Abstract: A refill for devices for evaporating volatile substances includes a body (1) provided with a neck (2). The body has a first coupling means (4; 5; 6) for coupling the body to a device (10; 20; 30) for evaporating volatile substances and also at least a second coupling means (4; 5; 6) for coupling the body to a device for evaporating volatile substances (10; 20; 30). The refill can be used with different devices for evaporating volatile substances by using one of said coupling means, depending on the means provided in the device.

Abstract: Material comprising a flexible porous hydrophilic polymer foam or fibre matrix comprising two matrix faces and therebetween a structural matrix framework defining a network of cells, having a cell network surface and therein a network of pores and a powder charge comprising antimicrobial additive and/or wound dressing additive, wherein said powder charge is comprised at said matrix face or faces and/or within said cell network or within said structural matrix framework and wherein said additive is micronized, wherein said micronized additive has single particle size population greater than or equal to 1 micron and/or has loss on drying (L.O.

Abstract: A medical dressing material having a chitosan fabric sponge structure according to the present disclosure has a structure in which chitosan fibers derived from a chitosan fabric are located on a porous structure formed using freeze-drying. Therefore, the medical dressing material has an excellent hemostatic effect and exudate-absorbing ability while exhibiting a strong tensile force, is convenient to use, and is capable of being molded into various forms so as to be widely used for wounds by an edged thing, scalds, pressure ulcers, diabetes-related foot disorders, or various surgical areas in various body tissue parts such as the spine, brain, eye, ear, nose, and cervix.

Abstract: The present disclosure describes a wound dressing that incorporates a biopolymer scaffold, such as a keratin-based scaffold, into collagen-based materials to increase the mechanical strength of the wound dressing. The biopolymers can increase retention times in the wound environment so that the wound dressing may serve not as a catalyst for progressing beyond the inflammatory phase of wound healing. The longer retention times also enable the wound dressing to server as a structural scaffold for tissue integration.

Abstract: A temperature-responsive hydrogel includes water, a poly(N-alkylacrylamide) copolymer of a first monomer and a second monomer that is different than the first monomer, and an adhesion-enhancing additive. One type of adhesion-enhancing additive is selected from the group consisting of Arg-Gly-Asp-Ser amino sequence (RGDS), 3-guanidinopropionic acid (GPA), manganese(II) chloride tetrahydrate, and combinations thereof. Characteristically, the temperature-responsive hydrogel has a failure pressure that is at least 2 times greater than a failure pressure for a base temperature-responsive hydrogel having the same composition without the adhesion-enhancing additive. Another type of adhesion-enhancing additive is selected from the family of plant polyphenols, and issued as a priming layer before deployment of the temperature-responsive hydrogel. It not only improves the adhesion of temperature-responsive polymer gels to biological tissues, but also reserves the thermal reversibility of the polymers.

Abstract: The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.

Abstract: The present disclosure relates to polymer implants for procedures such as reconstructive and aesthetic surgery, wound healing, and closure and protection of incision sites. The implants can include a matrix from a bioerodible biopolymer. The biopolymer can be porous and conducive to cell growth for providing a beneficial interface between the matrix and host tissue. The biopolymer can be polyurethane formulation, which can include polycaprolactone soft segments.

Abstract: An injectable composition having dermal filling and tissue expanding activity comprises: (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion; and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen; in other alternatives, the composition can further comprise hyaluronic acid; and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition. Proanthocyanidin can act as a cross-linker and as a protector of elastin against UV degradation. Proanthocyanidin combined with a collagen or gelatin-hyaluronic acid matrix can inhibit matrix degradation and contraction with fibroblasts.

Abstract: The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.

Abstract: The present invention describes in vitro methods for producing a cellular composition with in vivo bone forming potential.

Abstract: A method includes covering or contacting a portion of a parathyroid of a subject with a shield including extraembryonic tissue and/or a stem cell. The covering or contacting occurs during a neck or reconstructive surgery of the subject.

Abstract: Provided herein is a cell macroencapsulation device composed of hydrogel in a 3D conformation that optimizes encapsulated cell viability and function when transplanted into a vascularized tissue space. The hydrogel macroencapsulation device is intended to reduce or eliminate immune response to the cell graft, while allowing exchange of encapsulated cell-secreted products, such as insulin. Also described herein is an injection-mold and fabrication process to generate the hydrogel macroencapsulation devices for use in the clinic.

Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.

Abstract: The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.

Abstract: Drug delivery devices are provided in which much of a drug payload within the device remains within an area proximal to a wall of the device through which the drug must pass for release of the drug from the device into a patient. In one case, the device may include a drug reservoir portion which has a drug reservoir lumen bounded by a reservoir wall having an inner surface; a drug located in the drug reservoir lumen; and a core region which does not comprise the drug, wherein the drug is disposed between the inner surface of the reservoir wall and the core region. The device may be elastically deformable between a first shape suited for insertion through a lumen into a body cavity of the patient and a second shape suited to retain the device within the body cavity.

Abstract: A catheter configured to release nitric oxide and chlorhexidine providing anti-platelet and antimicrobial properties is manufactured by impregnating a thermoplastic polyurethane catheter extrusion with a nitric oxide releasing compound and with chlorhexidine. Thereafter, the impregnated catheter extrusion is coated with a polyurethane coating comprising chlorhexidine and/or a nitric oxide releasing compound. In the impregnating step, the catheter extrusion may be exposed to a solvent having the nitric oxide releasing compound and chlorhexidine dissolved therein. The solvent is removed from the catheter extrusion. In the coating step, the impregnated catheter extrusion may be dip coated in a polymer solution comprising polyurethane and chlorhexidine and/or a nitric oxide releasing compound in a suitable solvent. The nitric oxide releasing compound, impregnated and/or coated, may be selected from s-nitroso-n-acetylpenicillamine (SNAP), s-nitrosoglutathione (GSNO), and mixtures thereof.

Abstract: A novel two-step process for batch coating surgical needles with cross-linked silicone coatings is disclosed. The surgical needles are cured using a two-step process. The coatings on the needles are partially cured in the first step and mechanically separated. The coatings on the needles are then fully cured in the second step.

Abstract: The present invention is directed to compositions containing polymer matrix, fiber and/or additives which are suitable for load bearing applications for medical devices. The matrix can be formed from a group of polymers which resorb inside the body after implantation. These compositions contain reinforcing fibers that are incorporated into a resorbable polymer matrix to improve properties such as mechanical. The reinforcing fibers can be resorbable, non-resorbable, natural, or metallic. Additives can be incorporated into the matrix material or the fibers or both to provide a secondary effect. These additives can be bioceramics to provide an osteoconductive effect; antimicrobial particles such as silver; coloring agents, and radiopaque additives to make the implants visible under fluoroscopy. The additives may also contribute to improve mechanical properties.

Abstract: A bodily fluid drainage assembly can include a fluid bag and one or more covers. The assembly can include one or more volume indicators from which an approximate volume of a bodily fluid that is retained within the be can be ascertained. In some arrangements, a cover includes a volume indicator that defines an opening through which a transparent or semitransparent portion of the bag can be viewed.

Abstract: The present invention relates to a device for use in processing fatty tissue, characterised in that it comprises, in a closed circuit, a first tissue collection unit (1) connected to a second tissue collection unit (2), wherein the first tissue collection unit (1) has an opening (3) that allows the inlet of tissue and an opening (4) in the base of the first unit that allows the outlet of tissue, and wherein the second tissue collection unit (2) has an opening (6) in the base of the second unit that allows the outlet of tissue.

Abstract: A medical system includes a medical instrument including an irrigation and aspiration channel to carry irrigation fluid to, and remove aspirated matter from, a distal end of the medical instrument, a reservoir to store the irrigation fluid, a receptacle to collect the aspirated matter, and a vane pump including a pump housing having an inner surface around a pumping chamber, the pump housing including irrigation inlet and outlet ports coupled to the pumping chamber and respectively connected to the reservoir and the irrigation channel, and aspiration inlet and outlet ports coupled to the pumping chamber and respectively connected to the aspiration channel and the receptacle, and wherein the vane pump is configured to simultaneously pump via the pumping chamber, at substantially the same flow rate, the irrigation fluid from the reservoir to the distal end and the aspirated matter from the distal end to the receptacle.

Abstract: A tissue interface having visually contrasting portions, systems for using the same, and methods of manufacturing the same are provided. The wound filler includes a first portion having a first color and a second portion having a second color. The second color contrasts to the first color. The first color and the second color both contrast to red and purple. The first color and the second color are complementary.

Abstract: Embodiments of a negative pressure wound closure system and methods for using such a system are described. Certain disclosed embodiments facilitate closure of a wound by preferentially exerting a negative pressure on tissue. Some embodiments may utilize a collapsible sheet with a plurality of cells.

Abstract: In some embodiments, a negative pressure wound closure system and methods for using such a system are described. Certain disclosed embodiments facilitate closure of the wound by preferentially contracting to exert force on the tissue. Some embodiments may utilize a collapsible structure with a plurality of cells.

Abstract: An external catheter system can comprise an external catheter comprising an engagement portion that is configured to receive and sealingly engage at least a portion of a penis of a user and an outlet. The system can further comprise a negative pressure source. A conduit can couple the negative pressure source to the external catheter. At least one of the external catheter and the conduit can comprise a portion that, upon application of a negative pressure by the negative pressure source, is configured to collapse to provide a pressure drop between the negative pressure source and the engagement portion of the external catheter.

Abstract: A system for subatmospheric pressure therapy in connection with healing a wound is provided. The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source. The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.

Abstract: Methods and systems for the manual collection of whole blood are disclosed. The methods and systems include delivering a replacement fluid to the donor after or during the course of the blood collection.

Abstract: A cost-effective, single use bag or container is provided for storing biological substances that incorporates on its inner wall an electronic device that is configured to measure physiological and/or physical parameters of the enclosed biological substances, such as source history, identification, demographics, time stamping, temperature, pH, conductivity, glucose, O2, CO2 levels etc. The electronic device of the disclosed bag comprises a sensor configured to measure physiological and/or physical parameters of the biological substances enclosed within the bag, and a radio-frequency (RF) device communicably coupled to the sensor and configured to: (a) acquire from the sensor data associated with the measured parameters, (b) store the acquired sensor data in nonvolatile memory, and (c) communicate the stored data wirelessly to a RF reader.

Abstract: The present invention relates to a dialysis machine comprising a balancing system that has at least one balancing chamber for a volumetrically exact supply and removal of dialysis solution to and from a dialyzer fluidically connected to the balancing system in operation; a water inlet system connected to the balancing system for the supply of fresh dialysis liquid, with the water inlet system having an apparatus for degassing water that is connected to an air separator of the dialysis machine, with a first subsection of the air separator serving as a mixing chamber and being connectable to at least one concentrate source via at least one concentrate line and being in fluid communication with the balancing system via at least one dialysate line, wherein the filling volume of a balancing chamber corresponds to or exceeds the sum of the volume of the mixing chamber and the inner volume of the dialysate line.

Abstract: A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet.

Abstract: The present system and method are useful for the removal of immune inhibitors such as soluble TNF receptors from the body fluid of cancer patients. In some embodiments, soluble TNF-Receptors 1 and 2 are selectively removed from plasma at 80% or more efficiency. In some embodiments, the system includes an immobilized capture ligand of a single chain TNF?. The system and method are useful for the treatment of different cancer types, stages and severity.

Abstract: The present system and method are useful for the removal of immune inhibitors such as soluble TNF receptors from the body fluid of cancer patients. In some embodiments, soluble TNF-Receptors 1 and 2 are selectively removed from plasma at 80% or more efficiency. In some embodiments, the system includes an immobilized capture ligand of a single chain TNF?. The system and method are useful for the treatment of different cancer types, stages and severity.

Abstract: An extracorporeal photopheresis system includes a separator with a disposable fluid circuit including a treatment container, an irradiation device configured to treat the contents of the treatment container, and a controller configured to control the system to perform a procedure including drawing anticoagulated whole blood into the fluid circuit from a blood source and returning to the blood source a treated target cell component, a portion of a red blood cell component remaining in the fluid circuit, and/or a portion of a plasma component remaining in the fluid circuit. The controller is further configured to estimate an end-of-procedure fluid balance estimated based on manual or automatic inputs including a patient body weight associated with the blood source and a total blood volume of the blood source, indicate the fluid balance to an operator, and receive one or more changes that affect the fluid balance after indicating the fluid balance.

Abstract: A method and apparatus are provided for use with a pump. The method includes, (a) placing liquid in a tube coupled to the pump, (b) injecting an air bubble into the tube in a manner that does not increase pressure within the tube, and such that there is a predetermined volume of liquid between the air bubble and the pump, (c) using the pump to advance the air bubble along the tube to the bubble detector of the pump, (d) using the pump, assessing accuracy of the pump by automatically measuring the volume of liquid pumped to advance the air bubble to the bubble detector, and (e) using the pump to continue advancing the air bubble along the tube, past the bubble detector, and using the pump to measure a volume of the air bubble. Other applications are also described.

Abstract: An ambulatory pump and a battery compartment for use in an ambulatory pump. The ambulatory pump includes a pump, a controller coupled to the pump for controlling the pump to deliver fluid to a patient, and a battery compartment electrically coupled to the pump and the controller. The battery compartment defines a cavity for alternately receiving a battery pack and a plurality of household batteries. A flex guide is positioned within the cavity. The flex guide has a compressed state and a non-compressed state where a profile of the flex guide has a height that is greater than half the insertion depth of the household batteries in the non-compressed state and that is less than half the insertion depth in the compressed state.

Abstract: A system and method for calibrating an IV pump infusion system tube comprises a fluid source, an infusion system comprising, an IV pump, a drive unit, a chamber with known constant volume, a control unit, and IV tubing with a known inner diameter tolerance, and a sensor and floating detection object. The system administers medicinal fluid, calculates the flow rate of the medicinal fluid in the chamber by measuring the time the floating detection object and medicinal fluid rises in the chamber, compares the calculated flow rate with a set flow rate of the IV pump input in the control unit prior to infusion, and adjusts the IV pump and flow rate based on the compared deviations for more accurate delivery to a patient. This configuration may provide a more precise delivery rate of medicinal fluid, preventing harm to the patient and waste of medicine.

Abstract: An infusion system comprises an infusion pump that comprises an input unit and a display unit. The input unit is adapted for adjusting a value of at least one parameter for controlling operation of the infusion pump and/or an infusion process, and the display unit displays the value of the at least one parameter. The input unit comprises at least one slide bar adapted to be touched by a user's finger and moved along its length to change the value of the parameter, wherein movement in a first direction increases the value of the parameter and in a reversed, second direction decreases the value. The slide bar is adapted so that the rate of change of the parameter value correlates with the speed of the finger movement and in an idle mode is decelerated in a similar way as under influence of an inertia load and/or a friction.

Abstract: Aspects of the present disclosure provide systems, devices, and methods for delivering substances such as fluids, solutions, medications, and drugs to patients using infusion devices having a set of advanced features. These advanced features include aspects related to the programming of infusion devices, the configuration of infusion sequences performed by the infusion devices, and the interconnection of multiple infusion devices for interoperation during an infusion having a sequence of infusion steps.

Abstract: A system for providing multiple infusions to a patient (P), the system comprises a multiplicity of infusion devices (10) for administering a multiplicity of medical fluids through an infusion line (102) of an infusion set (103) to the patient (P), and a control device (2) for controlling the multiplicity of infusion devices (10). Herein, the control device (2) comprises a multiplex module (22) configured to multiplex the multiplicity of medical fluids for a multiplexed administration of the medical fluids through said infusion line (102) of the infusion set (103), the multiplex module (22) comprising a scheduling module (222) configured to define at least two packets, each packet comprising at least one medical fluid out of the multiplicity of medical fluids, and to arrange the at least two packets in a sequence for administration of the medical fluids of the at least two packets.

Abstract: An accessory attachment mechanism for a wagon is provided. The mechanism has a mounting bracket, a pivot arm, and a retention mechanism. The mounting bracket is connected to the wagon and has a first opening, a second opening, and a pivot member. The pivot arm is pivotally connected to the mounting bracket at the pivot member and pivots about a plane generally parallel to a base of the wagon between a storage position and a use position. A pin extends through the pivot arm into separate openings in the mounting bracket to retain the pivot arm in the storage and use positions. The retention mechanism is provided at an end of the pivot arm and has a moveable clamp member adapted to secure an accessory thereto.

Abstract: Priming systems and infusion assemblies are provided. For example, a priming system comprises a priming conduit having a priming portion and a pressure portion. The priming portion is in fluid communication with a first fluid source, with an inlet and an outlet for ingress and egress of a first fluid from the first fluid source. The pressure portion is in fluid communication with a second fluid source connected by a connector. Disposed within the priming conduit are a biasing member and a valve having an open position and a closed position. The biasing member is in operable communication with the valve to urge the valve into the closed position such that the valve defaults to the closed position. The open position allows the first fluid to flow from the inlet to the outlet and the closed position prevents the first fluid from flowing from the inlet to the outlet.

Abstract: A peristaltic infusion pump system has a convex platen surface opposite a linear peristaltic pumping mechanism. The convex platen surface may be part of a cassette of an administration set removably loadable in an infusion pump, or the convex platen surface may be a feature of the pump itself. Pumping efficiency is improved without giving up the ability to have independently controlled compensating fingers. The convex platen surface may have a trapezoidal profile, a curved profile, or a hybrid profile having upstream and downstream inclined portions connected by an intermediate curved portion.

Abstract: A system and method can provide for a remote electronic device to be used to remotely initiate delivery of a medicament bolus with a medical device, such as an insulin pump, with the medical device providing audible or tactile confirmation of the programmed bolus. The bolus amount can be calculated by or programmed or otherwise entered into the smartphone, etc., and then transmitted to the medical device. When the pump receives the transmitted bolus amount, it issues one or more indications such as audible sounds and/or vibrations in any number of desired combinations. For instance, each individual sound or vibration may correspond to an increment of the medicament. The user can therefore determine the size of the medicament bolus by the number of sounds or vibrations and can confirm or cancel delivery of the bolus.

Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Abstract: An inventive medical device for transcutaneously inserting a cannula into body tissue. The device has a cannula with a wall that at least partially encloses a lumen. The device also has a patch for mounting onto skin of a user. The patch has a base and has a reservoir for storing a medical fluid. The patch also has a spring driven inserter. The inserter has a drive that urges the cannula from a storage position within the patch to an inserted position within the body tissue. The inserter also has a lock configured for securing the drive in a fixed position. The lock is fixedly connected to the drive and has a snap closure. Also disclosed is a medication pump that is fluidly connectable to the cannula. A method of transcutaneously using the medical device to transcutaneously insert a cannula into body tissue is also disclosed.

Abstract: A cassette with free flow prevention for use with an ambulatory pump. The cassette includes a free flow prevention clamp and a housing. The free flow prevention clamp includes a clamping section having a first side and a second side, a first elongate section extending from the first side, and a second elongate section extending from the second side. The housing supports the free flow prevention clamp and defines a channel for receiving a tube. The elongate sections extend parallel to the channel and the clamping section extends across the channel. The free flow prevention clamp is configurable within the housing in an open condition that allows fluid flow through the tube when force is applied to one of the elongate sections and in a closed condition that prevents fluid flow through the tube when the force is removed from the elongate sections.

Abstract: The subject matter of this disclosure generally relates to a medical device system and related methodologies that leverage data associated with the use of a meal transaction application, such as an application for ordering food delivery. Data generated by the meal transaction application can be leveraged by a patient care system or application for purposes of diet or calorie logging. Alternatively or additionally, the meal transaction data can be leveraged for purposes of controlling the administration of therapy by a medication delivery system, such as an insulin infusion pump.

Abstract: Systems and methods are provided for adjusting long acting insulin medicament dosages for a subject. A plurality of timestamped glucose measurements of the subject is obtained. A titration glucose level (246) is computed as a measure of central tendency (244, 268, 274) of a titration subset of small glucose measurements (240, 269, 273) identified within the timestamped glucose measurements, wherein the measure of central tendency represents a measure of small glucose measurements for the primary time window. A long acting insulin medicament dosage (216) is adjusted or maintained based upon the obtained titration glucose level (246).

Abstract: Disclosed herein are combined devices and methods of manufacturing such combined devices. The combined devices disclosed herein include an analyte sensor including a sensor probe; an infusion set hub including a cannula; and a flexible base. The analyte sensor and infusion set hub are attached to the flexible base such that movement of one of the analyte sensor and the infusion set hub is substantially not transferred to the other one of the analyte sensor and the infusion set hub.

Abstract: The present disclosure relates to an administration mechanism for a medicament delivery device having a movable sleeve, and a delivery member cover having a distal end portion configured to receive the movable sleeve. The delivery member being configured to be linearly displaceable between a first position and a second position relative to the movable sleeve, wherein the distal end portion has an end face defining a guide surface and the movable sleeve has a radially outwards extending first follower structure configured to cooperate with the guide surface when the delivery member cover is moved from the first position towards the second position, causing the movable sleeve to rotate.