Abstract: A simply lockable quick coupling for releasably connecting a hose to an implantable apparatus, comprises a first attachment piece that can be connected to the hose and a second attachment piece that can be connected to the apparatus, wherein the attachment pieces can be rotated relative to each other in the locked state.

Abstract: A coupling system is configured to couple a catheter to a port. The coupling system can include a toothed grip connector system configured to retain a portion of an end portion of a catheter. The toothed grip connector system can include a recess extending longitudinally from a first end of the coupling system and including an internal stem with a gripping member extending radially about the internal stem. The gripping member can include a plurality of teeth extending radially inward, the plurality of teeth configured to engage an outer surface of the end portion of the catheter to prevent longitudinal movement in at least a first direction following insertion of the end portion of the catheter into the recess. A sealing member can be included to provide a seal between the end portion of the catheter and the internal stem.

Abstract: An infusion apparatus comprises a reservoir and a catheter having a proximal portion coupled to the reservoir. The apparatus comprises at least one antimicrobial barrier. The antimicrobial barrier may be configured to elute an antimicrobial agent into the surrounding area, such as into a fibrin sheath or clot on the external surface of the catheter.

Abstract: Fluid connector systems that can include first and second valve assemblies that are couplable together to form a fluid pathway through the fluid connector system when the first and second valve assemblies are coupled together, and can resist fluid flow through each of the first and second valve assemblies when the first and second valve assemblies are separated from each other, where the first and second valve assemblies can include a compressible element or post positioned within a channel and configured resist fluid flow through the respective first or second valve assembly in a first position and to reduce the resistance to fluid flow through the first or second valve assembly in a second position, and the first and second valve assemblies including a sleeve and one or more arm configured to engage each other to form a snap fitting feature that can resist separation therebetween.

Abstract: A catheter priming apparatus may include a barrier forming a reservoir. Fluid may be disposed within the reservoir. A support structure may be disposed within the barrier. The support structure may include an opening extending through the support structure and a connector configured to couple the catheter priming apparatus to a catheter system. A one-way valve may be coupled to the support structure and configured to allow the fluid to flow out of the reservoir through the connector in response to compression of a portion of the barrier aligned with the opening.

Abstract: A fluid pump conveys a fluid, such as blood. A fluid channel that is bounded by a channel wall and a rotor arranged in the fluid channel and that is rotatably mounted about a pivot point of the bearing with a mechanical, hydrodynamic and/or hydrostatic, axial and radial bearing. The fluid channel has a spherical section and the rotor has a rotor body and a conveying element that is arranged within the spherical section of the fluid channel and configured to generate a substantially spherical rotational area of the rotor. The spherical center of the spherical section of the fluid channel and the spherical center of the spherical rotational area substantially coincide with the pivot point so that a minimum distance between the rotor and the channel wall is maintained in the spherical section upon a tilting of the rotor.

Abstract: A transmandibular sterile conduit system provides sterile access to the subcutaneous space through a conduit inserted through the mandible. The transmandibular sterile conduit system provides a sterile bacterially impervious pathway for drivelines and catheters to enter the body and connect with deeply implanted medical devices, like a Left Ventricular Assist Device, while reducing the risk of deadly infection experienced with current techniques.

Abstract: A device and method for treating, for example the Restless Leg Syndrome, an individual comprising a pair of leggings, at least one electrode, the at least one electrode attached to the pair of leggings, and a pulse generator, the pulse generator connected to the at least one electrode.

Abstract: The present invention relates to the field of wearable neurotherapy devices, and particularly relates to a wrist-worn nerve stimulator. The nerve stimulator is suitable for the wrist and other parts of limbs. For the nerve stimulator, a conducting medium attached to a strap not only ensures no tingling sensation during electrical stimulation therapy, but also alleviates the problem of discomfort without prejudice to the therapeutic effect, thereby reducing the difficulty of assembling the nerve stimulator and improving wearing adaptability; in addition, it can be seen from the use of a first strap and an electrical stimulation part that the wrist-worn nerve stimulator has a split structure and is composed of the first strap and the electrical stimulation part, such that the difficulty of disassembling basic frameworks for electrical stimulation therapy is significantly reduced, and it can be understood that the consumable first strap is easier to be replaced.

Abstract: A soft, stretchable, multifunctional bioelectronic interface can be used to monitor and/or modulate an entire organ, such as a stomach, heart, bladder, or spinal cord. The interface's softness translates to reduced mechanical mismatch with the tissue, and the interface's stretchability reduces interfacial stress with dynamically expanding and contracting organs. The electronics are stretchable thanks in part to liquid-metal conductors sealed within hollow channels of elastomeric fibers embedded in the interface. The liquid metal is largely strain-insensitive, non-toxic, and has a melting point of less than 37° C., so it remains liquid when implanted in a mammalian body. The liquid metal conductors connect microelectronic components, such as micro light-emitting diodes (?LEDs), electrodes, photodiodes, and temperature sensors, to a flexible printed circuit board (fPCB) at one end of the fiber.

Abstract: The present invention provides an implantable electrode device, a medical device/system thereof, and a diagnostic and/or therapeutic method using the medical device/system. The implantable electrode device includes a flexible non-conductive flap, one or more electrodes integrated with the flap, and one or more wires embedded within the flap and connected to the one or more electrodes. The invention exhibits numerous technical merits such as stable fixation of the electrode to a biological target in a patient.

Abstract: A patient monitoring system within an Electroconvulsive Therapy (ECT) device includes a patient monitoring channel including a first electrode and a second electrode, with each electrode coupled to a respective lead. The monitoring system also includes an Alternating Current source structured to inject a test current to the first electrode lead or the second electrode lead and a differential amplifier structured to measure differences between signals received from the first electrode lead and the second electrode lead. Related methods include evaluating a quality of an electrode contact with a skin surface by injecting a lead of the electrode and one input of a differential amplifier with a known electrical current, comparing a difference between an electrical signal received from the lead of the injected electrode as well as from a lead of a passive signal electrode, and evaluating the compared difference.

Abstract: An iontophoresis system includes a preloaded reservoir containing one or more doses of a therapeutic agent. As a result, the therapeutic agent does not have to be loaded into the reservoir prior to use. In such a system, the preloaded reservoir is generally disposable. Various components of the iontophoresis system can be combined with the reservoir in a disposable cartridge that is selectively connectable to other, reusable components of the iontophoresis system. In addition, the entire iontophoresis system can be formed from one or more disposable, one-time-use modules.

Abstract: Methods for treating urinary stress incontinence by non-invasively delivering energy to one or more submucosal regions of vaginal tissue to induce remodeling within the vaginal tissue are provided. In some embodiments, the energy delivery results in heating of the target tissue to a temperature that ranges from about 38° C. to about 46° C. In some embodiments, the subject methods involve cooling a mucosal epithelial layer over the vaginal tissue. In some embodiments, a reverse thermal gradient is produced as the mucosal epithelium is cooled while energy is delivered to the underlying vaginal tissue.

Abstract: The present invention refers to a medical device (10) for stimulating neurons of a patient to suppress a pathologically synchronous activity of the neurons. The medical device (10) comprises a non-invasive therapeutic stimulation unit (12) configured to administer a plurality of stimuli to a patient's body which is configured to suppress the pathologically synchronous activity; a clock unit (24) configured to generate at least one periodic or cyclical clock signal (S(t); S?(t); S(t), S?(t)) related to a physiological activity or physiological cycle of the patient; and a control unit (18) configured to control operation of the medical device (10) in dependence on the at least one clock signal (S(t); S?(t); S(t), S?(t)).

Abstract: Provided herein are methods for treating autism; and systems and devices for administering transcutaneous auricular vagal nerve stimulation (taVNS).

Abstract: Systems and methods for enhancing muscle function of skeletal muscles in connection with a planned spine surgery intervention in a patient's back are provided. The method includes implanting one or more electrodes in or adjacent to tissue associated with one or more skeletal muscles within a back of a patient, the one or more electrodes in electrical communication with a pulse generator programmed for enhancing muscle function of the one or more skeletal muscles. Electrical stimulation is delivered, according to the programming during a time period associated with the planned spine surgery intervention, from the pulse generator to the tissue associated with the one or more skeletal muscles via the one or more electrodes, thereby improving neuromuscular control system performance of the one or more spine stabilizing muscles in connection with the planned spine surgery intervention to reduce the patient's recovery time associated with the planned spine surgery intervention.

Abstract: A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

Abstract: Techniques for placing implantable electrodes to treat sleep apnea, and associated devices, systems, and methods are disclosed herein. A representative method includes percutaneously implanting one or more signal delivery devices, each at or near a respective target signal delivery location in a patient. Each signal delivery device can include one or more electrodes, and individual ones of the electrodes can be positioned to produce a net positive protrusive motor response of the patient’s tongue. The representative method further includes providing power to one or more of the electrodes from a wearable power source to cause the electrode(s) to deliver an electrical signal to the respective target signal delivery location(s) to produce the net positive protrusive motor response.

Abstract: An example of a system for delivering neurostimulation from a stimulation device to a patient may include a programming control circuit, a sensory profiling circuit, and a stimulation control circuit. The programming control circuit may be configured to program the stimulation device for controlling delivery of the neurostimulation according to one or more stimulation waveforms and one or more stimulation fields. The sensory profiling circuit may be configured to receive information regarding painful symptoms of the patient and to determine a pain sensory profile for the patient using the received information. The stimulation control circuit may be configured to determine a recommendation for one or more spinal cord stimulation (SCS) therapies using the determined pain sensory profile and to determine the one or more stimulation waveforms and the one or more stimulation fields using the recommended one or more SCS therapies.

Abstract: A system to provide flexible stimulation pattern definition, delivery, and control to dynamically adjust a therapy regimen for electrical stimulation therapy based on patient needs. Firmware in an electrical stimulation delivery device that executes the therapy regimen may be implemented as a “player” of a series of instructions for the received stimulation patterns. The system may include a wearable device or an implantable device. An external computing device configured to program the electrical stimulation delivery device may include a stimulation pattern construct collection from which a clinician can select, assemble, and modify waveforms, bursts, pattern, sensing or other event triggers etc. to create a therapy regimen. The external computing device may transmit software that defines the selected regimen to the electrical stimulation delivery device memory, where the device “plays” the instructions to deliver electrical stimulation according to the therapy regimen.

Abstract: Disclosed is a method of computing a probability distribution of the suitability of measurement electrode configurations for a neuromodulation device. The method comprises: computing the probability distribution of suitability of measurement electrode configurations from: a predetermined stimulus program vector of the neuromodulation device; and prior patient data. Also disclosed is an automated method of setting a measurement electrode configuration for a neuromodulation device configured to deliver a neural stimulus to a neural pathway of a patient.

Abstract: The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.

Abstract: A system and method for determining parameters of stimulation electrical signals for vagus nerve stimulation is discussed. Initial parameters of the signals are selected to provide reliable response to stimulation in physiological measurements of a subject. One or more physiological and neurological indices are determined based on a vagus nerve response model. For a selected vagus nerve activation, the electrical parameters of the signals are varied while monitoring changes in physiological parameters and values of the indices. The electrical parameters are varied until desired response in the physiological measurements and the values of the indices is observed. The electrical parameters are then stored as preferred parameters and can be used to activate the selected vagus nerve of the subject.

Abstract: An example method includes establishing a communications link between an electrophysiology (EP) monitoring system and an implantable medical device (IMD). IMD electrical data is received at the monitoring system via the communications link. The IMD electrical data may be synchronized with EP measurement data to provide synchronized electrical data based on timing of a synchronization signal sensed by an IMD electrode and/or EP electrodes. The method also includes computing reconstructed electrical signals for locations on a surface of interest within the patient's body based on the synchronized electrical data and geometry data. The geometry data represents locations of the EP electrodes, a location of the IMD electrode within the patient's body and the surface of interest.

Abstract: A device comprises external electrodes configured to be held proximate to a patient's skin and to sense conductive communication signals transmitted by an implantable medical device (IMD) within the patient. A dielectric layer is provided on at least a first electrode of the external electrodes to space the first electrode apart from the patient's skin to form a non-contact capacitively coupled interface between the patient's skin and the first electrode. The capacitively coupled interface is sensitive to the conductive communication signals. A circuit is connected to the external electrodes and is configured to output a differential signal corresponding to the conductive communication signals.

Abstract: The instant application relates to inductive charging of devices subject to migration. Embodiments described herein provide charging to devices at variable depths and locations to accommodate both net displacement of an implantable device as well as angular rotation of the implantable device by selecting appropriate sets or subsets of available field generation coils.

Abstract: In some examples, the disclosure describes devices, systems, and methods for determining settings of a second implantable medical device (IMD) based on patient information stored in a first IMD. The first IMD may be a device already implanted in a patient and a clinician may remove and replace the first IMD with the second IMD. The second IMD may include may be an upgrade over the first IMD (e.g., the second IMD is of the same device type but of a different model as the first IMD), may be an update to the first IMD (e.g., the second IMD is the same device type and model as the first IMD but includes different features), and/or a different device type than the first IMD.

Abstract: A biostimulator and a biostimulator system for septal pacing, is described. The biostimulator includes a burrowing nose to allow the biostimulator to embed within a target tissue. The embedded biostimulator has a reduced exposed length within a heart chamber, and is less likely to interfere with adjacent heart structures. Embodiments include burrowing ridges on a nose or a housing of the biostimulator to affix the embedded biostimulator to the target tissue. Other embodiments are also described and claimed.

Abstract: An implantable neural stimulation device is provided, comprising a body containing stimulation electronics, and a battery to provide stimulation energy, a lid, coupled to the body, the lid configured to at least partially seal the body and a header coupled to the body of the device. The header comprises a contact assembly electrically coupled to the stimulation electronics via at least one feedthrough wire extending through the lid, the contact assembly configured to connect to a stimulation lead to deliver the stimulation energy from the battery under control by the stimulation electronics, a charge coil configured to charge the battery, and a support component configured to support the charge coil. The support component is supported in position by the contact assembly.

Abstract: An automated external defibrillator includes: an operation accepter that accepts an operation input from a user; and a self-test executor that executes a self-test for checking a state of the automated external defibrillator when a first condition or a second condition has been satisfied. The first condition is that a setting time instant set in advance comes. The second condition is that the operation accepter accepts a predetermined operation input.

Abstract: A wearable therapeutic device is provided. The wearable therapeutic device includes a garment, and the garment includes an electrode and a conductive thread. A control unit is coupled to the conductive thread and identifies an electrical connection between a conductive surface of the electrode and the conductive thread, and an alarm module can provide information about the positioning of the electrode in the garment based on the electrical connection.

Abstract: A patient-worn ambulatory cardiac monitoring device for monitoring a patient during a patient activity includes at least one physiological sensor configured to detect signals indicative of cardiac activity, an activity sensor and associated circuitry configured to monitor patient movements, and a vibrational sensor configured to monitor a cardio-vibrational signal of the patient. The at least one physiological sensor can include one of an ECG sensor and a heart rate sensor. At least one processor in communication with the at least one physiological sensor, the activity sensor, and the vibrational sensor, is configured to measure, during the patient activity, at least one time interval between an ECG fiducial point in an ECG signal and a cardio-vibrational fiducial point in the cardio-vibrational signal during a cardiac cycle of the patient’s heart.

Abstract: A method of treating a subject that includes measuring at least one alpha burst associated with the subject's brain, determining at least one intrinsic frequency of the subject's brain based on the at least one measured alpha burst, selecting a stimulation frequency based on the at least one intrinsic frequency of the subject's brain, and providing a stimulation treatment at the stimulation frequency close to a head of the subject to influence at least one alpha burst parameter of the subject's brain.

Abstract: A method for anti-inflammatory treatment of diabetic retinopathy can include systemic administration of an A2aAR agonist and providing local electric field stimulation to the retina. The electric field stimulation causes translocation of A2aRs from cytosol to the cell membranes and makes them active and available for binding with adenosine and adenosine agonists. Increased numbers of active A2aRs on cellular membranes leads to several-fold increase in the anti-inflammatory signal transduced into the cells. Amplified adenosine-A2aR signaling pathway causes significant inhibition of production of proinflammatory cytokines and other cytotoxic activity of microglia thus protecting the retina from destruction by the immune system and preserving eyesight. A treatment apparatus can include a multicoil applicator with coils adapted for positioning near eyes for stimulating retina, a pulse generator functionally coupled to the applicator and a power supply.

Abstract: In methods for treating a patient, a time varying magnetic field is applied to a patient's body and causes a muscle contraction. The time-varying magnetic field may be monophasic, biphasic, polyphasic and/or static. The method may reduce adipose tissue, improve metabolism, blood and/or lymph circulation. The method may use combinations of treatments to enhance the visual appearance of the patient.

Abstract: In one aspect, a method is provided for performing light therapy on a subject. The method comprises providing a device which emits electromagnetic radiation that oscillates between at least first and second distinct polarization states; and illuminating the subject with the emitted electromagnetic radiation. In another aspect, a fixture is provided which comprises a first source of electromagnetic radiation which emits electromagnetic radiation in a first polarization state; a second source of electromagnetic radiation which emits electromagnetic radiation in a second polarization state which is distinct from said first polarization state; and an oscillator which oscillates electromagnetic radiation output by the fixture between at least said first and second polarization states.

Abstract: A volumetric modulated arc therapy (VMAT) treatment plan may be optimized by obtaining a VMAT treatment plan and calculating a radiation dose matrix corresponding to each a plurality of beamlets, wherein each beamlet represents a change in field when an MLC leaf is moved a predetermined unit distance. The method includes defining an enhanced objective function (EOF) for achieving one or more clinical objectives and minimizing the EOF for proposed leaf positions iterating through each leaf of at least a subset of the leaves of the VMAT treatment plan (wherein the proposed leaf positions move each leaf into the field or out of the field by the predetermined unit distance and correspond to the addition or subtraction of the corresponding radiation dose matrix). The set of leaf positions of the VMAT treatment plan is updated according to the proposed leaf positions of the minimized EOF.

Abstract: The invention relates to a slat for collimating therapy radiation, comprising a collimation region made from a first material; and a holding region made from a second material, wherein the collimation region and the holding region are connected together by a connection point, the first material is configured to collimate therapy radiation, and the holding region is couplable to an adjusting facility for adjusting the slat.

Abstract: The present invention relates to an ultrasound generation device capable of adjusting an ultrasound focus depth, comprising: a handpiece; a cartridge housing detachably coupled to the handpiece; an ultrasonic wave-generating unit provided in the handpiece or the cartridge housing; a rotating unit of which the outer circumferential surface makes contact with a support unit of the ultrasonic wave-generating unit, and which has a shape of a section with a rotation radius gradually increased from the center of the rotating unit; and a rotation adjusting unit coupled to the rotating unit to apply force for driving the rotating unit, wherein the rotating unit adjusts the focal depth of the ultrasonic waves from the ultrasonic wave-generating unit, as the rotation adjusting unit rotates the rotating unit to change a rotation radius of the rotating unit, such that the ultrasonic wave-generating unit is moved.

Abstract: The improvement of olfactory sensitivity. A method for improving olfactory sensitivity, comprising reducing body odor.

Abstract: An impact tool includes a core and a plurality of projections. The core is formed of a first material that has a first specific gravity and each projection is formed of a second material that has a second specific gravity. The plurality of projections is configured on the core such that at least two projections intersect a first hypothetical plane disposed on the first side of the core and at least two projections intersect a second hypothetical plane disposed on the second side of the core and that is opposably facing the first side. Each of the first and second hypothetical planes is disposed a distance from the central lengthwise axis of the core that is greater than the radius of the core and less than the sum of the radius of the core and the length of a projection.

Abstract: A breathing apparatus includes a blower unit including a blower. The breathing apparatus further includes a battery pack including at least one electrochemical cell. The breathing apparatus further includes an adaptor including an adaptor housing physically connected to the blower unit and the battery pack. The adaptor further includes electrical contacts that engages with corresponding electrical terminals of the blower unit and the battery pack, such that the blower is electrically coupled to the electrochemical cell. The adaptor further includes at least one communication interface for receiving data from at least one of the blower unit and the battery pack, and transmitting data to an external device.

Abstract: A respiratory protection composite facepiece is disclosed and includes a polymeric rigid facepiece body portion having a first surface and a second surface and a silicone sealing facepiece element chemically bonded at least one of the first surface or the second surface. The first and second surfaces can be opposing major surfaces. A second silicone element is chemically bonded to at least one of the first surface or the second surface. Methods of making the same are also disclosed.

Abstract: A compact, mask-mountable powered air purifying respirator (“PAPR”) includes a housing and an impeller driven by a motor to draw air in through an inlet in the housing and direct the air to an outlet at an opposite end of the housing. The impeller comprises S-shaped fan blades that direct the air radially outward from the bottom of the impeller. The radial airflow meets S-shaped fins on a flow straightener that redirect the airflow downward through the PAPR housing outlet. The fan blades and flow straightener drive the airflow directly and efficiently, without unnecessary travel of air through the PAPR assembly, thus providing an improved airflow efficiency.

Abstract: The present invention relates to a sealing foam, a respirator, and a method for manufacturing a sealing foam. The sealing foam includes: a main body part, the main body part being a porous foam; an air-proof film on a continuous surface; and an anchor layer, the anchor layer being continuously provided on the upper layer of the main body and provided between the air-proof film and the main body part, and the anchor layer being partially embedded in pores of the porous foam. The respirator includes a respirator main body and a sealing foam of the present invention. The method for manufacturing a sealing foam includes: providing a porous foam to prepare a main body part of a sealing foam, and providing an anchor layer and an air-proof film on the porous foam, so that the air-proof film is continuously provided on an upper surface of the main body part, wherein the anchor layer is provided between the air-proof film and the main body part, and is partially embedded in pores of the porous foam.

Abstract: Provided herein is a face mask that has a flexible filter body that is configured to fit over at least the mouth and the nose of a wearer. The face mask includes a shape-preserving strip extending along the periphery of the filter body. The shape-preserving strip is integral with the filter body and is configured to sufficiently seal the face mask against the wearer's face to minimize or prevent entry and/or exit of airborne particulate matter.

Abstract: A fire extinguishing robotic service device is described for use on a robotic picking system grid. The fire extinguishing robotic service device is capable of driving to any location on the grid in order to extinguish a fire. The service device may also be provided with a camera or a sensor to locate the fire.

Abstract: A method, devices and system for detecting power line issues are described. A variety of sensors detect conductor movement, operating temperature, and remote line current. The data is analyzed based on a neural network to determine galloping or swinging conductors, broken jumpers or connectors, vegetation interference, a fallen line, and equipment failure. Once a determination is made about a line issue, appropriate measures are undertaken to fix the detected issues.

Abstract: A smoke and toxic gas suction removal-type firefighting nozzle device is disclosed. The smoke and toxic gas suction removal-type firefighting nozzle device includes a spray head configured to receive water supplied from a fire hose and spray the water forward through an inner passage, the spray head having a plurality of intake holes that opens the inner passage to the outside, and a gas introduction guider embedded in the spray head and configured to guide an inlet gas flowing into the spray head through the intake hole by the Venturi phenomenon implemented by the sprayed water such that the inlet gas is mixed with water.