanism generates analytical data based on test data generated by measuring the solution mixture. The data processing circuitry performs control such that the analytical data is generated in a first measurement section if it is determined that continuation of the reaction of the solution mixture is unnecessary, and the analytical data is generated by measuring the solution mixture after the first measurement section if it is determined that continuation of the reaction of the solution mixture is necessary.

Abstract: Disclosed herein are methods, devices, and systems for loading and retrieval of particles. In some embodiments, a loading station comprise a tray configured to receive a microwell array, a first magnet, a second magnet, and an actuation mechanism configured to cause movement of at least one of the first magnet and the second magnet.

Abstract: An air data computer configured to be installed on an aircraft includes an inertial sensor assembly having a plurality of accelerometers and a plurality of rate gyroscopes. The air data computer is configured to: determine a pressure altitude of the aircraft based on measured pressure of the airflow about the exterior of the aircraft; determine an estimated attitude of the aircraft based on rotational rate sensed by the plurality of rate gyroscopes; and determine a vertical acceleration of the aircraft based on the estimated attitude of the aircraft and the acceleration sensed by the plurality of accelerometers. The air data computer is further configured to blend the vertical acceleration and the pressure altitude using a complementary filter to produce a blended altitude rate that is output to consuming systems.

Abstract: Provided are a particle image velocimetry and a method of controlling the particle image velocimetry. The particle image velocimetry includes a light source unit including two or more light sources that generate lights of different colors, wherein each of the light sources irradiates tracking particles in a flow field with a predetermined time difference; a camera that captures an image of the tracking particles; a controller that calculates migration distances of the tracking particles by splitting an image of the tracking particles captured by using the camera, into an image of each color, and calculates a velocity of the flow field by using the time difference at which the light of each of the light sources is irradiated and the migration distances of the tracking particles; and a display unit that receives velocity information of the flow field from the controller to display the velocity information.

Abstract: An attitude estimation apparatus for estimating the attitude of a movable body includes an attitude estimation unit for estimating the roll angle of the movable body and for using a calculation process to estimate the offset error for at least one of first and second angular velocity detection units and first, second and third acceleration detection units. The attitude estimation unit includes a plurality of Kalman filters that each receive at least two or more imaginary offset quantities for a detection unit of interest, the imaginary offset quantities being different from each other. Each of the Kalman filters uses detected values from the detection units, estimated values from the previous estimation operation and the imaginary offset quantities to calculate a likelihood, which indicates how reliable the estimated values are. The attitude estimation unit weights the estimated values from the Kalman filters based on the likelihood to estimate the roll angle of the movable body.

Abstract: A force sensor includes a sensor chip that detects displacements in multiple axial directions, and a strain body that transfers force applied thereto to the sensor chip. The strain body includes a sensor chip mount on which the sensor chip is mounted, multiple columns disposed around and apart from the sensor chip mount, and connecting beams via which the sensor chip mount is fixed to the columns.

Abstract: A multi-axis accelerometer may include a proof mass, a first electrode set, and a second electrode set. The first electrode set may detect acceleration along a second axis of the accelerometer, and may include a first electrode (C1) and a second electrode (C2). The second electrode set may detect acceleration along a first axis of the accelerometer that is orthogonal to the second axis, and may include a third electrode (C3) and a fourth electrode (C4). Application of a force along only the second axis may result in the exhibition of a non-zero change in differential capacitance between at least C1 and C2, but a zero net change in the differential capacitance between at least C3 and C4. As such, the accelerometer may exhibit little or no cross axis sensitivity in response to the applied force.

Abstract: It is an object of the present invention to reduce noise in a detection circuit for use in a sensor system. According to an aspect of the present invention, provided is a high-sensitivity sensor system which includes an acceleration sensor, a detection circuit system that detects an output of the acceleration sensor, a feedback circuit system including a reference voltage power source that generates a feedback signal to be fed back to the acceleration sensor based on an output of the detection circuit system, and a correction circuit system.