Abstract: A device comprising: a dispenser (1) comprising a reservoir (2) containing the fluid product, a dispensing head (3) provided with a dispensing orifice (4), able to move axially relative to the reservoir (2), and a dispensing member (5) actuated when the reservoir (2) is moved axially upwards relative to said dispensing head (3), an inner body (10) comprising a hollow cylinder (11) receiving said dispenser (1), an outer body (20) receiving said inner body (10), a push member (30), and an actuating system; said push member (30) being movable relative to said inner body (10) between a rest position and an actuating position, a spring (40) being interposed between said inner body (10) and said push member (30), said spring (40) being compressed in the rest position of said push member (30) in order to urge it towards its actuating position, said actuating system comprising a reset gear (50), a pawl (60), a floating wheel (70), a motor wheel (75), and a motor (80), wherein: said pawl (60) interacts with said pu

Abstract: The present invention relates to a closed system intranasal treatment device that is preferably in round, square, rectangular, triangular prism, quadrilateral, pentagon etc. form and that ensures the person who will use it gets maximum efficiency from the drug by creating a closed structure by completely wrapping noses of pediatric, adult and geriatric patient groups and preventing the drug from passing out of the system and maximizes patient compliance, in which all liquid pharmaceutical compositions in the state of the art are applicable.

Abstract: The respirator comprises an air bag that is pressurized to provide air to a user, wherein the air bag is a tubular membrane (2) housed within a pressure chamber (1). Furthermore, the pressure chamber (1) comprises fluid inlets and outlets, the fluid pressurizing the tubular membrane (2) to provide air to a user, and protrusions (9) that pressurize the tubular membrane (2). It provides a respirator with reduced dimensions, number of parts, weight, and cost, as well as reusable after autoclave disinfection of the auto-inflatable bag as a standard element.

Abstract: The invention relates to a respiratory therapy device (1) for treating the musculature of respiratory tracts, lung functions and/or mucous deposits in the lungs, nose and/or throat of a patient (2), consisting of a hollow body (3) in which at least one through-channel (4, 5) is provided, a mouthpiece or nosepiece (6) which is inserted into the hollow body (3) and which is connected to the patient (2) during the duration of the treatment by the respiratory therapy device (1), and consisting of at least one vibration body (11, 12) which is arranged in the interior of the hollow body (3) and which is caused to vibrate in an oscillating manner by the inhalation and/ or exhalation of the patient (2), wherein an oscillating, resistive and/or threshold-typical air pressure vibration occurs, the individual resistances during the inhalation and exhalation being adjustable specific to the patient and a modification or repositioning of the respiratory therapy device (1) not being required.

Abstract: A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Abstract: Over-enthalpy conditions when using a respiratory and/or surgical humidifier system can be prevented. A heating element power in an inspiratory conduit can be limited based at least in part on one or more parameters of the gases flow, and/or on an ambient temperature. The limit on the heating element power in the inspiratory conduit can be achieved using a processor and/or protection circuit(s) located outside the processor. For example, the system can use the processor to determine and/or apply the limit as a level of protection and use the protection circuit(s) as another level of protection.

Abstract: A stylet is disclosed for insertion into an endotracheal tube for guiding the tube during intubation. The stylet has a body (3) with a pivotable tip portion (5) at its distal end which is movable in either of two opposing directions away from the axis of the stylet. The tip portion (5) may carry an image acquisition device for video imaging. A control mechanism for controlling the pivot angle of the pivotable tip has a hand-operated actuator (7) at the proximal end of the stylet and flexible control wires (23) extending down the stylet to connect the actuator to the pivotable tip portion (5). Also disclosed is an endotracheal tube (100) usable with the stylet and having a bending portion (103), defined by a concertina or thinned portion, at its distal end to facilitate bending of its tip portion (104) by the stylet tip portion (5).

Abstract: A multi-lumen catheter for cleaning an inner surface of a tracheal ventilation tube is provided, which enables single-handed simultaneous activation of inflation of an inflatable element and suctioning in a closed suction system for use with the tracheal ventilation tube. The closed suction system allows catheters to be used repeatedly without being detached from the tube system including the ventilation air supply. The cleaning catheter is insertable into the tracheal ventilation tube, and is shaped so as to define one or more distal suction orifices. The cleaning catheter comprises an elongate, flexible, tubular catheter main body, and an inflatable element, which is mounted to the catheter main body. An input module is coupled to the cleaning catheter, and comprises an inflation module, which comprises an inflation chamber separate from a suction source.

Abstract: An endotracheal tube assembly and methods of use are disclosed. The endotracheal tube assembly may include a tube having a distal end and a proximal end, a pull line extending through the tube, and a guide structure configured to guide a proximal portion of the pull line at a location proximal of the tube. The pull line may be configured such that when tension is applied to the pull line extending through the guide structure, the distal end of the endotracheal tube may bend in response to the tension applied to the pull line to form a curvature in the tube.

Abstract: A patient interface assembly includes an elastomeric piece configured to receive a flow of pressurized respiratory gas and sealingly engage the patient’s face. The elastomeric piece forms a plenum and includes a mouth sealing portion, a nasal sealing portion, and an anterior surface with an air inlet opening configured to be coupled to a connector and/or an air delivery tube. The patient interface assembly also includes a stiffening structure that is attached to the anterior surface of the elastomeric piece. The stiffening structure comprises a central aperture that is sized so that the air inlet opening and a portion of the anterior surface surrounding the air inlet opening remain exposed through the central aperture. The stiffening structure is configured so that the entirety of the stiffening structure is inferior to the patient’s nose in use.

Abstract: A patient interface may include a plenum chamber and a positioning and stabilising structure. The plenum chamber may include a seal-forming structure and a fascia portion. At least a medial portion of the fascia portion is flexible. In embodiments, the patient interface may include a rigidiser to control flexing of the fascia portion.

Abstract: A patient interface comprising a plenum chamber pressurisable to a therapeutic pressure, a seal-forming structure constructed and arranged to maintain said therapeutic pressure in the plenum chamber, a positioning and stabilising structure to provide a force to hold a seal-forming structure in a therapeutically effective position on a patient's head. The positioning and stabilising structure comprising at least one arm configured to be positioned adjacent to a cheek of the patient, and a strap removably received around the arm and configured to contact a posterior region of the patient's head. The strap comprising a first coupling having a mechanical connector that is configured to engage the arm and limit movement of the arm into and out of the cavity, a second coupling spaced apart from an outer surface of the first coupling, and a sleeve being folded over the second coupling and positioned between the first and second couplings.

Abstract: A gas measurement adapter includes a flow tube portion configured to allow gas to pass through the flow tube portion and a window portion configured to allow measurement light for measuring a component of the gas passing through the flow tube portion to pass through the window portion. The adapter is prepared by using an adapter forming material containing a cycloolefin-based resin as a main component.

Abstract: The present invention provides a practical method for treating atopic dermatitis. By subjecting patients suffering from atopic dermatitis to filtered temperature controlled laminer air flow disease symptoms have been significantly reduced and even removed. The velocity of the laminar air flow is balanced such that body convections are braked without the generation of draught..

Abstract: Provided herein are NO generating systems, methods for generating NO for inhaled therapy, and methods of treating patients in need of inhaled NO. The systems can include a reaction vessel having a headspace for NO accumulation, a NO storage system, and a gas mixing chamber. NO gas generated in the reaction vessel can be delivered to the NO storage system via pressure generated by generation of the NO gas, then the NO gas is mixed with a carrier gas in a gas mixing chamber. NO can be generated at the point of patient delivery.

Abstract: A thermogenic emergency airway management device configured to prevent or treat hypothermia in a patient. The device may be configured to receive inlet air and modify one or more properties of the inlet air to output air at a temperature and/or humidity associated with the prevention and/or treatment of hypothermia. In an embodiment, the device may receive input via a user interface to determine a temperature and/or humidity associated with the air to be output to the patient. In an embodiment, the input may additionally include an amount of air to be output to the patient. In such an embodiment, the device may be configured to cause the amount of air to be output to the patient to prevent and/or treat hypothermia.

Abstract: The present invention refers to a respiratory assistance device that provides respiratory support to patients when they are unable to do it on their own or have difficulties in doing so, where it is made up of a series of electronic, mechanical and control arrangements to execute such actions, providing a constant flow of air/oxygen to the patient.

Abstract: A handpiece tip for refrigerant injection of an RF high frequency device for skin treatment including a refrigerant injection nozzle configured to inject a refrigerant for local anesthesia in a plane direction is disclosed. Also disclosed is a handpiece tip for refrigerant injection of an RF high frequency device configured such that a needle is inserted into a projecting piece of the skin, which is projected as the result of being suctioned by a skin adsorption contact unit, whereby the needle is located in a place at a position desired by an operator.

Abstract: A wearable article, comprising a treatment delivery system, the system having a pliable assembly of layers, including an absorbent layer or other receptacle layer having a surface for absorbing or containing a treatment agent and intended to orient against a wearer's skin (dermal embodiment) or outside of the article oriented towards the wearer's olfactory system (aromatherapy embodiment); a base layer for the wearable article; a barrier or other backing layer for selectively blocking the passage of the treatment agent, while preferably allowing skin moisture to pass through the backing layer disposed between the receptacle layer and the backing layer.

Abstract: A fidget device is disclosed that can be customized with one or more modular components and manipulated by a user to perform a series of tricks. The fidget device includes a center hub that has a pivotal attachment mechanism and a component grip configured to be pivotally attached to the center hub. The component grip comprises a component attachment mechanism configured to attach one or more modular components to the component grip.

Abstract: Distributed feedback-circuitry uses operant conditioning to train a subject to achieve a target state of consciousness. The distributed feedback-circuitry includes remote circuitry having both a feature-extraction circuit and a controller. The former receives a real-time electroencephalogram and information indicative of a target state from the subject and generates a measured feature-set and a target feature-set therefrom. The latter causes transmission of a conditioning stimulus to be listened to by the subject. The conditioning stimulus causes the measured feature-set to be driven towards the target feature-set. The controller also causes the conditioning stimulus to comprise a conditioning-audio stimulus that transitions between being a base-audio stimulus with no reward stimulus and being a base-audio stimulus that has been operated on to incorporate a reward stimulus. The controller causes this transition based on progress made in causing the measured feature-set to conform to the target feature-set.

Abstract: System and method for delivering a therapy treatment to help people release emotions and distress attached to disturbing memories. The system and method can be used in conjunction with web-based or mobile-based applications to provide horizontal eye movement or bilateral auditory or tactile stimulation to process out the emotional disturbances, specifically, using the application together with headphones, light bars or tactile objects. In some instances, sensors and monitors including blood pressure, heart rate, breathing rate and body temperature may be incorporated in conjunction with tactile, visual or auditory devices.

Abstract: Disclosed herein are methods, kits, and devices for improving cognitive function and memory through olfactory stimulation. In some embodiments, olfactory stimulation is performed by releasing one or more scents according to an olfactory stimulation regimen or schedule. The methods, kits and devices described herein can provide a large impact on cognition with minimal effort and cost. They can be used widely and effectively among older adults, children, and other populations in need of improved cognitive performance.

Abstract: The present invention describes a diagnostic kit comprising an indwelling catheter, a set volume of a saline solution (or corresponding solution) contained in a syringe and a drainage and diagnosis container with volume markings. Moreover, the present invention also refers to a method for performing a diagnostic test before a potential prostate surgery/treatment.

Abstract: A guiding catheter includes: a shaft that includes a main lumen and a sub-lumen; a balloon attached to a distal end portion of the shaft; a distal end tip connected to a distal end side of the shaft; and a hub connected to a proximal end side of the shaft. The shaft is formed by layering: an inner layer that forms the main lumen; a first reinforcing layer formed on the inner layer; an intermediate layer formed on the first reinforcing layer and enclosing the sub-lumen; a second reinforcing layer formed on the intermediate layer; and an outer layer formed on the second reinforcing layer from a proximal end to a distal end.

Abstract: A catheter assembly includes a catheter body extending from a catheter proximal portion to a catheter distal portion. The catheter body includes an inner liner and an outer sleeve. A braid assembly is within the catheter body and between the inner liner and the outer sleeve. The braid assembly includes a first filar array including one or more first filars helically extending around the catheter body in a first direction. The braid assembly further includes a second filar array including one or more second filars helically extending around the catheter body in a second direction opposed to the first direction.

Abstract: Torque devices for use with intravascular devices and associated systems and methods are disclosed. In some embodiments, a torque device for use with an intravascular device includes a first component having a body defining a tapered opening for receiving a proximal portion of the intravascular device, a first arm extending from the body, and a second arm extending from the body; and a second component movably coupled to the first component, wherein the second component is movable relative to the first component between an open position where the torque device is configured to slidably receive the proximal portion of the flexible elongate member between the first and second arms of the first component and a closed position where the torque device fixedly engages the proximal portion of the flexible elongate member between first and second arms of the first component.

Abstract: This document illustrates all the new features of the ROSES system (RObotic System for Endovascular Surgery) which Is extended by angioplasty to all possible endovascular applications, starting with the increase in size of the passage hole through the RA to allow not only thrust, of catheters and stents of large diameter, but even the passage of hemostatic valves, and then move on to the description of disposable catheters and guides not for angioplasty, then moving on to the RA handling trolley which also allows the measurement of the forces that the organism of the patient opposes the advancement of the catheters, but even that which meets the guide in the advancement inside the catheter. The curvature control system of a catheter is then illustrated, ending with the definition of a new family of RAs that can control two independent rotations and four further independent parameters.

Abstract: The deflectable tip catheters can be used with a primary delivery system (e.g., a bronchoscope, endoscope, or other surgical access device) to access a certain target tissue, such as a tumor (e.g., a lung tumor). The primary access device provides initial access and the deflectable tip catheter can be passed through the primary access device to reach the target tissue which is not otherwise accessible by the primary access device. The deflectable tip catheters have an internal bore free of obstructions such that a drug delivery device (e.g., a needle) or a diagnostic tool can be passed therethrough to directly access the target tissue.

Abstract: An anchor assembly for securing a catheter to a human body. An anchor assembly includes an anchor comprising an anchor body and a flange coupled with the anchor body. The flange has a top side and a bottom side opposite the top side, the bottom side configured to engage a human body. The anchor body defines at least one bore configured to receive a catheter therein. An adhesive dressing is disposed on the top side of the flange. The adhesive dressing includes a first portion and a second portion. The first portion at least partially covers the first side of the flange, and the second portion extends radially outward of the flange relative to the anchor body.

Abstract: Provided herein is a stabilization device for a catheter, including a base defining a base perimeter, the base having a top surface and a bottom surface, a support surface arranged on the top surface of the base, the support surface having a wall extending away from the top surface of the base and defining a support surface perimeter, the support surface perimeter having substantially the same shape as a catheter adapter, and a dressing defining a dressing perimeter, the dressing configured to cover the base and the support surface.

Abstract: A medical clip for holding a medical device. The medical clip includes a first jaw and a second jaw rotatably coupled to the first jaw, the first jaw and the second jaw being rotatable with respect to each other between a closed position and an open position; an elastomeric insert configured to be positioned between the first jaw and the second jaw. The elastomeric insert defining a proximal cavity having a cavity depth that is receives a medical device between the first jaw and the second jaw. In the closed position, a distal face of the first jaw and the second jaw define a distal opening configured to receive a portion of the medical device through the distal opening; and, a proximal face of the first jaw and the second jaw define a proximal opening configured to receive a second portion of the medical device through the proximal opening.

Abstract: A catheter arrangement and use of a catheter arrangement in infusion therapy. The catheter arrangement includes a catheter with a housing body, a hollow needle, a tube fitted onto a distal end of the housing body, a valve element arranged in the housing body with a fluid passage, and a fluid-conducting path extending through the housing body, the fluid passage and the tube. The needle extends longitudinally through the fluid-conducting path in a state of readiness of the catheter arrangement, and is drawn out of the fluid-conducting path in a state of use of the catheter arrangement. The valve element has an elastic wall portion through which the fluid passage extends. The fluid passage can be shifted by a fluid-pressure-induced elastic deformation of the wall portion between an open state, in which the fluid passage is open, and a closed state, in which the fluid passage is closed.

Abstract: An attachment for a catheter assembly may include a platform, which may include an upper surface and a bottom surface. The bottom surface may be configured to contact skin of a patient. At least a portion of the upper surface may be configured to support the catheter assembly. The upper surface may support the catheter assembly at an angle with respect to skin of the patient that is approximately equal to an insertion angle of a catheter of the catheter assembly. The attachment may include snap feature coupled to the upper surface of the platform. The attachment may include a blunt cannula extending distally from the snap feature. The blunt cannula and the portion of the upper surface may provide a generally straight pathway for an instrument inserted distally through the attachment into the catheter assembly.

Abstract: A catheter assembly may include a catheter hub, which may include a distal end, a proximal end, a lumen extending through the distal end and the proximal end, and a side port disposed between the distal end and the proximal end. The catheter assembly may also include a catheter extending distally from the catheter hub, an extension set coupled to the catheter hub, a catheter hub stabilization device coupled to the catheter hub, a needle hub coupled to the proximal end of the catheter hub, and an introducer needle coupled to the needle hub and extending through the catheter. One or more of the extension set, the catheter hub, or the catheter hub stabilization device may be phosphorescent. An instrument advancement device or a syringe may include one or more phosphorescent features.

Abstract: An expandable delivery sheath includes an elastic outer tubular layer and an inner tubular layer. The inner tubular layer include a thick wall portion integrally connected to a thin wall portion. The thin wall portion can include longitudinal reinforcing members/rods that facilitate unfolding during the passage of the implant, thus decreasing the push force and increasing the consistency of the push force. The inner tubular layer can have a non-expanded or folded condition wherein the thin wall portion folds onto an outer surface of the thick wall portion under urging of the elastic outer tubular layer. When an implant passes therethrough, the outer tubular layer stretches and the inner tubular layer unfolds into an expanded lumen diameter. Once the implant passes, the outer tubular layer again urges the inner tubular layer into the non-expanded condition with the sheath reassuming its smaller profile.

Abstract: Three groups of guidewire embodiments are described with particularly suitable structures for navigating circuitous vessels, especially blood vessels of the brain. Some of the guidewires have a hyperbolic taper that provides desired flexibility. In some embodiments, an integrated guide structure provides for extension in the blood vessel of a corewire to provide for extended reach of the guidewire. In further embodiments, the guidewire has a flexible tip that can be guided directly by the flow in the vessel.

Abstract: A guide wire includes a core shaft having an elongated outer shape, a first coil body disposed to surround a distal end portion of the core shaft, a second coil body disposed radially outside from the first coil body, and a distal tip fixing a distal end of the core shaft and a distal end of the first coil body. In the longitudinal direction of the core shaft, a distal end of the second coil body is positioned between the distal end of the first coil body and a proximal end of the first coil body, a proximal end of the second coil body is positioned on the more proximal end side than the proximal end of the first coil body, and bending stiffness of the first coil body is smaller than bending stiffness of the second coil body.

Abstract: An elongated medical device includes a first layer having a hollow cylindrical shape and containing a fluororesin having an adhesive functional group (adhesive resin) and a first colorant, and a second layer arranged in contact with an outer peripheral surface of the first layer and having a predetermined colored region formed of a second colorant having a color different from a color of the first colorant. The predetermined colored region is formed on a part of the outer peripheral surface of the first layer.

Abstract: Devices, systems, and methods are disclosed that help deliver catheters or other medical devices to locations within a patient's body. The device includes a transporter catheter having a proximal end and a distal end, at least a first balloon located adjacent to the distal end, and at least a second balloon located between the first balloon and the proximal end of the transporter catheter. The first balloon is configured for holding a prosthetic device in place. In another embodiment, the transporter catheter has a third balloon, an orienting balloon, substantially at the tip of the distal end of the transporter catheter.

Abstract: A method of managing cancer in a patient’s cerebrospinal fluid (“CSF”) forms a fluid circuit by fluidly communicating a set of catheters (“a catheter”) with the patient’s brain ventricle and the patient’s lumbar and, while controlling the flow rate of the CSF through the CSF fluid circuit, filters cancer cells from the CSF through the fluid circuit. The method also determines both a variable indicative of cancer cell concentration in the CSF, and at some point, that the variable has attained or passed through a threshold value (e.g., greater than a maximum threshold value or below a minimum threshold value). The method stops controlling the CSF flow rate in response to the variable attaining and/or passing through the threshold value. The CSF flow rate therefore preferably returns to a natural CSF flow rate of the patient after stopping control of the CSF flow rate. A system preferably performs these acts.

Abstract: An implantable cranial medical device includes a first fluid flow path, a second fluid flow path, and upper flange portion, and a lower portion. The upper flange portion is configured to rest on a skull of a subject about a burr hole. The lower portion is configured to be placed within the burr hole. The first fluid flow path may extend from a first opening in the upper flange portion to a first opening in the lower portion. The second fluid flow path may extend from a second opening in the upper flange portion to a second opening in the lower portion.

Abstract: A surgical system and method are used to position a guidewire within an anatomical passageway includes the guidewire, a dilator, a reference feature, and a marker. The guidewire has a guidewire body extending to a distal body end portion. The dilator is secured on the distal body end portion and configured to expand from a contracted state to an expanded state. The dilator in the contracted state is configured to pass through an isthmus of a Eustachian tube. The dilator in the expanded state is configured to dilate the Eustachian tube. The reference feature secured relative to the guidewire, and the marker is positioned on the guidewire a predetermined distance from the reference feature. Thereby, the marker is configured to indicate the predetermined distance to an operator for determining a depth of the reference feature in the anatomical passageway.

Abstract: A capsule device (100) suitable for insertion into a lumen, such as a gastrointestinal lumen, of a subject. The capsule device (100) comprises: a capsule housing (110, 120), a drug chamber (B) configured to accommodate a drug substance, the drug chamber leading to a drug outlet (190),—an actuation chamber (A),—a movable separator (160) arranged between the actuation chamber and the drug chamber, wherein movement of the movable separator expels drug substance from the drug chamber (B) through the drug outlet (190), and—a gas generator (140, 150) configured actuatable to generate pressurized gas in the actuation chamber (A) for exerting mechanical load on the moveable separator (160) to expel the drug substance.

Abstract: Applicators and a method of coloring antiseptics are provided. More specifically, in one embodiment, an applicator having a flexible hollow body containing antiseptic to be applied is provided. The applicator also has a porous element containing colorant positioned such that the antiseptic flows through the porous element containing colorant. Colorant is transferred to the antiseptic as it flows through the porous element. The resulting colored solution may be applied to the desired surface, wherein it may achieve improved visualization across various tones of surfaces.

Abstract: An automated external defibrillator (AED) system includes shock generating electronics configured to provide at least one electrical shock suitable for a patient experiencing a cardiac event, a battery configured for providing power to the shock generating electronics, power management circuitry configured for managing the shock generating electronics and the battery, a single microprocessor configured for controlling the power management circuitry, and an enclosure configured to house the shock generating electronics, the battery, the power management circuitry, and the single microprocessor. In an embodiment, the AED system includes at least two cardiac pads in electrical connection with the shock generating electronics and including a medication delivery mechanism configured for delivering a predetermined dose of a medication to a patient when the cardiac pads are placed on the patient for shock delivery.

Abstract: A burn/wound healing suit with circulating healing anesthetizing and antiseptic liquid. The healing suit is formed of modular parts, including a torso part, upper extremity parts, and lower extremity parts. Each modular part tapers at an end where it connects to another modular part, or seals at this end to be used individually. A connection part is a rigid tube that goes between the connecting parts to enable fluid connection between the different parts. The fluid is circulated by a pump, and heated and filtered to maintain a sterile environment.

Abstract: A gelatin-based (e.g., gelatin methacryloyl (GelMA)) patch is disclosed with an array of microneedles (MNs) for minimally invasive sampling of bodily fluids such as interstitial fluid (ISF). The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time. The GelMA-based MN patch demonstrated efficient extraction of ISF. Furthermore, in experimental testing, the patch efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA microneedle enables to detection and analysis of target molecules from patients. The target molecules captured in the patch may be released and analyzed to detect the presence of and/or concentration of target molecules. In other embodiments, the patch itself may be analyzed directly to detect the presence of and/or concentration of target molecules.

Abstract: Microneedle arrays for introducing an active ingredient through a skin surface of a patient can include a base layer, a plurality of microneedles projecting from the base layer, and a shell layer having an active ingredient. Each of the microneedles includes an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles can also include at least one dissolvable polymer. The active ingredient is incorporated in the shell layer, which extends around at least a portion of the elongate body.

Abstract: A hemostasis valve device includes a valve body having an open first end and an open second end with a main lumen extending from the open first end to the open second end. The valve includes a valve member disposed within the main lumen of the valve body at or proximate to the open first end, the valve member having an open position and a closed position. An actuator is disposed between the valve member and the open second end. The actuator is configured to move the valve member between the open position and the closed position.