Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting PCSK9 expression, which may be useful for treating, preventing, or ameliorating a disease associated with PCSK9.

Abstract: The present invention relates to a polymeric glycoconjugate compound comprising a terminal alpha-galactosyl moiety for use in the treatment of anti-?Gal IgE antibodies-mediated diseases. It further relates to new polymeric glycoconjugate compounds, a composition comprising thereof, a method for obtaining thereof and its therapeutic or prophylactic use.

Abstract: The present invention relates to peptide tags and binding partners which are capable of interacting via the spontaneous formation of an isopeptide bond, as well as to associated peptide pairs and methods for designing peptide tags, binding partners and peptide pairs with improved properties.

Abstract: Antibody-drug conjugates (ADCs) binding to human AXL for therapeutic use, particularly for treatment of melanoma in combination with one or more MAPK pathway inhibitors such as, e.g., a BRAF inhibitor and/or a MEK inhibitor.

Abstract: Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DUX4. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.

Abstract: Conjugate (KTAC) compounds that include a peptidic kappa opioid receptor agonist linked through a protease-sensitive linker and/or acid-sensitive linker to an antibody molecule are provided. The linker may include spacer regions on either side of the protease sensitive cleavage site. The antibody can be a monoclonal antibody such as a therapeutic monoclonal antibody. The KTAC compounds may be incorporated into pharmaceutical compositions useful for the treatment of diseases and conditions, particularly those that include an inflammatory component.

Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

Abstract: The present description relates to a conjugated compound an antibody covalently linked to enhancer moiety composed by a nuclear localization sequence (NLS), covalently linked to a sterol variant, such as cholic acid (ChAc) or a variant thereof. The enhancer moiety as encompassed herein is able to induce endosome escape of the compound-conjugates by direct membrane destabilization or indirectly by ROS and ceramide production which destabilize endosome-lysosome membrane. The conjugated compound can further comprise payload.

Abstract: The present disclosure provides antibody drug conjugates that bind human cMET, their methods of making, and their uses to treat patients having cancer.

Abstract: The invention is directed to nucleic acid therapy for modulating host microflora, useful in the management of dysbiosis. The invention in embodiments thereof provides compositions and methods for alleviating dysbiosis and conditions associated therewith. According to additional embodiments, compositions and methods of the invention may be used for treating or preventing gut barrier dysfunction in a subject in need thereof, and for reducing the risk of developing adverse events related to expansion of gastrointestinal bacteria in patients at risk for developing dysbiosis, for example in hospitalized patients and immune suppressed subjects.

Abstract: The present invention concerns synthetic polynucleotides encoding a human fukutin-related protein (FKRP) wherein the synthetic polynucleotides contain at least a mutation avoiding supplementary transcript(s) generated from frameshift start codon(s). The synthetic polynucleotides are useful, especially for treating a pathology linked to a FKRP deficiency or induced by a defect in ?-dystroglycan (?-DG) glycosylation, such as LGMD2I.

Abstract: Disclosed herein are viral vector delivery systems and methods for the targeted delivery of genes to a predetermined skin cell. The viral vector delivery systems may be adeno-associated viral (AAV) vector delivery systems.

Abstract: The present invention relates to regulatory nucleic acid sequences, in particular NS-specific promoters, cell specific promoters, multi-cell specific promoters, and elements thereof. The invention also relates to expression constructs, vectors, virions, pharmaceutical compositions and cells comprising such promoters and to methods of their use. The regulatory nucleic acid sequences are of particular utility for gene therapy applications.

Abstract: The present disclosure relates to a pharmaceutical composition for the treatment of Leber congenital amaurosis, and a method for treating Leber congenital amaurosis using the pharmaceutical composition.

Abstract: Provided herein are compositions for treating or preventing Retinitis Pigmentosa. The compositions comprise a first polynucleotide and a second polynucleotide. The compositions may further comprise a third sequence and a fourth sequence. Also provided herein are the recombinant adeno-associated virus particles, systems, methods, and kits for practicing or using the same.

Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.

Abstract: Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo (Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.

Abstract: The present invention relates to a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. In the formula (1), R1 to R3 are each independently a predetermined amino group or a predetermined amide group, or a group represented by the formula (2), and at least one of R1 to R3 is a group represented by the formula (2).

Abstract: The present invention relates to combinations for use and methods of treating cancers that express prostate specific membrane antigen (PSMA). In particular, the invention provides novel therapies based on the combination of a PSMA therapeutic agent, such as radiolabeled Compound of the Formula I, and immuno-oncology (I-O) therapeutic agents, wherein said I-O therapeutic agents are selected from the group consisting of LAG-3 inhibitors, TIM-3 inhibitors, GITR agonists, TGF-? inhibitors, IL15/IL-15RA complex, PD-1 inhibitors, PD-L1 inhibitors, and CTLA-4 inhibitors.

Abstract: Advantage is taken of the enhanced permeability and retention effect (EPR effect) to shield normal tissue from exposure to combinations of chemotherapeutic agents. Imaging agents that exhibit the enhanced permeability and retention (EPR) effect in solid tumors are useful in mimicking the behavior of chemotherapeutic or other drugs for treatment of said tumor conjugated to carriers of similar size and shape to the carriers of said imaging agents.

Abstract: The present disclosure relates to gastrin-releasing peptide receptor (GRPR) targeting pharmaceuticals and their use in a theragnostic approach for selection and therapy of subjects with GRPR-expressing malignancies. In particular, the present disclosure relates to a pharmaceutical composition of a radiolabeled GRPR-antagonist, for use in treating GRPR-positive tumors in a human subject selected for said treatment, wherein said subject has been selected for the treatment by PET/CT or PET/MRI imaging with a corresponding 68Ga-labelled GRPR antagonist as contrast agent.

Abstract: The present disclosure relates to a riboflavin photochemical treatment (RPT)-based inactivation method of pathogens in a biological liquid sample. Aiming at the problems existing in the current riboflavin-based pathogen inactivation methods, a technical solution of the present disclosure is to provide an RPT-based inactivation method of pathogens in a biological liquid sample, including the following steps: adding riboflavin to a biological liquid sample to be treated, and conducting irradiation on the biological liquid sample with light; where the light is narrow-spectrum ultraviolet (UV) light with a wavelength of 360 nm to 370 nm and/or 390 nm to 400 nm. In the present disclosure, parameters such as an irradiation time, an irradiation intensity, and a riboflavin concentration are further optimized. The inactivation method can achieve an excellent pathogen inactivation effect, and has little damage to other components in the biological liquid sample.

Abstract: A method for sterilizing and decontaminating post-consumer absorbent sanitary products contaminated by organic compounds deriving from human metabolism and comprising drug residue, said post-consumer absorbent sanitary products comprising fractions of plastic, super-absorbent polymers (SAPs), and optionally cellulose, the method comprising at least the steps of: i) sterilizing (SR) said post-consumer absorbent sanitary products by heating to a temperature equal to or lower than 140° C. and at a pressure comprised between 1 bar and 3.6 bar to obtain sterilized post-consumer absorbent sanitary products; and ii) decontaminating (DC) from organic compounds said sterilized post-consumer absorbent sanitary products by means of an oxidizing treatment. The oxidizing treatment is carried out by putting the sterilized post-consumer absorbent sanitary products in contact with a gas containing ozone preferably at a temperature equal to or higher than 60° C., more preferably comprised between 60° C. and 80° C.

Abstract: A docking station is provided for holding at least a part of a domestic appliance and for decontaminating the at least one nozzle thereof. The domestic appliance is provided including an air inlet, an air outlet with at least one nozzle, and a compressor configured to compress incoming air received at the inlet and to expel the compressed air through the at least one nozzle. The domestic appliance further includes at least one light source for emitting light in a violet portion of the visual spectrum, the at least one light source being arranged in such a way as to illuminate the at least one nozzle for the decontamination thereof.

Abstract: A system, having at least one radiation source and at least one mobile terminal, which has at least one optical sensor and a data-processing device, wherein the at least one optical sensor of the at least one mobile terminal is designed and configured to receive reflected radiation of the radiation source, so that surface structures, more particularly fouling, are detected from the received radiation of the radiation source by means of the data-processing device and, in particular, are stored in the data-processing device.

Abstract: A shoe care apparatus including a cabinet, a shoe care compartment inside the cabinet, a door coupled to the cabinet and configured to open and close the shoe care compartment, a supply duct formed on a first wall of the cabinet to supply air to the shoe care compartment, a shoe support device configured to communicate with the supply duct to receive the air from the supply duct and protruding from an inner surface of the first wall of the cabinet so that shoes are placeable in the shoe care compartment, and a sterilizer installed on a second wall of the cabinet or on the door and including an ultraviolet (UV) lamp to sterilize shoes placed in the shoe care compartment.

Abstract: Disinfectors that are touchless, high speed, or both for personal electronic devices and the like. A housing defines an internal volume including a disinfection zone and an object entry port of a size to permit entry by an object of interest with exposed surface area. At least one emitter projects a stripe of UV-C light into the disinfection zone. Wherein the apparatus has a small footprint and the emitter to exposes the surface area to greater than 3 mJ/cm2 of UV-C light in less than 90 seconds.

Abstract: A connector is configured to electrically connect a plasma emitter array with an identification chip to a power supply controller, and to further mechanically support the emitter device supporting the array during use. Cooperating components of the connector and emitter device form a magnetic latch assembly: the connector includes one or more magnets flush with a top receiving surface of the connector, and one or more alignment pegs extending outward from the receiving surface; the emitter device includes a steel plate attached to a substrate, and one or more holes disposed through the plate and the substrate. The holes align with the alignment pegs and the magnets attract the plate and secure the emitter device against the top receiving surface. Electrical contacts of the connector establish electrical communication with the identification chip, providing power to the emitter device and enabling the controller to read data stored in the identification chip.

Abstract: Various implementations of the invention are directed toward a sanitizing door handle and/or components of such sanitizing door handle. Some implementations of the invention are directed toward a manual sanitizing door handle while some implementations of the invention are directed toward an auto-sanitizing door handle. According to some implementations of the invention, a sanitizing fluid is dispensed directly onto an exterior surface of the sanitizing door handle in connection with an operation of the door handle to sanitize the door handle. According to some implementations of the invention, a sanitizing fluid is dispensed directly onto a user's hand(s) in connection with an operation of the door handle to sanitize the user's hand(s).

Abstract: Disclosed are a novel coronavirus disinfection and sterilization movable workstation for a refrigerated container yard and a method using the movable workstation. The movable workstation comprises a moving device, a lifting device, a disinfection gas supply device, a vacuumizing device, a gas transmission pipeline, a gas inlet and outlet pipe orifice and a control system, wherein the lifting device and the disinfection gas supply device are arranged on the upper surface of the moving device; the lifting device comprises a lifting support and an operation table, and a manual operation fence is arranged on the operation table; the control system is arranged in the manual operation fence; the gas inlet and outlet pipe orifice is formed in the end of the gas transmission pipeline; and the disinfection gas supply device is connected with the gas transmission pipeline through a first branch pipeline.

Abstract: A sterilant storage device according to an embodiment of the present disclosure includes a first container storing a sterilant therein and including at least a part having air-permeability, and a second container surrounding the first container and formed to be entirely air-impermeable to maintain an internal airtight condition.

Abstract: A disinfecting system for a room having at least a first and second wall defining a room dimension including a housing having a reservoir containing a disinfecting fluid, a nozzle assembly including a nozzle and a nozzle controller for dispensing the disinfecting fluid into a room, and a pump for communicating the disinfecting fluid from the reservoir to the nozzle assembly. A controller controls the dispensing of the disinfectant. A dispensing profile controls the dispensing of said disinfectant. The dispensing profile utilizes the dimensions of the room as instructions for the central controller to identify the range for dispensing the disinfecting fluid. The central controller utilizes the dispensing profile instructions for manipulating either the pump, fan or nozzle assembly to dispense a desired volume of the disinfectant fluid at a range as identified by the dispensing profile.

Abstract: A disinfection device includes at least two disinfection units movable into an unfolded position for operation thereof, the at least two disinfection units including a first disinfection unit and a second disinfection unit, and each of the disinfection units including a light source for disinfection, and a base configured to provide a moving force to the disinfection units.

Abstract: A sterilization process test device for verifying the efficacy of a sterilization process includes a tubular body defining a chamber for containing at least one sterilization indicator and a cap to sealingly close the tubular body. The tubular body includes at least one hole, which is covered by a gas and steam permeable cover. The only flow path into the chamber is provided through the steam and gas permeable cover and the at least one hole, which when combined are configured to control and restrict a flow of steam or a gaseous sterilization medium from an external environment.

Abstract: A volatile dispensing device having a housing having opposing first and second walls that are joined along their peripheries to one another. Each of the first and second walls has at least one aperture and define a cavity for receiving a solid article having a volatile composition. A dispenser mount is located at a center of one of the first wall and the second wall and extending from an exterior surface of the one of the first wall and the second wall, wherein the dispenser mount has a planar mount surface and is characterized by a height greater than a thickness of the one of the first wall and the second wall.

Abstract: A solid deodorizer for concealing a visual indicator associated with a product life signal of the solid deodorizer before use, wherein the deodorizer is constructed of an elastomeric polymer material and includes a volatile composition, wherein the solid deodorizer has at least a region characterized by a Haze measurement of at least 40%.

Abstract: A volatile composition dispenser including a solid article having a volatile composition and a peripheral evaporative surface. The solid article shrinks relative to the peripheral evaporative surface from an initial size to a reduced size smaller than the initial size upon exposure of the solid article to the environment in an interior space. The solid article is characterized by a shrinkage in a direction away from the peripheral evaporative surface of greater than 1% to less than 40%. A visual indicator is located proximal to the peripheral evaporative surface of the solid article. The dispenser has a first configuration in which the visual indicator is not visually perceptible, and a second configuration in which the visual indicator is visually perceptible upon shrinkage of at least a portion of the solid article from the initial size to the reduced size for indicating a state of use of the dispenser.

Abstract: A flexible solid deodorizer for releasably interlocking to a volatile composition dispenser, the solid deodorizer has a first central evaporative surface, a second central evaporative surface, and a peripheral evaporative surface. The peripheral evaporative surface circumscribes at least a part of the first and second central evaporative surfaces to define a side of the deodorizer. The deodorizer is configured for releasably interlocking to the dispenser, wherein at least a portion of the deodorizer is configured to releasably interlock with at least a portion of the dispenser to form a solid surface substantially free of an opening.

Abstract: An essential oil diffusion using device is provided and includes: a housing, a water tank is arranged in the housing, a support frame is arranged in the water tank, an essential oil pipe is arranged at a side of the support frame, a water stopping sheet is arranged at another side of the support frame, an atomizing sheet is arranged at the another side of the support frame, a middle holder is arranged below the support frame, a fan is arranged on the middle holder, a power supply box is arranged above the fan, an atomization control circuit board is arranged between the power supply box and a top of the middle holder, an atomization circuit is arranged on the atomization control circuit board. The device can achieve diffusion delaying of essential oil, make smell diffusion of an aromatherapy machine more lasting, easy to use, safe and reliable.

Abstract: An aromatherapy nebulizer and an aroma diffuser of the same are proposed in the present invention. The aroma diffuser includes the aromatherapy nebulizer and a main body to mount the aromatherapy nebulizer. The aromatherapy nebulizer includes an atomizer; and an essential oil container. The atomizer includes an atomizing seat defined an atomization chamber therein and an outer cover defining a mist outlet. The atomizing seat is provided with an air conduit and a liquid conduit; the liquid conduit defines an essential oil channel therethrough. The essential oil channel is bent at one end of the liquid conduit which forms a liquid outlet, thereby the essential oil is absorbed upwards to the liquid conduct from the essential oil container and changes a direction sprayed out from the liquid outlet.

Abstract: An air scrubber/purifying filter includes filter material having a substrate, an adhesive coating applied to the substrate and a plurality of flock fibers flocked into the adhesive coating. In one embodiment, bi-component flock fibers are flocked on a Reticulated Foam (RF) substrate and subsequently fibrillated. In another embodiment, Cross-Flow Flock Fiber (CFF) filter material includes edgewise, cross cut, bonded, stacked fabric layers such that the passage of air through the flock fibers is normal to the flock fiber orientation. In some embodiments the flock fibers are coated with biocidal, virucidal and/or metalized coatings or finishes to provide biocidal or virucidal properties to the filter media.

Abstract: The invention relates to an irradiation device for UV irradiation, in particular UV-C irradiation, of a medium flowing through the irradiation device, in particular water or a gaseous medium, preferably air, in particular for the inactivation of microorganisms present in the medium, such as bacteria, germs, mould and/or viruses, having a housing through which the medium is to flow and which has an inlet and an outlet, and at least one radiation source arranged in the interior of the housing for irradiating the medium flowing through the housing, wherein the housing is reflective on the inner side facing the radiation source with a reflectance for the UV radiation emitted by the radiation source of at least 0.6, wherein the radiation source is arranged in the housing in such a way that the radiation emitted by the radiation source is reflected on the inner side of the housing.

Abstract: A cable rack system apparatus for assisting the user with installation, disinfection, and mounting to a surface includes one or more cables, one or more ultraviolet (“UV”) emitters, one or more clips, and two or more surface mounts. The one or more UV emitters are coupled to the one or more cables with one or more clips. Other embodiments are described herein.

Abstract: The sterilization mask with UVC reflective chamber includes a chamber with reflective liner, through which inhaled and exhaled air passes. The reflective chamber is also referred to as a sterilization chamber. Using a reflective chamber ensures each photon of UVC light has a long life, thus dissipating slowly. Increasing the life of the UVC photons decreases the quantity of photons that must be created. Thus, less power is required to achieve the sterilization. Sterilization is defined as a 6-log reduction (99.9999%) of various microbes including viruses, bacteria, and spores. Heat generated by the UVC lights is carried away from the mask by a heat transfer fluid, the heat dissipated away from the user.

Abstract: Contact lens treatment systems and methods for disinfecting contact lenses are described. These systems and methods utilize a coated catalytic disc, which contains a support disc and a manganese oxide present on at least a portion of the support disc. The coated catalytic disc contains 300 ?g to 1800 ?g of manganese, often in the form of manganese dioxide.

Abstract: A variety of methods and compositions are disclosed, including, in one embodiment, a method of making a superabsorbent material including: providing dried seaweed flakes comprising ?-carrageenan; hydrating the dried seaweed flakes to produced hydrated seaweed flakes; contacting the hydrated seaweed flakes with a non-aqueous solvent thereby producing the superabsorbent material; and drying the superabsorbent material.

Abstract: The present disclosure provides fibrous composition comprising a soluble or a dispersible N-halamine, for example 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (i.e., compound I). Additionally, the disclosure provides methods for producing the fibrous compositions comprising a soluble or a dispersible N-halamine as well as methods for protecting a person from an infection using the fibrous compositions comprising a soluble or a dispersible N-halamine. The compositions and methods according to the present disclosure provide several advantages, such as stability, less time to provide sufficient antimicrobial inactivation, and are inexpensive and require lower amount of active concentrations to be effective.

Abstract: Disclosed herein are feminine hygiene articles and multilayer film structures. According to one or more embodiments disclosed herein, a feminine hygiene article may include a feminine hygiene pad including an absorbent body, an adhesive layer positioned on at least a surface of the absorbent body, and a pouch wrap in contact with the adhesive layer of the feminine hygiene pad. The pouch wrap may include a release layer in direct contact with the adhesive layer. The release layer may include a polymer composition including low density polyethylene covalently bonded to polydimethylsiloxane.

Abstract: This disclosure relates to methods and materials for embolization of one or more blood vessels (e.g., one or more arteries). For example, biomaterial compositions (e.g., BEM compositions containing PRF and one or more nanoclay materials) for embolization of one or more blood vessels (e.g., one or more arteries) within a mammal (e.g., a human) are provided.

Abstract: Disclosed are devices, systems and related surgical methods including implantable devices having a plurality of osteo-inductive, osteoconductive and/or osseointegrative surface features that may be useful in joint and/or bone replacement implants used in spinal surgeries, dental surgeries and/or other orthopedic and/or general surgical procedures.