Ion Beam Pulsing Means With Detector Synchronizing Means Patents (Class 250/286)
  • Patent number: 7932491
    Abstract: A mass spectrometer includes a pulsed ion source that generates an ion beam comprising a plurality of ions. A first timed ion selector passes a first group of ions. A first ion mirror generates a reflected ion beam comprising the first group of ions that at least partially compensates for an initial kinetic energy distribution of the first group of ions. A second timed ion selector passes a second group of ions. A second ion mirror generates a reflected ion beam comprising the second group of ions that at least partially compensates for an initial kinetic energy distribution of the second group of ions. A timed ion deflector deflects the second group of ions to a detector assembly comprising at least two ion detectors which detects the deflected ion beam.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: April 26, 2011
    Assignee: Virgin Instruments Corporation
    Inventor: Marvin L. Vestal
  • Publication number: 20110068264
    Abstract: An ion mobility sensor system including an ion mobility spectrometer and a differential mobility spectrometer coupled to the ion mobility spectrometer. The ion mobility spectrometer has a first chamber having first end and a second end extending along a first direction, and a first electrode system that generates a constant electric field parallel to the first direction. The differential mobility spectrometer includes a second chamber having a third end and a fourth end configured such that a fluid may flow in a second direction from the third end to the fourth end, and a second electrode system that generates an asymmetric electric field within an interior of the second chamber. Additionally, the ion mobility spectrometer and the differential mobility spectrometer form an interface region. Also, the first end and the third end are positioned facing one another so that the constant electric field enters the third end and overlaps the fluid flowing in the second direction.
    Type: Application
    Filed: September 23, 2009
    Publication date: March 24, 2011
    Inventors: Jun Xu, David B. Watson, William B. Whitten
  • Patent number: 7910879
    Abstract: A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: March 22, 2011
    Assignee: JEOL Ltd.
    Inventors: Takaya Sato, Michisato Toyoda, Morio Ishihara
  • Patent number: 7906759
    Abstract: An inexpensive mass spectrometer system is provided. This mass spectrometer is capable obtaining structural information of a substance at an improved efficiency, and the time required for the analysis and identification of the substance has been reduced. Identification precision has also been improved. More specifically, this invention provides a tandem mass spectrometer system in which the sample is ionized at the desired polarity, fragment ions obtained by dissociating the ion is analyzed in first or second mass spectrometer section, polarity of the second mass spectrometer is determined based on the result of the analysis, and the mass spectroscopy is carried out. A method for the mass spectroscopy is also provided.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: March 15, 2011
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Naomi Manri, Takashi Baba, Hiroyuki Satake
  • Patent number: 7904253
    Abstract: A method for determining elemental composition of ions from mass spectral data, comprising obtaining at least one mass measurement from mass spectral data; obtaining a search list of candidate elemental compositions whose exact masses fall within a given mass tolerance range from the accurate mass; reporting a probability measure based on a mass error; calculating an isotope pattern for each candidate elemental composition from the search list; constructing a peak component matrix including at least one of the isotope pattern and mass spectral data; performing a regression against at least one of isotope pattern, mass spectral data, and the peak component matrix; reporting a second probability measure for at least one candidate elemental composition based on the isotope pattern regression; and combining the two the probability measures into an overall probability measure. A method for determining elemental isotope ratios from mass spectral data.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: March 8, 2011
    Assignee: Cerno Bioscience LLC
    Inventors: Yongdong Wang, Ming Gu
  • Publication number: 20110049346
    Abstract: In a mass spectrometer, a dual stage axial extraction field is applied to transport ions from an accumulator with a shutter and an ion guide to a detector cell. Ions of the same mass may be transported to the detector cell or a point axially preceding the detector cell at the same time by selecting the relative strengths of a first axial electric field applied to the accumulator and a second axial electric field applied to the shutter and further by selecting relative axial lengths of the accumulator, shutter, and an ion guide. A dual stage decelerating field may also be applied to slow ion down prior to and after entering the detector cell.
    Type: Application
    Filed: August 25, 2009
    Publication date: March 3, 2011
    Inventor: Gregory J. Wells
  • Publication number: 20110042561
    Abstract: The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification.
    Type: Application
    Filed: November 4, 2010
    Publication date: February 24, 2011
    Applicant: DH Technologies Development PTE. LTD.
    Inventors: Raanan A. Miller, Erkinjon G. Nazarov, Lawrence A. Kaufman, Gary A. Eiceman
  • Publication number: 20110042563
    Abstract: A device 6 for separating ions according to differences in their ion mobility as a function of electric field strength is disclosed. The device 6 comprises an upper electrode 7a, a lower electrode 7b and a plurality of intermediate electrodes 8. An asymmetric voltage waveform is applied to the upper electrode 7a and a DC compensating voltage is applied to the lower electrode 7b.
    Type: Application
    Filed: November 2, 2010
    Publication date: February 24, 2011
    Applicant: MICROMASS UK LIMITED
    Inventor: Kevin Giles
  • Patent number: 7888636
    Abstract: Techniques for measuring energy contamination using time-of-flight (TOF) sensor are disclosed. In one particular exemplary embodiment, the techniques may be realized as a method for detecting energy contamination in an ion beam using time-of-flight comprising directing an ion beam towards an entrance of a sensor, wherein the ion beam may include charged particles and neutral particles, blocking the ion beam periodically from entering the sensor and allowing a pulse of the ion beam to enter the sensor periodically using a gate mechanism, separating the charged particles and the neutral particles of the ion beam pulse based at least in part upon different transit times over a distance caused by variations in at least one of mass and energy associated with the charged particles and the neutral particles, and detecting at least one of the charged particles and the neutral particles separately at a detector based at least in part upon the different transit times.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: February 15, 2011
    Assignee: Varian Semiconductor Equipment Associates, Inc.
    Inventors: Bon Woong Koo, Jonathan Gerald England
  • Publication number: 20110031393
    Abstract: The invention relates to a multi-sensor laser system for the selective trace analysis of organic material, the multi-sensor system having at least one laser ion mobility spectrometer, an absorption spectrometer and a fluorescent measuring device. The system is characterized in that it is equipped with a device for the simultaneous generation of a common laser beam with different wavelengths and pulses for the simultaneous operation of the laser ion mobility spectrometer, the absorption spectrometer and the fluorescent measuring device. This avoids the disadvantages of the known solutions in prior art and provides an improved solution for the highly sensitive and highly selective trace analysis of organic material, in particular hazardous substances such as explosives and warfare agents in the air.
    Type: Application
    Filed: November 20, 2008
    Publication date: February 10, 2011
    Applicant: EADS Deutschland GmbH
    Inventors: Johann Goebel, Peter Peuser
  • Patent number: 7880137
    Abstract: Apparatuses and method are provided. For example, in one embodiment, a ring electrode includes a plurality of sub-rings adapted to provide an electric field inside a spectrometer. The sub-rings have an internal sub-ring radius. There is a ring insulator between adjacent sub-rings. Each said ring insulator has substantially the same internal radius as the sub-rings. In another embodiment, a method is provided for insertion of the ring electrode inside the spectrometer.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: February 1, 2011
    Assignee: Morpho Detection, Inc.
    Inventors: William J. McGann, Stephen L. Crook
  • Publication number: 20110017907
    Abstract: The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof.
    Type: Application
    Filed: December 22, 2008
    Publication date: January 27, 2011
    Inventors: Alexander A. Makarov, Dmitry E. Grinfield, Mikhail A. Monastyrskiy
  • Publication number: 20110015875
    Abstract: The concept underlying the invention is the development of a generic method for the detection and identification of gases in airplane interior spaces and an associated device, which is small and manageable, has a simple design, and allows the immediate and simultaneous detection and identification of the gases to be examined. This is achieved in that the supply air of the airplane interior space (20) is fed to a measuring device (1) and the measurement results of the measuring device (1) are analyzed by means of mathematical methods. Such methods and the associated devices for the detection and identification of gases in airplane interior spaces are used in order to spot and verify gases, particularly odors and explosive gases and/or gases harmful to people's health.
    Type: Application
    Filed: March 10, 2008
    Publication date: January 20, 2011
    Applicant: AIRSENSE ANALYTICS GMBH
    Inventors: Andreas Walte, Wolf Münchmeyer, Mario Schmidt
  • Publication number: 20110011158
    Abstract: Chemical sampling systems and methods that can inexpensively and efficiently provide accurate chemical sampling in dusty environments are disclosed. The system can include a chemical detector, an elastomeric membrane, and a support structure for the elastomeric membrane. The gas chromatograph can have a sample inlet through which chemicals from the gaseous environment can enter the gas chromatograph. The sample inlet can be covered with the elastomeric membrane, the elastomeric membrane being configured to extract chemicals from the gaseous environment while excluding dust and other particles from passing into the gas chromatograph. The support structure can be disposed between the elastomeric membrane and the sample inlet and can provide mechanical support to the elastomeric membrane.
    Type: Application
    Filed: July 16, 2009
    Publication date: January 20, 2011
    Applicant: Seer Technology, Inc.
    Inventors: Gary R. Bodily, Neil Arnold, Jed W. Bodily, Daniel C. Maxwell
  • Patent number: 7872226
    Abstract: In a time-of-flight mass spectrometer having an ion source with a first accelerating electrode, a distance between the surface of a sample and the first accelerating electrode is maintained at a predetermined distance which is critical for determining the mass and quantity of ions generated by the ion source. A digital image of the sample surface is obtained with a digital camera and a predetermined characteristic of the digital image is determined. The predetermined characteristic is then used to compute an adjustment amount by which the sample surface is moved to maintain the predetermined distance. Determining the predetermined characteristic can be simplified by projecting a light pattern onto the sample surface at an angle and determining the predetermined characteristic from the digital image of the pattern.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: January 18, 2011
    Assignee: Bruker Daltonik GmbH
    Inventors: Jens Höhndorf, Andreas Haase
  • Publication number: 20110001045
    Abstract: A substance detection device, including a chemical substance analyzer, including an ion mobility spectrometer (IMS), a desorber, a conduit, and a membrane. The membrane extends across a cross-section of the conduit, and the membrane is positioned to have a desorber side in gas communication with the desorber and an analysis side opposite the desorber side. The substance detection device can be configured to direct a portion of a chemical substance to the desorber through the conduit so that at least a portion of the entrained chemical substance is transferred to the membrane by interacting with the desorber side of the membrane. The membrane is adapted to diffuse at least a portion of the chemical substance transferred to the membrane through the membrane to the analysis side. The device also includes a particle separator including a protuberance extending into a collection chamber of the particle separator.
    Type: Application
    Filed: December 11, 2008
    Publication date: January 6, 2011
    Inventor: Stephen Richardson
  • Patent number: 7858931
    Abstract: A method for the mass-selective transport of ions, especially in a mass spectrometer, comprises the steps movement of the ions on a movement path on which a plurality of electrodes are arranged, and loading the electrodes with pulse-shaped acceleration voltages under the effect of which the ions experience a mass-dependent change of speed, wherein the electrodes are loaded with the pulse-shaped acceleration voltages such t at target ions with a pre-determined target mass are accelerated along the movement path Furthermore, an ion conductor for mass-selective transport of ions, especially in a mass spectrometer, is described.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: December 28, 2010
    Assignee: GeoForschungsZentrum Potsdam Stiftung des Offentlichen Rechts
    Inventor: Michael Wiedenbeck
  • Patent number: 7858930
    Abstract: Disclosed are ion cyclotron resonance (ICR) cells and other ion-trapping cells with plural groups of multiple trapping electrodes for shaping (e.g., flattening) the radial electric field within the ICR cell. Also disclosed are methods for controlling the electric field to diminish effects of de-phasing. The diminished effects are achieved by decreasing space-charge contributions by increasing the length of the ion-oscillation path along the z-axis of the ICR cell. The methods and devices enhance the time-domain signal of a Fourier-transform ion-cyclotron resonance mass spectrometer (FTICR-MS) and provide enhanced resolution and accuracy of mass measurements.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: December 28, 2010
    Assignee: Washington State University
    Inventors: Nathan K. Kaiser, James E. Bruce
  • Patent number: 7858387
    Abstract: A method of scanning a sample plate surface mask in an area adjacent to a conductive area using mass spectrometry is disclosed. The method comprises the steps of providing a sample plate including a mask applied with a rough surface to the electrically conductive surface to produce a sample site comprising a central portion formed from the electrically conductive surface and a marginal portion of the mask, preparing an analyte comprising mixing a biomolecule with an organic solvent, an aqueous solution, and a matrix selected from the group of ?-cyano-4-hydroxycinnamic acid and3,5-dimethoxy-4-hydroxycinnamic acid; applying the analyte to the sample site; forming at least one crystal of the analyte in an area on the mask adjacent to the conductive area, and scanning the area on the mask adjacent to the conductive area with a laser beam.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: December 28, 2010
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Joseph L. DiCesare
  • Publication number: 20100319463
    Abstract: A substance detection device including a chemical substance analyzer, including, a conduit, and a membrane, wherein the membrane extends across a cross-section of the conduit, wherein the membrane is positioned to have one side and an analysis side opposite the one side, wherein the substance detection device is adapted to direct a portion of a chemical substance to the one side through the conduit, the substance detection device further including a particle separation apparatus, including a particle collection device having a collection chamber containing a first fluid and including an outlet, wherein the outlet is in fluid communication with the conduit such that particles directed through the outlet travel through the conduit and chemical substances which may be on those particles directed through the outlet are transferred to the membrane by interacting with the one side of the membrane.
    Type: Application
    Filed: December 11, 2008
    Publication date: December 23, 2010
    Inventor: Stephen Richardson
  • Patent number: 7851746
    Abstract: The invention relates to determining the masses from the time-of-flight values of ions in time-of-flight mass spectrometers where the accelerating voltage for the ions is not applied permanently, but is switched on at a certain time, resulting in a temporally changing acceleration for a short time after the voltage has been switched on. An aspect of the invention includes formally describing the effect of the temporally changing acceleration on the calibration curve—an effect which cannot be subjected to a strict mathematical-analytical calculation—by introducing a “reduced mass” m?m0 instead of the mass m. The mass reduction factor m0 does not describe a real mass difference, but a mass-dependent shortfall in the final kinetic energy after the ions have passed through the acceleration, a shortfall which can be observed with the temporally changing acceleration.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: December 14, 2010
    Assignee: Bruker Daltonik GmbH
    Inventor: Andreas Brekenfeld
  • Patent number: 7851745
    Abstract: A high field asymmetric waveform ion mobility spectrometer (FAIMS) includes at least two focusing electrodes that are separated one from the other by a gap, which decreases in width along a direction of ion flow. Within the gap is disposed an electrode assembly including a first electrode and a second electrode, approximately flat surfaces of the first and second electrodes facing one another so as to define a space of approximately uniform thicknesses therebetween. During use electrical signals are applied via an electrical contact on at least one of the first electrode and the second electrode, and on each one of the at least two focusing electrodes. The electrical signals are for establishing electrode electric field conditions within the space between the first electrode and the second, for selectively transmitting ions therethrough and for directing the selectively transmitted ions in a direction away from one of the at least two focusing electrodes and toward a central portion of the space.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: December 14, 2010
    Assignee: Thermo Finnigan LLC
    Inventors: Michael W. Belford, Viatcheslav V. Kovtoun
  • Patent number: 7851744
    Abstract: A Matrix Assisted Laser Desorption Ionization ion source or ion imaging device is disclosed comprising a laser (1) and a zoom lens (3, 4, 5). The zoom lens (3, 4, 5) is arranged to be able to vary the magnification of a laser beam which is directed onto a target region, sample surface or target plate (13) of the ion source or ion imaging device.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: December 14, 2010
    Assignee: Micromass UK LImited
    Inventors: Jeffery Mark Brown, Daniel James Kenny
  • Patent number: 7851751
    Abstract: A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: December 14, 2010
    Assignee: Micromass UH Limited
    Inventor: Robert Harold Bateman
  • Patent number: 7838823
    Abstract: An ion mobility spectrometer does not require a physical aperture grid to prevent premature ion detector response. The last electrodes adjacent to the ion collector (typically the last four or five) have an electrode pitch that is less than the width of the ion swarm and each of the adjacent electrodes is connected to a source of free charge, thereby providing a virtual aperture grid at the end of the drift region that shields the ion collector from the mirror current of the approaching ion swarm. The virtual aperture grid is less complex in assembly and function and is less sensitive to vibrations than the physical aperture grid.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: November 23, 2010
    Assignee: Sandia Corporation
    Inventors: Kent B. Pfeifer, Arthur N. Rumpf
  • Patent number: 7829849
    Abstract: A device (6) for separating ions according to differences in their ion mobility as a function of electric field strength is disclosed. The device (6) comprises an upper electrode (7a), a lower electrode (7b) and a plurality of intermediate electrodes (8). An asymmetric voltage waveform is applied to the upper electrode (7a) and a DC compensating voltage is applied to the lower electrode (7b).
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: November 9, 2010
    Assignee: Micromass UK Ltd.
    Inventor: Kevin Giles
  • Patent number: 7820965
    Abstract: An apparatus for detecting chemical substances which is high in sensitivity and selectivity is provided. An organic acid or an organic acid salt is used to generate an organic acid gas from an organic acid gas generator 3 to be mixed with a sample gas for introduction into an ion source 4 for ionization, thereby obtaining a mass spectrum by a mass analysis region 5. A data processor 6 determines the detection or non-detection of a specific m/z of an organic acid adduct ion obtained by adding a molecule generated from the organic acid to a molecule with specific m/z generated from a target chemical substance to be detected based on the obtained mass spectrum. When there is an ion peak with the m/z of the organic acid adduct ion, the presence of the target chemical substance to be detected is determined, and an alarm is sounded. False detection can be prevented.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: October 26, 2010
    Assignee: Hitachi, Ltd.
    Inventors: Hisashi Nagano, Izumi Waki, Yasuaki Takada
  • Patent number: 7820980
    Abstract: The present invention combines ionization modes produced by, for example, electrospray (ESI), atmospheric pressure chemical ionization (APCI), and thermospray for analysis of molecules. Specifically, this invention relates to the creation of a new source apparatus combining APCI and ESI which will interface with existing mass spectrometers, as well as the creation of new mass spectrometers where the present invention would be the ionization source.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: October 26, 2010
    Assignee: Waters Technologies Corporation
    Inventor: Michael P. Balogh
  • Publication number: 20100252728
    Abstract: A mass spectrogram employs a set of controllable electrodes to produce a time varying axially inhomogenous electric field and enhance separation of charged particles by exposing the charged particles to different electric field strengths based on their spatial positions. The fields may be tailored to provide a traveling wave that expands portions of a spectrographic plot of the particles and/or to provide focusing or other effects.
    Type: Application
    Filed: April 7, 2009
    Publication date: October 7, 2010
    Inventors: Thomas R. Mackie, Adam A. Hecht, Joseph J. Bisognano
  • Patent number: 7807964
    Abstract: An ion mobility spectrometer and method thereof are disclosed. The ion mobility spectrometer comprises an electrode and an ion source arranged adjacent to the electrode, wherein the ion mobility spectrometer further comprises: a single or a group of focusing guide electrodes arranged on the side of the ion source far away from the electrode and shaped as a funnel to output ions from the ion source; and a storage section arranged on the ion-outputting side of the focusing guide electrode for storing ions generated from the ion source. With the scheme of separating the ion source and the storage region, the present invention can facilitate exchange of different ion sources, so that a source can be replaced with another different source without any change in the subsequent configuration. The storage section can be made very thin in the direction of ion movement, its diameter can be very large, and the internal electric field is almost zero.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: October 5, 2010
    Assignees: Nuctech Company Limited, Tsinghua University
    Inventors: Yuanjing Li, Zhiqiang Chen, Qingjun Zhang, Hua Peng
  • Publication number: 20100237237
    Abstract: A mass spectrometer is disclosed comprising a first storage ion trap (2) arranged upstream of a high performance analytical ion trap (3). According to an embodiment ions are simultaneously scanned from both the first and second ion trap (2, 3). At any instant in time the quantity of charge present within the second ion trap (3) is limited or restricted so that the second ion trap (3) does not suffer from space charge saturation effects and hence the performance of the second ion trap (3) is not degraded.
    Type: Application
    Filed: September 3, 2008
    Publication date: September 23, 2010
    Applicant: MICROMASS UK LIMITED
    Inventors: Martin Raymond Green, Jason Lee Wildgoose
  • Patent number: 7800054
    Abstract: Time-of-flight mass spectrometer instruments are disclosed for monitoring fast processes with large dynamic range using a multi-threshold TDC data acquisition method or a threshold ADC data acquisition method. Embodiments using a combination of both methods are also disclosed.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: September 21, 2010
    Assignee: Ionwerks, Inc.
    Inventors: Katrin Fuhrer, Marc Gonin, Thomas F. Egan, William Burton, J. Albert Schultz, Valerie E. Vaughn, Steven R. Ulrich
  • Patent number: 7800055
    Abstract: LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: September 21, 2010
    Assignee: Waters Technologies Corporation
    Inventors: Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li, Marc Victor Gorenstein
  • Patent number: 7781730
    Abstract: Time-of-flight mass spectrometer comprising a first drift region and a second drift region enclosed within an evacuation chamber; a means of introducing an analyte of interest into the first drift region; a pulsed ionization source which produces molecular ions from said analyte of interest; a first foil positioned between the first drift region and the second drift region, which dissociates said molecular ions into constituent atomic ions and emits secondary electrons; an electrode which produces secondary electrons upon contact with a constituent atomic ion in second drift region; a stop detector comprising a first ion detection region and a second ion detection region; and a timing means connected to the pulsed ionization source, to the first ion detection region, and to the second ion detection region.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: August 24, 2010
    Assignee: Los Alamos National Security, LLC
    Inventor: Herbert O. Funsten
  • Patent number: 7781728
    Abstract: A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: August 24, 2010
    Assignee: Thermo Finnigan LLC
    Inventors: Michael W. Senko, Viatcheslav V. Kovtoun, Paul R. Atherton, Jean Jacques Dunyach, Eloy R. Wouters, Maurizio Splendore, William Siebert
  • Patent number: 7777181
    Abstract: The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: August 17, 2010
    Assignee: IonSense, Inc.
    Inventor: Brian D. Musselman
  • Patent number: 7777180
    Abstract: The invention includes an ion mobility spectrometer having a liquid filled drift chamber. The chamber has an ionization region partitioned from and an ion separation region by a reversible ion-migration block. An electrical field within the chamber allows ions to migrate toward the electrode collector. Passage of ions from the ionization region is triggered by reversing the block allowing ions to migrate into the ion separation region. The invention includes a method of ion mobility analysis in liquid phase. Ions are mobilized to migrate through a drift liquid and are detected at an end of a drift chamber. The invention also includes a method of generating ions in a sample. A sample containing molecules in a first solvent is introduced into a second solvent through a charged capillary where the electrically charged sample is electro-disperses to ionize the molecules.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: August 17, 2010
    Assignee: Washington State University Research Foundation
    Inventors: Herbert Henderson Hill, Jr., Maggie Tam
  • Patent number: 7772549
    Abstract: One or more methods for determination and/or deconvolution of complex mass spectra, using quadrupole ion trap mass spectrometry.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: August 10, 2010
    Assignee: University of Massachusetts
    Inventors: Richard W. Vachet, Jonathan Wilson
  • Patent number: 7755036
    Abstract: A novel instrument and method for TOF/TOF mass spectrometry is offered. A spiral trajectory time-of-flight mass spectrometer satisfies the spatial focusing conditions for the direction of flight and a direction orthogonal to the direction of flight whenever ions make a turn in the spiral trajectory. An ion gate for selecting precursor ions is placed in the spiral trajectory of the spiral trajectory time-of-flight mass spectrometer. Electric sectors are placed downstream of the ion gate.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: July 13, 2010
    Assignee: Jeol Ltd.
    Inventor: Takaya Satoh
  • Patent number: 7745780
    Abstract: A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: June 29, 2010
    Assignees: Ionwerks, Inc., Texas A&M University System
    Inventors: John A. McLean, David H. Russell, Thomas F. Egan, Michael V. Ugarov, J. Albert Schultz
  • Publication number: 20100148060
    Abstract: Aspects of the present invention are directed generally toward atom probe and three-dimensional atom probe microscopes. For example, certain aspects of the invention are directed-toward an atom probe or a three-dimensional atom probe that includes a sub-nanosecond laser to evaporate ions from a specimen under analysis and a reflectron for reflecting the ions. In further aspects of the invention, the reflectron can include a front electrode and a back electrode. At least one of the front and back electrodes can be capable of generating a curved electric field. Additionally, the front electrode and back electrodes can be configured to perform time focusing and resolve an image of a specimen.
    Type: Application
    Filed: June 16, 2006
    Publication date: June 17, 2010
    Applicant: Imago Scientific Instruments Corporation
    Inventor: Peter Panayi
  • Patent number: 7728292
    Abstract: An ion detector includes collision surfaces for converting both positively and negatively charged ions into emitted secondary electrons. Secondary electrons may be detected using an electron detector, than may, for example include an electron multiplier. Conveniently, secondary electrons (or electrons emitted by the multiplier) may be detected using an electron pulse counter.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: June 1, 2010
    Assignee: Ionics Mass Spectrometry Group Inc.
    Inventors: Charles Jolliffe, Lisa Cousins, Gholamreza Javahery
  • Patent number: 7723676
    Abstract: A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase radical species separately from the analyte ions, and mixes the gas-phase analyte ions and the radical species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase radical species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the radical species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: May 25, 2010
    Assignee: Science & Engineering Services, Inc.
    Inventors: Andrey Vilkov, Vladimir M. Doroshenko
  • Patent number: 7714279
    Abstract: In a time-of-flight mass spectrometer with orthogonal ion injection performed by a pulser to which the ions are fed by an RF ion guide, compensation is provided for mass discrimination that occurs when the ions are injected into the pulser. This is accomplished by designing at least a part of the ion guide as an ion storage device, by emptying the filled ion storage device mass-selectively in ion groups, group-by-group, and by serially feeding the ion groups to the pulser with correct timing, using the mass selectivity of the pulser filling process to compensate for the mass discrimination.
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: May 11, 2010
    Assignee: Bruker Daltonik, GmbH
    Inventor: Jochen Franzen
  • Patent number: 7714281
    Abstract: The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: May 11, 2010
    Assignee: IonSense, Inc.
    Inventor: Brian D. Musselman
  • Publication number: 20100108878
    Abstract: A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter (7), a collision cell (8), an ion mobility spectrometer or separator, an ion guide or collision cell (13) arranged downstream of the ion mobility spectrometer or separator, a second quadrupole rod set mass filter (16) and an ion detector (15).
    Type: Application
    Filed: December 7, 2005
    Publication date: May 6, 2010
    Applicant: MICROMASS UK LIMITED
    Inventors: Robert Harold Bateman, Kevin Giles
  • Patent number: 7709787
    Abstract: An apparatus and method for measuring low or trace concentrations of compounds and mixture of gases. A method and apparatus of the invention permits separating ions of different mobilities by passing them through an abrupt change or step in electric field magnitude. By using the separation method, the compounds of interest may be measured with less interference from other compounds of the gas mixture, which reduces or eliminates the need for prior separation of the components of the gas mixture. Several embodiments of the invention are described including the use of current amplifiers on one, or more, parts of the apparatus. While a single screen can provide a chamber which is divided into two regions of different electric fields, it is within the scope of the invention to include multiple screens to provide several steps in the electric field permitting it to be possible to trap and measure ions with successively higher mobilities.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: May 4, 2010
    Assignee: The United States of America as represented by the Secretary of the Department of Commerce
    Inventors: Roger G. Carter, Shane A. Beard, Debbie J. LaCroix, Randall C. Johnson
  • Publication number: 20100102220
    Abstract: A detector apparatus supplies samples of gas or vapour to an ion mobility spectrometer (1) via a tube (2). The tube is made of fluorinated ethylene propylene selected to reduce adhesion of substances of interest to the tube, which may also be heated along its length further to reduce adhesion. The tube (2) is closely spaced from the inlet orifice (10) of the spectrometer 1 and opens into an enclosure (3) housing a fan (4), which draws gas and vapour through the tube. The tube (2) may be flexible and extend for some distance to enable sampling from locations remote from the spectrometer (1).
    Type: Application
    Filed: June 13, 2008
    Publication date: April 29, 2010
    Inventor: James Andrew Breach
  • Patent number: 7705297
    Abstract: The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: April 27, 2010
    Assignee: IonSense, Inc.
    Inventor: Brian D. Musselman
  • Patent number: 7696475
    Abstract: An electrospray-assisted laser desorption ionization device includes: an electrospray unit including a nozzle; a voltage supplying member disposed to establish between the nozzle and a receiving unit a potential difference such that liquid drops of the electrospray medium formed at the nozzle are laden with charges, and such that the liquid drops are forced to leave the nozzle toward the receiving unit along a traveling path; a laser desorption unit adapted to irradiate a sample such that, upon irradiation, analytes contained in the sample are desorbed to fly along a flying path which intersects the traveling path so as to enable the analytes to be occluded in the liquid drops, and such that as a result of dwindling in size of the liquid drops when moving along the traveling path, charges of the liquid drops will pass on to the analytes occluded therein to form ionized analytes.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: April 13, 2010
    Assignee: National Sun Yat-Sen University
    Inventors: Jentaie Shiea, Min Zong Huang