Ion Beam Pulsing Means With Detector Synchronizing Means Patents (Class 250/286)
  • Patent number: 8816711
    Abstract: An electrical probe assembly includes a flexible circuit. A plurality of electrically conductive regions is on a first side of the flexible circuit. The flexible circuit is arranged about an axis formed by rolling the flexible circuit such that the electrically conductive regions form a plurality of isolated electrically conductive bands.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: August 26, 2014
    Assignee: United Technologies Corporation
    Inventors: David R. Lyders, George Alan Salisbury
  • Patent number: 8809772
    Abstract: Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: August 19, 2014
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Ronald F. Bonner, Stephen A. Tate
  • Patent number: 8803085
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: August 12, 2014
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Publication number: 20140217279
    Abstract: A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture. The effective area of the opening between the two vacuum chambers may be varied by rotating a disk having an aperture in front of the differential pumping aperture so as to vary the gas flow rate through the opening and between the two chambers.
    Type: Application
    Filed: June 1, 2012
    Publication date: August 7, 2014
    Applicant: MICROMASS UK LIMITED
    Inventor: Daniel James Kenny
  • Patent number: 8779353
    Abstract: An ion guide that transports ions from an ion source at generally a high-pressure level to a mass analyzer at generally a low-pressure level has a plurality of identical electrodes fabricated with protruding elements that forming an ion tunnel or an ion funnel, when the electrodes are assembled around a common longitudinal axis. The protruding elements allow the generation of the radio frequency field necessary to radially confine ions. Each electrode may be machined from a solid block of conductive material, such as metal. The disclosed arrangement greatly simplifies the manufacturing process, reducing cost, and improving robustness and reliability of the ion guide itself.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: July 15, 2014
    Assignee: Bruker Daltonics, Inc.
    Inventors: Stephen Zanon, Maurizio A. Splendore
  • Patent number: 8772974
    Abstract: A method and apparatus for transmission of charged particles along a laser-induced conduction path of concentric plasma channels in atmosphere. The apparatus comprises a high power laser array in operable communication with a high energy output means to accomplish initiation of at least two concentric plasma channels in atmosphere, a second energy source for outputting the charged particles to be transmitted, and means for introducing the charged particles to be transmitted into the wall of at least one of the laser-induced conduction channels. Other embodiments further include means for inducing the energy across the conduction path to a target capable of receiving and storing the energy, and a plurality of charging rods bearing a negative or positive charge and in communication with each conductive channel for shaping and stabilizing the charge transmitted therethrough.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: July 8, 2014
    Assignee: Glenn Lane Family Limited Liability Limited Partnership
    Inventor: Glenn E. Lane
  • Publication number: 20140183350
    Abstract: Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.
    Type: Application
    Filed: December 31, 2012
    Publication date: July 3, 2014
    Applicant: 908 DEVICES INC.
    Inventors: Christopher D. Brown, Kevin J. Knopp, Evgeny Krylov, Scott Miller
  • Patent number: 8754364
    Abstract: A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: June 17, 2014
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 8742362
    Abstract: According to one embodiment, a laser ion source is configured to generate ions by application of a laser beam, the laser ion source including a case to be evacuated, an irradiation box disposed in the case and including a target which generates ions by irradiation of laser light, an ion beam extraction mechanism which electrostatically extracts ions from the irradiation box and guides the ions outside the case as an ion beam, a valve provided to an ion beam outlet of the case, the valve being opened at ion beam emission and being closed at other times, and a shutter provided between the valve and the irradiation box, the shutter being intermittently opened at ion beam emission and being closed at other times.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: June 3, 2014
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Kazuo Hayashi, Akiko Kakutani, Akihiro Osanai, Kiyokazu Sato, Tsutomu Kurusu, Takeshi Yoshiyuki
  • Patent number: 8735810
    Abstract: A time-of-flight mass spectrometer includes a sample plate that supports a sample for analysis. A pulsed ion source generates a pulse of ions from the sample positioned on the sample plate. An ion accelerator receives the pulse of ions generated by the pulsed ion source and accelerates the ions. An ion detector includes an input in a flight path of the accelerated ions emerging from the field-free drift space and an output that is electrically connected to the sample plate. The ion detector converts the detected ions into a pulse of electrons.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: May 27, 2014
    Assignee: Virgin Instruments Corporation
    Inventor: Marvin L. Vestal
  • Publication number: 20140138538
    Abstract: A distance-of-flight mass spectrometer (DOFMS) includes an ion source, a field-free region, an extraction region in which ions are accelerated, and a spatially-selective detector for spatially selectively detecting ions extracted by the extraction region. A method for operating a distance-of-flight mass spectrometer DOFMS comprises controlling a detection time in such a way as to permit ions with progressively greater mass-to-charge (m/z) ratios to enter the extraction region of the DOFMS at positions which will permit the ions with progressively greater m/z ratios to enter the detector of the DOFMS, generating a component mass spectrum at each selected value of detection time, and then assembling a composite mass spectrum by shifting the distance-of-flight axis of each component mass spectrum by a distance corresponding to the change in detection time.
    Type: Application
    Filed: April 16, 2012
    Publication date: May 22, 2014
    Applicants: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: Gary M. Hieftje, Christie George Enke, Alexander W. Graham, Steven J. Ray, Elise Dennis, Charles J. Barinaga, David W. Koppenaal
  • Patent number: 8729461
    Abstract: A mass spectrometer is disclosed comprising a first storage ion trap arranged upstream of a high performance analytical ion trap. According to an embodiment ions are simultaneously scanned from both the first and second ion trap. At any instant in time the quantity of charge present within the second ion trap is limited or restricted so that the second ion trap does not suffer from space charge saturation effects and hence the performance of the second ion trap is not degraded.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: May 20, 2014
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Jason Lee Wildgoose
  • Patent number: 8716674
    Abstract: The present invention provides a timing device, especially a timing device for use in mass spectrometers, for example TOF mass spectrometers, for processing trigger signal data containing a trigger signal indicating the occurrence of a trigger event, the timing device having: a trigger signal deserialiser configured to receive trigger signal data containing a trigger signal indicating the occurrence of a trigger event as serial data and to output the trigger signal data as parallel data, and wherein suitably the timing device has a processing means configured to process trigger signal data outputted by the trigger signal deserialiser as parallel data.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: May 6, 2014
    Assignee: Kratos Analytical Limited
    Inventor: Ian Sherwood
  • Patent number: 8716660
    Abstract: A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: May 6, 2014
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, David J. Langridge, Jason Lee Wildgoose
  • Publication number: 20140117227
    Abstract: The length of a delay time d from a suspension period starting point t1 until the application of a pulse voltage is begun is changed according to the length of the suspension period during which no data is collected at the time of m/z switching. It is thus ensured that the amount of product ions can be reliably restored at a suspension period termination point t2. In addition, the peak value of the pulse voltage is also changed according to the ionic strength immediately before entering the suspension period. The ion removal rate is thus increased when the amount of remaining ions is high, and the amount of remaining ions is reliably brought to zero within the same pulse width. As a result, crosstalk can be completely removed.
    Type: Application
    Filed: October 28, 2012
    Publication date: May 1, 2014
    Applicant: SHIMADZU CORPORATION
    Inventor: Shinjiro FUJITA
  • Patent number: 8686351
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: April 1, 2014
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Patent number: 8674291
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: March 18, 2014
    Assignee: Quest Diagnostics Investments Inc.
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Patent number: 8669520
    Abstract: An ion trap comprises a ring electrode and opposite first and second endcap electrodes situated at opposite ends of the ring electrode. A waveform generator is configured to vary both frequency and amplitude of an AC waveform applied across the first and second endcap electrodes as a function of time, thereby exciting ions with a band of resonant secular frequencies substantially without exciting ions with adjacent secular frequencies.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: March 11, 2014
    Assignee: Hamilton Sundstrand Corporation
    Inventor: Brian M. Sutin
  • Patent number: 8658972
    Abstract: An ion mobility tube comprises an ionization source chamber having a center ionization source chamber hole, an ion door, a mobility region unit having a center mobility tube chamber, a constraining grid, and a Faraday disk, and the ionization source chamber, the ion door, the mobility region unit, the constraining grid, and the Faraday disk are laminated together in sequence in a front-rear direction, wherein the mobility region unit comprises a first insulator and first metal electrode sheets concentrically fixed to a front surface and a back surface of the first insulator respectively. The mobility region unit comprises the first insulator and the first metal electrode sheets which are integral. Therefore, the ion mobility tube is advantageous in simplified manufacturing, and convenient for detachment and assembly.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: February 25, 2014
    Assignee: Nuctech Company Limited
    Inventors: Yangtian Zhang, Hua Peng, Xiuting Zhang, Xiaoyong Zheng
  • Patent number: 8653446
    Abstract: A method is provided increasing the useful dynamic range of an ion mobility spectrometry (IMS) or an IMS-mass spectrometry (IMS-MS) device. The method includes accumulating a first sample of ions over a first time interval; providing the first sample of ions to an ion detector to provide a first frame, accumulating a second sample of ions over a second time interval, where the second time interval is different than the first time interval, and providing the second sample of ions to the ion detector to provide a second frame. First data points of the first frame are selectively combined with second data points of the second frame to provide an accumulation frame of the first and second samples of ions.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: February 18, 2014
    Assignee: Agilent Technologies, Inc.
    Inventors: Alexander Mordehai, Edward Darland
  • Patent number: 8653449
    Abstract: An ion mobility spectrometer (IMS) for the detection of trace gaseous molecular compounds dissolved or suspended in a carrier gas, particularly in ambient air, without preconcentration or the trapping of analyte particles. The IMS of the invention comprises an ionization volume of greater than 5 cm3 and preferably greater than 100 cm3. The larger size ionizers of this invention enable analysis of trace (<1 ppb) of sample compounds in the gas phase. To facilitate efficient ion motion through the large volume ionization and reaction regions of the IMS, an electric field gradient can be provided in the ionization region or in both the ionization and reaction regions. The systems can be implemented with radioactive ionization sources, corona discharge ion sources or ions can be formed by photoionization.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: February 18, 2014
    Assignee: The Arizona Board of Regents on behalf of the University of Arizona
    Inventors: M. Bonner Denton, Roger P. Sperline
  • Patent number: 8637815
    Abstract: Methods and analysers useful for time of flight mass spectrometry are provided.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: January 28, 2014
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander A. Makarov, Anastassios Giannakopulos
  • Patent number: 8637816
    Abstract: A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be analyzed without significant ion loss or undue time expenditure. The collision cell may provide a large ion acceptance aperture and relatively smaller ion emission aperture. The collision cell may pulse ions out to the mass analyzer. The mass analyzer may be a time-of-flight analyzer. The timing of pulsing of ions out from the collision cell may be matched with the timing of pulsing of ions into the time-of-flight analyzer.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 28, 2014
    Assignee: Agilent Technologies, Inc.
    Inventors: Alexander Mordehai, Kenneth R. Newton
  • Patent number: 8637809
    Abstract: All data obtained from an A/D converter during a summation period with values exceeding a prescribed threshold is excluded from summation up to a prescribed maximum number of deletions, and the values of the remaining data are summed to find one piece of measurement data corresponding to that summation period. The number of pieces of noise data reflecting the influx of particles that cause spike-like noise is extremely small, so noise data is removed in a state in which there are no signals and no target ions are present. When target ions are present, legitimate data which is not noise data may be removed, but the number of pieces of removed data is small in comparison to the total number of pieces of data, so the effects of the removal of legitimate data essentially do not emerge in the summation results. It is therefore possible to effectively reduce spike-like noise.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: January 28, 2014
    Assignee: Shimadzu Corporation
    Inventor: Shigetoshi Harada
  • Patent number: 8633436
    Abstract: Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement a combination of drift-type ion mobility (IM) separation and time-of-flight mass spectrometry (TOF MS). Both separation techniques are carried out in tandem while applying mass filtering with a wide window of ion isolation. One mode of operation entails utilizing a mass filter to limit ion packets to ions in a selected m/z range that remains constant over the entire course of data acquisition. Another mode entails utilizing the mass filter to limit ion packets to an m/z range that varies over the course of data acquisition.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: January 21, 2014
    Assignee: Agilent Technologies, Inc.
    Inventor: Michael Ugarov
  • Patent number: 8618475
    Abstract: An ion mobility spectrometer comprises a drift tube defining a drift tube inlet configured to receive ions and a drift tube outlet. The drift tube is configured to separate ions in time as a function of ion mobility. The drift tube defines a first ion activation region between the drift tube inlet and the drift tube outlet. The first ion activation region is configured to selectively induce structural changes in at least some of the ions.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: December 31, 2013
    Assignee: Indiana University Research and Technology Corporation
    Inventors: David E. Clemmer, Stormy L. Koeniger, Stephen J. Valentine
  • Patent number: 8610058
    Abstract: Silver nanoparticles as a sample matrix for Matrix Assisted Laser Desorption Ionization (MALDI) along with a novel method for nanoparticle development is described herein. The silver nanoparticles were generated from silver ions on the surface of a MALDI plate utilizing a Soft Landing Ion Mobility (SLIM) instrument. Upon interaction with the surface the incident silver ions were labile and aggregated into the nanoparticle structures in a time dependent fashion. Post landing analysis were completed by Time of Flight mass spectrometry (TOF), and of particular interest in the spectra were the elimination of low mass interference peaks that generally plague organic based matrices. The approach of the present invention significantly decreases sample preparation time and may lead to a preparation free MALDI source by soft landing a matrix directly on the sample surface.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: December 17, 2013
    Assignee: University of North Texas
    Inventors: Guido Fridolin Verbeck, IV, Stephen Davila
  • Patent number: 8612162
    Abstract: A method creates an accurate mass spectrum with a high resolving power based on a plurality of TOF spectra, while reducing the computation to assure real-time processing. TOF spectra are measured when ions are ejected from the loop orbit. Then a coincidence detection method determines what mass-to-charge ratio a peak appearing on the TOF spectra originates from. The time range in which a corresponding peak appears on other TOF spectra is set, and the existence of the peak in that range is determined. When the corresponding peak is found on other TOF spectra, the m/z is deduced from the peak on the TOF spectrum with the highest resolving power and a mass spectrum is created. From the peak density around the peak of interest, the reliability of the deduction is computed. For a low reliability peak, the ion ejection time is optimized and the TOF spectrum is measured again.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: December 17, 2013
    Assignee: Shimadzu Corporation
    Inventors: Osamu Furuhashi, Kiyoshi Ogawa, Shigeki Kajihara, Tohru Kinugawa
  • Publication number: 20130327936
    Abstract: Microchips which are particularly suitable for use with a mass spectrometer include a microchip body with at least one fluid channel formed into the microchip body and at least two flat monolithic closely spaced integrated ESI (electrospray ionization) emitters defined by shaped projections formed to extend from one side of the microchip body, a respective one being in fluid communication with a fluid channel. Related systems and methods are also described.
    Type: Application
    Filed: March 5, 2012
    Publication date: December 12, 2013
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Andrew Chambers
  • Patent number: 8604422
    Abstract: The subject of the invention is a method for identification of analytes with an ion mobility spectrometer by performing a series of measurements while varying the residence time of the analytes in the reaction space and identifying of monomer and nascent dimer analytes in the spectra so obtained.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: December 10, 2013
    Assignee: Dragerwork AG & Co. KGaA
    Inventors: Wolfgang Bather, Frank Gunzer
  • Patent number: 8598516
    Abstract: The present invention relates to the analytical electronics used to identify compositions and structures of substances, in particular, to the analyzers comprising at least one mass-spectrometer (MS) and may be applied in such fields as medicine, biology, gas and oil industry, metallurgy, energy, geochemistry, hydrology, ecology. Technical result provides the increase in MS resolution, gain in sensitivity, precision and measurement rates of substances compositions and structures concurrently with enhancement of analyzer functional capabilities, downsizing and mass reduction. In claimed invention the ion flux generation and its guiding are performed in off-axis single-flow mode; parallel multi-stage mode; through use of three-dimensional field with mean meridian surface including without limitation three-dimensional reflecting and dual-zoned reflecting modes or by method of multi-reflection arrays. Devices to implement the claimed method are embodied.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: December 3, 2013
    Inventors: Yerbol Aldanovich Sapargaliyev, Aldan Asanovich Sapargaliyev
  • Patent number: 8592756
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: November 26, 2013
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Patent number: 8592751
    Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: November 26, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Raanan A. Miller, Erkinjon G. Nazarov, Lawrence A. Kaufman, Gary A. Eiceman
  • Patent number: 8590791
    Abstract: A test swipe for testing drugs, explosives or a chemical compound includes a base; and one or more swipe pads positioned on the base to receive one or more chemicals thereon, the one or more swipe pads displaying an array of colors after receiving the chemicals to uniquely identify a chemical compound.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: November 26, 2013
    Assignee: Chemspectra, Inc.
    Inventors: Jeffrey Haas, Douglas Haas
  • Patent number: 8581185
    Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: November 12, 2013
    Assignee: Thermo Finnigan LLC
    Inventors: Alexander A. Makarov, Eduard V. Denisov, Alexander Kholomeev
  • Patent number: 8581179
    Abstract: In a mass spectrometer, sample ions are produced by using matrix assisted laser desorption with a matrix substance that supports spontaneous, non-ergodic ISD fragmentation and a laser light source with nanosecond light pulses and a multiple spot beam profile. A plurality of individual time-of-flight spectra are recorded from the resulting ions in such a way that amplification of ion signals in the mass spectrometer detector is initially reduced so that only ions with masses near a mass range limit are initially recorded. During the repeated acquisitions of the individual time-of-flight spectra, both the detector amplification and the mass range limit are increased. By these methods, it is possible to evaluate c and z fragment ions in lower mass ranges and to directly read N-terminal sequences from near terminus up to 80 amino acids and beyond, and C-terminal sequences up to more than 60 amino acids.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: November 12, 2013
    Assignee: Bruker Daltonik GmbH
    Inventor: Jochen Franzen
  • Patent number: 8581178
    Abstract: The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using a mass analyzer in combination with a differential mobility spectrometer to enhance the analysis process of constituents of a sample.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: November 12, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Raanan A. Miller, Erkinjon G. Nazarov, Paul Vouros, Daren Levin
  • Patent number: 8575544
    Abstract: An atom probe includes a detector which registers the time of flight of ions evaporated from a specimen, as well as the positions on the detector at which the ions impact and the kinetic energies of the ions. The detected position allows the original locations of the ions on the specimen to be mapped, and the times of flight and kinetic energies can be spectrally analyzed (e.g., binned into sets of like values) to determine the elemental identities of the ions. The use of kinetic energy data as well as time of flight data can allow more accurate identification of composition than where time of flight data are used alone, as in traditional atom probes.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: November 5, 2013
    Assignee: Cameca Instruments, Inc.
    Inventors: Thomas F. Kelly, Daniel R. Lenz, Scott A. Wiener
  • Patent number: 8563322
    Abstract: A method for separating molecules, such as enantiomers, other stereoisomers and constitutional isomers by ion mobility spectrometry (IMS). Molecules of interest are ionised after addition of a suitable chiral reference compound, resulting in the formation of cluster ions that can be separated by IMS techniques such as ion drift mobility (IDM) spectrometry or FAIMS. This method allows, for example, for fast and sensitive quantification of one enantiomer in presence of an excess of the other enantiomer.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: October 22, 2013
    Inventors: Axel Mie, Curt Reimann, Magnus Jornten-Karlsson, Bengt-Olof Axelsson
  • Patent number: 8563923
    Abstract: An orthogonal acceleration time-of-flight mass spectrometer has: an ion source for ionizing a sample; a conductive box into which the ions are introduced; ion acceleration device causing the ions to be accelerated in a pulsed manner in synchronism with a signal giving a starting point of measurement; and ion detector for detecting the ions in synchronism with the acceleration of the ions. The conductive box is provided with an ion injection port and an ion exit port. A lift voltage is applied to the conductive box. This voltage is switched in synchronism with the signal giving the starting point of the measurement.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: October 22, 2013
    Assignee: JEOL Ltd.
    Inventor: Takaya Satoh
  • Patent number: 8546751
    Abstract: In a tandem mass spectrometer with mass selector spatially separated from a mass analyzer, ions are fragmented in a three-dimensional RF by electron transfer dissociation. The fragment ions are then extracted from the 3D ion trap and introduced into the mass analyzer. The extraction is accomplished by providing, in one of the ion trap end cap electrodes, an aperture with a relatively large area covered by a conductive mesh or formed by closely spaced smaller apertures. The fragment ions are extracted from the RF ion trap by applying a DC voltage to one of the end cap electrodes.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: October 1, 2013
    Assignee: Bruker Daltonik GmbH
    Inventor: Jochen Franzen
  • Patent number: 8530831
    Abstract: An algorithm-based system and method for tandem mass spectrometry data acquisition in which multiple precursor ion attributes, such as mass, intensity, mass-to-charge ratio and charge state, as well as results from previously performed mass spectrometry scans, are used to determine the likelihood of identification for each precursor ion. This information is then used to prioritize subsequent tandem mass spectrometry events, such as which precursor ions are to be fragmented and undergo further mass spectrometry analysis. By interrogating precursor ions in order of probability of successful identification, an increase in identified proteins and peptides is achieved.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: September 10, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Joshua Coon, Douglas Phanstiel, Graeme McAlister
  • Patent number: 8525111
    Abstract: Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: September 3, 2013
    Assignee: 908 Devices Inc.
    Inventors: Christopher D. Brown, Michael Jobin, Kevin J. Knopp, Evgeny Krylov, Scott Miller
  • Patent number: 8519327
    Abstract: In an ion detector, power supplies (21 through 23) generating independently controllable voltages are provided to respectively apply voltages to first to fifth dynodes (11 through 15), a final dynode (16), and an anode (17) in a secondary electron multiplier (10). Furthermore, the signal from the anode (17) is extracted, and the signal from the fifth dynode (15), which has a low electron multiplication rate, is extracted. These two signals are concurrently converted into digital values, taken in by a data processing unit (34), and stored in a data storage unit (35). When a mass spectrum is created in the data processing unit (34), the two detected data for the same time are read out and the presence or absence of signal saturation or waveform deformation is determined from the values of one of the detection data. If there is a high probability of signal saturation, the detection data based on the signals in the intermediate stages are selected, and the level of the selected data is corrected.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: August 27, 2013
    Assignee: Shimadzu Corporation
    Inventor: Hideaki Izumi
  • Patent number: 8513593
    Abstract: In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: August 20, 2013
    Assignee: Agilent Technologies, Inc.
    Inventors: Bruce D. Quimby, Michael J. Szelewski, Michael K. Freed, Harry F. Prest
  • Patent number: 8514398
    Abstract: Techniques, apparatus, material and systems are described for implementing a three-dimensional composite mushroom-like metallodielectric nanostructure. In one aspect, a surface plasmon based sensing device includes a substrate and a layer of an anti-reflective coating over the substrate. The surface Plasmon based sensing device includes a dielectric material on the anti-reflective coating shaped to form a 2-dimensional array of nanoholes spaced from one another. Also, the surface Plasmon based sensing device includes a layer of a metallic film formed on the 2-dimensional array of nanoholes to include openings over the nanoholes, respectively, wherein the sensing device is structured to support both propagating surface plasmon polariton (SPP) waves and localized surface plasmon resonant (LSPR) modes.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: August 20, 2013
    Assignee: The Regents of the University of California
    Inventors: Lin Pang, Haiping Matthew Chen, Yeshaiahu Fainman
  • Patent number: 8507848
    Abstract: This invention presents a kind of ion guide device comprising multiple layers of stretched wire electrodes crossing in space. These wire electrodes are distributed along a defined ion guiding axis in the ion guide device. Each layer of wire electrodes contains at least two wire electrodes with some distance away from the guiding axis, and rotates with an angle relative to wire electrodes on neighboring layer. The ion guide contains multiple layers of wire electrodes to form a cage-like ion guide tunnel and keeps the mounting framework of those wire electrodes outside of the ion guide tunnel, thus reducing the interference of the gas flows from the ion guide device. A power supply provides voltage to each layer of wire electrodes, creates an electric field which focuses the ions towards the guiding axis.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: August 13, 2013
    Assignees: Shimadzu Research Laboratory (Shanghai) Co. Ltd., Shimadzu Corporation
    Inventors: Li Ding, Gongyu Jiang, Wenjian Sun
  • Patent number: 8508729
    Abstract: Apparatus for performing Raman analysis may include a laser source module, a beam delivery and signal collection module, a spectrum analysis module, and a digital signal processing module. The laser source module delivers a laser beam to the beam delivery and signal collection module. The beam delivery and signal collection module delivers the laser source beam to a sample, collects Raman scattered light scattered from the sample, and delivers the collected Raman scattered light to the spectrum analysis module. The spectrum analysis module demultiplexes the Raman scattered light into discrete Raman bands of interest, detects the presence of signal energy in each of the Raman bands, and produces a digital signal that is representative of the signal energy present in each of the Raman bands. The digital signal processing module is adapted to perform a Raman analysis of the sample.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: August 13, 2013
    Assignee: PD-LD, Inc.
    Inventors: Vladimir Sinisa Ban, Boris Leonidovich Volodin, Neal R. Stoker
  • Patent number: 8502138
    Abstract: An ion mobility spectrometer includes a plurality of substrates defining a measurement region for receiving a singular laminar gas flow without any carrier or sheath gas. The measurement region includes an ionization region that is continuous with a detection region. An ionizing electrode, which may include a plurality of asymmetric electrodes, produces ions in the gas sample within the ionization region. The ionizing electrode may apply a time varying voltage to the gas sample to generate a time dependent ion production. A field generating electrode generates an electric field to deflect the ions in the gas sample, and a detection electrode array detects the deflected ions within the detection region. A controller is configured to determine ion species based on the detection of ions by the detection electrode array.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: August 6, 2013
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Sinead Marie Matthews, Lesley Anne Parry-Jones, Allan Evans
  • Publication number: 20130187041
    Abstract: A charged particle spectrum analysis apparatus comprising an electric field generator arranged to subject charged particles to a time-varying electric field, a detector to record charged particle time spectrum data of charged particles which have passed through the electric field, the detector comprising a position-sensitive detection portion, and the time-varying electric field arranged to be activated in synchrony with activation of detector, and the time-varying electric field arranged to subject a predetermined region of said detection portion to consecutive charged particle deflection cycles.
    Type: Application
    Filed: July 20, 2011
    Publication date: July 25, 2013
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Mark Brouard, Claire Vallance, Andrei Nomerotski