Abstract: A monodose inhaler for powdered medicaments consists of a hollow substantially pipe-shaped body that has a first portion (H), for housing a capsule or cartridge of powdered medicament, defined by a wall (W) in which there are formed slots (S) as air intakes to an inner region where the powder drops, and a second portion (M) connected to the first portion (H) for delivering the medicament by means of a primary stream (F) that carries the powder from the drop region along a delivery duct (D) whose end is suitable to be placed in the patient's mouth, and it further includes a secondary duct (D?) located under the delivery duct (D) and provided with its own air intake (S?) for delivering a powderless secondary stream (F?).

Abstract: The device is a portable inhalers. It is an electronic device that uses air pressure to deliver, flavor, aroma and possibly active elements utilizing air pressure, airflow and room temperature volatilization or vaporization. It has a ducted blower to blow room temperature air through a filter embedded with liquid, powder, paste or other source material. The user would insert the nozzle into the nose or mouth and inhale to enjoy the aroma and to receive the benefits of active elements.

Abstract: A device for delivering an incision sealant includes a housing, a seal, and a cannula. The housing at least partially encloses a chamber that holds a quantity of a sealant. The seal is located on one end of the housing and contains the sealant in the chamber. Likewise, a similar seal may be located at the tip end of the fan-shaped cannula. The cannula is fluidly coupled to the chamber, is disposed along an axis, and has a generally fan-shaped end. The generally fan-shaped end has a top surface and an opening for dispensing the sealant. The shape of the generally fan-shaped end is configured to apply sealant to an incision geometry or to conform to the geometry of an eye.

Abstract: A method and system for generating and delivering nitric oxide directly to a patient. A reaction chamber is provided that is located at or in close proximity to the patient and reactants within the reaction chamber react together to produce a predetermined amount of nitric oxide. The reaction is controlled by metering at least one of the reactants into the reaction chamber to generate a predetermined quantity of nitric oxide as required by the patient. The reactants can include a nitrite salt, such as sodium nitrite, and a reductant such as ascorbic acid, maleic acid or a mixture thereof. By generating and delivering the nitric oxide directly to the patient in close proximity thereto, the formation of NO2 is minimized. One or both of the reactants may be in liquid form.

Abstract: A specified concentration of oxygen in a medical gas delivered to a patient by a gas delivery system can be achieved through the use of pulse width modulation control of the flows of one or more component medical gases. The flow of component medical gases can be controlled to improve the resolution and concentration range of medical gas delivered at low flow rates. A first flow of a first medical gas is provided and a second flow of a second medical gas is introduced to achieve a desired average medical gas concentration. When the second flow of the second medical gas is introduced, the first flow of the first medical gas is reduced to maintain a desired total medical gas flow rate.

Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Abstract: The invention described herein relates to methods of treating emphysema and COPD with a GHK tripeptide. The invention further relates to methods of determining the state of the lungs using biomarkers described herein.

Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damaged or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

Abstract: This invention provides an improved respiratory care system for patients. This system uses vapor generated by a humidifier device to provide a humidified vapor mist directly to a trachea patient via a tubing element. A vapor controller attaches to a conventional humidifier device and controls the flow rate of vapor mist from the humidifier to the patient. A tubing element attaches to the outlet of the vapor controller and channels to humidified vapor directly to the patient. In one embodiment of the present invention, the tubing element can attach directly to the trachea of the patient through a trachea mask.

Abstract: The present invention relates to an inhaler for administering a defined dose of an active ingredient into the respiratory tracts of a user. The inhaler has an elongate shape defining a longitudinal axis and a cross-sectional profile, wherein the maximum cross-sectional area is at most 4 cm2 and the maximum extension of the cross-section is at most 2.85 cm.

Abstract: One or more anesthetic vaporizers may be fluidly connected to the anesthetic delivery machine via a vaporizer mounting bar. The vaporizer mounting bar may include multiple vaporizer mounting positions. Each vaporizer includes interlock pins that extend when the vaporizer is opened and prevent the vaporizer from being opened when pushed in. When a first vaporizer is opened, its interlock pins may extend and cause the interlock pins of adjacent vaporizers, and vaporizers within a chain of interlock pin connections, to be pushed in, preventing the other vaporizers from being opened simultaneously with the first vaporizer. In various embodiments, a paddle system may translate the extension of an interlock pin from one vaporizer to the interlock pins of each of the other vaporizers in the direction of the extension, including the interlock pins of vaporizers in non-adjacent and non-chain positions.

Abstract: An acoustic ventilator using feedback control is designed to generate and exert a desired mixture of pressure oscillations into a supply of gas entering a subject's airways to maintain optimal ventilation and perfusion in the lungs. According to the subject's biological specifications and real-time medical condition, computers and human interface control the vibrations in intensity and frequency along with the pressure and composition of blended gases in order to enhance oxygenation and CO2 clearance. Acoustic ventilation will cause the ventilating gases to diffuse through the subject's lungs without the aid of a separate ventilator, and with or without spontaneous breathing.

Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

Abstract: An aerosol dispensing device comprises a tubular body that provides a plenum, a mouthpiece having an outlet, a valve for dispensing fluid from a canister as an aerosol with relatively large and small droplet sizes into the plenum for supply to a user through the mouthpiece, and a baffle arrangement that provides first and second passageways each coupled at one end to the plenum and so configured to receive relatively small and large size droplets in the aerosol respectively, the other end of the first passageway extending to the outlet in the mouthpiece to supply the small size droplets to the user, and the other end of the second passageway being closed to inhibit passage of the large size droplets to the mouthpiece outlet, and containing a absorbent pad to prevent leakage of liquid from the canister. The pad may be pre-loaded with a flavourant.

Abstract: This invention relates to a compliance monitor for monitoring patient usage of a medicament delivery device, where the medicament delivery device includes a store of medicament and a medicament dispensing means. The compliance monitor includes a housing adapted to enclose the medicament delivery device, and a dose counter, associated with the housing, for recording the delivery of a dose of medicament to the patient from the medicament delivery device. The arrangement and construction is such that the housing is loosely coupled to the medicament delivery device, whereby the housing is able to move relative to the medicament delivery device during the delivery of the dose of medicament, and it is this movement which actuates the dose counter, either directly or indirectly, in order to record the delivery of the dose of medicament.

Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets containing the inhalation formulation in doses. The inhaler comprises a metallic piercing member with two piercing elements extending parallel to each other and inclined to the lid of a blister pocket to be punctured. To operate the inhaler, an air stream of ambient air can be sucked or delivered in order to discharge the respective dose from an opened blister pocket and to deliver the dose with the ambient air as an aerosol cloud.

Abstract: The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.

Abstract: Apparatus, methods, and kits for treating symptoms associated with common ailments, such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus comprises dispensers for carbon dioxide and other therapeutic gases. The methods comprise delivering small volumes of these gases to patients in a manner where the gas infuses into a body region in order to bathe the mucous membranes therein. It has been found that even very short exposure of patients to small volumes and high concentrations of such gases can provide significant relief from symptoms.

Abstract: A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.

Abstract: 1-Phenyl-2-pyridinyl alkyl alcohol compounds are effective as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and may be used to prevent and/or treat certain diseases or conditions.

Abstract: 8?-Hydroxy-Dihydroergotamine (8?-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of migraine disorders using the compounds, compositions, dosage forms and administration techniques disclosed herein.

Abstract: The invention relates to the field of medicine, in particular to the field of veterinary medicine. The invention relates to a pharmaceutical (medicament) formulation of glucocorticoids, especially ciclesonide or a pharmaceutically acceptable derivative thereof.

Abstract: An anesthetic circuit is provided for treating a patient. The anesthetic circuit includes a membrane having a plurality of hollow fibers. Also provided is a fluid separation apparatus connectable to an anesthetic circuit. In a further embodiment, a method is provided for anesthetic treatment of a patient.

Abstract: Provided herein are 8?-Hydroxy-2-CF3-dihydroergotamine (8?OH-2-CF3-DHE) compounds, compositions, and dosage forms containing such compositions. Also provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.

Abstract: Methods for reducing the risk of a thromboembolic event, and a related drug delivery system are provided. In some embodiments, a dose of acetylsalicylic acid can be provided in powder form to a patient using a dry powder inhaler. The dose can be effective to reduce a risk of a thromboembolic event in a patient. A dry powder inhaler used for the method can have a mouthpiece, a reservoir for receiving the dose of acetylsalicylic acid, and an actuation member for making available the dose of acetylsalicylic acid for inhalation by a patient through the mouthpiece.

Abstract: 8?-Hydroxy-Dihydroergotamine (8?-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of diseases, conditions or disorders selected from amyotrophic lateral sclerosis (ALS), Parkinson's disease, stress/anxiety, nausea, emesis, aggression, pain, neuropathic pain, sleeplessness, insomnia, restless leg syndrome and depression using the compounds, compositions, dosage forms and administration techniques disclosed herein.

Abstract: A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

Abstract: A fluid dispenser device including a body (10), an elongate flexible strip (20) supporting a plurality of reservoirs (21), a reservoir opening mechanism (30); a first displacement mechanism (40) for causing the flexible strip to advance so as to bring a full reservoir into register with the reservoir-opening mechanism; and a second displacement mechanism (45) for displacing a reservoir (21) against the reservoir opening mechanism (30). The leading end (25) of the flexible strip (20), in the advance direction of the strip is fastened to a receiver element (50), which is displaceable on a path along a guide mechanism (100), between a first position that corresponds to the first actuation of the device and a second position that corresponds to the last actuation of the device.

Abstract: An indexed drug delivery device (70) comprising a valve assembly (13) comprising a housing (26) and a valve, the valve disposed within the housing, one or more keys (34,38) integral to the housing, the keys complementary to corresponding openings on a collar (12), a pressurized canister (28) in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and an inactive carrier gas, a receiving assembly comprising a receptacle adapted to engage at least a portion of the housing, a seat adapted to engage the valve, and, a plunger assembly adapted to linearly actuate the valve assembly and canister along an axis and to engage the valve and seat, the plunger assembly comprising a carriage fixed to the collar, and, a lever having a cam adapted to engage a spring, the spring adapted to linearly actuate the carriage, valve assembly, canister and collar along the axis.

Abstract: The present application discloses devices and methods for delivering a therapeutic compound to the olfactory epithelium of an animal or human. The device having one or more channels for imparting a circumferential and axial velocity to the discharged fluid, and an outlet that discharges an aerosol spray having a circumferential and axial velocity as it enters the nasal cavity of a user. The device is designed to displace the air in the upper nasal cavity in order to specifically deposit a therapeutic agent on the olfactory epithelium while minimizing pressure and discomfort experienced by the user.

Abstract: The present invention provides an apparatus and methods for the administration of positive airway pressure therapies. The apparatus can include a housing, a blower and a mask. The housing is configured to be stably secured on the head of a patient. The blower is secured relative to the housing. A mask in fluid communication with the blower is configured to communicate pressurized air produced at least in part by the blower to the airways of a user.

Abstract: Multimodal particulate formulations of medicaments and methods for their use, e.g. by nasal or pulmonary administration for the treatment of various medical conditions, are provided.

Abstract: A nebulizer dispenser has a T-piece, a body sealingly coupled to the T-piece and configured to contain a liquid medication, and a breathing piece sealingly coupled to the T-piece. The dispenser also has a ball-and-socket joint coupled between the T-piece and either the breathing piece or the body. The ball-and-socket joint allows relative rotational motion of the T-piece in a pitch axis, a yaw axis, and a roll axis.

Abstract: A nebulizer comprises a body, a patient interface, an air inlet, an air outlet, and at least one breathing incentive. The air inlet is coupled with the body and configured for admittance of ambient air into the body in response to inhalation through the patient interface. The air outlet is coupled with the body and configured for discharging exhaled breath. The at least one breathing incentive is integrated with the nebulizer and configured to provide feedback in response to the inhalation. The feedback describes a propriety of a flow rate of the inhalation so as to assist a patient using the nebulizer in achieving a therapeutically effective flow rate for delivery of a medical aerosol.

Abstract: An apparatus for supplying a respiratory gas includes a conveyor device for conveying the respiratory gas, a conduit for feeding the respiratory gas conveyed by the conveyor device to a person, and a humidification device for humidifying the respiratory gas. A sensor device is configured to generate a signal indicative of the respiratory gas humidity and a control device is configured to control the humidification device with regard to the signal which is generated by the sensor device. A method of supplying a respiratory gas to a patient, in which the respiratory gas is introduced by means of a conveyor device into the conduit leading to the patient and is humidified, includes operating the conveyor device so that a respiratory gas pressure which is above ambient pressure is provided in the conduit, and adjusting the humidity on the basis of signals indicative of the relative and/or absolute humidity of the respiratory gas generated by the sensor device.

Abstract: The invention relates to an inhaler component for forming a vapor-air mixture and/or condensation aerosol by vaporising a liquid material and optionally condensing the vapor formed, including: a heating element for vaporising a portion of the liquid material; a wick for automatically supplying the liquid material to the heating element, wherein the wick comprises at least two end sections arranged apart from each other; a first capillary gap for automatically supplying the liquid material to the wick, wherein a first end section of the wick projects into the first capillary gap. In order that the heating element can be supplied more quickly and more reliably with the liquid material, a second capillary gap is provided, which receives therein the second end section of the wick.

Abstract: Compounds of formula (I) described herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

Abstract: An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.

Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

Abstract: An apparatus and method for supplying anesthetic agent to an anesthesia system. The system is connecting detachably with at least two such apparatuses. The apparatus includes a storage volume for a liquid anesthetic agent and a space for evaporating the liquid agent. The apparatus also includes a gas inlet port for receiving a fresh gas for mixing with evaporated agent and a gas outlet port for conducting the gas mixture including evaporated agent to the system. The apparatus also includes a logic circuit for controlling anesthetic agent supply and an apparatus signal connector to exchange information. The apparatus signal connector includes at least one first apparatus contact for receiving from the system a signal indicating whether anesthetic agent supply is allowed or prevented, and a second apparatus contact to indicate that this apparatus is configured to supply anesthetic agent.

Abstract: Compounds of formula (I) defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

Abstract: A fluid preconditioning apparatus used to pretreat fluids for an air disbursement machine. A first portion includes a first outlet for a treated gas, a second outlet for a treated liquid, a third outlet for a hose and a cover. A second portion includes a first inlet to receive a gas, a second inlet to receive liquid, a gas treatment chamber, a gas flow generator for moving the gas from the first inlet through the gas treatment chamber and the first outlet. The second portion also includes a liquid treatment chamber that connects to the second inlet, and a liquid flow generator for moving the liquid from the second inlet through the liquid treatment chamber and the second outlet. The gas treatment chamber treats gas by filtering and disinfecting the gas and the liquid treatment chamber creates the treated liquid by filtering and disinfecting the liquid.

Abstract: A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

Abstract: A medicament dispenser for use with at least one medicament carrier carrying multiple distinct medicament portions, said medicament dispenser comprising (a) a dispensing mechanism actuable for dispensing the distinct medicament portions carried by the at least one medicament carrier; (b) a mouthpiece; and (c) a cover for the mouthpiece, the cover being movably mounted to the dispenser for sequential movement from a first position, in which the mouthpiece is covered, to a second position, in which the mouthpiece is at least part-uncovered, to a third position in which the mouthpiece is uncovered; wherein the cover is adapted to couple with the dispensing mechanism such that movement of the cover from the second position to the third position, but not the first position to the second position, results in actuation of the dispensing mechanism.

Abstract: Inhaler for inhaling powdered medicaments from capsules, comprising a lower part (6), a plate (3) accommodated in the lower part (6), and a holder (18) inserted in the lower part (6), a mouthpiece (2) that can be latched to the lower part (6) on the plate (3), a cover (1) that covers the mouthpiece (2) in a closed position and latches by means of a closure element (14), the lower part (6) and the cover (1) being rotatably (4) connected to one another by a spindle (4), and an actuating member (7, 10) that can be moved from a resting position and set in motion and at the same time co-operates with at least one pin (8, 11) that can be stuck into the holder (18) and is located in a pin holder in the inner actuating member (10). In the holder (18) an exchangeable tube (22) can be inserted, as expulsion channel, which comprises a capsule chamber (21) with the capsule.

Abstract: An improved medication introducing device for airtight connection in a ventilation circuit or similar emergency respiratory device, including an endo-tracheal tube, the device comprising a tubular manifold including an upstream opening, a downstream opening, a top opening for an MDI (metered dose inhaler) device connection and a bottom opening for a mini-nebulizer device connection. This system provides quick and easy to use ports in a one piece component for introduction of medications and drugs to patients for which an intravenous line cannot be established. The two ports include attached closures or caps to prevent contamination and are sized for friction fit connection of commonly used medication devices. The MDI port includes a toothed lug which operates a mechanical counter in the applicator head of an MDI device.

Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.

Abstract: In various embodiments, flow rate of fluids, such as oxygen, nitrous oxide, and air, may be electronically and/or mechanically controlled. An electronically controlled auxiliary common gas output (ACGO) valve may direct the gas mixture, including one or more gases and/or anesthetics, either to a primary breathing machine or to an ACGO of an anesthesia delivery machine. The ACGO valve may include a piloted shuttle valve comprising a valve body and a piston configured to translate within the valve body. The piston may divert the gas mixture to a primary breathing system outlet when translated to a first position and to an ACGO when translated to a second position. An electronically controlled drive gas may toggle the position of the piston. In some embodiments, the piloted shuttle valve may be spring loaded and default to directing the gas mixture to the primary breathing system.

Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. A flexible guiding element receives the used blisters strip.

Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.