Ion Beam Pulsing Means With Detector Synchronizing Means Patents (Class 250/286)
  • Patent number: 8227765
    Abstract: This invention provides a method of combining an array-type nanospray ionization source comprising a set of externally wetted proud features and a contact electrode with a pneumatic nebuliser acting to enhance the flux of sprayed ions. Methods of fabricating a substrate combining a set of proud features with analyte delivery and gas flow channels in silicon-based materials are described.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: July 24, 2012
    Assignee: Microsaic Systems PLC
    Inventor: Richard Syms
  • Patent number: 8212684
    Abstract: An electrometer for use in measuring current is provided. The electrometer includes an enclosure capable of containing various components of the electrometer. A pre-amplifier is present and is one of the components of the electrometer. The pre-amplifier is contained by the enclosure. The pre-amplifier has a pre-amplifier enclosure that contains the pre-amplifier and provides radio frequency shielding and magnetic shielding to the pre-amplifier.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: July 3, 2012
    Assignee: Savannah River Nuclear Solutions, LLC
    Inventors: Joseph V. Cordaro, Michael B. Wood
  • Publication number: 20120160998
    Abstract: A mass spectrometer having first and second mass analyzers for selecting first and second desired ions and a controller that provides control such that those of the first desired ions which have larger masses have larger kinetic energies in the direction of the optical axis in the first mass analyzer and that those of the second desired ions which have larger masses have larger kinetic energies in the direction of the optical axis in the second mass analyzer.
    Type: Application
    Filed: December 21, 2011
    Publication date: June 28, 2012
    Applicant: JEOL LTD.
    Inventor: Junkei Kou
  • Publication number: 20120145893
    Abstract: A time-of-flight mass spectrometer includes an ion source that generates ions. A two-field ion accelerator receives the ions generated by the ion source and generates an electric field that accelerates the ions through an ion flight path. A pulsed ion accelerator generates an accelerating electric field that focuses the ions to a focal plane where the ion flight time to the focal plane for an ion of predetermined mass-to-charge ratio is substantially independent to first order of an initial velocity of the ions prior to acceleration. An ion detector is positioned at the focal plane to detect ions. The two-field ion accelerator generates electric fields that cause the ion flight time to the ion detector for an ion of predetermined mass-to-charge ratio to be substantially independent to first order of both the initial position and the initial velocity of the ions prior to acceleration.
    Type: Application
    Filed: December 14, 2010
    Publication date: June 14, 2012
    Applicant: VIRGIN INSTRUMENTS CORPORATION
    Inventor: Marvin L. Vestal
  • Patent number: 8198585
    Abstract: A chromatograph mass spectrometer is provided for obtaining the information pertinent to a structural analysis, with a simple operation, on a compound series including a plurality of compounds whose structures and characters are similar. First, based on the data obtained by a normal LC/MS analysis, a two-dimensional isointensity line graph is created and displayed with a retention time and a mass-to-charge ratio on the two axes and with a signal intensity represented in contour (S1 and S2). When the operator specifies a desired range by a drag operation or the like by a mouse (S3), peaks included in the range specified are extracted and based on the peaks, precursor ions are selected (S4 through S6). Then a schedule is created so that an MS2 analysis is performed for the precursor ions selected in the course of an LC/MS analysis for the sample to be targeted (S7).
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: June 12, 2012
    Assignee: Shimadzu Corporation
    Inventor: Shinichi Yamaguchi
  • Patent number: 8198584
    Abstract: A method is provided for measuring mobility spectrum of ions in an ion mobility spectrometer having an ion source, a modulator, an ion drift region and an ion detector disposed at the end of the ion drift region. The method includes the steps of modulating an ion current from the ion source, and measuring the mobility spectrum, where a predistortion of the continuous modulation function substantially compensates for a distortion created by the modulator. The ion current is modulated with the modulator by varying an instantaneous frequency of a continuous modulation function across a frequency range. The mobility spectrum is measured by correlating the ion current measured at the detector and the modulation function.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: June 12, 2012
    Assignee: Bruker Daltonik GmbH
    Inventor: Uwe Renner
  • Patent number: 8198582
    Abstract: A method of pulsing gas in a quadrupole ion trap to reduce excess internal energy of ions formed externally to the trap at high-vacuum conditions by laser desoprtion is disclosed. With pulsed gas introduction, pressures greater than those under which traps are normally operated can be achieved over a few milliseconds. Under these elevated pressure transients, the process of translational cooling is accelerated and ions undergo thermalized collisions before dissociation occurs. Minimization of uncontrolled fragmentation (thermalization) and enhanced sensitivity are observed at pressures exceeding a threshold of about 1 mTorr.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: June 12, 2012
    Assignee: Kratos Analytical Limited
    Inventors: Emmanuel Raptakis, Dimitris Papanastasiou, Andrew Bowdler
  • Patent number: 8193488
    Abstract: A measuring system comprising: a MIMS probe 1 comprising a membrane inlet 3, a mass spectrometer 2 coupled to the probe, and a vibrator controllable 7 to vibrate the probe 1 to disturb a boundary layer 13 at the membrane inlet 3 when the probe 1 is in a liquid under analysis.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: June 5, 2012
    Assignee: New Zealand Forest Research Institute Limited
    Inventors: Daniel Gapes, Grant Emms
  • Patent number: 8193484
    Abstract: A method and apparatus involve: performing a plurality of analytical scans during normal operation of a mass spectrometer having a detection section, wherein data is generated during the analytical scans in a manner that includes use of the detection section; and automatically evaluating the data from the analytical scans to monitor whether an actual gain of the detection section changes over time.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: June 5, 2012
    Assignee: Thermo Finnigan LLP
    Inventors: Scott T. Quarmby, Michael W. Senko
  • Publication number: 20120132795
    Abstract: Differential mobility spectrometer with spatial ion detector and methods related thereto are disclosed. The use of one or more spatial detector within differential mobility spectrometry can provide for the identification and separation of ions with similar mobility and mass.
    Type: Application
    Filed: December 20, 2010
    Publication date: May 31, 2012
    Inventors: Tuan A. DUONG, Isik Kanik, Vu A. Duong
  • Patent number: 8188423
    Abstract: A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: May 29, 2012
    Assignee: Science & Engineering Services, Inc.
    Inventors: Vladimir M. Doroshenko, Vadym D. Berkout, Andrey Vilkov
  • Patent number: 8183524
    Abstract: A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap or alternatively from a travelling wave ion guide arranged upstream of an orthogonal acceleration electrode which forms part of the Time of Flight mass analyser. Ions in the pulse or packet or ions which is released become temporally dispersed and the orthogonal acceleration electrode is energized multiple times prior the release of a subsequent pulse or packet of ions.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: May 22, 2012
    Assignee: Micromass UK Limited
    Inventors: Daniel James Kenny, Jason Lee Wildgoose, Martin Green
  • Patent number: 8173961
    Abstract: While applying a square wave voltage to the ion electrode (21) so that ions already captured in the ion trap (20) do not disperse, the timing of irradiating a laser light for ion generation is controlled in such a manner that ions reach the ion inlet (25) at a predetermined timing of a cycle of the voltage. In the case of a positive ion (cation) for example, the timing of laser light irradiation is adjusted in such a manner that the target ions reach the ion inlet (25) in the low level period of a cycle of the square wave voltage. By injecting ions in addition to the ions already captured in the ion trap (20) in this manner, the amount of ions can be increased, and by performing a mass separation and detection after that, the signal intensity in one mass analysis can be increased. Accordingly, by decreasing the number of repetitions of the mass analysis for summing up mass profiles, the measuring time can be shortened.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: May 8, 2012
    Assignee: Shimadzu Corporation
    Inventors: Shinichi Iwamoto, Kei Kodera, Sadanori Sekiya
  • Publication number: 20120061561
    Abstract: An apparatus for elemental analysis of particles such as single cells or single beads by mass spectrometry is described. The apparatus includes means for particle introduction; means to vaporize, atomize and ionize elements associated with a particle; means to separate the ions according to their mass-to-charge ratio; means to detect the separated ions, means to digitize the output of the means to detect the ions; means to transfer and/or to process and/or record the data output of the means to digitize, having means to detect the presence of a particle in a mass spectrometer; and means to synchronize one of the means for ion detection, data digitization, transfer, processing and recording with the means to detect the presence of a particle. Methods and computer readable code implementing aspects of the apparatus, and for reducing the rates of data generation, digitization, transfer, processing and recording are also described.
    Type: Application
    Filed: June 24, 2011
    Publication date: March 15, 2012
    Applicant: DVS SCIENCES INC.
    Inventors: Alexei Antonov, Dmitry Roman Bandura
  • Patent number: 8134122
    Abstract: Systems, methods and computer program products for the multi-modal detection of particles are described herein. An embodiment of the present invention is a particle detector that includes a first chamber wherein analyte particles are subjected to a first particle detection mechanism, and a second chamber coupled to the first chamber, wherein the analyte particles are subjected to a second particle detection mechanism, and wherein the detection characteristics of second particle detection mechanism are orthogonal to detection characteristics of the first particle detection mechanism.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: March 13, 2012
    Assignee: The Mitre Corporation
    Inventor: Samar K. Guharay
  • Patent number: 8134119
    Abstract: A reflectron (1) for deflecting an ion from a specimen in a time-of-flight mass spectrometer comprises a front electrode (2) and a back electrode (3). At least one of the front and back electrodes (2, 3) is capable of generating a curved electric field. The front and back electrodes are configured to perform time focusing and resolve an image of a specimen.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: March 13, 2012
    Assignee: Cameca Instruments, Inc.
    Inventor: Peter Panayi
  • Publication number: 20120056084
    Abstract: A mass spectrometer is disclosed comprising a first chamber and a second chamber. The second chamber is located downstream of the first chamber and an inter-chamber aperture is provided between the two chambers. An ion guide is located in the first chamber and an ion mobility spectrometer is located in the second chamber. Helium gas is provided to the first chamber. As ions are accelerated towards the ion mobility spectrometer from a relatively low pressure region they pass initially into the first chamber. The helium gas provided in the first chamber minimises ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide and are subsequently transmitted to the ion mobility spectrometer located in the second chamber.
    Type: Application
    Filed: November 16, 2011
    Publication date: March 8, 2012
    Applicant: MICROMASS UK LIMITED
    Inventor: Kevin Giles
  • Patent number: 8129676
    Abstract: Detecting and identifying ions using surface enhanced Raman spectroscopy (SERS) and an ion separation pre-filter, such as an ion spectrometer, are provided. The combination of an ion separator as a pre-filter for SERS provides a highly sensitive detector with very low false alarm rates. Target ions from an ionized sample are identified and separated by the ion separator. The target ions are steered and deposited onto a SERS substrate for Raman spectroscopic analysis with an optical probe. The Raman spectrum is compared with reference spectra and the composition of the sample is identified. The ion current from the target ions can also be measured, preferably concurrently with the Raman spectrum measurement. Types of ion separators include a differential ion mobility spectrometer, an ion mobility spectrometer, or a mass spectrometer.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: March 6, 2012
    Assignees: SRI International, DH Technologies Development Pte. Ltd., Renishaw Diagnostics Limited
    Inventors: Michael Vestel, Caterina Netti, Erkinjon Nazarov, Gareth S. Dobson, Stephen L. Coy, Richard Copeland, Michael Coggiola, Lawrence Dubois, Alexander Hallock, Joseph R. Stetter
  • Patent number: 8115167
    Abstract: The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: February 14, 2012
    Assignee: Ionwerks, Inc.
    Inventors: Valeri V. Raznikov, J. Albert Schultz, Thomas F. Egan, Michael V. Ugarov, Agnès Tempez, Gennadiy Savenkov, Vladislav Zelenov
  • Patent number: 8106352
    Abstract: Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: January 31, 2012
    Assignee: Excellims Corporation
    Inventor: Wu Ching
  • Publication number: 20120018631
    Abstract: An ion-mobility analyser is disclosed comprising a plurality of axially segmented upper electrodes 12a-12g, a plurality of axially segmented lower electrodes 13a-13g, a first plurality of axially segmented intermediate electrodes and a second plurality of axially segmented intermediate electrodes which together define an ion pathway. An asymmetric voltage waveform is applied to the upper electrodes 12a-12g and a DC compensating voltage is applied to the lower electrodes 13a-13g in order to separate ions in a vertical radial direction according to their rate of change of ion mobility with electric field strength. At the same time, a DC axial voltage gradient is maintained along the axial length of the analyser in order to separate ions axially according to their ion mobility.
    Type: Application
    Filed: June 23, 2011
    Publication date: January 26, 2012
    Applicant: MICROMASS UK LIMITED
    Inventor: Kevin Giles
  • Publication number: 20120012743
    Abstract: The present invention discloses a filter device. The filter device comprises a housing with an air inlet and an filtered air outlet; a high voltage electric field region provided between two ends of the housing, wherein the direction of the electric field is perpendicular to the direction along which the air is introduced into the housing; an ionization source provided in the electric field region to ionize the ionizable pollutants present in the air introduced from the air inlet and form the resultant ionized pollutants which will move towards both ends of the housing under the influence of the electric field; and a discharging device for discharging the ionized pollutants which have arrived at the ends of the housing out of the filter device. The present invention also relates to a filtering method of using the filter device, and a trace detector.
    Type: Application
    Filed: June 25, 2010
    Publication date: January 19, 2012
    Inventors: Yangtian Zhang, Jin Lin
  • Patent number: 8093552
    Abstract: A process and device is provided for the separation of electronegative molecules from non electronegative molecules using electric fields. The molecules are ionized in a non thermal discharge plasma which produces negative and positive ions of the electronegative and non electronegative molecules. The ions are spatially separated by an average DC electric field. A means to filter is disposed in the path of the separated ions and it allows ions to pass through more easily than uncharged molecules. After the ions pass through the filter they are electrically neutralized back to uncharged molecules.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: January 10, 2012
    Inventor: John Macknis
  • Patent number: 8084733
    Abstract: Systems and methods are provided for optimizing the performance of a mass spectrometer system when multiple measurements are made. For example, the total settling time of different components or stages of a mass spectrometer, such as a tandem mass spectrometer, are decreased by optimally ordering the measurements.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: December 27, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: Charles William Russ, IV, Frank Erich Kuhlmann
  • Patent number: 8080782
    Abstract: A detection signal generated in response to incident ions accelerated at temporally-irregular intervals having an average repetition rate greater than a reference repetition rate represents detection events each having an event time and an intensity. For each detection event, respective allowed TOFs between the event time and the transient times are calculated. Using respective initial probabilities, initial apportionments of the intensity of each detection event among the allowed TOFs linked thereto are determined. For each allowed TOF, the intensity apportionments thereto are accumulated to generate an intensity accumulation linked thereto. For each detection event, respective revised probabilities are iteratively determined using the intensity accumulations linked to the allowed TOFs linked thereto, and the respective intensity is iteratively reapportioned among the allowed TOFs linked thereto using the revised probabilities to transform the detection signal to a time-of-flight spectrum.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: December 20, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: August Hidalgo, Brian D Setterberg, George Stennis Moore, Michael Manlove
  • Publication number: 20110303841
    Abstract: A mass analysis device with wide angular acceptance, notably of the mass spectrometer or atom probe microscope type, includes means for receiving a sample, means for extracting ions from the surface of the sample, and a reflectron producing a torroidal electrostatic field whose equipotential lines are defined by a first curvature in a first direction and a first center of curvature, and a second curvature in a second direction perpendicular to the first direction and a second center of curvature, the sample being positioned close to the first center of curvature.
    Type: Application
    Filed: February 12, 2010
    Publication date: December 15, 2011
    Applicant: CAMECA
    Inventor: Mikhail Yavor
  • Patent number: 8076638
    Abstract: A drift tube structure for ion mobility spectrometer is disclosed comprising electrode sheets and insulation parts arranged in alternation, with each electrode sheet being a mesh metal sheet having a radian or taper portion which is convexly curved toward an ion input. Further, the radian or taper portion of the electrode sheet has meshes of higher transparency. With the above structure of the present invention, an electric field having a periphery of uniform focusing center can be formed in the migration zone. The circular ring configuration of the electric field periphery can shield the migration electric field from any influence of external electric fields. The electrodes are each meshlike and have a circular hole at the center, thus they can focus and collect as many as possible ions that do not move along the central axis, and those ions moving along the central axis can pass through the electrodes transparently.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: December 13, 2011
    Assignee: Nuctech Company Limited
    Inventors: Haifeng Hu, Yuanjing Li, Qingjun Zhang, Zhiqiang Chen
  • Patent number: 8071938
    Abstract: Systems, methods and computer program products for the multi-modal detection of particles are described herein. An embodiment of the present invention is a particle detector that includes a first chamber wherein analyte particles are subjected to a first particle detection mechanism, and a second chamber coupled to the first chamber, wherein the analyte particles are subjected to a second particle detection mechanism, and wherein the detection characteristics of second particle detection mechanism are orthogonal to detection characteristics of the first particle detection mechanism.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: December 6, 2011
    Assignee: The Mitre Corporation
    Inventor: Samar K. Guharay
  • Publication number: 20110272572
    Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).
    Type: Application
    Filed: May 5, 2011
    Publication date: November 10, 2011
    Inventors: Akos Vertes, Peter Nemes
  • Patent number: 8049167
    Abstract: A FAIMS device for separating ions has a pair of electrodes for providing a compensation voltage and an asymmetric waveform that are separated and insulated where at least one porous spacer reside in the proximity of the analyzer region of the FAIMS cell. The porous spacers allow a focusing gas to flow into the analyzer region to provide pneumatic focusing of the ions traversing the analyzer region to improve the ion transmission.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: November 1, 2011
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Leonard C. Rorrer, III, Richard Alan Yost
  • Patent number: 8044343
    Abstract: A plurality of molecule components included in a gas are to be ionized at the same time by PI method. For instance, a plurality of molecule components included in a gas generated at a certain instance are accurately analyzed in real time based on PI method. A gas analyzer is provided with a gas transfer apparatus for transferring a gas generated from a sample in a sample chamber to an analyzing chamber; an ionizer for ionizing the gas; a quadruple filter for separating ions by mass/charge ratio; and an ion detector for detecting the separated ions. The ionizer is provided with an ionizing region arranged in the vicinity of a gas exhaust of the gas transfer apparatus, and a lamp for applying light on the ionizing region. Since the lamp outputs light which has light directivity lower than that of a laser beam and travels by spreading, the gas entered the ionizing region in the ionizer receives light in a wide range, and the gas components inside are ionized at the same time.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 25, 2011
    Assignees: Rigaku Corporation, Hamamatsu Photonics K.K.
    Inventors: Tadashi Arii, Yoshihiro Takata, Satoshi Otake, Shigeki Matsuura
  • Patent number: 8034567
    Abstract: The present invention relates to a method for measuring the amount of a target nucleic acid in a sample using a standard which is designed to have one base difference compared with the gene of interest or a “target nucleic acid sequence.” Use of such standard in combination with a method of “enhancing” the difference in the standard and the test nucleic acid sample using, for example, a base extension reaction carried right at the mutation site allowing amplification of the standard and target nucleic acids with the same efficiency and facilitating quantification of the target nucleic acid. Thereafter a means of quantifying the “enhanced” standard and target nucleic acid samples is used to determine the amount of the target nucleic acid. In the preferred embodiment, the quantification means is Mass Spectrometry.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: October 11, 2011
    Assignee: Trustees of Boston University
    Inventors: Charles R. Cantor, Chunming Ding
  • Patent number: 8030610
    Abstract: In various aspects, the present teachings provide systems and methods for reducing chemical noise in a mass spectrometry instrument that use a neutral chemical reagent and one or more mass filters to reduce interfering chemical background ion signals that are generated by ionization sources of mass spectrometers. In various embodiments, the neutral chemical reagent belongs to the class of organic chemical species containing a disulfide functionality.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: October 4, 2011
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Xinghua Guo, Andries P. Bruins, Tom Covey
  • Patent number: 8026477
    Abstract: In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the device incorporates the source for ionization in combination with a jet separator to efficiently remove excess carrier gas while permitting ions to be more efficiently transferred into the vacuum chamber of the mass spectrometer. In an embodiment of the invention, improved collection of ions produced by the carrier gas containing metastable neutral excited-state species at greater distances from between the position of the analyte and the position of the mass spectrometer are enabled.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: September 27, 2011
    Assignee: Ionsense, Inc.
    Inventor: Brian D. Musselman
  • Patent number: 8017907
    Abstract: A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector and a processing circuit. The processing circuit may include an initial processing module and a spectra processing module. According to one embodiment, the spectra processing module generates stick spectra and supplies the stick spectra to an external processor. The stick spectra comprise a peak intensity, resolution, and a location in the spectra for each detected peak. The stick spectra may be generated in real time.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: September 13, 2011
    Assignee: Leco Corporation
    Inventors: Peter M. Willis, Michael C. Mason, Mark R. Wheeler, Viatcheslav B. Artaev, Julie R. Pitz
  • Patent number: 8013296
    Abstract: Ions and charged droplets move from the nozzle (6) towards the orifice (22) of a charged-particle transport device or the desolvation pipe (7). This particle motion is governed by the distribution of the pseudo-potential along particle trajectories. There are RF-voltages applied to neighboring electrodes (241-246) of the electrode array (24) cause the charged particles to substantially hover above the electrode array (24). Right before the ions come to the electrode array (24) they thus experience a repelling force “F” perpendicular to the surface of the electrode array (24). This force “F” causes an effective barrier (B) right before the electrode array (24) and consequently a pseudo-potential well (A) where the charged particles stop their motion parallel to the plume axis (D). Thus they accumulate around the center line (C) of this well (A).
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: September 6, 2011
    Assignee: Shimadzu Corporation
    Inventors: Hermann Wollnik, Yoshihiro Ueno
  • Patent number: 8003934
    Abstract: Disclosed are methods, apparatus, systems, processes and other inventions relating to: ion sources with controlled electro-pneumatic superposition, ion source synchronized to RF multipole, ion source with charge injection, optimized control in active feedback system, radiation supported charge-injection liquid spray, ion source with controlled liquid injection as well as various embodiments and combinations of each of the foregoing.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: August 23, 2011
    Inventor: Andreas Hieke
  • Publication number: 20110198493
    Abstract: An ion mobility spectrometer comprises a drift tube defining a drift tube inlet configured to receive ions and a drift tube outlet. The drift tube is configured to separate ions in time as a function of ion mobility. The drift tube defines a first ion activation region between the drift tube inlet and the drift tube outlet. The first ion activation region is configured to selectively induce structural changes in at least some of the ions.
    Type: Application
    Filed: March 2, 2011
    Publication date: August 18, 2011
    Inventors: David E. Clemmer, Stormy L. Koeniger, Stephen J. Valentine
  • Publication number: 20110198490
    Abstract: An ion mobility spectrometer is described which makes use of a pulsed flow pump to draw gas through an ion filter in pulsed operation. A gas counterflow may also be provided, in some embodiments this may also be a pulsed counterflow.
    Type: Application
    Filed: June 19, 2007
    Publication date: August 18, 2011
    Inventor: David Ruiz Alonso
  • Patent number: 7985949
    Abstract: Methods and systems are provided for detecting analytes in a gas phase sample. An ion mobility spectrometer is provided for detecting analytes having an excess amount of dopant in its separation region. In an embodiment, the dopant is added directly to the separation region, such as with a drift gas or by diffusion, thereby providing excess dopant that dominates subsequent cluster formation and maintenance. Excess dopant in the separation region minimizes or reduces interfering signals associated with unwanted substances, such as water vapor, that are introduced to the IMS. In an aspect, the invention provides IMS systems and methods having increased sensitivity and reliability for analyte detection.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: July 26, 2011
    Assignee: Particle Measuring Systems, Inc.
    Inventor: Dan Rodier
  • Publication number: 20110174966
    Abstract: A filter for a mass- or mobility-spectrometer that bars gases or vapors of a high-pressure ion source, as well as ions of high mobility and charged droplets, from entering an evacuated mass spectrometer or a mobility spectrometer at a lower pressure than the filter. The buffer gas of the high pressure ion source is blown into the volume of this filter directly or through tubes from where buffer gas and embedded ions are sucked through the aperture of a diaphragm or through an aperture of a capillary mainly from an “extraction volume” filled with a separately supplied clean gas, into which ions of interest are pushed by electric fields formed by electrodes that are substantially rotational symmetric around the “extraction volume” and a substantially flat electrode with respect to an axis of ion extraction and the end of the capillary and the end of a coaxial tube surrounding the capillary.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 21, 2011
    Applicant: SHIMADZU CORPORATION
    Inventors: Hermann Wollnik, Alexander Tarassov, Gary A. Eiceman
  • Patent number: 7977626
    Abstract: A method and apparatus for performing time of flight mass spectrometry wherein the number of sums of transients taken for generating a given spectra is determined as a function of a characteristic of the incoming data for that spectrum. For instance, the number of transient measurements taken for a given spectrum output can be determined as a function of the abundance of ions in the sample or the abundance of ions corresponding to a base peak or another selected peak. In yet another embodiment, the collection of transients is terminated when a threshold signal to noise ratio is attained.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: July 12, 2011
    Assignee: Agilent Technologies, Inc.
    Inventors: August Jon Hidalgo, Bryan David Miller, Gregor T. Overney
  • Publication number: 20110147582
    Abstract: This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
    Type: Application
    Filed: January 18, 2011
    Publication date: June 23, 2011
    Inventors: Alexander Alekseevich MAKAROV, Oliver LANGE, Stevan Roy HORNING
  • Patent number: 7960690
    Abstract: An automatic gain control (AGC) technique and apparatus is introduced herein for any temporally non-uniform ion beam, such as, for example, an ion beam produced by a MALDI ion source so as to minimize space charge effects. The disclosed configurations and techniques can be achieved by using an ion optical gating element and applying a desired signal waveform (e.g., a square wave) having a predetermined duty cycle. The applied voltage amplitude of such a signal can be configured to switch between a voltage which fully transmits the ions, and a voltage which does not transmit any ions. The frequency is chosen to result in a period which is significantly lower than the smallest non-uniformity period. Techniques of the present invention can also be extended to methods of AGC which can use a single ion injection event from the ion source to avoid variations in ion numbers from an unstable ion source.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: June 14, 2011
    Assignee: Thermo Finnigan LLC
    Inventors: Jae C. Schwartz, Viatcheslav V. Kovtoun
  • Patent number: 7960711
    Abstract: An improved electrospray ion source for increasing the current generated from the electrospray process and of the type having a needle (10), a counter-electrode (20), a saddle or outer electrode (30), and concurrent flow of gas (92). A method and device is disclosed that utilizes a controlled electrospray nebulizer where an aerosol comprised of charged droplets and gas-phase ions is sprayed into a field-free or near field-free desolvation or reaction region (120).
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: June 14, 2011
    Assignee: Chem-Space Associates, Inc.
    Inventors: Edward William Sheehan, Ross Clark Willoughby
  • Publication number: 20110121171
    Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path. Techniques are disclosed for operating the ion mobility spectrometer to produce highly resolved ion mobility spectra.
    Type: Application
    Filed: November 22, 2010
    Publication date: May 26, 2011
    Inventors: David E. Clemmer, Ruwan T. Kurulugama, Fabiane M. Nachtigall, Zachary Henson, Samuel I. Merenbloom, Stephen J. Valentine
  • Publication number: 20110114837
    Abstract: Disclosed is an ion mobility spectrometer.
    Type: Application
    Filed: July 6, 2009
    Publication date: May 19, 2011
    Applicants: NUCTECH COMPANY LIMITED, TSINGHUA UNIVERSITY
    Inventors: Yuanjing Li, Qingjun Zhang, Hua Peng, Yangtian Zhang
  • Publication number: 20110113862
    Abstract: A leak detection system has: a test chamber connected to a vacuum pump; a filling device for filling a test piece with helium gas; a transfer device for transferring the test piece between a ready-for-detection position in which the test piece is ready to be carried into the test chamber and a filling-operation position in which the operation of filling helium gas by the filling device is performed; a carrying device for carrying the test piece from the ready-for-detection position to a detection position inside the test chamber; a sealing device for hermetically sealing the test chamber in a state in which the helium-gas-filled test piece is in the detection position; and a leak detector for detecting helium to be leaked out of the test piece when, after having sealed the test chamber by the sealing device, the test chamber is evacuated by the vacuum pump to a predetermined pressure.
    Type: Application
    Filed: January 29, 2010
    Publication date: May 19, 2011
    Inventors: Takayuki MAEHIRA, Ryuichi Wakamatsu, Eiichi Sato
  • Patent number: 7943901
    Abstract: This invention describes an ion mobility spectrometer system for chemical detection in the field. The system allows: a high throughput operation, an interface to new ionization methods, and an interface to a mass spectrometer.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: May 17, 2011
    Assignee: Excellims Corporation
    Inventor: Ching Wu
  • Publication number: 20110095175
    Abstract: A mass spectrometer is disclosed comprising a FAIMS device comprising two parallel electrodes (9a, 9b) in series with an ion mobility separator (12) forming part of a mass spectrometer. Ions are separated in the FAIMS device (9a, 9b) according to their rate of change of ion mobility with electric field strength. The ions which are onwardly transmitted from the FAIMS device (9a, 9b) are then passed to an ion separator device (12) comprising a plurality of electrodes (12) and an optional ion trapping region (33). Ions are radially confined with the ion separator by application of an AC or RF voltage to the electrodes (12) and ions are separated according to their ion mobility by applying an axial DC voltage gradient which may remain constant as a function of time or which may vary with time.
    Type: Application
    Filed: April 20, 2005
    Publication date: April 28, 2011
    Applicant: MICROMASS UK LIMITED
    Inventor: Robert Harold Bateman