Abstract: A corneal reflection position estimation system according to an embodiment includes: an image acquisition unit configured to continuously acquire an image of an eye of a subject by controlling a camera equipped with a light source, the image acquisition unit being configured to acquire a plurality of pupil images taken by using light from the light source and then acquire one unilluminated image taken without using light from the light source; and an estimation unit configured to calculate positions of corneal reflection or corneal sphere centers, which correspond to the plurality of pupil images, as reference positions, calculate a movement vector of the corneal reflection or the corneal sphere center based on a plurality of the reference positions, and estimate the corneal reflection position in the unilluminated image based on at least the movement vector.

Abstract: A fundus imaging system is used to generate fundus images when a patient has not received mydriatic pharmaceuticals. The fundus imaging system includes a processor and memory, an infrared light source, and an image sensor array. The infrared light source illuminates the patient's fundus using only infrared light. The fundus imaging system uses one or more different near-infrared wavelengths to illuminate the patient's fundus, and the fundus imaging system captures images during infrared light illumination. Then the fundus imaging system generates a color image of the patient's eye fundus based on generated lightness maps of the infrared-illuminated images.

Abstract: Curvature of field transformation of OCT images during ophthalmic surgery may be performed with an OCT scanning controller that interfaces to an OCT scanner used with a surgical microscope. Real-time OCT images may be acquired by the OCT scanner, while an anamorphic transformation is applied to the OCT images to match the curvature of field for optical images viewed using the surgical microscope. The transformed OCT images may be displayed during surgery.

Abstract: An image generation method includes an acquisition step of acquiring a plurality of pieces of tomogram data of a subject, the plurality of pieces of tomogram data representing cross-sections at a substantially identical position of the subject; a calculation step of calculating a motion contrast by using pieces of pixel data corresponding to one another among the plurality of pieces of tomogram data that have been acquired; a comparison step of comparing the motion contrast with a threshold; a generation step of generating a motion contrast image in which a brightness corresponding to the motion contrast that is lower than the threshold is lower than a brightness corresponding to the motion contrast that is higher than the threshold; and a change step of changing the threshold.

Abstract: Provided is a document reading apparatus that is able to determine a document size even when there is a large number of target document sizes to be determined. The diagonal-line-identifying unit identifies a diagonal line for determining size in image data that is read by the scanner. The document-size-determining unit determines document size in either a first determining operation or a second determining operation. The first determining operation is based on determining data that is read by arranging the scanner at a large-size determining position after a second opening/closing detecting sensor detects a closed state after detecting an open state. The second determining operation is based on change in the diagonal line for determining size in determining data that is read while the scanner scans from the large-size determining position after a first opening/closing detecting sensor detects a closed state.

Abstract: In an ophthalmic operation microscope, an illumination optical system illuminates a patient's eye with illumination light. An observation optical system is used for observing the patient's eye illuminated. An objective lens is disposed in an observation optical path. An interference optical system splits light from a light source into measurement light and reference light, and detects interference light generated from returning light of the measurement light from the patient's eye and the reference light. A first lens group is disposed between the light source and the patient's eye in an optical path of the measurement light. A second lens group is disposed between the first lens group and the patient's eye in the optical path of the measurement light. A deflection member is disposed between the first lens group and the second lens group in the optical path of the measurement light.

Abstract: Methods for improving gaze tracking are presented. These methods eliminate the need for a separate initial calibration step to determine whether the subject is properly centrally fixated during testing. In one embodiment, whether the subject is centrally fixated is determined by identifying inlier and outlier gaze descriptors; the inliers are assumed to be associated with central fixation. This reduces the total time required for testing. These methods also improve the accuracy of gaze tracking during testing without the need for individual subject calibration. Instead, a database of reference eyes is used. The subject's eye can be compared to the reference eyes, and the mapping function for one or more reference matches can be used to estimate the subject's gaze direction. In another embodiment, previous calibration data from the same subject can be used to determine whether the subject is properly centrally fixated and/or the direction of the subject's gaze.

Abstract: A fundus imaging system includes: an image sensor array, where the image sensor array includes monochrome photodiodes and global shutter control, an illumination unit with one or more light-emitting diodes that have one or more dies, a computing system including a processor and memory, one or more lenses, one or more reflective mirrors, and a display. In an example method of use, a clinician positions a patient, initiates a focal adjustment, initiates a retinal imaging process, and the same or a different clinician views the image. In some embodiments, the imaging system is configured to analyze the image and identify detected physical attributes in the image relating to the diagnosis and treatment of diabetic retinopathy.

Abstract: An ophthalmic system and method for imaging an eye includes an eye guard, an objective lens, such that light passes through the objective lens along an illumination path that passes through the eye guard, a light source positioned to emit imaging light along the illumination path, a camera assembly positioned to receive emitted light that is emitted from a back surface of the eye. The light source and the objective lens are positioned such that, when the eye guard is positioned proximate the eye of the patient, the imaging light passes through a first portion of a pupil opening in the eye, and the emitted light passes through a second portion of the pupil opening of the eye that is different from the first portion, and wherein the camera assembly captures an image of the eye using the emitted light.

Abstract: Provided are a method and system for noncontact vision-based 3D cognitive fatigue measuring. The method comprises: acquiring pupil images of a subject exposed to visual stimuli; extracting a task evoked pupillary response (TEPR) by using the pupil images; detecting dominant peaks from the TEPR; calculating latency of dominant peaks; and determining cognitive fatigue of the subject by comparing a value of the latency to a predetermined reference value.

Abstract: Techniques for improved diagnosis, treatment, and monitoring of corneal pathologies use enhanced mapping of the cornea or corneal regions, to develop three-dimensional mapping of corneal thickness, while retaining particular corneal micro-layer thickness data. Anterior and posterior surface identifications, along with surface apex determinations, are used for registration of segmentation of these micro-layers. 3D heat maps and bull's-eye maps are generated from resulting thickness date. The maps provided enhanced evaluation and diagnosis of a corneal pathologies, such as keratoconus, pellucid marginal degeneration, post-refractive surgery ectasia, keratoglobus, corneal transplant rejection and corneal transplant failed grafts, Fuchs dystrophy, corneal limbal stem cell deficiency, dry eye syndrome, and post-corneal collagen crosslinking evaluation.

Abstract: Methods and systems in ophthalmic imaging are presented that increase the sensitivity of automated diagnoses by the use of a combination of both functional and structural information derived from a variety of ophthalmic imaging modalities. An example method to analyze image data of an eye of a patient includes processing a first image dataset to obtain one or more functional metrics; processing a second image dataset to obtain one or more structural metrics; comparing the one or more structural metrics to the one or more functional metrics; and processing the results of said comparison to derive the probability of a disease or normality of the eye.

Abstract: A fundus imaging system comprises: a reflection mirror that reflects a light beam incident on the reflection mirror after passing through a first focus so as to cause the light beam to pass through a second focus; a two-dimensional scanning unit that is disposed at a position that coincides with a position of the first focus of the reflection mirror and that reflects a light beam incident on the two-dimensional scanning unit so as to perform scanning with the light beam in two-dimensional directions; and a compensating unit that compensates for illuminance ununiformity of a light beam illuminating the retina, the illuminance ununiformity resulting from unevenness of a ratio of an angular change of a light beam emitted from the first focus during scanning of the two-dimensional scanning unit to an angular change of a light beam incident on the second focus resulting from being reflected by the reflection mirror.

Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.

Abstract: An ophthalmologic apparatus includes an error obtaining unit configured to obtain a value corresponding to a difference between a first imaging position which tracks a predetermined position of an eye portion under control of a tracking unit and the predetermined position, a determination unit configured to determine a position which is shifted from the first imaging position which tracks the predetermined position as a second imaging position in accordance with the value corresponding to the difference. The ophthalmologic apparatus averages tomographic images of the first and second imaging positions.

Abstract: An information processing system includes: first and second information processing apparatuses; a detector that detects an eye-gaze direction of a user that uses the first information processing apparatus; a gaze point information generator that generates, on the basis of the eye-gaze direction, gaze point information indicating a position at which the user gazes on first screen information commonly displayed on the first and second information processing apparatuses; and a display controller that controls a display image to be displayed on the second information processing apparatus when calibration for determining a correspondence relation between the eye-gaze direction of the user and an actual gaze position is executed. The display image is generated on the first screen information and includes a second image displayed at a position indicated by the gaze point information and a third image displayed at a gaze instruction position at which the user is made to gaze.

Abstract: A method, controller, and medium to control an adaptive optics scanning laser ophthalmoscope. Receiving from the ophthalmoscope a plurality of wavefront elements. Each element may be associated with an area of a beam of light received from a fundus. Each element includes shape data. The shape data represents a shape of a wavefront in a area of the beam. Each element includes status data. The status data is a confidence indicator of ability of the shape data to represent the shape of the wavefront with a particular level of accuracy. Calculating control data based on the shape data in the wavefront data and local gain. The local gain includes local gain elements. Each local gain elements is adjusted based on status data. Using the control data to adjust a shape of an illumination wavefront of an illumination beam used to illuminate the fundus.

Abstract: An ophthalmic imaging apparatus that captures a tomographic image of an subject's eye based on light obtained by combining a return light with a reference light, the return light being from the subject's eye when irradiated with a measurement light, the reference light corresponding to the measurement light includes a first optical fiber disposed in an optical path of the reference light and including a light guide portion for guiding the reference light, and a second optical fiber disposed in an optical path of the measurement light and including a light guide portion for guiding the measurement light, wherein a diameter of each of the light guide portions of ejection ends of the first optical fiber and the second optical fiber is larger than a diameter of a light guide portion in a position different from a position of each of the ejection ends.

Abstract: A head-up display device includes a first mirror having power, a second mirror having power, and a light-blocking member that is provided with an aperture. An image reflective surface has a convergence action. Display light emitted from an image display surface is reflected by the first mirror and the second mirror in this order, passes through the aperture, and reaches the image reflective surface. The image display surface is disposed on the same side as an observer and on a side opposite to the first mirror with respect to luminous flux that travels toward the aperture from the second mirror. The first mirror is a concave mirror. The shape of the cross-section of the second mirror taken along a front-rear direction is a convex shape.

Abstract: Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

Abstract: A method is provided for determining the thickness of a retina. A single beam is used to illuminate the retina of a patient. Interference between reflections off different layers within the retina cause autocorrelation in the returned signal. A spectrometer produces a frequency spectrum of the beam reflected by the retina, and an FFT applied to the frequency spectrum produces a spatial domain signal (SDS). Autocorrelation within the reflected beam results in edges within the spatial domain signal, and the spatial coordinate of the SDS at which the power of the SDS drops precipitously indicates the distance between the nerve fiber layer (NFL) and the layers between the inner segment/outer segment (IS/OS) and the retinal pigment epithelium (RPE), the dominant scatterers. By analyzing autocorrelation, a single beam can be used.

Abstract: An example eye fundus imaging apparatus can include: a display device; an image capture device configured to capture at least one image of a fundus of an eye; and a control module programmed to: display a target, the target indicating a desired position for the image capture device to capture the at least one image of the fundus of the eye; monitor a relative position of the eye with respect to the target; and when the relative position of the eye corresponds to the target, automatically capture the at least one image of the fundus of the eye.

Abstract: The present invention relates to an ophthalmic apparatus and to a treatment site measuring method for the apparatus. The ophthalmic apparatus according to the present invention comprises: a first image unit for capturing the lower region of a retina so as to generate an image of the captured retina; a second image unit for capturing the local region of the retina indicated by a surgical operator so as to generate an image of the captured local region of the retina; and a control unit for mapping the image of the local region of the retina generated by the second image unit to the image of the retina generated by the first image unit based on the image of the retina generated by the first image unit.

Abstract: A binocular see-through AR head-mounted display device is disclosed. Based on that the mapping relationships fc?s and fd?i are pre-stored in the head-mounted device, the position of the target object in the camera image is obtained through an image tracking method, and is mapped to the screen coordinate system of the head-mounted device for calculating the left/right image display position. Through a monocular distance finding method, the distance between the target object and the camera is real-time calculated referring to the imaging scale of the camera, so as to calculate a left-right image distance, thereby calculating the right or the right image display position. Correspondingly, the present invention also provides an information display method for a binocular see-through AR head-mounted display device and an augmented reality information display system. The present invention is highly reliable with low cost.

Abstract: An embodiment of the invention receives by an interface a retinal image from a patient, and identifies by a feature extraction device vessel fragments in the retinal image. The vessel fragments include at least a portion of a major vessel and at least a portion of a branch connected to a major vessel. A processor computes estimated blood flow velocities in the vessel fragments with a blood flow velocity estimation model and determines actual blood flow velocities in the vessel fragments. An analysis engine compares the actual blood flow velocities in the vessel fragments to the estimated blood flow velocities in the vessel fragments. The analysis engine detects a candidate plaque affected vessel fragment when the estimated blood flow velocities in the vessel fragments differs from the actual blood flow velocities in the vessel fragments by a predetermined amount.

Abstract: Described embodiments include systems and methods for acquiring iris biometric data. An optical entrance of an optical medium may receive a ray incident on the optical entrance, the ray comprising biometric data. An interface of the optical medium with a second medium may receive the received ray at a first angle greater than a critical angle of the interface to enable total internal reflection of the received incident ray. A reflective coating, prism or other mechanism may be used in place of the interface to redirect the received ray or bend the optical path of the received ray. An optical exit of the optical medium may couple the reflected or redirected ray to a sensor for acquiring the biometric data. The ray may be incident on the optical entrance at a second angle relative to an axis of the sensor that is less than 90 degrees.

Abstract: An ophthalmoscope (10) comprising a light source (12), a first scanner (14), a first scan transfer element (16), a second scanner (18), and a second scan transfer element (20), which provide a two-dimensional scan of incident light from an apparent point source at a pupillary point of an eye (22) onto the fundus of the eye, and which descan a two-dimensional scan of return light from the fundus of the eye to provide return light from an apparent point source at the first scanner, wherein the first scan transfer element comprises a free-form element which has a shape defined to provide aberration correction of the return light from the fundus of the eye.

Abstract: A portion of a holder is in contact with a lens surface, a holding portion configured to hold a lens in the holder is provided, and a mold shrinkage factor of a material that forms the holder is smaller than a mold shrinkage factor of a material that forms the lens by no less than 0.3%.

Abstract: [Problem] To allow imaging light to be appropriately received by a second camera in the case where a first imaging mode (color imaging mode) is changed to a second imaging mode (autofluorescence imaging mode). [Solution] In the first imaging mode, using a dichroic mirror 30 allows light LB to be received by both a first camera C1 and a second camera C2. In the second imaging mode, using a transparent glass 31 allows light LB to be received by the second camera C2. With this configuration, both in the first imaging mode and in the second imaging mode, light LB from an ocular fundus is appropriately received by the second camera C2 whereby an appropriate ocular fundus image can be taken.

Abstract: An ophthalmic surgical apparatus includes an observation optical system, an illumination optical system, an interference optical system, and an image forming unit. The observation optical system is configured to observe an eye through an objective lens. The illumination optical system is configured to illuminate the eye through the objective lens. The interference optical system includes a reference optical path and a signal optical path which leads to the eye through the deflecting member located between the objective lens and the eye, and is configured to detect interference light based on light having passed through the signal optical path and returning from the eye and the reference light having passed through the reference optical path. The image forming unit forms an image of the eye based on a detection result obtained by the interference optical system.

Abstract: Provided is an image processing apparatus, including: an acquisition unit configured to acquire information on a layer boundary in tomographic structure of a current subject to be inspected; a determination unit configured to determine a depth range relating to a current en-face image of the subject to be inspected based on information indicating a depth range relating to a past en-face image of the subject to be inspected and the information on the layer boundary; and a generation unit configured to generate the current en-face image through use of data within the depth range relating to the current en-face image among pieces of three-dimensional data acquired for the current subject to be inspected.

Abstract: A method and system for authenticating a user. An expected digital representation of an iris of at least one authentic user is a combination of a first digital representation of an iris of an eye of at least one authentic user and a second digital representation of at least one authentic overlay pattern. In response to a determination that a third digital representation of a captured image of an iris of a user to be authenticated does not match the expected digital representation: the expected digital representation is modified to alter a relative rotational alignment between the representation of the at least one authentic overlay pattern and the expected digital representation of the iris; and a further comparison between the modified expected digital representation and the third digital representation is performed. From the further comparison, an authentication signal indicative of whether authentication of the user has been successful is generated.

Abstract: The present invention discloses systems and methods for determine preoperative estimation of postoperative IOL position (or the EAPD) in accordance with one or both of the following mathematical relationships, which are derived from linear regression: EAPD=S1+(S2×AND)+(S3×NT)+(S4×AL),??(1a) EAPD=W1+(W2×AND)+(W3×RND)+(W4×AL),??(1b) where S1, S2, S3, and S4 for equation (1a) and W1, W2, W3, and W4 for equation (1b) are statistically derived linear regression constant coefficients.

Abstract: A binocular see-through AR head-mounted display device and an information display method therefor are disclosed. The present invention uses the scene depth image and the user stared point to calculate the position of the target object stared by the user and maps coordinates to the screen coordinate system to determine the overlapping position of AR information. In addition, the present invention can tolerate small changes of human eye sight, and the AR information can be stably stacked in the same position with good robustness. The present invention can distinguish the target object stared by the user from the background, and when the user eye sight is put on different parts of the target object, the AR information is still superimposed at the same position without frequent movement with changes of the eye sight.

Abstract: In one aspect, disclosed herein are devices, systems, and methods for assessing human health states based on non-shadow imaging of sclera, or whites, of one or both eyes. In one aspect, the device is an on-body device. In one aspect, the system comprises a positioning aperture, an illuminating apparatus, an imaging apparatus, and/or a processing apparatus. In one aspect, the process only takes a short period of time to take images of the sclera without any operation of splicing multiple images. In one aspect, the device or system improves the quality of images by avoiding the formation of reflection of the illuminating apparatus on the images of the sclera. In a further aspect, the system can utilize the sclera images to obtain information of eye diseases and to predict the physiological and pathological changes in the health status of subject or diagnostic results, which can provide helpful information for medical diagnosis.

Abstract: A method and apparatus are disclosed for integrating optical coherence tomography (OCT) and very high frequency ultrasound (VHFU) imaging systems. An OCT probe and reference arm are mounted along with an ultrasound probe on a carriage capable of rotational, linear, and/or arcuate motion. The probe carriage may be immersed in water or other suitable medium. The OCT and VHFU probes move about the cornea surface such that the probe axes are substantially perpendicular relative to the cornea surface throughout a scan. The probes are able to be scanned in an arcuate path across the entire cornea surface. The method and apparatus disclosed are also directed towards providing a positioning mechanism and scan head comprising an arcuate guide track wherein only an OCT probe is mounted on the probe carriage. This embodiment allows the OCT probe beam to remain substantially perpendicular to the cornea and lens surfaces.

Abstract: An image signal acquisition unit acquires a first image signal corresponding to a first wavelength band, a second image signal corresponding to a second wavelength band, a third image signal corresponding to a third wavelength band, and a fourth image signal corresponding to a fourth wavelength band. A correlation storage unit stores a correlation between oxygen saturation degree and a first calculated value obtained from a specific calculation based on the second image signal, the third image signal, and the fourth image signal. A correlation correction unit calculates a correlation correction amount on the basis of the first image signal, the second image signal, the third image signal, and the fourth image signal, and corrects the correlation on the basis of the correction amount.

Abstract: Methods and systems for registering a manipulator assembly and independently positionable surgical table are provided herein. In one aspect, methods include reading a fiducial marker on the surgical table with a sensor associated with the manipulator assembly and localizing the manipulator assembly and surgical table with respect to a common reference frame. Methods may further include translating a 3D configuration of the surgical table to a 2D frame of reference so as to estimate a 3D pose of the surgical table relative the manipulator assembly for use in coordinating movements therebetween.

Abstract: A wide field fundus camera is disclosed to implement multiple illumination beam projectors and to capture multiple retinal images at a various viewing angles to mimic wide field retinal examination with an indirect ophthalmoscope. The wide field fundus camera may incorporate a consumer image recording device with fast auto focusing so as to make the device quick to respond and easy to use. The wide field fundus camera may include narrow and broad slit beam illuminations to enhance autofocusing and imaging through less transparent crystalline lens and through haze due to Purkinje reflections from crystalline lens surfaces. Control of multiple illumination beam projectors in a programmable manner can be used to assess alignment of each illumination beam projector with the eye and to capture said multiple retinal images. Furthermore, a method is disclosed to montage said multiple retinal images into a single montage and to remove haze and reflections.

Abstract: In one embodiment, a portable pupillometer including a testing compartment, at least one ocular disposed on the testing compartment, two or more light sources disposed in the testing compartment and forming a plurality of visual stimuli for a subject looking through the at least one ocular, at least one camera configured to capture images of a pupil of the subject via infrared detection, the images indicating pupillary responses to the two or more light sources, and an interface for connection with a computing device external to the pupillometer, the interface adapted to (i) provide, to the computing device, images from the at least one camera, and (ii) receive, from the computing device, control signals for controlling the plurality of light sources.

Abstract: A head-mounted display (HMD) includes an eye tracking system that determines user's eye tracking information based on depth information derived from time-of-flight methods. The eye tracking system includes an illumination source, an imaging device and a controller. The illumination source illuminates the user's eye with a temporally varying irradiance pattern. The imaging device includes a detector that captures temporal phase shifts (temporal distortions) caused by a local geometry and the illumination pattern being reflected from a portion of the eye. The detector comprises multiple pixels, each pixel having multiple units for capturing, over multiple time instants, light signals related to the temporally distorted illumination pattern. The controller determines phase differences between the temporally distorted illumination pattern and the temporally varying irradiance pattern, based on the captured light signals.

Abstract: The invention relates to an ocular therapy device having a radiation source emitting UV light and an optical imaging system disposed downstream of the radiation source for imaging a therapy beam coming from the radiation source in an ocular imaging plane, wherein an optical condenser unit is disposed downstream of the radiation source and comprising a diaphragm unit, an optical means for influencing a spatial energy distribution which can be associated with the therapy beam and is oriented along the therapy beam cross-section, and comprising an optical means for influencing a beam form, which can be associated with the therapy beam.

Abstract: An ophthalmologic photographing apparatus includes a determination unit configured to determine, using the detected information, whether or not an imaging area for imaging an eye is beyond an edge of a predetermined range of movement of the eye to be examined, and a tracking control unit configured to track the imaging area using the detected information, in a case where an imaging mode different from a follow-up imaging mode is selected and the imaging area is determined not to be beyond the edge, to not track the imaging area, in a case where an imaging mode different from the follow-up imaging mode is selected and the imaging area is determined to be beyond the edge, and to track, using the detected information, the imaging area without making the determination by the determination unit, in a case where the follow-up imaging mode is selected.

Abstract: To provide pathological support for users to effectively perform follow up on diseases, using polarization information obtained from polarization-sensitive tomographic images. An image processing apparatus includes a positioning unit configured to position multiple polarization-sensitive tomographic images corresponding to multiple tomographic luminance images, based on the plurality of tomographic luminance images obtained by photographing an object at different times; and a comparing unit configured to compare the plurality of polarization-sensitive tomographic images which are positioned.

Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient's eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient's tear film and corneal shape.

Abstract: A retinal imager for imaging a retina of an eye includes an illumination source operable to generate illumination light and a beam splitter operable to receive the illumination light and direct the illumination light along an optical axis. The retinal imager also includes a field lens disposed along the optical axis and an objective lens disposed along the optical axis and operable to contact a cornea of the eye. An aerial image is formed adjacent to the field lens. The retinal imager further includes an image sensor and one or more lenses disposed along the optical axis between the beam splitter and the image sensor. The one or more lenses are operable to form a sensor image at the image sensor.

Abstract: An optical coherence tomograph that provides wavelength tunable source radiation and an illumination and measurement beam path, a dividing element that divides source radiation into illumination radiation and reference radiation, and collects measurement radiation. The illumination and measurement beam path has scanner. A detection beam path receives measurement radiation and reference radiation and conducts them onto at least one flat panel detector in a superposed manner. A beam splitter separates the measurement radiation from the illumination radiation. The beam splitter conducts the separated measurement radiation to the detection beam path and sets the numerical aperture of the illumination of the illumination field in the eye. An optical element sets the numerical aperture with which the measurement radiation is collected in the eye and a multi-perforated aperture defines the size of an object field and a number of object spots, from which the measurement radiation reaches the flat panel detector.

Abstract: Methods for improved acquisition and processing of optical coherence tomography (OCT) angiography data are presented. One embodiment involves improving the acquisition of the data by evaluating the quality of different portions of the data to identify sections having non-uniform acquisition parameters or non-uniformities due to opacities in the eye such as floaters. The identified sections can then be brought to the attention of the user or automatically reacquired. In another embodiment, segmentation of layers in the retina includes both structural and flow information derived from motion contrast processing. In a further embodiment, the health of the eye is evaluating by comparing a metric reflecting the density of vessels at a particular location in the eye determined by OCT angiography to a database of values calculated on normal eyes.

Abstract: Systems and methods are described for measuring angular direction of individual photoreceptors in an eye. A light source is projected through the pupil of the eye onto the retina. An image of the light reflected back from the plurality of photoreceptors is captured at a first focal depth and then at a second focal depth, where the first focal depth is different than the second focal depth. At least one individual photoreceptor is identified in both images and a lateral difference of the position of the identified photoreceptor is measured. The angular direction of the photoreceptor is then calculated based on the measured lateral difference.

Abstract: A fundus camera for photographing a fundus of an eye that includes a plurality of light sources with differing frequencies for illuminating the fundus, a plurality of fixation lights configured to orient the fundus in varying positions, and an imaging sensor. The fundus camera further includes at least one processor configured to cause the illumination of the plurality of light sources and the plurality of fixation lights in a predetermined pattern to obtain a plurality of narrow bandwidth images of the fundus and to manipulate and stitch the resulting narrow bandwidth images into a composite color image.