Abstract: Real-Time Dosimetry System, RTDS, is dose measurement system consisting of an ionization chamber and electrometer with the ability to measure, record, and display the high radiation doses required to meet approved standards for sterilization of medical, industrial and food products.

Abstract: In a charged particle beam analyzer irradiating a charged particle beam to a sample in a vacuum container and detecting an X-ray generated from the sample to analyze the sample, two or more X-ray lenses configured in different manners are provided in the vacuum container. This no longer requires air opening in the vacuum container following X-ray lens replacement and also no longer requires vacuuming, making it possible to perform analysis with high efficiency and high sensitivity.

Abstract: The disclosure relates to systems and methods for interleaving operation of a standing wave linear accelerator (LINAC) for use in providing electrons of at least two different energy ranges, which can be contacted with x-ray targets to generate x-rays of at least two different energy ranges. The LINAC can be operated to output electrons at different energies by varying the power of the electromagnetic wave input to the LINAC, or by using a detunable side cavity which includes an activatable window.

Abstract: A method is proposed for accurate and efficient modeling of head scatter phase space for treatments with dynamic jaws. Specifically, the method enables the efficient calculation of the head scatter phase space in case of a dynamic treatment where jaws and MLC leaves move during the delivery. In one embodiment, the invention can be used to calculate the head scatter contribution during final dose calculation of dynamic treatments. This novel method also enables an accurate calculation of the head scatter contribution from optimal fluence and from jaw positions without having to calculate the leaf sequence. In this embodiment, the invention can be used in optimization of large field IMRT treatments.

Abstract: A radiotherapy system is disclosed, comprising a support for supporting a patient undergoing radiotherapy treatment, a gantry that is rotatable about an axis, a source of radiation mounted on the gantry and producing a beam of radiation directed towards a target region of the patient, a collimator coupled to said radiation source for collimating said radiation beam, the collimator comprising a plurality of beam-limiting elements, each movable to collectively define a shaped aperture through which the radiation beam passes, a portal imager mounted on the gantry opposite the radiation source for detecting the radiation after it has passed through the patient and generating corresponding images, and associated circuitry for controlling at least the gantry, the source, the collimator, and the portal imager, collating detected data comprising a plurality of images acquired from the imager including images at a plurality of angles of rotation of said gantry and images at a plurality of collimator shapes, and genera

Abstract: In one example, a method of examining a container is disclosed comprising detecting a potential threat within contents of a container using radiation scanning and disabling the potential threat with radiation. In another example, a method of examining a container is disclosed comprising scanning at least a portion of the container with a first radiation beam, detecting radiation interacting with contents of the container, identifying a potential threat contained based, at least in part, on the detected radiation, and disabling the potential threat with a dose of radiation from a second radiation beam. The potential threat may be a nuclear, chemical, and/or biological weapon, for example. Chemical and/or biological detectors may also be provided. The threat and/or electronics associated with the threat, may be disabled. Systems are also disclosed.

Abstract: This invention describes a system for generating multiple simultaneous tunable electron and photon beams and monochromatic x-rays for all field simultaneous radiation therapy (AFSRT), tumor specific AFSRT and screening for concealed elements worn on to the body or contained in a container. Inverse Compton scattering renders variable energy spent electron and tunable monochromatic x-rays. It's spent electron beam is reused for radiation with electron beam or to generate photon beam. Tumor specific radiation with Auger transformation radiation is facilitated by exposing high affinity tumor bound heavy elements with external monochromatic x-rays. Heavy elements like directly iodinated steroid molecule that has high affinity binding to estrogen receptor in breast cancer and to iodinated testosterone in prostate cancer or with directly implanted nanoparticles into the tumor are exposed with tuned external monochromatic x-rays for tumor specific radiation therapy.

Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

Abstract: Methods of treating wood and wood products include irradiating untreated wood having a first molecular weight with ionizing radiation to cause an increase in the molecular weight of a cellulosic component of the wood to a second, relatively higher molecular weight.

Abstract: Improved radiation devices and their associated fabrication and applications are described herein. The microirradiators generally include a non-radioactive conducting electrode, an insulating sheath, a radioactive source, and, optionally, a contact electrode. The microirradiators generally produce low absolute radiation levels with high radiation flux densities.

Abstract: A small tabletop stationary five-degree of freedom device such as a “robot” is used to define the treatment region by tracing the region under direct visualization and then to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other in a predetermined parallel or similar geometry, each source equipped with blocking and attenuation mechanisms, at a plurality of positions in a planar fashion across or through a selected treatment field, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue and can be used to treat regions on or below the surface of tissue, in a cavity and underlying region created following a surgical resection, on or below the surface of an internal cavity, hollow viscus,

Abstract: An apparatus for Flash X-ray irradiation of material includes a Flash X-ray source comprised of an electron gun and an anode. The electron gun comprises a field emission cold cathode having an electron emitting surface, and a grid for controlling electron flow from the cathode to the anode. The anode has an electron-receiving main surface and an X-ray emitting, oppositely facing main surface. The X-ray emitting surface, emits X-radiation into an irradiation volume. The X-ray emitting surface of the anode has orthogonally oriented first and second dimensions of greater than 2 millimeters each. A high voltage pulse power supply powers the Flash X-ray source. The electron gun, anode and high voltage pulse power supply are so constructed as to create sufficient X-radiation in said irradiation volume to achieve a desired level of irradiation of material in said volume.

Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues.

Abstract: A rotating irradiation therapy apparatus used for particle beam therapy includes a rotating gantry equipped with a charged particle beam irradiation device beam transport devices for guiding a charged particle beam to the irradiation device and a roller in contact with a ring member included in the rotating gantry and supporting the gantry. A front ring is disposed in contact with the roller of a rotating body support device at one end in the axial direction of the rotating gantry, and a rear ring is disposed in contact with the roller at the other end in the axial direction of the rotating gantry. At least one intermediate ring is disposed in a position different in the axial direction of the gantry between the front and rear rings and in contact with the roller.

Abstract: A low-density sensor panel assembly system is provided for use with remote marker assemblies that generates a marker signal and for use with a radiation therapy source that generates a radiation beam during radiation therapy. The system includes a sensor array having a layer of sensor coils arranged in a selected pattern and configured to receive the marker signal from the remote marker. A support panel is connected to the sensor array and retains each of the sensor coils in a substantially fixed and unmoving position relative to the other sensor coils. The sensor panel and sensor array define a low-density panel structure configured to dwell in the radiation beam during the radiation therapy.

Abstract: S-band, C-band or X-band microwave powered linear accelerators capable of delivering therapeutic photon and electron beams are mounted to a gantry with extensions to hold multiple accelerators and are combined with a kV CT for 3-D conformal—IMRT and IGRT to treat a patient by SSD or SAD methods and in a full circle. The invention's tertiary collimator system consists of semi-automated reusable custom field shaping with tungsten powder or melted Cerrobend blocks. The beam's intensity modulation is by means of simultaneous but independently operating multiple accelerators. This system's multiple accelerators enable to avoid interrupted subfractionated radiation therapy to each treatment fields. Hence its effective dose rate at the tumor site is high. The improved radiobiology reduces the total radiation dose to treat a tumor, reducing the incidence of developing second primary tumors is also minimized.

Abstract: An operation room may comprise both an object scanning apparatus for examining an object using x-ray radiation and an irradiation component for treating an object using particle radiation. A support article upon which the object may reside during (both) the examination and treatment may be configured to rotate about an axis substantially perpendicular to a plane through which x-ray radiation travels, may be configured to tilt with respect to the axis, and/or may be configured to yaw with respect to the axis. In this way, the relative orientation of the support article and the object remain substantially constant during the examination and treatment to facilitate treating a desired area of the object.

Abstract: Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.

Abstract: Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.

Abstract: The invention is directed to a radiation therapy method, and in particular, to a method of conducting an intensity modulated arc therapy (IMAT). The invention provides a planning technique that translates traditional static fixed-field IMRT plans into deliverable IMAT plans and allows IMAT to be realized as a routine clinical delivery technique.

Abstract: A medical accelerator system is provided for simultaneous radiation therapy to all treatment fields. It provides the single dose effect of radiation on cell survival. It eliminates the inter-field interrupted, subfractionated fractionated radiation therapy. Single or four beams S-band, C-band or X-band accelerators are connected to treatment heads through connecting beam lines. It is placed in a radiation shielding vault which minimizes the leakage and scattered radiation and the size and weight of the treatment head. In one version, treatment heads are arranged circularly and connected with the beam line. In another version, a pair of treatment heads is mounted to each ends of narrow gantries and multiple such treatment heads mounted gantries are assembled together. Electron beam is steered to all the treatment heads simultaneously to treat all the fields simultaneously.

Abstract: The present invention provides a system 10 for irradiating a breast 20 of a patient 22. The system 10 comprises a gantry 12 rotatable about a horizontal axis 14 and comprising a radiation source 16 for generating a radiation beam 18 and a detector 24 spaced from the radiation source 16, and a barrier 26 disposed between the patient 22 and the gantry 12. The barrier 26 is provided with an opening 30 adapted to allow a breast 20 passing therethrough to be exposed to the radiation beam 18. In some embodiments, the barrier 26 is provided with an opening 30 adapted to allow both the breast 20 and the tissue leading from the breast to axilla and the muscle tissue of the adjacent chest wall passing therethrough to be exposed to the radiation beam 18.

Abstract: An attenuated soft x-ray neutralizer for neutralizing aerosols. The apparatus includes a soft x-ray emitter that emits soft x-rays into an aerosol conditioning chamber. An attenuating window may be included that reduces the intensity of the soft x-rays that bombard the aerosol, thus generating fewer radiolytically generated particles. Another way to reduce or control the intensity of the soft x-rays is to control emission of the cathode in the soft x-ray emitter. The reduced intensity of the soft x-rays was found by experiment to satisfactorily condition an aerosol stream without substantial radiolytic generation of particles precipitation.

Abstract: An X-ray convergence element and an X-ray irradiation device including the X-ray convergence element are provided. The X-ray convergence element can extend a working distance from an exit-side opening end thereof to a specimen, and can perform analysis of the specimen with rough surface, a fluorescent X-ray analysis, and a X-ray diffraction analysis, regardless of a size of the specimen. An X-ray blocking member 23 is provided with three supporting members 233 for supporting the X-ray blocking member 23, which extend from an annular member 232 having approximately the same diameter as a diameter of an entrance-side opening end (outer diameter of a capillary 20) toward the center of the X-ray blocking member 23 to fix the annular member 232 to the capillary 20. The annular member 232, the supporting members 233, and the X-ray blocking member 23 are integrally formed of a metal that shields X-rays, such as tantalum, tungsten, or molybdenum.

Abstract: Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.

Abstract: The invention concerns a device for monitoring an imaging or radiotherapy unit (1) for treating members of the human body subject to displacements related to movements of the diaphragm. The invention is characterized in that said monitoring device is designed to enable, in a prior preparation phase, to store two values, called rest value and triggering value, respectively representing, for each patient, of his suspended ventilatory level and an inhalation or exhalation ventilatory level, triggering acquisition of images or irradiation, then, during the real monitoring of the unit (1), in commanding an image or irradiation acquisition, once the correspondence between the measured value of the suspended ventilatory level and the stored rest value has been established, and only when the correspondence between the measured respiratory value of the patient and the stored triggering value has been subsequently established.

Abstract: A particle therapy system is provided. The particle therapy system includes an imaging unit and a rotatable gantry with an irradiation unit. The irradiation unit projects into an irradiation room delimited by a wall. The imaging unit is arranged on a C-arm. The C-arm is operable to be moved between a retracted parking position and an extended diagnostic position for imaging purposes.

Abstract: Systems, methods, and other modalities are described for (a) obtaining an indication relating to an emission module (which may be dangerous, e.g.) or its user (who may be untrained, e.g.) and for (b) configuring the module or causing an irradiation (for imaging, e.g.) in response to the indication.

Abstract: The present disclosure describes a self-contained irradiator comprising at least one X-ray source inside a shielded enclosure, the one or more sources each operable to emit X-ray flux across an area substantially equal to the proximate facing surface area of material placed inside the enclosure to be irradiated. The irradiator may have multiple flat panel X-ray sources disposed, designed or operated so as to provide uniform flux to the material being irradiated. The advantages of the irradiator of the present disclosure include compactness, uniform flux doses, simplified thermal management, efficient shielding and safety, the ability to operate at high power levels for sustained periods and high throughput.

Abstract: A method for conducting irradiation of all logs of a whole vehicle with X-rays as a phytosanitary treatment may include: connecting a traction device and a goods carrying vehicle outside a shielding door; opening the door; the traction device pulling the vehicle into a tunnel; closing the shielding door; upon the vehicle reaching an irradiation region, accelerators generating X-rays; the traction device pulling the vehicle to pass through the irradiation region; stopping the X-rays; opening the door; the traction device pulling the vehicle away from the irradiation treatment tunnel; and disconnecting the traction device from the vehicle. A device may include a shielding structure, a tunnel formed therethrough; a rail along the tunnel; accelerators within the tunnel; and a traction device for pulling a vehicle carrying goods for quarantine treatment, the accelerators symmetrically arranged at both sides of and on the top of an irradiation region in the tunnel.

Abstract: The invention relates to a patient-positioning device for positioning a patient in an irradiation position in a radiation therapy arrangement, in particular in a particle radiation therapy arrangement comprising a patient supporting module, which is provided with a patient supporting device for holding the patient in a body holder where the irradiation is to be carried out, wherein, said patient supporting device is mounted on a base unit in such a way that it is rotatable about an axis by means of a bearing, said base unit is provided with a coupling element, the inventive device is also provided with a positioning arm, which comprises several joints and a coupling point for coupling the coupling element and for freely positioning the patient in any predefined irradiation position by adjusting the angle of rotation of the patient supporting module.

Abstract: Disclosed is a method for modifying wettability of a surface of an inorganic material, the method comprising the steps of: preparing an inorganic material with a surface; and charging the surface of the inorganic material with positive surface charges obtained from photoelectron-emission by an X-ray irradiation to the surface of the inorganic material.

Abstract: A CT scanner and method are designed to scan a preselected portion of a patient's lower abdomen. The scanner may include a source and detector array designed to rotate about a rotation axis oriented substantially parallel to or coincident with the hips of the a patient so that a scanning plane does not pass through the patient's pelvic bones Higher-resolution image CT images can be achieved by using a detector array of the type used for digital radiography. The presence of prostatic cancer can be detected by first injecting the patient with a material including a high contrast material for X-ray imaging and a material for binding the high contrast material to a specific biological site if present in the preselected portion of the lower abdomen of the patient; and generating a CT image of the preselected portion of the lower abdomen.

Abstract: An inspection system provides for inspection of cargo containers. A scanning tunnel has an entrance and an exit, a plurality of scanning entrance doors, each having an open position and a closed position, at least one of the plurality of scanning entrance doors interior to the scanning tunnel; a plurality of scanning exit doors, each having an open position and a closed position, at least one of the plurality of scanning exit doors interior to the scanning tunnel. A scanner is adapted to scan the contents of a container inside the scanning tunnel when at least one of the plurality of scanning entrance doors is in the closed position and at least one of the plurality of scanning exit doors is in the closed position. A carrier carries the container through the tunnel.

Abstract: A method and apparatus for identifying and tagging a target, such an individual or an item, are described that provide an improved mechanism for identifying the target without alerting the target. In this regard, a method and apparatus can irradiate the target so as to create a radioisotope signature for the target. By thereafter monitoring the radioisotope signature, the target can be identified and tracked in a covert manner.

Abstract: A radiotherapy system includes: a waveguide, an adjustable waveguide, and a non-reciprocal circuit element. The waveguide transmits a high-frequency wave from a high-frequency power source to an acceleration tube. The adjustable waveguide is included in said waveguide and transforms a part of said waveguide. The non-reciprocal circuit element is provided between said acceleration tube and said adjustable waveguide in said waveguide. Said acceleration tube accelerates charged particles for generating therapeutic radiation by using said high-frequency wave.

Abstract: A method of automatically optimizing an inverse treatment plan by referencing data from an accepted plan library.

Abstract: A system for treating an ocular tumor having a cone, a collimator, a light source and a camera is disclosed. The cone includes a cone input and a cone output and is capable of being mounted and un-mounted to a treatment nozzle. The cone input receives radiation from the treatment nozzle for the treatment of the ocular tumor. The collimator is coupled to the cone output and configured to collimate radiation received by the cone output. This collimated radiation is directed to the patient having the ocular tumor. The light source coupled to the cone. The light source is configured to provide a focusing point of the eye of the patient. A camera coupled to the cone monitors the position of the eye of the patient.

Abstract: A method is provided for decontaminating biological pathogens residing in an enclosure of an electronic device. The method includes: identifying materials used to encase the enclosure of the electronic device; tailoring x-ray radiation to penetrate the materials encasing the enclosure; and directing x-ray radiation having a diffused radiation angle towards the electronic device.

Abstract: In a method for correction of an image in a series of images acquired with an x-ray detector; wherein the x-ray detector is composed of a number of detector elements and an acquired image is composed of image elements associated with the detector elements, a series of detector signals is generated in a detector element by x-ray radiation, the detector signals respectively exhibiting a detector-specific temporal decay curve; and an image element to be corrected and acquired over a predetermined acquisition interval contains signal portions of the current and preceding detector signals acquired during this acquisition interval. By calculating signal portions of preceding detector signals acquired in the acquisition interval and subtracting them from the image element to be corrected, the image quality of an image from a series of images acquired with a digital image acquisition apparatus is improved.

Abstract: Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.

Abstract: An X-ray device for irradiating a beam of X-rays on an object to capture an X-ray image of the object is smaller in size and weight than conventional ones. The X-ray device includes an X-ray tube for generating the beam of X-rays and irradiating the beam of X-rays on the object, a shutter arranged around an X-ray irradiation axis for regulating an X-ray irradiation region on which the beam of X-rays is irradiated through the object, and a visual indicator unit arranged on the shutter for movement together with the shutter, the visual indicator unit being designed to visually indicate the X-ray irradiation region. In the X-ray device, the X-ray irradiation region is visually indicated by laser light without having to use a lamp otherwise provided between the X-ray tube and the shutter.

Abstract: A system for detecting and classifying small amounts of explosives and other controlled substances while rejecting confounders, including a source/detector array formed of a plurality of sources and a plurality of detectors, a signal processor coupled to the source/detector array for processing data received from the detectors, a classifier coupled to the signal processor for classifying data received from the signal processor according to a plurality of algorithms, a maximal rejection classifier coupled to the classifier; and a declarative decision module coupled to the maximal rejection classifier for rendering an accurate decision regarding the contents of the object is provided. The apparatus includes an enclosure, a shield layer disposed within the enclosure, a cavity disposed within the shield layer, a plurality of neutron sources and a detection array disposed within the cavity, and a transport mechanism for moving objects through the cavity past the sources and detection array.

Abstract: The present invention refers to a radiation system (1) comprising an excentric gantry (100) arranged in connection with multiple treatment rooms (61-68) separated by radiation-shielding separating members (71-78). A movable rotation head (120) is connected to the gantry (100) and is able to move between, and direct a radiation beam (110) into, the treatment rooms (61-68). A simulator head (200-1 to 200-8) is preferably arranged together with the radiation system so it can be used in each respective treatment room (61-68). In such a case, while a first subject (40-1) is being irradiated in a first room (61), a treatment set-up procedure, including correct positioning of subjects (40-2 to 40-8) and irradiation simulation, can simultaneously take place for the other subjects (40-2 to 40-8) in the other treatment rooms (62 to 68).

Abstract: A method for routine monitoring and quality assurance of field asymmetry of high energy circular radiation beam producing equipment. The quality assurance process of field symmetry for devices such as stereotactic radiosurgery (SRS) systems is simplified by directly measuring the integration of the half-beam profile. The method of the invention provides that the field symmetry is obtained by positioning the tip of an ion chamber, with a collecting length approximately half the diameter of the beam, at the central axis of the beam, and rotating the ion chamber at varying angular positions, acquiring and comparing readings at desired angular positions. Each pair of readings from positions 180 degrees opposed from each other, are plugged into the equation, Asymmetry=2(R1?R2)/(R1+R2) to compute asymmetry.

Abstract: A method is provided for decontaminating biological pathogens in a contaminated environment. The method includes: tailoring x-ray radiation to match the absorption characteristics of a contaminated environment; generating x-ray radiation having a diffused radiation angle in accordance with the absorption characteristics of the contaminated environment; and directing the x-ray radiation towards the contaminated environment.

Abstract: A system to provide enhanced computational efficiency in determining dose in a media of varying density from a high-energy radiation-beam for radiation treatment, program product, and related methods are provided. The system can include a radiation treatment planning computer and radiation treatment planning program product adapted to enhance optimization of a radiation treatment plan for delivering radiation to a complex medium defining a patient volume.

Abstract: A device for irradiating tissue encompassing at least one electron source for generating an electron beam, numerous radiation heads that are firmly and annularly arranged in a supporting frame around an isocenter of the device and emit radiation towards the isocenter, and one beam guidance system to guide the electron beam in the housing towards the radiation heads. The beam guidance system has been built as a polygon, especially as a pentagon arranged like a ring around the isocenter, in which case media for deflecting the electron beam have been placed at every corner point of the polygon.

Abstract: Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements, for example, gold or iron, from these contrast agents, even small quantities, leads to a major dose increase in target tissue when combined with in vivo calibration of the amount of contrast agent. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. The technique is enhanced by employing oil-based contrast agents, which will remain in the target much longer than conventional agents. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue.

Abstract: Methods are disclosed for assessing the condition of a cartilage in a joint, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. Information on thickness of cartilage and curvature of cartilage or subchondral bone can be used to plan therapy. Information on movement pattern can be used to plan therapy.