Abstract: An injection device for injecting a liquid solution, includes a power source; a deformable piezoelectric bar, the deformation of which is activated by an application of energy coming from the electrical power source; a compression injector including: a piston actuated by the deformation of the piezoelectric bar; a chamber capable of receiving a first volume of a liquid solution including an inlet for its filling and an outlet for its evacuation under the effect of the piston; and an ejection nozzle connected to the outlet of the chamber.

Abstract: A needle-free injector monitors the compression of a gas bubble within a cartridge of injectate during operating of a plunger in a pre-injection phase. When the gas bubble becomes sufficiently compressed (e.g., at or near the equilibrium pressure during the piercing phase), the velocity of the plunger of the needle-free injector is changed to the piercing rate for delivery of the injectate to a target. By detecting the gas bubble compression prior to delivery of injectate in this manner, an injection stream can be controlled to more closely reproduce a target injection profile. For example, the integrator error for an injector control model can be mitigated, stream acceleration can be optimized/maximized, and overshoot in the injector response (e.g., stream velocity or plunger movement) can be minimized.

Abstract: A method and system of providing a needle-less injector specifically configured to the needs of a user. The method includes assembling a needle-less injector by positioning an inner housing within the outer housing such that the inner housing is axially movable within the outer housing between a ready position and a firing position. The method further includes receiving a user selection of a delivery spring weight from a plurality of available delivery spring weights. Then a delivery spring having the selected spring weight is placed within the inner housing. The completed needle-less injector having a delivery spring with the selected weigh may then be delivered to the user. In alternative injector configurations, the user may also select one or more of a skin tensioning spring weight or a hammer length along with or instead of the delivery spring weight.

Abstract: An injection device assembly including a housing, a syringe, a drive mechanism and a status sensing system and a module are described. The drive mechanism advances the syringe from a storage position to an injection position, and a plunger advances the syringe piston from an initial position to a final position. The status sensing system includes a light emitter that emits electromagnetic radiation into the housing transverse to the longitudinal axis, a light detector and a controller. The system determines a current status condition from at least three of the following five status conditions: 1) an injection ready state; 2) a needle insertion state; 3) a drug delivered state; 4) a needle guard present state; and 5) a needle retraction state.

Abstract: The disclosure relates to a drug delivery device comprising a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament (M) from the medicament container, an audible indicator that is arranged within a case pocket lateral to the plunger and that is in operative connection with the plunger, the audible indicator comprises at least one indicator spring and at least one locking element, wherein the indicator spring is biased by the locking element, and the indicator spring relaxes due to a release of the locking element by a movement of the plunger.

Abstract: The present disclosure relates to medical devices such as syringes, auto-injectors, and pens that inhibit oxygen permeation into the fluid chamber. The medical device includes a lubricant-free (e.g., silicone) or a siliconized barrel having an interior surface defining a fluid chamber, an elastomeric stopper, and a plunger rod. In one embodiment, at least a portion of the interior surface of the barrel is reduced to increase the interference fit between the stopper and the barrel. In another embodiment, the stopper may include a plurality of ribs and a valley between each pair of ribs may include a ring member provided in each of the valleys. The ring member includes an oxygen-absorbing, an oxygen-adsorbing material, or both, to bind any oxygen that permeates into the syringe, auto-injector, or pen. In yet another embodiment, the stopper may include a barrier coating including an oxygen barrier material to inhibit or prevent oxygen permeation.

Abstract: Drug delivery devices are configured to include a gas-driven piston assembly having a flexible pushrod, a non-linear guide include a non-linear guide pathway at least partially surrounding the flexible pushrod, a cylinder at least partially surrounding the flexible pushrod, and a piston movable within the cylinder in response to the pressurized gas entering the cylinder. Some arrangements include a roller pushrod guide system and/or a gear pushrod guide system.

Abstract: Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

Abstract: Handheld drug delivery devices for injection of a medicament into a target location are disclosed herein. The drug delivery devices of the present disclosure include drive mechanisms, needle insertion mechanisms, and fluid pathway connectors. These components may be arranged within a housing. The arrangement of these components may provide an easy to use device that is capable of delivering volumes larger than traditionally injected using syringes. Translation of a drug container of the device may cause connection of a fluid pathway from the drug container for delivery of a medicament to a target location.

Abstract: A syringe includes a dosage setter operatively coupled to a plunger rod and comprising a rotatable body that comprises a set of one or more stops for engaging the set of one or more protrusions of the plunger rod depending on at least a rotational position of the set of one or more stops relative to the set of one or more protrusions, wherein a first rotational adjustment associated with the dosage setter is configured to set a first dosage increment by adjusting a relative axial position between the rotatable body and the plunger rod, and a second rotational adjustment associated with the dosage setting assembly is configured to set a second dosage increment that is larger than the first dosage increment by adjusting a relative rotational alignment between the set of one or more stops and the set of one or more protrusions.

Abstract: Dosing device for an administration device with a limiting mechanism containing: a dosing sleeve with a first stop and a stop wheel with a second stop means adapted to continually and proportionally follow a movement of the dosing sleeve during dosing movements. During an ejection movement, there is no relative movement between dosing sleeve and stop wheel. The first stop and the second stop each describe a path curve by their movements such that the two path curves intersect in one point and the stops contact one another and tilt the stop wheel, thereby blocking the dosing movement of the dosing sleeve. The stop wheel comprises first and third sloped surfaces that may form first and second gear guidances with a clutch thereby returning the stop wheel to a non-tilted position during up or down dosing movements when the stops do not contact another.

Abstract: The invention relates to a torsion spring driven injection device for delivering set doses of a liquid drug wherein a torsion spring is strained by rotation of a rotatable dose setting structure and released by proximal movement of a piston rod driver. The dose setting structure is coupled to a drive element which is rotated during dose setting and which drive element is released during dosing to thereby rotate the piston rod driver. The piston rod driver is further coupled to the piston rod to generate a rotation and thus forward movement of the piston rod. The drive element and the piston rod driver are coupled to each other by a toothed engagement which is functional both during dose setting and during dose expelling.

Abstract: Medication delivery devices are provided having a dose delivery sensing capability. A sensed element is attached to a dose setting member of the device. The sensed element includes surface features radially-spaced from one another. A rotational sensor is attached to an actuator of the device. The rotational sensor includes a movable element that is contactable against the surface features. The rotational sensor is configured to generate a signal in response to the movement of the movable element over the surface features during their rotation. A controller is operatively coupled to the rotational sensor, and in response to receiving the generated signal, the controller is configured to determine a number of the surface features passing the movable element of the rotational sensor during dose delivery. The number can be associated with an amount of dose delivered. Sensing can be provided in a module or integrated in device.

Abstract: A position tracking system includes a member extending along a lengthwise axis. Multiple position tracking elements (such as conductive strips) are fabricated to be exposed on a surface of the member. The multiple position tracking elements form a sequence along the lengthwise axis and are spaced apart from each other. The position tracking system further includes a probe. The probe monitors for presences and absence of the position tracking elements disposed in the sequence as the member and corresponding sequence of position tracking elements moves with respect to the probe. Based on the detected presence and absence of position tracking elements, a monitor resource of the position tracking system monitors parameters such as: i) a position of the member along the axis, ii) a rate of movement of the member along the axis over time, iii) a direction of movement of the member along the axis, etc.

Abstract: An injector system for delivering a medical fluid may include at least one syringe defining a reservoir operatively connected to a piston; and at least one processor programmed or configured to, based on an air check protocol for detecting air in the reservoir, determine a baseline value comprising baseline compressibility data for the at least one syringe of the injector system, deliver the first amount of the medical fluid from the reservoir; refill the reservoir with a second amount of the medical fluid; based on the air check protocol, perform an air check pressurization sequence by gathering air check compressibility data for the at least one syringe of the injector system; and based on the air check protocol, compare the air check compressibility data with the baseline compressibility data to determine a volume of air present in the reservoir.

Abstract: A syringe (100) comprising a barrel (111) with a lumen is provided. The barrel (111) is adapted to contain a drug, the barrel (111) having a distal end wall portion (198) and a tubular wall (112) extending proximally from said distal end wall portion (198), whereby the barrel (111) extends along an axis (1000). The distal end wall portion (198) has an opening (199) extending into a syringe head (140) adapted to receive a syringe needle, said syringe head (140) having a lumen smaller in transversal cross-section than the barrel lumen; the syringe (100) further comprising: a plunger (196) extending along the axis, said plunger shaft being displaceable along the axis (1000) within said barrel (111).

Abstract: The invention relates to the field of inhalation methods and inhalation devices for liquids. In particular, the invention relates to an inhalation method using an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of an aqueous formulation comprising pirfenidone by means of such inhalation device.

Abstract: A cartridge and a nebulizer for nebulizing a fluid as well as a method for fluidically connecting the cartridge to the nebulizer are proposed. The cartridge comprises a closure with a valve, wherein the valve displaces fluid into the nebulizer when opened. Further, the cartridge forms two axially spaced sealings with the nebulizer when connected.

Abstract: The present disclosure relates to an inhaler component for producing a steam/air mixture or/and condensation aerosol in an intermittent and inhalation- or pull-synchronous manner, the inhaler component including: a housing; a chamber arranged in the housing; an air inlet opening for the supply of air from the surroundings to the chamber; an electrical heating element for evaporating a portion of a liquid material; and a wick having a capillary structure, which wick forms a composite structure with the heating element and automatically supplies the heating element with fresh liquid material after evaporation.

Abstract: The invention relates to the field of nozzles for inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle for an inhalation device, suitable for the generation of an aerosol of a medically active liquid, and to inhalation devices comprising such nozzle. Such nozzle (1) for an inhalation device for medically active liquids (F, F1, F2) for generation of an aerosol has a main axis (Z) and at least three ejection channels (1A, 1B, 1C, 1D) adapted to eject liquid (F, F1, F2) along respective ejection trajectories, wherein at least two collision points (X1, X2) are provided at which at least two of said ejection trajectories intersect with one another, and/or wherein further, all ejection angles (A, A1, A2) at which the individual trajectories leave the nozzle (1) are identical, or at least one of said ejection angles (A, A1, A2) differs from the other ejection angles (A, A1, A2).

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of a medically active liquid by means of such inhalation device.

Abstract: An assembly of an inhaler and a sensing element detachably attached to the inhaler. The sensing element has an activation detector detecting activation of the inhaler. The sensing element has a flow sensor sensing flow in the flow channel. The sensing element may determine, from activation and flow information, whether an inhalation, such as a correct or sufficient inhalation, has taken place. The sensing element may be used sequentially for multiple inhalers.

Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

Abstract: An operating unit (2) sets ventilation parameters of a control unit (11) of a ventilator (1) that includes a gas dispensing device (10) for ventilation gases. The operating unit includes a display unit and an ventilation parameters input element (23, 24). Two or more of the parameters are linked via a relation condition stored in a relation storage module (40). A relation monitor (3) includes a deviation detector (31) detecting a transgression of the relation condition during parameter setting, and outputs warning information via a warning unit (32). This avoids a need for an operator to note the sometimes complicated connections and dependencies expressed in the relations during the parameter setting. The warning may be sent before the new setting value is sent from the operating unit to the control unit. Operating safety is increased and a risk of setting errors is minimized.

Abstract: A device to monitor movement of a tracheostomy tube is described. The device includes a faceplate that is releasably attached to a tracheostomy collar such that the faceplate may be used without the tracheostomy collar. The tracheostomy collar includes a sensor component and an actuator component each located proximate the faceplate. The actuator component actuates when the sensor component moves from a first position to a second position. The second position is further from the actuator component than the first position. The sensor component transmits a signal to an alarm assembly in response to the actuator component actuating. The alarm assembly produces an alert in response to receiving the signal from the sensor component.

Abstract: The invention concerns an artificial resuscitation bag (5) comprising a deformable bag (54) comprising a gas inlet (54A) and a gas outlet (54B), a gas reservoir (59) comprising an outlet orifice (59A), a first conduit element (56) fluidly connected to the outlet orifice (59A) of the gas reservoir (59) and to the gas inlet (54A) of the deformable bag (54), a first one-way admission valve (57) arranged in the first conduit element (56) and fluidly communicating with the ambient atmosphere for allowing ambient air to enter into the first conduit element (56), and a second one-way valve (55) arranged in the first conduit element (56) between the first one-way admission valve (57) and the gas inlet (54A) of the deformable bag (54) for allowing gas to travel only from the first conduit element (56) to the deformable bag (54).

Abstract: The invention relates to an apparatus (1) for catalytic decomposition of nitrous oxide in a gas stream derived from exhalation air from a patient. The apparatus (1) comprises an inlet arrangement (2) with a gas inlet (3) for the exhalation air, an outlet arrangement (11) with a gas outlet (12) for an outlet gas, and between these arrangements a through-flow decomposition chamber (9) containing a catalyst material. According to the invention the apparatus is provided with a nitrous oxide adsorption/desorption means (4) in the inlet arrangement (2) for level out variations in the concentration of nitrous oxide fed to the decomposition chamber (9).

Abstract: Systems and methods are provided for detecting and sequestering waste anesthetic gases released by an anesthetic vaporizer. In one embodiment, a method for an anesthetic vaporizer installed in an anesthesia machine includes detecting an emission of waste anesthetic gases (WAGs) from the anesthetic vaporizer, and responsive to detecting the emission of WAGs, performing at least one of scavenging the WAGs and outputting an alert.

Abstract: A breathing circuit having a semipermeable membrane, an outer cage, and optionally an inner cage. The semipermeable membrane contains a poly(tetrafluoroethylene) membrane and a graphene anti-bacterial compound. The semipermeable membrane is affixed to the outer cage; optionally between the inner cage and the outer cage. Breathing circuits and breathing systems may contain such a cartridge.

Abstract: This disclosure provides an anesthesia machine and system, which may be used in the technical field of medical devices. The anesthesia machine may include a gas source interface and an oxygen supply apparatus and an anesthetic breathing apparatus separately connected to the gas source interface. The oxygen supply apparatus may provide an oxygen-containing gas to a patient. The anesthetic breathing apparatus may provide anesthetic breathing support to the patient. The anesthesia machine system may further include an anesthesia machine and an oxygen supply device. The anesthesia machine may be further provided with a fixing mechanism, and the oxygen supply device may be detachably fixed to the anesthesia machine by means of the fixing mechanism.

Abstract: A respiratory therapy device having a diagonal feedback array, and methods for the user thereof.

Abstract: A server is provided and is programmed to automatically determine, based on the identification data that uniquely identifies a patient device, whether there is an upgrade to the code or data (e.g., software or firmware) stored in the electronic memory of the patient device that can be applied thereto. In response to determination that there is an upgrade that can be applied, a data package is delivered to the patient device via the first wireless transceiver, the data package to be automatically applied to the electronic memory of the patient device.

Abstract: A resuscitation system is provided with a resuscitation device that is arranged away from the patient. Moreover, the resuscitation device is connected to a nozzle of a patient interface in an air-conducting manner by a respiratory gas tube. Near the patient, a remote control for the resuscitation device is arranged in the region of the patient interface. The remote control includes a casing with an upper side and a lower side. The upper side and/or the lower side are produced, at least in sections, from hard plastic. The remote control further has at least one operating element and comprises an electronic printed circuit board or, at least, an electronic component.

Abstract: In an embodiment, a method is described. The method comprises obtaining an indication of a speech pattern of a subject and using the indication to determine a predicted time of inspiration by the subject. A machine learning model is used for predicting the relationship between the speech pattern and a breathing pattern of the subject. The machine learning model can then be used to determine the predicted time of inspiration by the subject. The method further comprises controlling delivery of gas to the subject based on the predicted time of inspiration by the subject.

Abstract: A respiratory mask includes an air duct, a muting member and a mask body. The muting member includes an annular portion sleeved on the air duct and formed with multiple muting holes extending therethrough, and a securing portion. The mask body is made of a flexible material, and has a connecting portion secured to the securing portion, and a groove portion connected to the connecting portion and defining a deformation groove that surrounds a central axis and that has a groove opening which faces parallel to the central axis. A ratio of an inner radius of the mask body to a groove width of the deformation groove ranges from 4 to 8. A ratio of the groove width to a groove depth of the deformation groove ranges from 0.5 to 1.5.

Abstract: A nasal pillow system for treating sleep apnea is disclosed that may include a nasal pillow. The pillow has a cavity wall that defines a cavity, and two nasal interface structures connected to and extending away from the cavity wall. The nasal interface structures are in fluid communication with cavity. Each nasal interface structure includes a conical nasal interface, a cylindrical trunk structure connected to conical nasal interface and an annular relief pocket connected to the cylindrical truck structure and the cavity wall. The connection between the annular relief pocket and the cavity wall defines substantially a plane, and a first portion of the annular relief pocket extends away from the plane and a second portion extends towards the plane.

Abstract: A patient interface device is includes a cushion and a frame assembly coupled to the cushion, the frame assembly including a main frame member and a stiffening structure coupled to the main frame member, the stiffening structure having a main arm, a first Y-portion coupled to a first end of the main arm having first and second front branches extending at upward and downward angles, respectively, from the first end of the main arm, and a second Y-portion coupled to a second end of the main arm having first and second rear branches extending at upward and downward angles, respectively, from the second end of the main arm.

Abstract: Disclosed is a device for supplying therapeutic gas, notably NO/N2 or O2/N2O mixtures, including an internal passage with a valve for conveying and controlling the flow of therapeutic gas in the internal passage, a control unit controlling the valve, a graphic display for displaying choices that can be selected by a user, and a selector, such as touch-sensitive keys displayed on the graphic display for making a selection from among the selectable choices displayed on the graphic display. The control unit is configured to count a total number of patients treated by administration of the therapeutic gas from the selection, by a user, via the selector, of a first given choice corresponding to the start of a treatment by administering the therapeutic gas to a patient concerned.

Abstract: A gases humidifier comprising: a gases inlet and an outlet, a removable humidification chamber cartridge with a heater source adapted to vaporize fluid; and a metering arrangement adapted to connect to and transfer fluid from a fluid supply to the humidification chamber.

Abstract: An anesthesia vaporizer system having a reservoir fillable with anesthetic agent from a bottle. A fill body defines a cavity that receives the anesthetic agent from the bottle via an inlet. The fill body further defines main and vent ports each communicating between the cavity of the fill body and the reservoir. A fill valve is receivable within the cavity of the fill body and moveable between open and closed positions. The anesthetic agent from the bottle flows through the inlet only when the fill valve is in the open position. A lower seal is receivable within the cavity of the fill body and moveable between open and closed positions by the fill valve. The vent port communicates between the cavity and the fill body only when the lower seal is in the open position. The lower seal is positionable in the open position when the fill valve is in the closed position.

Abstract: A system is provided for waking a user up by a stimulus, wherein the stimulus is adapted to vary according to an intensity curve. A user interface is adapted to receive user preferences, such as a desired wake-up time and a preference indicator. The preference indicator indicates whether the user prefers to be more alert after waking up or to have a longer sleep. An alarm is used for providing a stimulus to the user and a processor is used for determining a stimulus intensity curve for the alarm. Determining the stimulus intensity curve is based on at least the user preferences.

Abstract: A vehicle may include: a feedback device; a bio-signal sensor configured to measure a bio-signal of a user; and a controller operatively coupled to the feedback device and the bio-signal sensor, the controller including a memory configured to store at least one program instruction and processor configured to execute the at least one program instruction. The controller may be configured to: determine information characterizing a current emotional state of the user based on the bio-signal; calculate, based on a difference value between the current emotional state and a target emotional state, an operation ratio between a first mode for controlling operation of the feedback device to decrease a degree of excitability of the user and a second mode for controlling the operation of the feedback device to increase a degree of positivity of the user; and control the operation of the feedback device for a predetermined time based on the operation ratio.

Abstract: A method for promoting continuous sleep of a subject by eliminating and/or preventing sleep associations includes: (a) providing an apparatus including at least one sensor and at least one output device; (b) monitoring a state of the subject using the apparatus; (c) determining the subject is in an awake state using the at least one sensor; (d) in response to determining the subject is in the awake state, initiating and maintaining an output using the at least one output device; (e) determining the subject is in a sleep state using the at least one sensor; (f) halting the output in response to determining that the subject is in the sleep state such that the apparatus does not produce any output; (g) repeating at least step (b) during a sleep session. The method further includes modifying an intensity of the output over time until the intensity reaches zero.

Abstract: A packaging system for storing a deployable medical device within a sterilized environment includes a sealed container; a tray disposed within the sealed container; a catheter assembly comprising at least one sheath; a deployable medical device engaged with the catheter assembly; and a sterilizing fluid. The tray comprises a first chamber; a second chamber in fluid communication therewith; and at least a third chamber between the first and second chambers, and in fluid communication with at least the first chamber. The deployable medical device is disposed within the tray in a storage configuration, in which the deployable medical device is disposed within the first chamber in a partially deployed state distally from a distal end of the catheter and the catheter assembly spans between the first chamber and the second chamber. The sterilizing fluid contacts at least a part of the deployable medical device in the storage configuration.

Abstract: A catheter comprising an elongated member having a distal end and a proximal end. The proximal end defines a drainage inlet extending from an external wall of the elongated member into the elongated member. The elongated member defines a first lumen that connects the drainage inlet with a drainage outlet defined by the distal end. The catheter also includes an inflatable retention balloon defined by the external wall of the elongated member and located between the drainage inlet and the drainage outlet. The catheter further includes a fluid inlet valve that protrudes from the elongated member and defines a second lumen that extends from the fluid inlet valve through the elongated member and to the inflatable retention balloon. The catheter additionally includes a secondary balloon that protrudes from the elongated member, the elongated member defining a third lumen that extends from the inflatable retention balloon to the secondary balloon.

Abstract: A catheter for insertion into a body of a patient, and methods of making and using. The catheter can include a distal portion that remains stable during fluid infusion into the patient, thus reducing or eliminating whipping of the catheter distal tip. The catheter can include a proximal portion including a first cross sectional lumen area; a distal portion including a second cross sectional lumen area larger than the first cross sectional lumen area such that the distal portion prevents whipping when the catheter is disposed in a patient and a fluid exits the catheter. The catheter can be attached to a vascular access port and a method can include power injecting a fluid through the vascular access port and the catheter.

Abstract: A midline catheter is provided. The midline catheter includes a shaft defining a lumen, the shaft having a distal end and a proximal end. The distal end includes two or more opposing notches thereon, each of the notches having an open notch distal end and an opposing notch proximal end formed as an arch. The catheter may also include written indicia thereon to indicate that it is a midline catheter and/or is power injectable or non-power-injectable.

Abstract: A movable catheter is provided with a tube having a main lumen. The tube has a plurality of wire lumens and is provided with a wire. A substantial half on one end portion side thereof is inserted through the wire lumen, an intermediate part thereof is folded back in the distal end portion of the tube, and a substantial half on the other end portion side thereof is inserted through the wire lumen. The one end portion and the other end portion thereof are disposed on the proximal end side of the tube. Various embodiments enable the number of components to be reduced, and to reduce the number of manufacturing steps.

Abstract: The invention provides a catheter positioning device which comprises a base fixed on a body, a positioning guide groove arranged on the base, and a self-locking module positioned on two opposite sides or one side of the positioning guide groove, wherein when the catheter is positioned at a preset position in the positioning guide groove, the self-locking module is in a released state; and when the catheter moves relative to the positioning guide groove to deviate from the preset position, the self-locking module is triggered to switch from the released state to a locking state, so that the self-locking module in locking state limits the movement of the catheter relative to the positioning guide groove so as to achieve the technical effect of positioning the catheter.

Abstract: Needle assemblies and related methods in which a valve opener is used to push into a valve to open one or more slits on the valve to open the valve. The needle assemblies each includes a needle hub with a needle, a catheter tube with a catheter hub and the valve and valve opener positioned in the interior cavity of the catheter hub. The valve can have a valve skirt and a nose section of the valve opener can locate therein. One or more reliefs can be provided with the valve opener so that an elbow or diagonal section on a needle guard can project from a holding space within the valve opener through the relief.